The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The FoxO–Autophagy Axis in Health and Disease
Abstract
Autophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion with lysosomes. Independently of transactivation, cytosolic FoxO proteins induce autophagy by directly interacting with autophagy proteins. Autophagy is also controlled by FoxOs through epigenetic mechanisms. Moreover, FoxO proteins can be degraded directly or indirectly by autophagy. Cutting-edge evidence is reviewed that the FoxO-autophagy axis plays a crucial role in health and disease.
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Cites
Biological Functions of Autophagy Genes: A Disease Perspective
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Redox regulation of FoxO transcription factors
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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
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Beige adipocyte maintenance is regulated by autophagy-induced mitochondrial clearance
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Foxo1 integrates insulin signaling with mitochondrial function in the liver
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Self-citationMatsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan0746 · Cited by 271
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Asymptomatic hyperuricaemia: a silent activator of the innate immune system
Joosten, L. A. B., Crişan, T. O., Bjornstad, P., & Johnson, R. J. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0334-3 · Cited by 319
Alves, R., Gonçalves, A. C., Rutella, S., Almeida, A. M., De Las Rivas, J., Trougakos, I. P., & Sarmento Ribeiro, A. B. (2021) · Cancers · doi:10.3390/cancers13194820 · Cited by 204
ApoE4 attenuates autophagy via FoxO3a repression in the brain
Sohn, H.-Y., Kim, S.-I., Park, J.-Y., Park, S.-H., Koh, Y. H., Kim, J., & Jo, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-97117-6 · Cited by 54
A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease
Chen, H., Chen, F., Jiang, Y., Zhang, L., Hu, G., Sun, F., Zhang, M., Ji, Y., Chen, Y., Che, G., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.881239 · Cited by 19
Metadata
- Authors
- Cheng, Z.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 30
- Issue
- 9
- Pages
- 658-671
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2969381424
- Cited by
- 255
- References
- 17
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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