Cited by 271Osteoarthritis Treatment and MechanismsFOXO transcription factor regulationProteoglycans and glycosaminoglycans research

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

Open access
Matsuzaki, Tokio, Alvarez-Garcia, Oscar, Mokuda, Sho, Nagira, Keita, Olmer, Merissa, Gamini, Ramya, Miyata, Kohei, Akasaki, Yukio +3 more·2018·Science Translational Medicine

Abstract

and synergized with transforming growth factor-β stimulation. In OA chondrocytes, overexpression of FoxO1 reduced inflammatory mediators and cartilage-degrading enzymes, increased protective genes, and antagonized interleukin-1β effects. Our observations suggest that FoxO play a key role in postnatal cartilage development, maturation, and homeostasis and protect against OA-associated cartilage damage.

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Authors
Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., & Lotz, M. K.
Affiliations
  • Scripps Research Institute (US)
  • Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Corresponding author
Lotz, Martin K.
Venue
Science Translational Medicine
Published
2018-02-14
Volume
10
Issue
428
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2786308277
Cited by
271
References
65
Citations by year
2026: 15 · 2025: 24 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 47 · 2020: 23 · 2019: 19 · 2018: 12
FWCI
21.50
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (award315935, AG007996, award315936, AG049617)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Keywords
FOXO transcription factors, FOXO1, autophagy, proteoglycan 4, cartilage homeostasis, osteoarthritis, chondrocytes, chondrogenesis, IL-1β, TGF-beta, cartilage degeneration, inflammation
MeSH terms
Proteoglycan 4, Animals, Animals, Newborn, Autophagy, Bone and Bones, Cartilage, Articular, Cell Survival, Gene Expression Regulation, Growth Plate, Homeostasis, Humans, Osteoarthritis, Proteoglycans, Transforming Growth Factor beta, Gene Deletion, Mice, Knockout, Chondrocytes, Cell Proliferation, Body Size, Forkhead Transcription Factors, Interleukin-1beta

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