FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis
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and synergized with transforming growth factor-β stimulation. In OA chondrocytes, overexpression of FoxO1 reduced inflammatory mediators and cartilage-degrading enzymes, increased protective genes, and antagonized interleukin-1β effects. Our observations suggest that FoxO play a key role in postnatal cartilage development, maturation, and homeostasis and protect against OA-associated cartilage damage.
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Activating FoxO transcription factors protects against osteoarthritis-associated cartilage damage.
“Activating FoxO transcription factors protect against OA-associated cartilage damage [26].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [26]
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Self-citation
- Authors
- Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., & Lotz, M. K.
- Affiliations
- Scripps Research Institute (US)
- Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
- Corresponding author
- Lotz, Martin K.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-02-14
- Volume
- 10
- Issue
- 428
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6204214
- OpenAlex
- W2786308277
- Cited by
- 271
- References
- 65
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 38 · 2023: 47 · 2022: 46 · 2021: 47 · 2020: 23 · 2019: 19 · 2018: 12
- FWCI
- 21.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award315935, AG007996, award315936, AG049617)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- FOXO transcription factors, FOXO1, autophagy, proteoglycan 4, cartilage homeostasis, osteoarthritis, chondrocytes, chondrogenesis, IL-1β, TGF-beta, cartilage degeneration, inflammation
- MeSH terms
- Proteoglycan 4, Animals, Animals, Newborn, Autophagy, Bone and Bones, Cartilage, Articular, Cell Survival, Gene Expression Regulation, Growth Plate, Homeostasis, Humans, Osteoarthritis, Proteoglycans, Transforming Growth Factor beta, Gene Deletion, Mice, Knockout, Chondrocytes, Cell Proliferation, Body Size, Forkhead Transcription Factors, Interleukin-1beta
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