Cited by 542Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsAdipose Tissue and Metabolism

The obese adipose tissue microenvironment in cancer development and progression

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Quail, Daniela F., Dannenberg, Andrew J.·2019·Nature Reviews Endocrinology

Abstract

Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These associations are driven, in part, by metabolic and inflammatory changes in adipose tissue that disrupt physiological homeostasis both within local tissues and systemically. However, the mechanisms underlying the obesity-cancer relationship are poorly understood. In this Review, we describe how the adipose tissue microenvironment (ATME) evolves during body-weight gain, and how these changes might influence tumour initiation and progression. We focus on multiple facets of ATME physiology, including inflammation, vascularity and fibrosis, and discuss therapeutic interventions that have the potential to normalize the ATME, which might be translationally relevant for cancer prevention and therapy. Given that the prevalence of obesity is increasing on an international scale, translational research initiatives are urgently needed to provide mechanistic explanations for the obesity-cancer relationship, and how to best identify high-risk individuals without relying on crude measures, such as BMI.

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  • Variably increased risk has been reported for cancers of the postmenopausal breast, endometrium, ovary, gall bladder, stomach, esophagus, kidney, thyroid (papillary, follicular, and anaplastic but not medullary), colon, bladder, and pancreas.

    “Variably increased risk has been reported for cancers of the breast (postmenopausal) endometrium ovary gall bladder, stomach and esophagus, kidney, thyroid (papillary, follicular, and anaplastic but not medullary), colon, bladder, and pancreas.1733,1734,1739–1752”

    From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1744]

    The Abstract (page unavailable) reports that excess body fatness is associated with increased risk of 13 cancer types in adults, supporting the general risk claim. It does not identify those types or substantiate the sentence’s full list, particularly the distinction between thyroid cancer subtypes; searches for those subtypes and the listed cancer sites did not establish that detail. (LLM, conf=0.84)

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Authors
Quail, D. F., & Dannenberg, A. J.
Affiliations
  • McGill University (CA)
  • Weill Cornell Medicine (US)
Corresponding author
  • Quail, Daniela F.
  • Dannenberg, Andrew J.
Venue
Nature Reviews Endocrinology
Published
2018-11-20
Volume
15
Issue
3
Pages
139-154
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2900496024
Cited by
542
References
203
Citations by year
2026: 59 · 2025: 62 · 2024: 74 · 2023: 81 · 2022: 74 · 2021: 107 · 2020: 65 · 2019: 18 · 2018: 2
FWCI
6.86
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA215797, U54CA210184)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
obesity, adipose tissue microenvironment, tumor progression, tumor initiation, adipose tissue inflammation, adipose tissue fibrosis, adipose tissue metabolism, weight gain, cancer prevention, obesity as cancer risk factor
MeSH terms
Adipose Tissue, Animals, Cell Transformation, Neoplastic, Female, Humans, Male, Neoplasms, Obesity, Sensitivity and Specificity, Comorbidity, Body Mass Index, Prevalence, Adipocytes, Risk Assessment, Mice, Tumor Microenvironment

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