Reference Interval Mean Clotting Times Should Not Be Used to Calculate Lupus Anticoagulant Mixing Test Ratios Unless They Match the Normal Pooled Plasma Clotting Time
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NPP characteristics can influence mixing test results; some NPPs have shorter clotting times, requiring a stronger LA for a mixing test to be positive.
“Finally, NPP characteristics can influence the results of mixing tests, as some NPPs have shorter clotting times, requiring a stronger LA for a mixing test be positive [107].”
From Lupus Anticoagulant Detection under the Magnifying Glass (2023) · cites this paper as [107]
Cites
Update of the guidelines for lupus anticoagulant detection
PENGO, V., TRIPODI, A., REBER, G., RAND, J. H., ORTEL, T. L., GALLI, M., & DE GROOT, P. G. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03555.x · Cited by 1,197 · see citing works
Mixing studies in lupus anticoagulant testing are required at least in some type of samples
Devreese, K. M. J., & de Laat, B. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13020 · Cited by 63 · cited 2× · see citing works
“However, mixing tests increase diagnostic specificity and confidence, and are useful when other coagulation disturbances are known or suspected to be present, or where a LA is sufficiently potent achieve a degree of resistance against the overwhelming effect of high PL concentration confirmatory reagents [2,5,8].”
BackgroundMoore, G. W., Culhane, A. P., Daw, C. R., Noronha, C. P., & Kumano, O. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.01.019 · Cited by 42 · see citing works
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Mixing studies for lupus anticoagulant: mostly no, sometimes yes
Moore, G. W. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-1248 · Cited by 19 · see citing works
Self-citationLupus Anticoagulant Detection under the Magnifying Glass
Molinari, A. C., Martini, T., Banov, L., Ierardi, A., Leotta, M., Strangio, A., & Santoro, R. C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206654 · Cited by 9 · see citing works
“Finally, NPP characteristics can influence the results of mixing tests, as some NPPs have shorter clotting times, requiring a stronger LA for a mixing test be positive [107].”
BackgroundAnalytical dilemmas in lupus anticoagulant detection
Moore, G. W. (2023) · Exploration of Immunology · doi:10.37349/ei.2023.00104 · Cited by 5 · see citing works
Self-citation
- Authors
- Moore, G. W.
- Affiliations
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Corresponding author
- Moore, Gary W.
- ORCID
- Moore, Gary W.
- Venue
- Thrombosis Research
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 159
- Pages
- 16-18
- ISSN
- 0049-3848 (ISSN-L)
- OpenAlex
- W2754629388
- Cited by
- 8
- References
- 3
- Citations by year
- 2025: 1 · 2023: 4 · 2022: 2 · 2019: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- lupus anticoagulant, antiphospholipid syndrome, thrombosis
- MeSH terms
- Blood Coagulation Tests, Humans, Plasma, Lupus Coagulation Inhibitor
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