Mammalian cyclin-dependent kinases

Specific protection against breast cancers by cyclin D1 ablation

Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Malumbres, M., Sotillo, R., Santamarı́a, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., & Barbacid, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.002 · Cited by 793

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Rane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., & Barbacid, M. (1999) · Nature Genetics · doi:10.1038/8751 · Cited by 700

Mouse development and cell proliferation in the absence of D-cyclins

Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647

Pocket proteins and cell cycle control

Cobrinik, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208619 · Cited by 601

Targeted disruption of the three Rb-related genes leads to loss of G 1 control and immortalization

Sage, J., Mulligan, G. J., Attardi, L. D., Miller, A., Chen, S., Williams, B., Theodorou, E., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.843200 · Cited by 582

Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions

Dannenberg, J.-H., van Rossum, A., Schuijff, L., & te Riele, H. (2000) · Genes & Development · doi:10.1101/gad.847700 · Cited by 413

Wide spectrum of tumors in knock‐in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

Sotillo, R., Dubus, P., Martn, J., de la Cueva, E., Ortega, S., Malumbres, M., & Barbacid, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6637 · Cited by 208

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957

Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Zhang, J., Bu, X., Wang, H., Zhu, Y., Geng, Y., Nihira, N. T., Tan, Y., Ci, Y., Wu, F., Dai, X., et al. (2018) · Nature · doi:10.1038/nature25015 · Cited by 1,013

Regulation of Homologous Recombination in Eukaryotes

Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066

Discovery of drug mode of action and drug repositioning from transcriptional responses

Iorio, F., Bosotti, R., Scacheri, E., Belcastro, V., Mithbaokar, P., Ferriero, R., Murino, L., Tagliaferri, R., Brunetti-Pierri, N., Isacchi, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000138107 · Cited by 816

Genome-wide association analysis identifies 20 loci that influence adult height

Initiative, D. G., Weedon, M. N., The Wellcome Trust Case Control Consortium, Cambridge GEM Consortium, Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.121 · Cited by 826

Therapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure

Dean, J. L., Thangavel, C., McClendon, A. K., Reed, C. A., & Knudsen, E. S. (2010) · Oncogene · doi:10.1038/onc.2010.154 · Cited by 393

MicroRNA‐124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast‐like synoviocytes from patients with rheumatoid arthritis

Nakamachi, Y., Kawano, S., Takenokuchi, M., Nishimura, K., Sakai, Y., Chin, T., Saura, R., Kurosaka, M., & Kumagai, S. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24475 · Cited by 332

A statistical approach for identifying differential distributions in single-cell RNA-seq experiments

Korthauer, K. D., Chu, L.-F., Newton, M. A., Li, Y., Thomson, J., Stewart, R., & Kendziorski, C. (2016) · Genome Biology · doi:10.1186/s13059-016-1077-y · Cited by 273

Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma

Pierson, J., Hostager, B., Fan, R., & Vibhakar, R. (2008) · Journal of Neuro-Oncology · doi:10.1007/s11060-008-9624-3 · Cited by 233

CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

Tigan, A.-S., Bellutti, F., Kollmann, K., Tebb, G., & Sexl, V (2016) · Oncogene · doi:10.1038/onc.2015.407 · Cited by 204

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

Bettayeb, K., Oumata, N., Echalier, A., Ferandin, Y., Endicott, J. A., Galons, H., & Meijer, L. (2008) · Oncogene · doi:10.1038/onc.2008.191 · Cited by 184

Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor

Manuel, M. N., Mi, D., Mason, J. O., & Price, D. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00070 · Cited by 153

Cdk2 is required for p53-independent G2/M checkpoint control

Chung, J. H., & Bunz, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000863 · Cited by 105

Sigma-2 ligands induce tumour cell death by multiple signalling pathways

Zeng, C., Rothfuss, J., Zhang, J., Chu, W., Vangveravong, S., Tu, Z., Pan, F., Chang, K. C., Hotchkiss, R., & Mach, R. H. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.602 · Cited by 94

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation

Lopez-Mejia, I. C., Lagarrigue, S., Giralt, A., Martinez-Carreres, L., Zanou, N., Denechaud, P.-D., Castillo-Armengol, J., Chavey, C., Orpinell, M., Delacuisine, B., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.034 · Cited by 71

Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling

An, Y., Kang, Q., Zhao, Y., Hu, X., & Li, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072042 · Cited by 71

Cdc2: A monopotent or pluripotent CDK?

Hu, X., & Moscinski, L. C. (2011) · Cell Proliferation · doi:10.1111/j.1365-2184.2011.00753.x · Cited by 69

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle

Li, Z., Tian, X., Ji, X., Wang, J., Chen, H., Wang, D., & Zhang, X. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000288 · Cited by 59

Human Eukaryotic Release Factor 3a Depletion Causes Cell Cycle Arrest at G1 Phase through Inhibition of the mTOR Pathway

Chauvin, C., Salhi, S., & Jean-Jean, O. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00035-07 · Cited by 58

Construction of a polycystic ovarian syndrome (PCOS) pathway based on the interactions of PCOS-related proteins retrieved from bibliomic data

Mohamed-Hussein, Z.-A., & Harun, S. (2009) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-6-18 · Cited by 46

Cyclin D3 Mediates Synthesis of a Hyaluronan Matrix That Is Adhesive for Monocytes in Mesangial Cells Stimulated to Divide in Hyperglycemic Medium

Ren, J., Hascall, V. C., & Wang, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806430200 · Cited by 41

Cyclers’ kinases in cell division: from molecules to cancer therapy

Milletti, G., Colicchia, V., & Cecconi, F. (2023) · Cell Death & Differentiation · doi:10.1038/s41418-023-01196-z · Cited by 39

Cdk5 Levels Oscillate during the Neuronal Cell Cycle

Zhang, J., Li, H., Zhou, T., Zhou, J., & Herrup, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.343152 · Cited by 34

Histone Deacetylase 3 Regulates Cyclin A Stability

Vidal-Laliena, M., Gallastegui, E., Mateo, F., Martínez-Balbás, M., Pujol, M. J., & Bachs, O. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458323 · Cited by 34

First BRET‐based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors

Corbel, C., Wang, Q., Bousserouel, H., Hamdi, A., Zhang, B., Lozach, O., Ferandin, Y., Tan, V. B. C., Guéritte, F., Colas, P., et al. (2011) · Biotechnology Journal · doi:10.1002/biot.201100138 · Cited by 35

T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes

Mueller, S., Huard, J., Waldow, K., Huang, X., D'Alessandro, L. A., Bohl, S., Börner, K., Grimm, D., Klamt, S., Klingmüller, U., et al. (2015) · Molecular Systems Biology · doi:10.15252/msb.20156032 · Cited by 23