PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,927

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1110 · Cited by 791

CIP2A inhibits PP2A in human malignancies

Junttila, M. R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Ala-aho, R., Nielsen, C., Ivaska, J., Taya, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.044 · Cited by 677

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

Neviani, P., Santhanam, R., Trotta, R., Notari, M., Blaser, B. W., Liu, S., Mao, H. C., Chang, J. S., Galietta, A., Uttam, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.015 · Cited by 481

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

Cho, U. S., & Xu, W. (2007) · Nature · doi:10.1038/nature05351 · Cited by 459

Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Y., Xing, Y., Chen, Y., Chao, Y., Lin, Z., Fan, E., Yu, J. W., Strack, S., Jeffrey, P. D., & Shi, Y. (2006) · Cell · doi:10.1016/j.cell.2006.11.033 · Cited by 450

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80963-0 · Cited by 442

PP2A: the expected tumor suppressor

Janssens, V., Goris, J., & Van Hoof, C. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.004 · Cited by 426

Regulation and role of the PP2A-B56 holoenzyme family in cancer

Peris, I., Romero-Murillo, S., Vicente, C., Narla, G., & Odero, M. D. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188953 · Cited by 30

Tristetraprolin and Its Role in Regulation of Airway Inflammation

Prabhala, P., & Ammit, A. J. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.095984 · Cited by 27

Phosphatase-regulated recruitment of the spindle- and Kinetochore-Associated (Ska) Complex to kinetochores

Sivakumar, S., & Gorbsky, G. J. (2017) · Biology Open · doi:10.1242/bio.026930 · Cited by 29

The subfamily II catalytic subunits of protein phosphatase 2A (PP2A) are involved in cortical microtubule organization

Yoon, J.-T., Ahn, H., & Pai, H. (2018) · Planta · doi:10.1007/s00425-018-3000-0 · Cited by 27

Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation

Lyons, S. P., Greiner, E. C., Cressey, L. E., Adamo, M. E., & Kettenbach, A. N. (2021) · Scientific Reports · doi:10.1038/s41598-021-02456-z · Cited by 27

SLE-Associated Defects Promote Altered T Cell Function

Crispín, J. C., Hedrich, C. M., Suárez‐Fueyo, A., Comte, D., & Tsokos, G. C. (2017) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2018025213 · Cited by 29

Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII

Levasseur, M., Dumollard, R., Chambon, J., Hebras, C., Sinclair, M., Whitaker, M., & McDougall, A. (2013) · Development · doi:10.1242/dev.096578 · Cited by 26

An axonemal PP2A B‐subunit is required for PP2A localization and flagellar motility

Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K., & Sale, W. S. (2011) · Cytoskeleton · doi:10.1002/cm.20519 · Cited by 26

Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks

Xu, G., Barrios‐Rodiles, M., Jerkić, M., Turinsky, A. L., Nadon, R., Vera, S., Voulgaraki, D., Wrana, J. L., Toporsian, M., & Letarte, M. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.033464 · Cited by 25

Preparing a cell for nuclear envelope breakdown: Spatio‐temporal control of phosphorylation during mitotic entry

Álvarez‐Fernández, M., & Malumbres, M. (2014) · BioEssays · doi:10.1002/bies.201400040 · Cited by 28

Cardiomyocyte specific deletion of PP2A causes cardiac hypertrophy.

Li, L., Fang, C., Xu, D., Xu, Y., Fu, H., & Li, J. (2016) · PubMed Central · Cited by 25

Microhomology-based CRISPR tagging tools for protein tracking, purification, and depletion

Lin, D., Chung, B. P., Huang, J., Wang, X., Huang, L., & Kaiser, P. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008422 · Cited by 22

PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis

Fujimitsu, K., & Yamano, H. (2019) · EMBO Reports · doi:10.15252/embr.201948503 · Cited by 24

Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome

Chu, H., Sacharidou, A., Nguyen, A. L., Li, C., Chambliss, K. L., Salmon, J. E., Shen, Y.-M., Lo, J. Y., Leone, G. W., Herz, J., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318941 · Cited by 24

Cellular inhibitors of Protein Phosphatase PP2A in cancer.

Haesen, D., Sents, W., Ivanova, E., Lambrecht, C., & Janssens, V. (2012) · Lirias · Cited by 24

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA

Brewer, A., Sathe, G. J., Pflug, B. E., Clarke, R. G., Macartney, T., & Sapkota, G. P. (2024) · iScience · doi:10.1016/j.isci.2024.109302 · Cited by 23

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

Pitman, M. R., Barr, R. K., Gliddon, B. L., Magarey, A. M., Moretti, P. A. B., & Pitson, S. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.11.001 · Cited by 23

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt

Suprynowicz, F. A., Kamonjoh, C. M., Krawczyk, E., Agarwal, S., Wellstein, A., Agboke, F. A., Choudhury, S., Liu, X., & Schlegel, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180897 · Cited by 22

Methylation of protein phosphatase 2A—Influence of regulators and environmental stress factors

Creighton, M. T., Kołton, A., Kataya, A. R. A., Maple‐Grødem, J., Averkina, I. O., Heidari, B., & Lillo, C. (2017) · Plant Cell & Environment · doi:10.1111/pce.13038 · Cited by 23

Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype

Kashani, E., & Vassella, E. (2022) · Cancers · doi:10.3390/cancers14215227 · Cited by 22

β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573

Ranieri, A., Kemp, E., Burgoyne, J. R., & Avkiran, M. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.12.016 · Cited by 23

Understanding the regulatory landscape of protein phosphatase 2A (PP2A): Pharmacological modulators and potential therapeutics

Neale, D. B., Morris, J. C., Verrills, N. M., & Ammit, A. J. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108834 · Cited by 25

Association of PPP2R1A with Alzheimer's disease and specific cognitive domains

Miron, J., Picard, C., Labonté, A., Auld, D. S., Breitner, J. C. S., & Poirier, J. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.06.008 · Cited by 21

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells

Cui, R., Jiang, N., Zhang, M., Du, S., Ou, H., Ge, R., Ma, D., & Zhang, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118858 · Cited by 21

PP2A interacts with KATANIN to promote microtubule organization and conical cell morphogenesis

Ren, H., Rao, J., Tang, M., Li, Y., Dang, X., & Lin, D. (2022) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13281 · Cited by 22

Targeting phosphatases: From molecule design to clinical trials

Guo, M., Li, Z., Gu, M., Gu, J., You, Q., & Wang, L. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.116031 · Cited by 23

Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A

Preuss, K., Pfreundschuh, M. G., Fadle, N., Regitz, E., Raudies, S., Murwaski, N., Ahlgrimm, M., Bittenbring, J. T., Klotz, M., Schäfer, K., et al. (2011) · Blood · doi:10.1182/blood-2011-04-351668 · Cited by 22

The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development

Hoffmeister, M., Prelle, C., Küchler, P., Kovacevic, I., Moser, M., Müller-Esterl, W., & Oess, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116150 · Cited by 21

Identification of the Adenovirus E4orf4 Protein Binding Site on the B55α and Cdc55 Regulatory Subunits of PP2A: Implications for PP2A Function, Tumor Cell Killing and Viral Replication

Mui, M. Z., Kucharski, M., Miron, M.-J., Hur, W. S., Berghuis, A. M., Blanchette, P., & Branton, P. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003742 · Cited by 21

Protein phosphatase 2A activity is required for functional adherent junctions in endothelial cells

Kása, A., Czikora, I., Verin, A. D., Gergely, P., & Csoŕtos, C. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.05.003 · Cited by 21

Light regulation of nitrate reductase by catalytic subunits of protein phosphatase 2A

Creighton, M. T., Sanmartín, M., Kataya, A. R. A., Averkina, I. O., Heidari, B., Nemie-Feyissa, D., Sánchez‐Serrano, J. J., & Lillo, C. (2017) · Planta · doi:10.1007/s00425-017-2726-4 · Cited by 21

Phosphorylation on the PPP2R5D B regulatory subunit modulates the biochemical properties of protein phosphatase 2A

Yu, U.-Y., & Ahn, J. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.4.263 · Cited by 21

Complex Phosphatase Regulation of Ca2+-activated Cl− Currents in Pulmonary Arterial Smooth Muscle Cells

Ayon, R. J., Sones, W. R., Forrest, A. S., Wiwchar, M., Valencik, M. L., Sanguinetti, A. R., Perrino, B. A., Greenwood, I. A., & Leblanc, N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050401 · Cited by 20

Inhibition of Protein Phosphatase 2A (PP2A) Prevents Mcl-1 Protein Dephosphorylation at the Thr-163/Ser-159 Phosphodegron, Dramatically Reducing Expression in Mcl-1-amplified Lymphoma Cells

Nifoussi, S. K., Ratcliffe, N. R., Ornstein, D. L., Kasof, G. M., Strack, S., & Craig, R. W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.587873 · Cited by 20

Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction

Yang, C., Bao, X., Zhang, L., Li, Y., Li, L., & Zhang, L. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.138 · Cited by 22

MHC Phosphopeptides: Promising Targets for Immunotherapy of Cancer and Other Chronic Diseases

Mahoney, K. E., Shabanowitz, J., & Hunt, D. F. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100112 · Cited by 20

Inhibition of PP2A enhances the osteogenic differentiation of human aortic valvular interstitial cells via ERK and p38 MAPK pathways

Xie, F., Li, F., Li, R., Liu, Z., Shi, J., Zhang, C., & Dong, N. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118086 · Cited by 19

Dephosphorylation of Sp1 at Ser-59 by Protein Phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole

Shimoyama, S., Kasai, S., Kahn‐Perlès, B., & Kikuchi, H. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.12.004 · Cited by 19

InAKTivation of insulin/IGF-1 signaling by dephosphorylation

Narasimhan, S. D., Mukhopadhyay, A., & Tissenbaum, H. A. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10072 · Cited by 19

Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells

Zhang, X., Damacharla, D., Ma, D., Qi, Y. A., Tagett, R., Drăghici, S., Kowluru, A., & Yi, Z. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.01.008 · Cited by 19

Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation

Zhang, Y., Zhang, J., Wang, E., Qian, W., Fan, Y., Feng, Y., Yin, H., Li, Y., Wang, Y., & Yuan, T. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx271 · Cited by 19

G Protein-Coupled Receptor Resensitization Paradigms

Gupta, M. K., Mohan, M. L., & Prasad, S. V. N. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.03.002 · Cited by 19

Effectiveness of intranasal vaccination against Angiostrongylus costaricensis using a serine/threonine phosphatase 2 A synthetic peptide and recombinant antigens

Solano, J., González-González, G., Pablos, L. M. D., dos Santos, M. F. B., Espino, A. M., Burgos, M., & Osuna, A. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.05.072 · Cited by 19

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

Luk, I. S. U., Bridgwater, C. M., Yu, A. Y. C., Boila, L. D., Yáñez-Bartolomé, M., Lampano, A., Hulahan, T. S., Boukhali, M., Kathiresan, M., Macarulla, T. M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj7685 · Cited by 19

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities

Sergienko, N. M., Donner, D. G., Delbridge, L. M. D., McMullen, J. R., & Weeks, K. L. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110213 · Cited by 19

Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

Löw, C., Quistgaard, E. M., Kovermann, M., Anandapadamanaban, M., Balbach, J., & Nordlund, P. (2014) · Biological Chemistry · doi:10.1515/hsz-2014-0106 · Cited by 18

Protein Phosphatase 2A (PP2A) Regulates Low Density Lipoprotein Uptake through Regulating Sterol Response Element-binding Protein-2 (SREBP-2) DNA Binding

Rice, L. M., Donigan, M., Yang, M., Liu, W., Pandya, D., Joseph, B. K., Sodi, V. L., Gearhart, T. L., Yip, J., Bouchard, M. J., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.570390 · Cited by 18

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells

Ding, Y., Yu, A., Tsokos, G. C., & Malek, T. R. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801570 · Cited by 17

The Interplay between PP2A and microRNAs in Leukemia

Ruvolo, P. P. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00043 · Cited by 17

Prediction of biological functions of Shewanella-like protein phosphatases (Shelphs) across different domains of life

Kutuzov, M. A., & Andreeva, A. V. (2011) · Functional & Integrative Genomics · doi:10.1007/s10142-011-0254-z · Cited by 16

Dissection of Cdk1–cyclin complexes in vivo

Ear, P. H., Booth, M. J., Abd-Rabbo, D., Kowarzyk, J., Hall, C., Chen, D., Vogel, J., & Michnick, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305420110 · Cited by 17

Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?

De, P. K., Carlson, J. H., Leyland-Jones, B. R., & Dey, N. (2015) · Europe PMC (PubMed Central) · Cited by 16

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Drouyer, M., Bolliger, M. F., Lobbestael, E., den Haute, C. V., Emanuele, M., Lefebvre, R., Sibran, W., Wit, T. D., Leghay, C., Mutez, E., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105426 · Cited by 16

Tau Phosphorylation Patterns in the Rat Cerebral Cortex After Traumatic Brain Injury and Sodium Selenate Effects: An Epibios4rx Project 2 Study

Saletti, P. G., Casillas-Espinosa, P. M., Lisgaras, C. P., Mowrey, W. B., Li, Q., Liu, W., Brady, R. D., Ali, I., Silva, J., Yamakawa, G. R., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0219 · Cited by 16

Visualization of Subunit Interactions and Ternary Complexes of Protein Phosphatase 2A in Mammalian Cells

Mo, S.-T., Chiang, S.-J., Lai, T.-Y., Cheng, Y.-L., Chung, C.-E., Kuo, S. C. H., Reece, K. M., Chen, Y.-C., Chang, N., Wadzinski, B. E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0116074 · Cited by 17

Protein carboxyl methylation and the biochemistry of memory

Li, Z., & Stock, J. B. (2009) · Biological Chemistry · doi:10.1515/bc.2009.133 · Cited by 16

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

Dovega, R., Tsutakawa, S. E., Quistgaard, E. M., Anandapadamanaban, M., Löw, C., & Nordlund, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101846 · Cited by 14

A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1

Sánchez, I., Piñol‐Jurado, P., Corral‐Juan, M., Pandolfo, M., & Matilla‐Dueñas, A. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt197 · Cited by 17

Greatwall Kinase, ARPP-19 and Protein Phosphatase 2A: Shifting the Mitosis Paradigm

Haccard, O., & Jessus, C. (2011) · Results and problems in cell differentiation · doi:10.1007/978-3-642-19065-0_11 · Cited by 16

PP2ACdc55is required for multiple events during meiosis I

Nolt, J. K., Rice, L. M., Ebert, C., Bisher, M. E., & Nickels, J. T. (2011) · Cell Cycle · doi:10.4161/cc.10.9.15485 · Cited by 16

Biology of the adenovirus E4orf4 protein: from virus infection to cancer cell death

Kleinberger, T. (2019) · FEBS Letters · doi:10.1002/1873-3468.13704 · Cited by 15

Expression and regulation of type 2A protein phosphatases and alpha4 signalling in cardiac health and hypertrophy

Eleftheriadou, O., Boguslavskyi, A., Longman, M. R., Cowan, J., Francois, A. A., Heads, R. J., Wadzinski, B. E., Ryan, A. J., Shattock, M. J., & Snabaitis, A. K. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0625-2 · Cited by 15

Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling

MacKay, K. B., Tu, Y., Young, S. G., & Clarke, S. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065967 · Cited by 14

Protein phosphatase methylesterase‐1 ( PME ‐1) expression predicts a favorable clinical outcome in colorectal cancer

Kaur, A., Elzagheid, A. I., Birkman, E., Avoranta, T., Kytölä, V., Korkeila, E. A., Syrjänen, K. J., Westermarck, J. K., & Sundström, J. T. T. (2015) · Cancer Medicine · doi:10.1002/cam4.541 · Cited by 14

Protein phosphatase 2A plays an important role in migration of bone marrow stroma cells

Chen, W., Wang, S., Xia, J., Huang, Z., Tu, X., & Shen, Z. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2624-7 · Cited by 14

The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway

Mui, M. Z., Zhou, Y., Blanchette, P., Chughtai, N., Knight, J. F., Gruosso, T., Papadakis, A. I., Huang, S., Park, M., Gingras, A., et al. (2015) · Journal of Virology · doi:10.1128/jvi.03710-14 · Cited by 14

Multifaceted roles ofArabidopsisPP6 phosphatase in regulating cellular signaling and plant development

Dai, M., Terzaghi, W., & Wang, H. (2013) · Plant Signaling & Behavior · doi:10.4161/psb.22508 · Cited by 14

Express yourself: how PP2A-B55Pab1 helps TORC1 talk to TORC2

Martín, R., & López‐Avilés, S. (2017) · Current Genetics · doi:10.1007/s00294-017-0721-8 · Cited by 15

Cdc14 activation requires coordinated Cdk1-dependent phosphorylation of Net1 and PP2A–Cdc55 at anaphase onset

Játiva, S., Calabria, I., Moyano-Rodríguez, Y., Garcia, P. S., & Queralt, E. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03086-5 · Cited by 14

A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism inDrosophila

Fischer, P., Preiss, A., & Nagel, A. C. (2016) · Fly · doi:10.1080/19336934.2016.1162362 · Cited by 14

Sensitization of FOLFOX-Resistant Colorectal Cancer Cells via the Modulation of a Novel Pathway Involving Protein Phosphatase 2A

Narayan, S., Raza, A., Mahmud, I., Koo, N., Garrett, T. J., Law, M. E., Law, B. K., & Sharma, A. K. (2021) · iScience · doi:10.1016/j.isci.2022.104518 · Cited by 13

Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal

Rodríguez‐Rodríguez, N., Madera-Salcedo, I. K., Cisneros-Segura, J. A., García-González, H. B., Apostolidis, S. A., Saint-Martin, A., Esquivel‐Velázquez, M., Nguyen, T., Romero‐Rodríguez, D. P., Tsokos, G. C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci129479 · Cited by 13

Posttranslational Regulation of Circadian Clocks

Vanselow, J. T., & Kramer, A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1262-6_3 · Cited by 12

Upregulated osterix expression elicited by Runx2 and Dlx5 is required for the accelerated osteoblast differentiation in PP2A Cα‐knockdown cells

Yang, D., Okamura, H., & Qiu, L. (2017) · Cell Biology International · doi:10.1002/cbin.10902 · Cited by 13

The neglected messengers: Control of cardiac myofilaments by protein phosphatases

Lorenzen‐Schmidt, I., Clarke, S. B., & Pyle, W. G. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.10.002 · Cited by 12

Regulation of XPO5 phosphorylation by PP2A in hepatocellular carcinoma

Li, J., Zhou, J., Mu, X., Shen, S. Y., Xu, X., Luo, Y., Luo, Y., Ming, Y., Wu, Y., & Peng, Y. (2022) · MedComm · doi:10.1002/mco2.125 · Cited by 12

Reduction of PP2A Cα stimulates adipogenesis by regulating the Wnt/GSK-3β/β-catenin pathway and PPARγ expression

Okamura, H., Yang, D., Yoshida, K., Teramachi, J., & Haneji, T. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.06.008 · Cited by 12

Specific regulation of protein phosphatase 2A PR72/B′′ subunits by calpain

Janssens, V., Derua, R., Zwaenepoel, K., Waelkens, E., & Goris, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.096 · Cited by 13

PP2ACdc55regulates G1cyclin stability

McCourt, P. C., Ebert, C., Yan, G., Jiang, Y., & Nickels, J. T. (2013) · Cell Cycle · doi:10.4161/cc.24231 · Cited by 13

Inactivation of protein‐phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits

Preuss, K., Fadle, N., Regitz, E., Held, G., & Pfreundschuh, M. G. (2014) · International Journal of Cancer · doi:10.1002/ijc.28864 · Cited by 11

Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation

Wu, J., Wang, J., Zeng, X., Chen, Y., Xia, J., Wang, S., Huang, Z., Chen, W., & Shen, Z. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.090 · Cited by 11

Liver PP2A-Cα Protects From Parenteral Nutrition-associated Hepatic Steatosis

Maitiabula, G., Tian, F., Wang, P., Zhang, L., Gao, X., Wan, S., Sun, H., Yang, J., Zhang, Y., Gao, T., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.05.008 · Cited by 11

Phosphorylation status of Bβ subunit acts as a switch to regulate the function of phosphatase PP2A in ethylene‐mediated root growth inhibition

Shao, Z., Zhao, B., Kotla, P., Burns, J. G., Tran, J., Ke, M., Chen, X., Browning, K. S., & Qiao, H. (2022) · New Phytologist · doi:10.1111/nph.18467 · Cited by 11

Roles of Phosphotase 2A in Nociceptive Signal Processing

Wang, Y., Lei, Y., Li, F., Mu, Y., Wu, J., & Zhang, X. (2013) · Molecular Pain · doi:10.1186/1744-8069-9-46 · Cited by 11

Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling

Ke, Y., Lei, M., Wang, X., & Solaro, R. J. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00116 · Cited by 11

Intranasal Immunization of Lambs with Serine/Threonine Phosphatase 2A against Gastrointestinal Nematodes

Fawzi, E. M., Bustos, T. C., Gómez-Samblás, M., González-González, G., Solano, J., González-Sánchez, M. E., Pablos, L. M. D., Corral, M. J., Cuquerella, M., Osuna, A., et al. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00336-13 · Cited by 11

Proteome‐wide search for PP2A substrates in fission yeast

Bernal, M., Zhurinsky, J., Iglesias-Romero, A. B., Sánchez-Romero, M. A., Flor‐Parra, I., Tomás‐Gallardo, L., Pérez‐Pulido, A. J., Jiménez, J., & Daga, R. R. (2014) · PROTEOMICS · doi:10.1002/pmic.201300136 · Cited by 10

Specific PP2A Catalytic Subunits Are a Prerequisite for Positive Growth Effects in Arabidopsis Co-Cultivated with Azospirillum brasilense and Pseudomonas simiae

Averkina, I. O., Paponov, I. A., Sánchez‐Serrano, J. J., & Lillo, C. (2020) · Plants · doi:10.3390/plants10010066 · Cited by 10

Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Protein

Kleinberger, T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4471-6458-6_4 · Cited by 10

Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast

Abd-Rabbo, D., & Michnick, S. W. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0418-0 · Cited by 9

Disturbances in PP2A methylation and one-carbon metabolism compromise Fyn distribution, neuritogenesis, and APP regulation

Taleski, G., Schuhmacher, D., Su, H. K., Sontag, J., & Sontag, E. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016069 · Cited by 10

Dynamic regulation of mitotic ubiquitin ligase APC/C by coordinated Plx1 kinase and PP2A phosphatase action on a flexible Apc1 loop

Fujimitsu, K., & Yamano, H. (2021) · The EMBO Journal · doi:10.15252/embj.2020107516 · Cited by 10

Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

Martin, M., Kettmann, R., & Dequiedt, S. (2010) · Open Repository and Bibliography (University of Liège) · Cited by 10

Targeting PP2A in cancer: an underrated option

Sarais, F., Krempien, F., Koehn, C., Brewing, L., Classen, C. F., Walter, M., & Shokraie, O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03560-y · Cited by 8

A functional interaction between liprin-α1 and B56γ regulatory subunit of protein phosphatase 2A supports tumor cell motility

Ripamonti, M., Lamarca, A., Davey, N. E., Tonoli, D., Surini, S., & de Curtis, I. (2022) · Communications Biology · doi:10.1038/s42003-022-03989-3 · Cited by 7

Serine/threonine protein phosphatases in DNA damage response

Liu, B., & Xu, X. (2011) · Chinese Science Bulletin · doi:10.1007/s11434-011-4679-5 · Cited by 8

Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit inXenopus laevisCell-Free Extracts

Kubiak, J. Z., & Dika, M. E. (2011) · Enzyme Research · doi:10.4061/2011/523420 · Cited by 8

Requirement of PP2A-B56Par1 for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/CSte9 during Pre-Start G1 in S. pombe

Stonyte, V., Martín, R., Segura-Peña, D., Sekulić, N., & López‐Avilés, S. (2020) · iScience · doi:10.1016/j.isci.2020.101063 · Cited by 8

Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation

Yoshida, K., Teramachi, J., Uchibe, K., Ikegame, M., Qiu, L., Yang, D., & Okamura, H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.11.005 · Cited by 7

The involvement of nicotinate and nicotinamide metabolism pathway in attenuating benzene-induced mouse hematotoxicity

Yang, R., Zhang, J., Xing, X., Zhong, S., Li, W., Wen, L., Zhang, Y., Zhou, H., Chen, S., Chen, W. L., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117388 · Cited by 7

Structural Genetics to Understand Holoenzyme Assembly and Substrate Selection of Diverse Multimeric Serine-threonine Phosphatases

Huang, W., Veis, J., Day, A., Cui, S., Leonard, D., Narla, G., Ogris, E., & Taylor, D. J. (2024) · Microscopy and Microanalysis · doi:10.1093/mam/ozae044.354

Determinants for Substrate Specificity of Protein Phosphatase 2A

Slupe, A. M., Merrill, R. A., & Strack, S. (2011) · Enzyme Research · doi:10.4061/2011/398751 · Cited by 91

Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

Martin, M., Kettmann, R., & Dequiedt, S. (2010) · Open Repository and Bibliography (University of Liège) · Cited by 10

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

Sents, W., Ivanova, E., Lambrecht, C., Haesen, D., & Janssens, V. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08579.x · Cited by 204

Assembly and structure of protein phosphatase 2A

Shi, Y. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0018-3 · Cited by 56