ATR: a master conductor of cellular responses to DNA replication stress

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

Mitotic and G 2 Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

Peng, C.-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., & Piwnica-Worms, H. (1997) · Science · doi:10.1126/science.277.5331.1501 · Cited by 1,341

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

TopBP1 Activates the ATR-ATRIP Complex

Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 787

UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4 DDB2 -Mediated Degradation To Regulate Cell Proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00809-15 · Cited by 36

Fine particulate matter exposure induces cell cycle arrest and inhibits migration and invasion of human extravillous trophoblast, as determined by an iTRAQ-based quantitative proteomics strategy

Qin, Z., Hou, H., Fu, F., Wu, J., Han, B., Yang, W., Zhang, L., Cao, J., Jin, X., Cheng, S., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2017.08.014 · Cited by 39

Identification of the proteome complement of humanTLK1 reveals it binds and phosphorylates NEK1 regulating its activity

Singh, V., Connelly, Z. M., Shen, X., & Benedetti, A. D. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1314421 · Cited by 37

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Beach, C., MacLean, D., Majorova, D., Melemenidis, S., Nambiar, D. K., Kim, R. K., Valbuena, G. N., Guglietta, S., Krieg, C., Darvish-Damavandi, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168277 · Cited by 37

Ferritinophagy Is Critical for Deoxynivalenol-Induced Liver Injury in Mice

Jiang, J., Ruan, Y., Liu, X., Ma, J., & Chen, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00556 · Cited by 34

The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage

侑磨, 橋., & Ueguchi, C. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04718.x · Cited by 33

Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR

Mao, S., Chaerkady, R., Yu, W., D’Angelo, G., Garcia, A., Chen, H., Barrett, A. M., Phipps, S. S., Fleming, R. L., Hess, S. Y., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0351 · Cited by 34

Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers

McGrail, D. J., Pilie, P. G., Dai, H., Lam, T., Liang, Y., Voorwerk, L., Kok, M., Zhang, X. H.-F., Rosen, J. M., Heimberger, A. B., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe6201 · Cited by 36

Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA Replication

Ning, K., Kuz, C. A., Cheng, F., Feng, Z., Yan, Z., & Qiu, J. (2023) · mBio · doi:10.1128/mbio.03528-22 · Cited by 33

Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

Shu, Z., Li, Z., Huang, H., Chen, Y., Fan, J., Yu, L., Wu, Z., Tian, L., Qi, Q., Peng, S., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01403-y · Cited by 31

Cellular Stress Amplifies TLR3/4-Induced CXCL1/2 Gene Transcription in Mononuclear Phagocytes via RIPK1

Zhao, C., Pavicic, P. G., Datta, S., Sun, D., Novotny, M., & Hamilton, T. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303396 · Cited by 33

RPA and POT1

Flynn, R. L., Chang, S. S., & Zou, L. (2012) · Cell Cycle · doi:10.4161/cc.11.4.19061 · Cited by 36

DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation

Pasquereau-Kotula, E., Faigle, W., Berthault, N., Dingli, F., Loew, D., Sun, J., Dutreix, M., & Quanz, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080313 · Cited by 30

Visualizing locus-specific sister chromatid exchange reveals differential patterns of replication stress-induced fragile site breakage

Waisertreiger, I. S.-R., Popovich, K., Block, M., Anderson, K. R., & Barlow, J. H. (2019) · Oncogene · doi:10.1038/s41388-019-1054-5 · Cited by 30

R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1

Marabitti, V., Valenzisi, P., Lillo, G., Malacaria, E., Palermo, V., Pichierri, P., & Franchitto, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031547 · Cited by 29

DNA repair in ischemic acute kidney injury

Pressly, J. D., & Park, F. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00492.2016 · Cited by 30

Lamin misexpression upregulates three distinct ubiquitin ligase systems that degrade ATR kinase in HeLa cells

Muralikrishna, B., Chaturvedi, P., Sinha, K., & Parnaik, V. K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1272-4 · Cited by 30

Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers

Lyu, X., Chastain, M., & Chai, W. (2019) · BMC Genomics · doi:10.1186/s12864-019-5934-4 · Cited by 28

N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma

Tatekawa, S., Tamari, K., Chijimatsu, R., Konno, M., Motooka, D., Mitsufuji, S., Akita, H., Kobayashi, S., Murakumo, Y., Doki, Y., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-15196-5 · Cited by 29

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

Cheng, A. N., Fan, C., Lo, Y.-K., Kuo, C., Wang, H., Lien, I.-H., Lin, S., Chen, C., Jiang, S. S., Chang, I., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17126-2 · Cited by 29

IL-6 signaling contributes to radioresistance of prostate cancer through key DNA repair-associated molecules ATM, ATR, and BRCA 1/2

Chen, X., Chen, F., Ren, Y., Weng, G., Xu, L., Xue, X. Y., Keng, P. C., Lee, S. O., & Chen, Y. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02917-z · Cited by 28

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13321-z · Cited by 28

The DNA damage response links human squamous proliferation with differentiation

Molinuevo, R., Freije, A., Contreras, L., Sanz, J. R., & Gandarillas, A. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.202001063 · Cited by 27

Host DNA damage response facilitates African swine fever virus infection

Simões, M., Martins, C. L. V., & Ferreira, F. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2013.01.007 · Cited by 26

ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress

Wu, X., Xu, S., Wang, P., Wang, Z., Chen, H., Xu, X., & Peng, B. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203783119 · Cited by 27

Diadenosine 5′, 5′′′-P1,P4-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication

Marriott, A. S., Copeland, N. A., Cunningham, R., Wilkinson, M. C., McLennan, A. G., & Jones, N. J. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.06.008 · Cited by 25

Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress

Gole, B., Baumann, C., Mian, E., Ireno, C. I., & Wiesmüller, L. (2014) · Oncogene · doi:10.1038/onc.2014.268 · Cited by 25

A crucial role for ATR in the regulation of deoxycytidine kinase activity

Beyaert, M., Starczewska, E., Neste, E. V. D., & Bontemps, F. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.022 · Cited by 26

TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury

Pressly, J. D., Hama, T., Brien, S. O., Regner, K. R., & Park, F. (2017) · Scientific Reports · doi:10.1038/srep43196 · Cited by 25

Targeting Replication Stress Response Pathways to Enhance Genotoxic Chemo- and Radiotherapy

Nickoloff, J. A. (2022) · Molecules · doi:10.3390/molecules27154736 · Cited by 30

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation

Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23

Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

Pellicanò, G., Mamun, M. A., Jurado-Santiago, D., Villa‐Hernández, S., Yin, X., Giannattasio, M., Lanz, M. C., Smolka, M. B., Yeeles, J. T. P., Shirahige, K., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.04.006 · Cited by 21

Mechanisms of stress response in the root stem cell niche

Ubogoeva, E. V., Zemlyanskaya, E. V., Xu, J., & Mironova, V. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab274 · Cited by 23

The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1

Liu, S., Song, N., & Zou, L. (2012) · Cell Cycle · doi:10.4161/cc.21041 · Cited by 22

ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response

Guo, Y., Feng, W., Sy, S. M.-H., & Huen, M. S. Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672626 · Cited by 25

The Protein Arginine Methylase 5 (PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage

Li, Q., Zhao, Y., Yue, M., Xue, Y., & Bao, S. (2016) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.02.007 · Cited by 22

An essential role for dNTP homeostasis following CDK-induced replication stress

Pai, C., Hsu, K., Durley, S. C., Keszthelyi, A., Kearsey, S. E., Rallis, C., Folkes, L. K., Deegan, R. S., Wilkins, S. E., Pfister, S. X., et al. (2019) · Journal of Cell Science · doi:10.1242/jcs.226969 · Cited by 22

Transcription-Replication Collisions—A Series of Unfortunate Events

Germain, C. S., Zhao, H., & Barlow, J. H. (2021) · Biomolecules · doi:10.3390/biom11081249 · Cited by 21

TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

Gao, L., Li, D., Ma, K., Zhang, W., Xu, T., Fu, C., Jing, C., Jia, X., Wu, S., Sun, X., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005346 · Cited by 22

LmHus 1 is required for the DNA damage response in L eishmania major and forms a complex with an unusual Rad 9 homologue

Damasceno, J. D., Nunes, V. S., & Tosi, L. R. O. (2013) · Molecular Microbiology · doi:10.1111/mmi.12418 · Cited by 21

Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR’s Anti-apoptotic Function at Mitochondria, and the Implications in Cancer

Makinwa, Y., Musich, P. R., & Zou, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00281 · Cited by 23

Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury–Induced Neointimal Hyperplasia

Ye, Q., Pang, S., Zhang, W., Guo, X., Wang, J., Zhang, Y., Liu, Y., Wu, X. B., & Jiang, F. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308401 · Cited by 20

Four pillars of the S-phase checkpointPreprint

Zou, L. (2013) · Genes & Development · doi:10.1101/gad.213306.113 · Cited by 22

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Yang, S. F., Nelson, C. B., Wells, J., Fernando, M., Lu, R., Allen, J. A. M., Malloy, L., Lamm, N., Murphy, V. J., Mackay, J. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46578-0 · Cited by 22

p38MAPK and MK2 Pathways Are Important for the Differentiation-Dependent Human Papillomavirus Life Cycle

Satsuka, A., Mehta, K. P. M., & Laimins, L. A. (2014) · Journal of Virology · doi:10.1128/jvi.02712-14 · Cited by 21

Phosphorylation-Dependent Interactions between Crb2 and Chk1 Are Essential for DNA Damage Checkpoint

Qu, M., Yang, B., Li, T., Yates, J. R., Russell, P. R., Dong, M., & Du, L. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002817 · Cited by 21

Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

Kang, S., Lim, Y., Kim, Y. J., Jung, E. S., Suh, D. H., Lee, C. H., Park, E., Hong, J., Velliquette, R. A., Kwon, O., et al. (2019) · Nutrients · doi:10.3390/nu11010101 · Cited by 21

Targeting Homologous Recombination Repair in Cancer

Willers, H., Pfäffle, H. N., & Zou, L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384999-1.10007-1 · Cited by 21

Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics

Sharma, R. L., Mishra, A., Bhardwaj, M., Singh, G., Harahap, L. V. I., Vanjani, S., Pan, C., & Nepali, K. (2025) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2025.2489720 · Cited by 20

Cell fate determination in cisplatin resistance and chemosensitization

Lương, K. V. Q., Wang, L., Roberts, B. J., Wahl, J. K., & Peng, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8110 · Cited by 19

DOCK7 protects against replication stress by promoting RPA stability on chromatin

Gao, M., Guo, G., Huang, J., Hou, X., Ham, H., Kim, W., Zhao, F., Tu, X., Zhou, Q., Zhang, C., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab134 · Cited by 19

NMR- and Circular Dichroism-monitored Lipid Binding Studies Suggest a General Role for the FATC Domain as Membrane Anchor of Phosphatidylinositol 3-Kinase-related Kinases (PIKK)

Sommer, L. A. M., Schaad, M., & Dames, S. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467233 · Cited by 22

Activation of ATR-Chk1 pathway facilitates EBV-mediated transformation of primary tonsillar B-cells

Mordasini, V., Ueda, S., Aslandogmus, R., Berger, C., Gysin, C., Hühn, D., Sartori, A. A., Bernasconi, M., & Nadal, D. (2016) · Oncotarget · doi:10.18632/oncotarget.14120 · Cited by 19

The DNA translocase RAD 5A acts independently of the other main DNA repair pathways, and requires both its ATP ase and RING domain for activity in Arabidopsis thaliana

Klemm, T., Mannuß, A., Kobbe, D., Knoll, A., Trapp, O., Dorn, A., & Puchta, H. (2017) · The Plant Journal · doi:10.1111/tpj.13602 · Cited by 19

DNA damage and oxidative injury are associated with hypomyelination in the corpus callosum of newborn Nbn CNS‐del mice

Liu, B., Chen, X., Wang, Z. Q., & Tong, W. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23313 · Cited by 19

Chenopodium album metabolites act as dual topoisomerase inhibitors and induce apoptosis in the MCF7 cell line

Chakraborty, D., Jain, C. K., Maity, A., Ghosh, S., Choudhury, S. R., Jha, T., Majumder, H. K., & Mondal, N. B. (2016) · MedChemComm · doi:10.1039/c5md00502g · Cited by 18

LncRNA MT1DP promotes cadmium-induced DNA replication stress by inhibiting chromatin recruitment of SMARCAL1

Feng, W., Qi, Z., Dong, Z., Liu, W., Xu, M., Gao, M., & Liu, S. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.151078 · Cited by 17

Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1

Liu, X., & Ladias, J. A. A. (2013) · Biochemistry · doi:10.1021/bi400714v · Cited by 16

Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting

Cicco, M. D., Rahim, M. S. A., & Dames, S. A. (2015) · Membranes · doi:10.3390/membranes5040553 · Cited by 19

Quantitative Proteomics Reveals Histone Modifications in Crosstalk with H3 Lysine 27 Methylation

Zhang, C., Gao, S., Molascon, A. J., Liu, Y., & Andrews, P. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.029025 · Cited by 16

S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability

Crawley, C. D., Kang, S., Bernal, G. M., Wahlstrom, J. S., Voce, D. J., Cahill, K. E., Garofalo, A., Raleigh, D. R., Weichselbaum, R. R., & Yamini, B. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991166 · Cited by 16

Buried territories: heterochromatic response to DNA double-strand breaks

Feng, Y.-L., Xiang, J.-F., Kong, N., Cai, X., & Xie, A. (2016) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmw033 · Cited by 16

Emerging drugs for the treatment of ovarian cancer: a focused review of PARP inhibitors

Lee, E. K., & Matulonis, U. A. (2020) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2020.1773791 · Cited by 16

Genome Damage Sensing Leads to Tissue Homeostasis in Drosophila

Khan, C., Muliyil, S., & Rao, B. J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2018.12.001 · Cited by 15

Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance

Sáez‐Ayala, M., Fernández-Pérez, M. P., Montenegro, M. F., Sánchez‐del‐Campo, L., Chazarra, S., Piñero, A., Cabezas‐Herrera, J., & Rodríguez‐López, J. N. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.03.022 · Cited by 15

The neuro-glial-vascular interrelations in genomic instability symptoms

Barzilai, A. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.06.001 · Cited by 15

Nucleotide excision repair (NER) alterations as evolving biomarkers and therapeutic targets in epithelial cancers

Mouw, K. W., D’Andrea, A. D., & Konstantinopoulos, P. A. (2015) · Oncoscience · doi:10.18632/oncoscience.283 · Cited by 15

PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses

Makinwa, Y., Cartwright, B. M., Musich, P. R., Li, Z., Biswas, H., & Zou, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00813 · Cited by 15

Regulation of ATR-dependent DNA damage response by nitric oxide

Yeo, C. T., Stancill, J. S., Oleson, B. J., Schnuck, J. K., Stafford, J. D., Naatz, A., Hansen, P. A., & Corbett, J. A. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100388 · Cited by 16

Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity

Hamidi, M., Eriz, A., Mitxelena, J., Fernández-Ares, L., Aurrekoetxea, I., Aspichueta, P., Iglesias–Ara, A., & Zubiaga, A. M. (2022) · Cancers · doi:10.3390/cancers14194952 · Cited by 15

CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break–Specific G2 Checkpoint

Hirokawa, T., Shiotani, B., Shimada, M., Murata, K., Johmura, Y., Haruta, M., Tahara, H., Takeyama, H., & Nakanishi, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3604 · Cited by 15

Targeting Aberrant Splicing in Myelodysplastic Syndromes

Brunner, A. M., & Steensma, D. P. (2019) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2019.10.003 · Cited by 14

Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway

Jang, S.-W., Jung, J. K., & Kim, J. M. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1201621 · Cited by 14

Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD‑L1 and MHC I in colon cancer cells

Hassan, M., Trung, V., Bedi, D., Shaddox, S., Gunturu, D. R., Yates, C. C., Datta, P. K., & Samuel, T. (2022) · Oncology Letters · doi:10.3892/ol.2022.13628 · Cited by 13

Cloning, Characterization and Functional Analysis of Caspase 8-like Gene in Apoptosis of Crassostrea hongkongensis Response to Hyper-Salinity Stress

Lin, J., Yu, Z., Leng, Y., Zhu, J., Yu, F., Lu, Y., Chen, J., He, W., Zhang, Y., & Wen, Y. (2024) · Fishes · doi:10.3390/fishes9050172 · Cited by 13

HPV 16 E7 alters translesion synthesis signaling

Wendel, S. O., Stoltz, A., Xu, X., Snow, J. A., & Wallace, N. A. (2022) · Virology Journal · doi:10.1186/s12985-022-01899-8 · Cited by 13

HIF1‐regulated ATRIP expression is required for hypoxia induced ATR activation

Ding, G., Liu, H., Liang, H., Ni, R.-F., Ding, Z.-Y., Ni, G.-Y., Hua, H.-W., & Xu, W. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.02.020 · Cited by 13

The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks

Osman, F., Ahn, J. S., Lorenz, A., & Whitby, M. C. (2016) · Scientific Reports · doi:10.1038/srep22837 · Cited by 13

The role of the DFF40/CAD endonuclease in genomic stability

Kulbay, M., Bernier-Parker, N., & Bernier, J. (2021) · APOPTOSIS · doi:10.1007/s10495-020-01649-7 · Cited by 13

PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency

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Overactivated Cdc42 acts through Cdc42EP3/Borg2 and NCK to trigger DNA damage response signaling and sensitize cells to DNA-damaging agents

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