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Cited by 787Mitochondrial Function and PathologyIon Channels and ReceptorsEndoplasmic Reticulum Stress and Disease

MAM: more than just a housekeeper

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Hayashi, Teruo, Rizzuto, Rosario, Hajnoczky, Gyorgy, Su, Tsung-Ping·2009·Trends in Cell Biology
DOI 10.1016/j.tcb.2008.12.002PMC PMC2750097
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Abstract

The physical association between the endoplasmic reticulum (ER) and mitochondria, which is known as the mitochondria-associated ER membrane (MAM), has important roles in various cellular 'housekeeping' functions including the non-vesicular transports of phospholipids. It has recently become clear that the MAM also enables highly efficient transmission of Ca(2+) from the ER to mitochondria to stimulate oxidative metabolism and, conversely, might enable the metabolically energized mitochondria to regulate the ER Ca(2+) homeostasis. Recent studies have shed light on molecular chaperones such as calnexin, calreticulin, ERp44, ERp57, grp75 and the sigma-1 receptor at the MAM, which regulate the association between the two organelles. The MAM thus integrates signal transduction with metabolic pathways to regulate the communication and functional interactions between the ER and mitochondrion.

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Authors
Hayashi, T., Rizzuto, R., Hajnoczky, G., & Su, T.-P.
Affiliations
  • National Institutes of Health (US)
  • University of Ferrara (IT)
Corresponding author
Su, Tsung-Ping
ORCID
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2009-02
Volume
19
Issue
2
Pages
81-88
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/j.tcb.2008.12.002
PMC
PMC2750097
OpenAlex
W2082315075
Cited by
787
References
1
Citations by year
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FWCI
4.69
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P01AG025532)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK051526)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Keywords
mitochondria-associated ER membranes, endoplasmic reticulum, mitochondria, calcium signaling, ER-mitochondria communication, calcium homeostasis, oxidative metabolism, phospholipid transport, molecular chaperones, calnexin, calreticulin, ERp44, ERp57, GRP75, sigma-1 receptor
MeSH terms
Animals, Calcium, Endoplasmic Reticulum, Humans, Lipids, Mitochondria, Molecular Chaperones, Calcium Signaling, Membrane Transport Proteins

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