The DOI matches its Crossref record; 92 of the 94 references it cites were found in a registry or an index.
Metabolic engineering of cyanobacteria for the synthesis of commodity products
Abstract
Through metabolic engineering cyanobacteria can be employed in biotechnology. Combining the capacity for oxygenic photosynthesis and carbon fixation with an engineered metabolic pathway allows carbon-based product formation from CO(2), light, and water directly. Such cyanobacterial 'cell factories' are constructed to produce biofuels, bioplastics, and commodity chemicals. Efforts of metabolic engineers and synthetic biologists allow the modification of the intermediary metabolism at various branching points, expanding the product range. The new biosynthesis routes 'tap' the metabolism ever more efficiently, particularly through the engineering of driving forces and utilization of cofactors generated during the light reactions of photosynthesis, resulting in higher product titers. High rates of carbon rechanneling ultimately allow an almost-complete allocation of fixed carbon to product above biomass.
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“native regulatory networks resist carbon flux redirection”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [19]
In the citing paper
“cultivation constraints—including light attenuation in dense cultures and mismatches between photosynthetic ATP/NADPH supply and heterologous pathway demand—further limit achievable yields.”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [19]
Citations
Cites
Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde
Atsumi, S., Higashide, W., & Liao, J. C. (2009) · Nature Biotechnology · doi:10.1038/nbt.1586 · Cited by 870
Manufacturing Molecules Through Metabolic Engineering
Keasling, J. D. (2010) · Science · doi:10.1126/science.1193990 · Cited by 829
Engineering cyanobacteria to generate high-value products
Ducat, D. C., Way, J. C., & Silver, P. A. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.12.003 · Cited by 536
Molecular biology of cyanobacterial salt acclimation
Hagemann, M. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00234.x · Cited by 518
Ethanol Synthesis by Genetic Engineering in Cyanobacteria
Deng, M.-D., & Coleman, J. R. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.2.523-528.1999 · Cited by 457
Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae
Wijffels, R. H., Kruse, O., & Hellingwerf, K. J. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.04.004 · Cited by 404
Self-citationPhotosynthetic production of ethanol from carbon dioxide in genetically engineered cyanobacteria
Gao, Z., Zhao, H. F., Li, Z., Tan, X., & Lü, X. (2012) · Energy & Environmental Science · doi:10.1039/c2ee22675h · Cited by 391
Metabolic engineering of cyanobacteria for 1-butanol production from carbon dioxide
Lan, E. I., & Liao, J. C. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.04.004 · Cited by 386
Cyanobacterial conversion of carbon dioxide to 2,3-butanediol
Oliver, J. W. K., Machado, I. M. P., Yoneda, H., & Atsumi, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213024110 · Cited by 382
ATP drives direct photosynthetic production of 1-butanol in cyanobacteria
Lan, E. I., & Liao, J. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200074109 · Cited by 374
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2 of the 94 references couldn’t be matched to a known paper.
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Fuelling the future: microbial engineering for the production of sustainable biofuels
Liao, J. C., Mi, L., Pontrelli, S., & Luo, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.32 · Cited by 604
Industrial biomanufacturing: The future of chemical production
Clomburg, J. M., Crumbley, A. M., & González, R. (2017) · Science · doi:10.1126/science.aag0804 · Cited by 565
Third-generation biorefineries as the means to produce fuels and chemicals from CO2
Liu, Z., Wang, K., Chen, Y., Tan, T., & Nielsen, J. (2020) · Nature Catalysis · doi:10.1038/s41929-019-0421-5 · Cited by 477
A Circular Bioeconomy with Biobased Products from CO 2 Sequestration
Mohan, S. V., Modestra, J. A., Amulya, K., Butti, S. K., & Velvizhi, G. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.02.012 · Cited by 307
Harnessing the power of microbial autotrophy
Claassens, N. J., Sousa, D. Z., dos Santos, V. A. P. M., de Vos, W. M., & John van der, O. O. S. T. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.130 · Cited by 291
Metadata
- Authors
- Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Hellingwerf, Klaas J.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 33
- Issue
- 6
- Pages
- 352-361
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2134069782
- Cited by
- 273
- References
- 94
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 10 · 2022: 30 · 2021: 22 · 2020: 30 · 2019: 37 · 2018: 38 · 2017: 30 · 2016: 33 · 2015: 8
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- cyanobacteria, metabolic engineering, cell factories, biofuels, bioplastics, commodity chemicals, photosynthetic carbon fixation, oxygenic photosynthesis, metabolic pathway engineering, product titer
- MeSH terms
- Cyanobacteria, Biotechnology, Carbon Dioxide, Humans, Light, Photosynthesis, Plastics, Biomass, Biofuels, Synthetic Biology, Metabolic Engineering
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