Cyanobacteria as whole-cell factories: Current status and future prospectives
Abstract
Cyanobacteria as phototrophic microorganisms bear great potential to produce chemicals from sustainable resources such as light and CO 2. Most studies focus on either strain engineering or tackling metabolic constraints. Recently gained knowledge on internal electron and carbon fluxes and their regulation provides new opportunities to efficiently channel cellular resources toward product formation. Concomitantly, novel photobioreactor concepts are developed to ensure sufficient light supply. This review summarizes the newest developments in the field of cyanobacterial engineering to finally establish photosynthesis-based production processes. A holistic approach tackling genetic, metabolic, and biochemical engineering in parallel is considered essential to turn their application into an ecoefficient and economically feasible option for a future green bioeconomy.
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This methodology has facilitated the development of photosynthetically powered microbial systems capable of transforming CO2 and sunlight into diverse chemical products through customised biosynthetic pathways.
“This methodology has facilitated the development of photosynthetically powered microbial systems capable of transforming CO2 and sunlight into diverse chemical products through customised biosynthetic pathways [142].”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [142]
By integrating genes from other organisms, cyanobacteria can be engineered to produce compounds absent from their native metabolic networks.
“By integrating genes from other organisms, cyanobacteria can be engineered to produce compounds absent from their native metabolic networks [141,142].”
From Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression (2026) · cites this paper as [142]
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Microalgae: a vision for sustainability
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Biotechnological Applications of Cyanobacteria: Synechocystis and Synechococcus Strains
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Self-citationHarnessing engineered cyanobacteria for next-generation therapeutics
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State-of-the-art: microalgae production systems and microalgae applications
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Toward Sustainability: Intensification of Light‐Driven Whole Cell Biocatalysis
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Guanidin – vom Chaotrop zur bio(techno) logisch relevanten Stickstoffquelle
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Self-citation
- Authors
- Toepel, J., Karande, R., Klähn, S., & Bühler, B.
- Affiliations
- Helmholtz Centre for Environmental Research (DE)
- Leipzig University (DE)
- Corresponding author
- Bühler, Bruno
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2023-04
- Volume
- 80
- Pages
- 102892
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W4317436337
- Cited by
- 52
- References
- 65
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 15 · 2023: 8
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
- Keywords
- cyanobacteria, strain engineering, metabolic engineering, electron flux, carbon flux, metabolic regulation, photobioreactors, photosynthetic production, bioeconomy
- MeSH terms
- Cyanobacteria, Photosynthesis, Carbon Cycle, Metabolic Engineering
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