Cited by 52Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionPhotosynthetic Processes and Mechanisms

Cyanobacteria as whole-cell factories: Current status and future prospectives

Toepel, Jörg, Karande, Rohan, Klähn, Stephan, Bühler, Bruno·2023·Current Opinion in Biotechnology

Abstract

Cyanobacteria as phototrophic microorganisms bear great potential to produce chemicals from sustainable resources such as light and CO 2. Most studies focus on either strain engineering or tackling metabolic constraints. Recently gained knowledge on internal electron and carbon fluxes and their regulation provides new opportunities to efficiently channel cellular resources toward product formation. Concomitantly, novel photobioreactor concepts are developed to ensure sufficient light supply. This review summarizes the newest developments in the field of cyanobacterial engineering to finally establish photosynthesis-based production processes. A holistic approach tackling genetic, metabolic, and biochemical engineering in parallel is considered essential to turn their application into an ecoefficient and economically feasible option for a future green bioeconomy.

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Crossref · 10.1016/j.copbio.2023.102892

Cites

63 of 63 references verified0 citation errors · 0 not checkable

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  • This methodology has facilitated the development of photosynthetically powered microbial systems capable of transforming CO2 and sunlight into diverse chemical products through customised biosynthetic pathways.

    “This methodology has facilitated the development of photosynthetically powered microbial systems capable of transforming CO2 and sunlight into diverse chemical products through customised biosynthetic pathways [142].”
  • By integrating genes from other organisms, cyanobacteria can be engineered to produce compounds absent from their native metabolic networks.

    “By integrating genes from other organisms, cyanobacteria can be engineered to produce compounds absent from their native metabolic networks [141,142].”

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Authors
Toepel, J., Karande, R., Klähn, S., & Bühler, B.
Affiliations
  • Helmholtz Centre for Environmental Research (DE)
  • Leipzig University (DE)
Corresponding author
Bühler, Bruno
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2023-04
Volume
80
Pages
102892
ISSN
0958-1669 (ISSN-L)
OpenAlex
W4317436337
Cited by
52
References
65
Citations by year
2026: 14 · 2025: 15 · 2024: 15 · 2023: 8
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords
cyanobacteria, strain engineering, metabolic engineering, electron flux, carbon flux, metabolic regulation, photobioreactors, photosynthetic production, bioeconomy
MeSH terms
Cyanobacteria, Photosynthesis, Carbon Cycle, Metabolic Engineering

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