Cited by 273Microbial Metabolic Engineering and BioproductionAlgal biology and biofuel productionPhotosynthetic Processes and Mechanisms

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Metabolic engineering of cyanobacteria for the synthesis of commodity products

Angermayr, S. Andreas, Gorchs Rovira, Aleix, Hellingwerf, Klaas J.·2015·Trends in Biotechnology

DOI 10.1016/j.tibtech.2015.03.009

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Abstract

Through metabolic engineering cyanobacteria can be employed in biotechnology. Combining the capacity for oxygenic photosynthesis and carbon fixation with an engineered metabolic pathway allows carbon-based product formation from CO(2), light, and water directly. Such cyanobacterial 'cell factories' are constructed to produce biofuels, bioplastics, and commodity chemicals. Efforts of metabolic engineers and synthetic biologists allow the modification of the intermediary metabolism at various branching points, expanding the product range. The new biosynthesis routes 'tap' the metabolism ever more efficiently, particularly through the engineering of driving forces and utilization of cofactors generated during the light reactions of photosynthesis, resulting in higher product titers. High rates of carbon rechanneling ultimately allow an almost-complete allocation of fixed carbon to product above biomass.

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Authors: Angermayr, S. A., Gorchs Rovira, A., & Hellingwerf, K. J.
Affiliations: University of Amsterdam (NL)
Corresponding author: Hellingwerf, Klaas J.
ORCID: Angermayr, S. Andreas
Hellingwerf, Klaas J.
Venue: Trends in Biotechnology
Publisher: Elsevier BV
Published: 2015-06
Volume: 33
Issue: 6
Pages: 352-361
ISSN: 0167-7799 (ISSN-L)
DOI: 10.1016/j.tibtech.2015.03.009
OpenAlex: W2134069782
Cited by: 273
References: 94
Citations by year: 2026: 9 · 2025: 16 · 2024: 10 · 2023: 10 · 2022: 30 · 2021: 22 · 2020: 30 · 2019: 37 · 2018: 38 · 2017: 30 · 2016: 33 · 2015: 8
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in biotechnology (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords: cyanobacteria, metabolic engineering, cell factories, biofuels, bioplastics, commodity chemicals, photosynthetic carbon fixation, oxygenic photosynthesis, metabolic pathway engineering, product titer
MeSH terms: Cyanobacteria, Biotechnology, Carbon Dioxide, Humans, Light, Photosynthesis, Plastics, Biomass, Biofuels, Synthetic Biology, Metabolic Engineering

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Metabolic engineering of cyanobacteria for the synthesis of commodity products

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