The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple ‘Omic’ Layers
Open accessAbstract
We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.
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Metadata
- Authors
- Yugi, K., Kubota, H., Hatano, A., & Kuroda, S.
- Affiliations
- Japan Science and Technology Agency (JP)
- Kyushu University (JP)
- The University of Tokyo (JP)
- Corresponding author
- Yugi, Katsuyuki
- Kuroda, Shinya
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 34
- Issue
- 4
- Pages
- 276-290
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2274879598
- Cited by
- 258
- References
- 140
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 19 · 2023: 18 · 2022: 29 · 2021: 23 · 2020: 43 · 2019: 38 · 2018: 32 · 2017: 25 · 2016: 11
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in biotechnology (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15H05582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- trans-omics, multi-omics integration, metabolic networks, biochemical interactions, lifestyle-related diseases, genetic and environmental factors
- MeSH terms
- Computational Biology, Gene Regulatory Networks, Metabolic Networks and Pathways, Protein Interaction Maps
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