Cited by 1,100Memory and Neural MechanismsMemory Processes and InfluencesNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Long-axis specialization of the human hippocampus

Abstract

Investigation of the hippocampus has historically focused on computations within the trisynaptic circuit. However, discovery of important anatomical and functional variability along its long axis has inspired recent proposals of long-axis functional specialization in both the animal and human literatures. Here, we review and evaluate these proposals. We suggest that various long-axis specializations arise out of differences between the anterior (aHPC) and posterior hippocampus (pHPC) in large-scale network connectivity, the organization of entorhinal grid cells, and subfield compositions that bias the aHPC and pHPC towards pattern completion and separation, respectively. The latter two differences give rise to a property, reflected in the expression of multiple other functional specializations, of coarse, global representations in anterior hippocampus and fine-grained, local representations in posterior hippocampus.

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Crossref · 10.1016/j.tics.2013.03.005

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Metadata

Authors
Poppenk, J., Evensmoen, H. R., Moscovitch, M., & Nadel, L.
Affiliations
  • Princeton University (US)
  • Norwegian University of Science and Technology (NO)
  • University of Toronto (CA)
  • University of Arizona (US)
Corresponding author
  • Poppenk, Jordan
  • Moscovitch, Morris
  • Nadel, Lynn
Venue
Trends in Cognitive Sciences
Publisher
Elsevier BV
Published
2013-05
Volume
17
Issue
5
Pages
230-240
ISSN
1364-6613 (ISSN-L)
OpenAlex
W2072427931
Cited by
1,100
References
110
Citations by year
2026: 93 · 2025: 88 · 2024: 96 · 2023: 87 · 2022: 68 · 2021: 110 · 2020: 110 · 2019: 88 · 2018: 78 · 2017: 76 · 2016: 71 · 2015: 67 · 2014: 46 · 2013: 20
FWCI
5.78
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cognitive Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampus, anterior hippocampus, posterior hippocampus, trisynaptic circuit, pattern completion, pattern separation, hippocampal subfields, spatial representation, functional specialization
MeSH terms
Animals, Brain Mapping, Hippocampus, Humans, Functional Laterality, Models, Neurological, Nerve Net, Mental Recall

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