Demonstrating the Efficiency of Sulphur Dioxide Replacements in Wine: A Parameter Review
Abstract
Sulphur dioxide seems indispensable in winemaking because of its properties. However, a current increasing concern about its allergies effects in food product has addressed the international research efforts on its replacement. This supposes a sufficient knowledge of its properties and conditions of use. Several studies compared SO2 properties against new alternatives that are supposed to overcome SO2 disadvantages. The question that lay on this review is how the efficiency of sulphur replacements in wine can be demonstrated. The state of the art and a deep revision of the parameters frequently determined in sulphur dioxide replacement studies in wine are summarized.
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Excessive consumption of SO2-treated foods can irritate the mucosal systems of the respiratory tract and lungs, and may be accompanied by headaches, eye inflammation, vomiting, and diarrhea.
“Some studies have indicated that excessive consumption of SO2-treated foods can irritate the mucosal systems of the respiratory tract and lungs, and may be accompanied by headaches, eye inflammation, vomiting, and diarrhea [100].”
From Current Status and Future Trends in Removal, Control, and Mitigation of Algae Food Safety Risks for Human Consumption (2022) · cites this paper as [100]
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“Emerging technologies, such as HHP and PEF, are interesting alternatives to reduce the doses of antimicrobial agents and antioxidants such as SO2 [114], especially in red wines, which are less susceptible to oxidation than white wines.”
BackgroundSome new findings on the potential use of biocompatible silver nanoparticles in winemaking
Gil‐Sánchez, I., Monge, M., Miralles, B., Heras, G. A., Cueva, C., Crespo, J., de Luzuriaga, J. M. L., Olmos, M. E., Bartolomé, B., de Llano, D. G., et al. (2018) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2018.04.017 · Cited by 35 · see citing works
Red Wine and Health: Approaches to Improve the Phenolic Content During Winemaking
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Enhancing wine shelf-life: Insights into factors influencing oxidation and preservation
Mercanti, N., Macaluso, M., Pieracci, Y., Brazzarola, F., Palla, F., Verdini, P. G., & Zinnai, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35688 · Cited by 40 · see citing works
“Indeed, there are two fractions of SO 2 in wine, the "free SO 2 ," comprising HSO 3 (cid:0) and SO 2 , and the "bound SO 2 " that primarily indicating sulphur dioxide bound to un-saturated compounds [132,133].”
BackgroundInfluentialGutiérrez‐Escobar, R., Fernández‐Marín, M. I., Richard, T., Fernández-Morales, A., Carbú, M., Cebrián‐Tarancón, C., Torija, M.-J., Puertas, B., & Cantos‐Villar, E. (2020) · Food Control · doi:10.1016/j.foodcont.2020.107684 · Cited by 34 · see citing works
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“Due to the risk to human health, the total sulfites content, expressed as sulfur dioxide, cannot exceed 150 and 200 mg/L for conventional red and white wines, respectively, and 100 and 150 mg/L in organic red and white wines, respectively [21].”
BackgroundAl-Bodour, A., Alomari, N., Gutiérrez, A., Aparício, S., & Atilhan, M. (2023) · Green Chemical Engineering · doi:10.1016/j.gce.2023.09.003 · Cited by 32 · see citing works
High‐Throughput Analysis of Materials for Chemical Looping Processes
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High pressure inactivation of Brettanomyces bruxellensis in red wine
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SERS-based pH-Dependent detection of sulfites in wine by hydrogel nanocomposites
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Zara, G., & Nardi, T. (2021) · Fermentation · doi:10.3390/fermentation7020057 · Cited by 28 · see citing works
“High residual quantities in wine may result in unpleasant flavors [3].”
BackgroundHigh pressure processing inactivation of Brettanomyces bruxellensis in seven different table wines
van Wyk, S., & Silva, F. (2017) · Food Control · doi:10.1016/j.foodcont.2017.05.028 · Cited by 27 · see citing works
Use of Non-Saccharomyces Yeasts in Red Winemaking
Ciani, M., & Comitini, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814399-5.00004-9 · Cited by 27 · see citing works
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Phenolic and Aroma Changes of Red and White Wines during Aging Induced by High Hydrostatic Pressure
Lukić, K., Ćurko, N., Tomašević, M., & Ganić, K. K. (2020) · Foods · doi:10.3390/foods9081034 · Cited by 25 · see citing works
“The use of alternative physical and chemical treatments to SO2 in wine production was reviewed not so long ago by several authors [17,22,23].”
BackgroundWine Spoilage Yeasts: Control Strategy
Escott, C., Loira, I., Morata, A., Bañuelos, M. A., & Suárez-Lepe, J. A. (2017) · InTech eBooks · doi:10.5772/intechopen.69942 · Cited by 27 · see citing works
“Researchers are looking for alternative methods to reduce the doses commonly added to grape juice and wine [29, 30].”
BackgroundExpanding the Horizons of Saccharomyces cerevisiae: Nutrition, Oenology, and Bioethanol Production
Elhalis, H. (2024) · Sustainability · doi:10.3390/su162411151 · Cited by 27 · see citing works
Korenika, A.-M. J., Biloš, J., Kozina, B., Tomaz, I., Preiner, D., & Jeromel, A. (2020) · Foods · doi:10.3390/foods9080996 · Cited by 24 · see citing works
“Color intensity and hue measurements give useful information about phenolic concentration and tendency for oxidation, especially for wines treated with alternative reduction agents [8].”
BackgroundQian, B., Zhao, J., He, Y., Peng, L., Ge, H., & Han, B. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126437 · Cited by 23 · see citing works
Grapevine-shoot stilbene extract as a preservative in white wine
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Methods of Evaluation of Fruit Wines
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Resveratrol: A Fair Race Towards Replacing Sulfites in Wines
Kontaxakis, E., Trantas, E., & Ververidis, F. (2020) · Molecules · doi:10.3390/molecules25102378 · Cited by 22 · see citing works
“In an effort to replace or reduce SO2 in wines, a wide range of natural or synthetic compounds as well as innovative winemaking techniques have been studied for their ability to protect the wine from oxidation and microbial contaminations, while preserving its organoleptic properties [40].”
BackgroundInfluentialJiang, C., Chen, X., Lei, S., Zhao, H., Liu, Y., & Shi, J. (2017) · Australian Journal of Grape and Wine Research · doi:10.1111/ajgw.12289 · Cited by 21 · see citing works
“Lipopeptides have no negative effect on wine sensory attributes and help to enhance ester content in wine As reported by Guerrero and Cantos‐Villar (2015), the replacement or reduction of SO2 addition has always been pursued in the winemaking industry, as the presence of SO2 unfavourably impacts…”
BackgroundGonzález‐Arenzana, L., López‐Alfaro, I., Viguera, A. R. G., López, N., Santamaría, P., & López, R. (2018) · Food Bioscience · doi:10.1016/j.fbio.2018.10.012 · Cited by 21 · see citing works
Towards Sulphite-Free Winemaking: A New Horizon of Vinification and Maturation
Mercanti, N., Macaluso, M., Pieracci, Y., Flamini, G., Scappaticci, G., Marianelli, A., & Zinnai, A. (2024) · Foods · doi:10.3390/foods13071108 · Cited by 20 · see citing works
“An excessive consumption of sulphites, however, can elicit symptoms such as headaches, nausea, stomach irritation, and respiratory distress, especially in asthmatic subjects [11,15,16].”
BackgroundImpact of tannin addition on the antioxidant activity and sensory character of Malagousia white wine
Strati, I. F., Tataridis, P., Shehadeh, A., Chatzilazarou, A., Bartzis, V., Batrinou, A., & Sinanoglou, V. J. (2021) · Current Research in Food Science · doi:10.1016/j.crfs.2021.11.017 · Cited by 20 · see citing works
Total SO2 levels and risk assessment of wine and fruit wine consumed in South Korea
Cho, Y. S., Kim, J. J., Jeon, G., Chung, M.-S., Joo, Y., & Lee, K. (2021) · Food Control · doi:10.1016/j.foodcont.2021.108124 · Cited by 20 · see citing works
Gil‐Sánchez, I., Bartolomé, B., & Moreno-Arribas, M. V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814399-5.00006-2 · Cited by 22 · see citing works
Biocontrol and Enzymatic Activity of Non-Saccharomyces Wine Yeasts: Improvements in Winemaking
Martín, M. C., Prendes, L. P., de Ambrosini, V. I. M., & Merín, M. G. (2024) · Fermentation · doi:10.3390/fermentation10040218 · Cited by 21 · see citing works
“However, there is an increasing tendency to reduce its concentration in wines due to its harmful effects on human health, especially hypersensitivity in some wine consumers [98].”
BackgroundGiovenzana, V., Beghi, R., Vagnoli, P., Iacono, F. L., Guidetti, R., & Nardi, T. (2016) · American Journal of Enology and Viticulture · doi:10.5344/ajev.2016.15115 · Cited by 18 · see citing works
“These concerns include health-related topics, such as sulfite reduction in wines (Guerrero and Cantos-Villar 2015), and environmental concerns, such as sustainability of the wine production chain (Pomarici and Vecchio 2014).”
BackgroundMedrano‐Padial, C., Puerto, M., Moreno, F. J., Richard, T., Cantos‐Villar, E., & Pichardo, S. (2019) · Antioxidants · doi:10.3390/antiox8100467 · Cited by 18 · see citing works
“Nevertheless, the exposure to SO2 may have health side effects such as dermatitis, urticarial, angioedema, diarrhea, abdominal pain, bronchoconstriction, and anaphylaxis [1].”
BackgroundMedrano‐Padial, C., Puerto, M., Prieto, A. I., Ayala-Soldado, N., Beaumont, P., Rouger, C., Krisa, S., & Pichardo, S. (2021) · Foods · doi:10.3390/foods10020439 · Cited by 18 · see citing works
“Although SO2 is usually added to wine for its antioxidant and antimicrobial properties, it has been clearly shown that there is risk to human health such as bronchospasm, bradycardia, gastrointestinal symptoms, urticaria, angioedema, hypotension, shock, and even anaphylactic reactions in sensitive individuals [3,4].”
BackgroundDesign, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives
Chen, S., Qin, S., Li, R., Qu, Y., Ampomah‐Wireko, M., Nininahazwe, L., Wang, M., Gao, C., & Zhang, E. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116293 · Cited by 17 · see citing works
Microbiological, Physical, and Chemical Procedures to Elaborate High-Quality SO2-Free Wines
Ferrer‐Gallego, R., Puxeu, M., Martín, L., Nart, E., Hidalgo, C., & Andorrà, I. (2018) · InTech eBooks · doi:10.5772/intechopen.71627 · Cited by 17 · see citing works
“Accordingly, new antioxidant and antimicrobial additives have been evaluated as possible alternatives to the use of the SO2 [37, 52].”
Methodvan Wyk, S., Hong, L., & Silva, F. (2021) · Beverages · doi:10.3390/beverages7040069 · Cited by 17 · see citing works
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Must protection, sulfites versus bioprotection: A metabolomic study
Lebleux, M., Alexandre, H., Romanet, R., Ballester, J., David-Vaizant, V., Adrian, M., Tourdot‐Maréchal, R., & Rouiller-Gall, C. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113383 · Cited by 16 · see citing works
Winstel, D., Marchal, A., & Nioi, C. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.138121 · Cited by 16 · see citing works
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Effects of Production Methods on Flavour Characteristics of Nonalcoholic Wine
Akyereko, Y. G., Wireko‐Manu, F. D., Alemawor, F., & Adzanyo, M. (2021) · Journal of Food Quality · doi:10.1155/2021/3014793 · Cited by 15 · see citing works
“)e addition of GOX also increases the number of carbonyl compounds that can bind sulphur dioxide (SO2), resulting in higher SO2 concentration in wine and its allergic effects on consumers [38, 40].”
BackgroundSelective Wine Aroma Enhancement through Enzyme Hydrolysis of Glycosidic Precursors
Rodríguez‐Nogales, J. M., Fernández‐Fernández, E., Ruipérez, V., & Vila‐Crespo, J. (2023) · Molecules · doi:10.3390/molecules29010016 · Cited by 15 · see citing works
Effect of a grapevine‐shoot waste extract on red wine aromatic properties
Ruiz‐Moreno, M. J., Raposo, R., Puertas, B., Cuevas, F. J., Chinnici, F., Moreno‐Rojas, J. M., & Cantos‐Villar, E. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9104 · Cited by 15 · see citing works
dos Santos, T. P. M., Alberti, A., Judacewski, P., Zielinski, A. A. F., & Nogueira, A. (2018) · Journal of the Institute of Brewing · doi:10.1002/jib.500 · Cited by 15 · see citing works
Chitooligosaccharide as A Possible Replacement for Sulfur Dioxide in Winemaking
Hao, Z., Zhang, Y., Sun, Z., & Li, X. (2020) · Applied Sciences · doi:10.3390/app10020578 · Cited by 15 · see citing works
“(referred to [34] with minor modification).”
An Efficient Iterative Approach to Explainable Feature Learning
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Chemical constituents of grapes and wine
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Digital colorimetric sensing for real‐time gas monitoring for smart green energy system
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The recycling of sulfur dioxide
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Adding α-pinene as a novel application for sulfur dioxide-free in red wine
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“alternative would increase the risk of wine spoilage by yeast and bacteria.([4]) Therefore, there is a great deal of interest in finding alternatives to SO2 in winemaking.”
BackgroundSynthesis and antimicrobial activity of an SO2-releasing siderophore conjugate
Black, C. M., Chu, A. J., Thomas, G. H., Routledge, A., & Duhme‐Klair, A. (2022) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2022.111875 · Cited by 14 · see citing works
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Medrano‐Padial, C., Puerto, M., Merchán-Gragero, M. D. M., Moreno, F. J., Richard, T., Cantos‐Villar, E., & Pichardo, S. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109738 · Cited by 12 · see citing works
- Authors
- Guerrero, R. F., & Cantos-Villar, E.
- Affiliations
- Andalusian Institute of Agricultural and Fisheries Research and Training (ES)
- Corresponding author
- Guerrero, Raúl F.
- ORCID
- Guerrero, Raúl F.
- Venue
- Trends in Food Science & Technology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 42
- Issue
- 1
- Pages
- 27-43
- ISSN
- 0924-2244 (ISSN-L)
- OpenAlex
- W2094208897
- Cited by
- 210
- References
- 54
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 25 · 2023: 27 · 2022: 21 · 2021: 19 · 2020: 25 · 2019: 13 · 2018: 20 · 2017: 14 · 2016: 8 · 2015: 6
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Food Science & Technology (publishedVersion)
- Funders
- European Social Fund
- INIA
- FEDER
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Fermentation and Sensory Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Horticultural and Viticultural Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Keywords
- sulfur dioxide, wine, wine preservatives, food allergy, wine spoilage
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