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The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.

Toward a new history and geography of human genes informed by ancient DNA

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Pickrell, Joseph K., Reich, David·2014·Trends in Genetics

Abstract

Genetic information contains a record of the history of our species, and technological advances have transformed our ability to access this record. Many studies have used genome-wide data from populations today to learn about the peopling of the globe and subsequent adaptation to local conditions. Implicit in this research is the assumption that the geographic locations of people today are informative about the geographic locations of their ancestors in the distant past. However, it is now clear that long-range migration, admixture and population replacement subsequent to the initial out-of-Africa expansion have altered the genetic structure of most of the world’s human populations. In light of this, we argue that it is time to critically re-evaluate current models of the peopling of the globe, as well as the importance of natural selection in determining the geographic distribution of phenotypes. We specifically highlight the transformative potential of ancient DNA. By accessing the genetic make-up of populations living at archaeologically-known times and places, ancient DNA makes it possible to directly track migrations and responses to natural selection.

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Metadata

Authors
Pickrell, J. K., & Reich, D.
Venue
Trends in Genetics
Publisher
Elsevier BV
Published
2014-09
Volume
30
Issue
9
Pages
377-389
ISSN
0168-9525 (ISSN-L)
OpenAlex
W1982952737
Cited by
273
References
150
FWCI
2.95
Type
journal article
Language
en
Open access
green

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Pickrell, J. K., & Reich, D. (2014). Toward a new history and geography of human genes informed by ancient DNA. Trends in Genetics. https://doi.org/10.1016/j.tig.2014.07.007

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