How genomics can help biodiversity conservation
Open accessAbstract
The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or closely related species. We review case studies to illustrate how reference genomes can facilitate biodiversity research and conservation across the tree of life. We conclude that the time is ripe to view reference genomes as fundamental resources and to integrate their use as a best practice in conservation genomics.
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High-quality reference genome assemblies are increasingly recognized as an important foundation of conservation genomics.
“High-quality reference genome assemblies are increasingly recognized as an important foundation of conservation genomics84–91.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [87]
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A Reference Genome Sequence for Giant Sequoia
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Self-citationIndividual heterozygosity predicts translocation success in threatened desert tortoises
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Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast
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The evolutionary history of extinct and living lions
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Self-citationA wealth of discovery built on the Human Genome Project — by the numbers
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Experimental separation of genetic and demographic factors on extinction risk in wild populations
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Transcriptomic responses to environmental change in fishes: Insights from RNA sequencing
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Self-citationOvercoming the pitfalls of merging dietary metabarcoding into ecological networks
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Rapid genetic adaptation to a novel environment despite a genome‐wide reduction in genetic diversity
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Purging of deleterious burden in the endangered Iberian lynx
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Self-citationStrain/species identification in metagenomes using genome-specific markers
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Reference genomes for conservation
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Self-citationMolecular ecology meets systematic conservation planning
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Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution
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Genomic Consequences of Long-Term Population Decline in Brown Eared Pheasant
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Genomic signatures of selection in bats surviving white‐nose syndrome
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Genomic basis for drought resistance in European beech forests threatened by climate change
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Self-citationThe genomic footprint of climate adaptation in Chironomus riparius
Waldvogel, A., Wieser, A., Schell, T., Patel, S., Schmidt, H., Hankeln, T., Feldmeyer, B., & Pfenninger, M. (2018) · Molecular Ecology · doi:10.1111/mec.14543 · Cited by 66 · see citing works
Self-citationMaximizing ecological and evolutionary insight in bisulfite sequencing data sets
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A reference genome of the European beech (Fagus sylvatica L.)
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Self-citationMassive genome inversion drives coexistence of divergent morphs in common quails
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Self-citationLeveraging massively parallel reporter assays for evolutionary questions
Romero, I. G., & Lea, A. J. (2023) · Genome biology · doi:10.1186/s13059-023-02856-6 · Cited by 61 · see citing works
Deciphering the Wisent Demographic and Adaptive Histories from Individual Whole-Genome Sequences
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Novel efficient genome-wide SNP panels for the conservation of the highly endangered Iberian lynx
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A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret
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Genomic evaluation of hybridization in historic and modern North American Bison (Bison bison)
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Spending limited resources on de-extinction could lead to net biodiversity loss
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The impact of endogenous content, replicates and pooling on genome capture from faecal samples
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Comprehensive evaluation of RNA-seq analysis pipelines in diploid and polyploid species
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Ethical, legal, and social issues in the Earth BioGenome Project
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Self-citationBottleneck‐associated changes in the genomic landscape of genetic diversity in wild lynx populations
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Self-citationDe-extinction in a crisis discipline
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Sequencing smart: De novo sequencing and assembly approaches for a non-model mammal
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Conservation genomics illuminates the adaptive uniqueness of North American gray wolves
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Regulatory Noncoding Small RNAs Are Diverse and Abundant in an Extremophilic Microbial Community
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Using multiple reference genomes to identify and resolve annotation inconsistencies
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Self-citationA strategy for building and using a human reference pangenome
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Mosquito control actions affect chironomid diversity in temporary wetlands of the Upper Rhine Valley
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Leveraging massively parallel reporter assays for evolutionary questionsPreprint
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Recently Integrated Alu Elements in Capuchin Monkeys: A Resource for Cebus/Sapajus Genomics
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Plant pangenomes for crop improvement, biodiversity and evolution
Schreiber, M., Jayakodi, M., Stein, N., & Mascher, M. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00691-4 · Cited by 158 · see citing works
Environmental DNA : The next chapter
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Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy
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Self-citationTranslating genomic advances into biodiversity conservation
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Pangenome graphs and their applications in biodiversity genomics
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Self-citationCartney, A. M. M., Formenti, G., Mouton, A., Panis, D. N. D., Marins, L. S., Leitão, H. G., Diedericks, G., Kirangwa, J., Morselli, M., Salces-Ortiz, J., et al. (2024) · npj Biodiversity · doi:10.1038/s44185-024-00054-6 · Cited by 74 · see citing works
Self-citationNatural products reverse cancer multidrug resistance
Zou, J.-Y., Chen, Q., Luo, X.-C., Damdinjav, D., Abdelmohsen, U. R., Li, H., Battulga, T., Chen, H., Wang, Y., & Zhang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1348076 · Cited by 54 · see citing works
Feng, J., Dan, X., Cui, Y., Gong, Y., Peng, M., Sang, Y., Ingvarsson, P. K., & Wang, J. (2024) · Plant Communications · doi:10.1016/j.xplc.2024.101044 · Cited by 53 · see citing works
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Microbial co-occurrence network demonstrates spatial and climatic trends for global soil diversity
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Metagenomic approaches and opportunities in arid soil research
Ejaz, M. R., Badr, K., Hassan, Z. U., Al-Thani, R. F., & Jaoua, S. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176173 · Cited by 44 · see citing works
Genomic investigations of successful invasions: the picture emerging from recent studies
Kołodziejczyk, J., Fijarczyk, A., Porth, I. M., Robakowski, P., Vella, N., Vella, A., Kloch, A., & Biedrzycka, A. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70005 · Cited by 48 · see citing works
Self-citationHuston, G. P., Lopez, M. L. D., Cheng, Y., King, L., Duxbury, L. C., Picard, M., Thomson‐Laing, G., Myler, E., Helbing, C. C., Kinnison, M. T., et al. (2023) · Environmental DNA · doi:10.1002/edn3.467 · Cited by 43 · see citing works
Self-citationMeier, R., Hartop, E., Pylatiuk, C., & Srivathsan, A. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0120 · Cited by 43 · see citing works
An epigenetic toolbox for conservation biologists
Balard, A., Baltazar‐Soares, M., Eizaguirre, C., & Heckwolf, M. J. (2024) · Evolutionary Applications · doi:10.1111/eva.13699 · Cited by 41 · see citing works
Real‐time genomics for One Health
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Self-citationGenomic insights into the conservation of wild and domestic animal diversity: A review
Ghildiyal, K., Nayak, S. S., Rajawat, D., Sharma, A., Chhotaray, S., Bhushan, B., Dutt, T., & Panigrahi, M. (2023) · Gene · doi:10.1016/j.gene.2023.147719 · Cited by 39 · see citing works
Meier, R., Lawniczak, M., & Srivathsan, A. (2024) · Annual Review of Entomology · doi:10.1146/annurev-ento-040124-014001 · Cited by 34 · see citing works
Abundance estimation with DNA metabarcoding – recent advancements for terrestrial arthropods
Sickel, W., Zizka, V. M. A., Scherges, A. M., Bourlat, S. J., & Dieker, P. (2023) · Metabarcoding and Metagenomics · doi:10.3897/mbmg.7.112290 · Cited by 34 · see citing works
Dealing With the Complexity of Effective Population Size in Conservation Practice
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Self-citationThe Ruminant Telomere-to-Telomere (RT2T) Consortium
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Self-citationEstablishing African genomics and bioinformatics programs through annual regional workshops
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Protist genomics: key to understanding eukaryotic evolution
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Finding genes and pathways that underlie coral adaptation
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Self-citation
- Authors
- Theissinger, K., Fernandes, C., Formenti, G., Bista, I., Berg, P. R., Bleidorn, C., Bombarely, A., Crottini, A., Gallo, G. R., Godoy, J. A., Jentoft, S., Malukiewicz, J., Mouton, A., Oomen, R. A., Paez, S., Palsbøll, P. J., Pampoulie, C., Ruiz-López, M. J., Secomandi, S., Svardal, H., Theofanopoulou, C., de Vries, J., Waldvogel, A.-M., Zhang, G., Jarvis, E. D., Bálint, M., Ciofi, C., Waterhouse, R. M., Mazzoni, C. J., Höglund, J., Aghayan, S. A., Alioto, T. S., Almudi, I., Alvarez, N., Alves, P. C., Amorim do Rosario, I. R., Antunes, A., Arribas, P., Baldrian, P., Bertorelle, G., Böhne, A., Bonisoli-Alquati, A., Boštjančić, L. L., Boussau, B., Breton, C. M., Buzan, E., Campos, P. F., Carreras, C., Castro, L. F. C., Chueca, L. J., Čiampor, F., Conti, E., Cook-Deegan, R., Croll, D., Cunha, M. V., Delsuc, F., Dennis, A. B., Dimitrov, D., Faria, R., Favre, A., Fedrigo, O. D., Fernández, R., Ficetola, G. F., Flot, J.-F., Gabaldón, T., Agius, D. R., Giani, A. M., Gilbert, M. T. P., Grebenc, T., Guschanski, K., Guyot, R., Hausdorf, B., Hawlitschek, O., Heintzman, P. D., Heinze, B., Hiller, M., Husemann, M., Iannucci, A., Irisarri, I., Jakobsen, K. S., Klinga, P., Kloch, A., Kratochwil, C. F., Kusche, H., Layton, K. K. S., Leonard, J. A., Lerat, E., Liti, G., Manousaki, T., Marques-Bonet, T., Matos-Maraví, P., Matschiner, M., Maumus, F., Mc Cartney, A. M., Meiri, S., Melo-Ferreira, J., Mengual, X., Monaghan, M. T., Montagna, M., Mysłajek, R. W., Neiber, M. T., Nicolas, V., Novo, M., Ozretić, P., Palero, F., Pârvulescu, L., Pascual, M., Paulo, O. S., Pavlek, M., Pegueroles, C., Pellissier, L., Pesole, G., Primmer, C. R., Riesgo, A., Rüber, L., Rubolini, D., Salvi, D., Seehausen, O., Seidel, M., Studer, B., Theodoridis, S., Thines, M., Urban, L., Vasemägi, A., Vella, A., Vella, N., Vernes, S. C., Vernesi, C., Vieites, D. R., Wheat, C. W., Wörheide, G., Wurm, Y., & Zammit, G.
- Affiliations
- Senckenberg Biodiversity and Climate Research Centre (DE)
- University of Lisbon (PT)
- Rockefeller University (US)
- Naturalis Biodiversity Center (NL)
- University of Oslo (NO)
- University of Göttingen (DE)
- University of Milan (IT)
- Universidade do Porto (PT)
- Estación Biológica de Doñana (ES)
- German Primate Center (DE)
- University of Liège (BE)
- University of Groningen (NL)
- Marine and Freshwater Research Institute (IS)
- University of Antwerp (BE)
- City University of New York (US)
- University of Cologne (DE)
- University of Copenhagen (DK)
- SIB Swiss Institute of Bioinformatics (CH)
- Berlin Center for Genomics in Biodiversity Research (DE)
- Uppsala University (SE)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Corresponding author
- Höglund, Jacob
- ORCID
- Theissinger, Kathrin
- Fernandes, Carlos
- Formenti, Giulio
- Bista, Iliana
- Berg, Paul R.
- Bleidorn, Christoph
- Bombarely, Aureliano
- Crottini, Angelica
- Gallo, Guido R.
- Godoy, José A.
- Jentoft, Sissel
- Malukiewicz, Joanna
- Mouton, Alice
- Oomen, Rebekah A.
- Paez, Sadye
- Palsbøll, Per J.
- Pampoulie, Christophe
- Secomandi, Simona
- Svardal, Hannes
- Theofanopoulou, Constantina
- Waldvogel, Ann-Marie
- Zhang, Guojie
- Jarvis, Erich D.
- Bálint, Miklós
- Waterhouse, Robert M.
- Mazzoni, Camila J.
- Höglund, Jacob
- Aghayan, Sargis A.
- Alioto, Tyler S.
- Alves, Paulo C.
- Antunes, Agostinho
- Arribas, Paula
- Bertorelle, Giorgio
- Böhne, Astrid
- Boštjančić, Ljudevit L.
- Boussau, Bastien
- Breton, Catherine M.
- Campos, Paula F.
- Carreras, Carlos
- Castro, L. FIlipe C.
- Chueca, Luis J.
- Čiampor, Fedor
- Conti, Elena
- Cook-Deegan, Robert
- Croll, Daniel
- Cunha, Mónica V.
- Delsuc, Frédéric
- Dennis, Alice B.
- Dimitrov, Dimitar
- Faria, Rui
- Favre, Adrien
- Fedrigo, Olivier D.
- Fernández, Rosa
- Ficetola, Gentile Francesco
- Flot, Jean-François
- Gabaldón, Toni
- Agius, Dolores R.
- Giani, Alice M.
- Gilbert, M. Thomas P.
- Grebenc, Tine
- Guschanski, Katerina
- Guyot, Romain
- Hausdorf, Bernhard
- Hawlitschek, Oliver
- Heintzman, Peter D.
- Heinze, Berthold
- Hiller, Michael
- Husemann, Martin
- Iannucci, Alessio
- Irisarri, Iker
- Jakobsen, Kjetill S.
- Klinga, Peter
- Kloch, Agnieszka
- Kratochwil, Claudius F.
- Kusche, Henrik
- Layton, Kara K.S.
- Leonard, Jennifer A.
- Lerat, Emmanuelle
- Liti, Gianni
- Manousaki, Tereza
- Matschiner, Michael
- Maumus, Florian
- Meiri, Shai
- Mengual, Ximo
- Monaghan, Michael T.
- Montagna, Matteo
- Mysłajek, Robert W.
- Neiber, Marco T.
- Nicolas, Violaine
- Novo, Marta
- Ozretić, Petar
- Palero, Ferran
- Pârvulescu, Lucian
- Pascual, Marta
- Paulo, Octávio S.
- Pavlek, Martina
- Pegueroles, Cinta
- Pellissier, Loïc
- Pesole, Graziano
- Primmer, Craig R.
- Riesgo, Ana
- Rüber, Lukas
- Rubolini, Diego
- Salvi, Daniele
- Seidel, Matthias
- Studer, Bruno
- Theodoridis, Spyros
- Thines, Marco
- Urban, Lara
- Vasemägi, Anti
- Vella, Adriana
- Vella, Noel
- Vernes, Sonja C.
- Vernesi, Cristiano
- Vieites, David R.
- Wheat, Christopher W.
- Wörheide, Gert
- Wurm, Yannick
- Zammit, Gabrielle
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 39
- Issue
- 7
- Pages
- 545-559
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W4321019193
- Cited by
- 401
- References
- 150
- Citations by year
- 2026: 117 · 2025: 132 · 2024: 120 · 2023: 32
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Genetics (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, cc-by)
- Repository of the University of Namur (publishedVersion, cc-by)
- Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- OAR@UM (University of Malta) (submittedVersion, other-oa)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- HAL (submittedVersion, cc-by)
- Agritrop (Cirad) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DiRROS repository (University of Maribor) (submittedVersion, cc-by-nc-nd)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research Information System (Fondazione Edmund Mach) (submittedVersion, cc-by)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- SERVAL (Université de Lausanne) (submittedVersion, cc-by)
- ReIn UW (University of Warsaw) (submittedVersion, cc-by-nc-nd)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- Florence Research (University of Florence) (submittedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- IRIS (submittedVersion, cc-by)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/T015683/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Physical Sciences › Environmental Science › Ecology › Environmental DNA in Biodiversity Studies
- Keywords
- conservation genomics, biodiversity conservation, reference genome, biodiversity assessment, species restoration, genomic resources, tree of life
- MeSH terms
- Conservation of Natural Resources, Genome, Genomics, Biodiversity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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