The Value of Reference Genomes in the Conservation of Threatened Species
Open accessAbstract
Conservation initiatives are now more crucial than ever—over a million plant and animal species are at risk of extinction over the coming decades. The genetic management of threatened species held in insurance programs is recommended; however, few are taking advantage of the full range of genomic technologies available today. Less than 1% of the 13505 species currently listed as threated by the International Union for Conservation of Nature (IUCN) have a published genome. While there has been much discussion in the literature about the importance of genomics for conservation, there are limited examples of how having a reference genome has changed conservation management practice. The Tasmanian devil (Sarcophilus harrisii), is an endangered Australian marsupial, threatened by an infectious clonal cancer devil facial tumor disease (DFTD). Populations have declined by 80% since the disease was first recorded in 1996. A reference genome for this species was published in 2012 and has been crucial for understanding DFTD and the management of the species in the wild. Here we use the Tasmanian devil as an example of how a reference genome has influenced management actions in the conservation of a species.
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High-quality reference genome assemblies are increasingly recognized as an important foundation of conservation genomics.
“High-quality reference genome assemblies are increasingly recognized as an important foundation of conservation genomics84–91.”
From Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics (2024) · cites this paper as [88]
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Self-citationAdvancing genomics through the Global Invertebrate Genomics Alliance (GIGA)
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Characterisation of non-classical MHC class I genes in the Tasmanian devil (Sarcophilus harrisii)
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Self-citationThe Role of Genomics in Conservation and Reproductive Sciences
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Self-citationIdentification and analysis of divergent immune gene families within the Tasmanian devil genome
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Self-citationTasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity
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Self-citationCheng, Y., & Belov, K. (2011) · Conservation Genetics Resources · doi:10.1007/s12686-011-9575-4 · Cited by 17 · see citing works
Self-citationEmerging genomic applications in mammalian ecology, evolution, and conservation
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SNP panel development for genetic management of wild and domesticated white bass (Morone chrysops)
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A case for genetic parentage assignment in captive group housing
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Self-citationMHC-associated mate choice under competitive conditions in captive versus wild Tasmanian devils
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Self-citationShaney, K. J., Adams, R., Kurniawan, N., Hamidy, A., Smith, E. N., & Castoe, T. A. (2016) · Conservation Genetics Resources · doi:10.1007/s12686-016-0534-y · Cited by 4 · see citing works
Corrigendum to : Advancing genomics through the Global Invertebrate Genomics Alliance (GIGA)
Voolstra, C. R., Scientists, G. C. O., Wörheide, G., & Lopez, J. V. (2017) · Invertebrate Systematics · doi:10.1071/is16059_co · Cited by 3 · see citing works
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Hogg, C. J., Fox, S., Pemberton, D., & Belov, K. (2019) · Cited by 2 · see citing works
Self-citationMiller, W., Hayes, V. M., Ratan, A., Petersen, D. C., Wittekindt, N. E., Miller, J., Walenz, B., Knight, J., Qi, J., Zhao, F., et al. (2011) · Smithsonian Digital Repository (Smithsonian Institution) · doi:10.1073/pnas.1102838108
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- [56]Grueber C.E. Chong R. Gooley R.M. McLennan E.A. Barrs V.R. Belov K. Hogg C.J. Genetic analysis of scat samples to inform conservation of Tasmanian devil Aust. Zool. (In press)
- [63]Hogg C.J. McLennan E.A. Wise P. Lee A. Pemberton D. Fox S. Belov K. Grueber C.E. Preserving the integrity of a single source population during multiple translocations Biol. Conserv. (In press)
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- Authors
- Brandies, P., Peel, E., Hogg, C. J., & Belov, K.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Belov, Katherine
- Venue
- Genes
- Publisher
- MDPI AG
- Published
- 2019-10-25
- Volume
- 10
- Issue
- 11
- Pages
- 846
- ISSN
- 2073-4425 (ISSN-L)
- PMC
- PMC6895880
- OpenAlex
- W2981549736
- Cited by
- 158
- References
- 113
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 25 · 2023: 28 · 2022: 24 · 2021: 22 · 2020: 11 · 2019: 1 · 2018: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Genes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Research Council (LP140100508, DP180102465)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Veterinary Oncology Research
- Keywords
- reference genome, conservation genomics, threatened species, Tasmanian devil, devil facial tumour disease, insurance population, genetic management, extinction risk, marsupials
- MeSH terms
- Animals, Marsupialia, Reference Standards, Genome, Genomics, Endangered Species, Genotyping Techniques
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