Life in the inflamed intestine, Salmonella style

Santos, Renato L.; Raffatellu, Manuela; Bevins, Charles L.; Adams, L. Garry; Tükel, Çagla; Tsolis, Renée M.; Bäumler, Andreas J.

doi:10.1016/j.tim.2009.08.008

Cited by 197Salmonella and Campylobacter epidemiologyEscherichia coli research studiesImmune Response and Inflammation

Life in the inflamed intestine, Salmonella style

Open access

Santos, Renato L., Raffatellu, Manuela, Bevins, Charles L., Adams, L. Garry, Tükel, Çagla, Tsolis, Renée M., Bäumler, Andreas J.·2009·Trends in Microbiology

DOI 10.1016/j.tim.2009.08.008PMC PMC3235402

Open this paper in CoChat — free account

Abstract

The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-gamma and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tim.2009.08.008

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Salmonella Typhimurium initially colonizes the intestines before invading through Peyer's patches to reach deeper tissues.
“The non-typhoidal Salmonella (NTS) serovar Salmonella Typhimurium initially colonizes the intestines before invading through Peyer’s patches to reach deeper tissues (Santos et al., 2009).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Santos et al., 2009

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Food-Related Illness and Death in the United States
Mead, P. S., Slutsker, L., DIETZ, V. J., McCaig, L. F., Bresee, J., Shapiro, C. A., Griffin, P. M., & Tauxe, R. V. (1999) · Emerging infectious diseases · doi:10.3201/eid0505.990502 · Cited by 7,305 · see citing works
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559 · see citing works
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,185 · see citing works
Surveillance for Foodborne Disease Outbreaks—United States, 2006
Gould, L. H., Walsh, K. A., Vieira, A. R., Herman, K., Williams, I. T., Hall, A. J., & Cole, D. J. (2009) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2009.11.004 · Cited by 2,372 · see citing works
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,910 · see citing works
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877 · see citing works
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works
Requirement of Interleukin 17 Receptor Signaling for Lung Cxc Chemokine and Granulocyte Colony-Stimulating Factor Expression, Neutrophil Recruitment, and Host Defense
Ye, P., Rodriguez, F. H., Kanaly, S. T., Stocking, K. L., Schurr, J. R., Schwarzenberger, P. O., Oliver, P., Huang, W., Zhang, P., Zhang, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.519 · Cited by 1,522 · see citing works
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432 · see citing works
The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron Acquisition
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355 · see citing works
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
Gewirtz, A. T., Navas, T. A., Lyons, S., Godowski, P. J., & Madara, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1882 · Cited by 1,345 · see citing works
Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
Cella, M., Fuchs, A. G., Vermi, W., Facchetti, F., Otero, K., Lennerz, J. K., Doherty, J. M., Mills, J. C., & Colonna, M. (2008) · Nature · doi:10.1038/nature07537 · Cited by 1,245 · see citing works
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works
Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense
Satoh‐Takayama, N., Vosshenrich, C. A. J., Lesjean‐Pottier, S., Sawa, S., Lochner, M., Rattis, F. M., Mention, J., Thiam, K., Cerf–Bensussan, N., Mandelboim, O., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.001 · Cited by 1,086 · see citing works
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048 · see citing works
Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host
Barthel, M., Hapfelmeier, S., Quintanilla-Martínez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Rüssmann, H., & Hardt, W.-D. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2839-2858.2003 · Cited by 1,020 · see citing works
Evolution in bacteria: Evidence for a universal substitution rate in cellular genomes
Ochman, H., & Wilson, A. C. (1987) · Journal of Molecular Evolution · doi:10.1007/bf02111283 · Cited by 780 · see citing works
Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin
Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765 · see citing works
Surveillance for Foodborne Disease Outbreaks—United States, 2009-2010
del Portal, D. A., & Karras, D. J. (2013) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2013.04.001 · Cited by 719 · see citing works
Identification of a pathogenicity island required for Salmonella survival in host cells.
Ochman, H., Soncini, F. C., Solomon, F., & Groisman, E. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7800 · Cited by 652 · see citing works
Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
Brandl, K., Plitas, G., Mihu, C. N., Ubeda, C., Jia, T., Fleisher, M., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2008) · Nature · doi:10.1038/nature07250 · Cited by 631 · see citing works
Determining Divergence Times of the Major Kingdoms of Living Organisms with a Protein Clock
Doolittle, R. F., Feng, D.-F., Tsang, S., Cho, G., & Little, E. (1996) · Science · doi:10.1126/science.271.5248.470 · Cited by 581 · see citing works
Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Raffatellu, M., Santos, R. L., Verhoeven, D. E., George, M. D., Wilson, R. P., Winter, S., Godinez, I., Sankaran, S., da Paixão, T. A., Gordon, M. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1743 · Cited by 568 · see citing works
Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U., Xu, W., Klevit, R. E., Moual, H. L., & Miller, S. I. (2005) · Cell · doi:10.1016/j.cell.2005.05.030 · Cited by 554 · see citing works
The role of microbiota in infectious disease
Stecher, B., & Hardt, W. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2007.12.008 · Cited by 533 · see citing works
Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525 · see citing works
Self-citation
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury
Berger, T., Togawa, A., Duncan, G. S., Elia, A. J., You-Ten, A., Wakeham, A., Fong, H. E. H., Cheung, C. C., & Mak, T. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510847103 · Cited by 460 · see citing works
Salmonella infections in immunocompromised adults
Gordon, M. A. (2008) · Journal of Infection · doi:10.1016/j.jinf.2008.03.012 · Cited by 453 · see citing works
Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and RORγt and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion1
Rachitskaya, A., Hansen, A., Horai, R., Li, Z., Villasmil, R., Luger, D., Nussenblatt, R., & Caspi, R. (2008) · Journal of Immunology · doi:10.4049/jimmunol.180.8.5167 · Cited by 444 · see citing works
Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract
Barman, M., Unold, D., Shifley, K., Amir, E., Hung, K.-C., Bos, N. A., & Salzman, N. H. (2007) · Infection and Immunity · doi:10.1128/iai.01432-07 · Cited by 428 · see citing works
The multifaceted Paneth cell
Porter, E. M., Bevins, C. L., Ghosh, D., & Ganz, T. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8412-z · Cited by 423 · see citing works
Self-destructive cooperation mediated by phenotypic noise
Ackermann, M., Stecher, B., Freed, N. E., Songhet, P., Hardt, W., & Doebeli, M. (2008) · Nature · doi:10.1038/nature07067 · Cited by 420 · see citing works
Non-typhoidal salmonellosis: emerging problems
Rabsch, W., Tschäpe, H., & Bäumler, A. J. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01375-2 · Cited by 401 · see citing works
The Salmonella Pathogenicity Island (SPI)-2 and SPI-1 Type III Secretion Systems Allow Salmonella Serovar typhimurium to Trigger Colitis via MyD88-Dependent and MyD88-Independent Mechanisms
Hapfelmeier, S., Stecher, B., Barthel, M., Kremer, M., Müller, A. J., Heikenwälder, M. F., Stallmach, T., Hensel, M., Pfeffer, K., Akira, S., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1675 · Cited by 394 · see citing works
MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070563 · Cited by 385 · see citing works
A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K‐12 chromosome
Mills, D. M., Bajaj, V., & Lee, C. A. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02382.x · Cited by 359 · see citing works
Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN
Hantke, K., Nicholson, G., Rabsch, W., & Winkelmann, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737682100 · Cited by 359 · see citing works
Surveillance for foodborne-disease outbreaks--United States, 1993-1997.
Olsen, S. J., MacKinnon, L. C., Goulding, J. S., Bean, N. H., & Slutsker, L. (2000) · PubMed · Cited by 359 · see citing works
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells
Kimura, A., Naka, T., & Kishimoto, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705268104 · Cited by 355 · see citing works
Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1 beta and tumour necrosis factor-alpha.
Cromwell, O., Hamid, Q. A., Corrigan, C. J., Barkans, J. R., Meng, Q., COLLINS, P. D., & Kay, A. B. (1992) · PubMed Central · Cited by 353 · see citing works
The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more
Gunn, J. S. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.03.007 · Cited by 331 · see citing works
entry into host cells: the work in concert of type III secreted effector proteins
Zhou, D., & Galán, J. E. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01489-7 · Cited by 325 · see citing works
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604636103 · Cited by 319 · see citing works
Contribution of Salmonella typhimurium Virulence Factors to Diarrheal Disease in Calves
Tsolis, R. M., Adams, L. G., Ficht, T. A., & Bäumler, A. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4879-4885.1999 · Cited by 319 · see citing works
SipA, SopA, SopB, SopD, and SopE2 Contribute to Salmonella enterica Serotype Typhimurium Invasion of Epithelial Cells
Raffatellu, M., Wilson, R. P., Chessa, D., Andrews‐Polymenis, H. L., Tran, Q. T., Lawhon, S. D., Khare, S., Adams, L. G., & Bäumler, A. J. (2004) · Infection and Immunity · doi:10.1128/iai.73.1.146-154.2005 · Cited by 311 · see citing works
Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal Microbiota
Lawley, T. D., Bouley, D. M., Hoy-Schulz, Y. E., Gerke, C., Relman, D. A., & Monack, D. M. (2007) · Infection and Immunity · doi:10.1128/iai.01189-07 · Cited by 307 · see citing works
Th17 cells and mucosal host defense
Aujla, S. J., Dubin, P. J., & Kolls, J. K. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.009 · Cited by 303 · see citing works
Molecular Pathogenesis ofSalmonella entericaSerotype Typhimurium-Induced Diarrhea
Zhang, S., Kingsley, R. A., Santos, R. L., Andrews‐Polymenis, H. L., Raffatellu, M., Figueiredo, J. F., Nunes, J. S., Tsolis, R. M., Adams, L. G., & Bäumler, A. J. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.1-12.2003 · Cited by 295 · see citing works
5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.
Madara, J., Patapoff, T. W., Gillece-Castro, B. L., Colgan, S. P., Parkos, C. A., Delp, C., & Mrsny, R. J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116462 · Cited by 290 · see citing works
Salmonella entericaSerovar Typhimurium Pathogenicity Island 2 Is Necessary for Complete Virulence in a Mouse Model of Infectious Enterocolitis
Coburn, B. A., Li, Y., Owen, D., Vallance, B. A., & Finlay, B. B. (2005) · Infection and Immunity · doi:10.1128/iai.73.6.3219-3227.2005 · Cited by 204 · see citing works
A mouse model for S. typhimurium-induced enterocolitis
Hapfelmeier, S., & Hardt, W. (2005) · Trends in Microbiology · doi:10.1016/j.tim.2005.08.008 · Cited by 199 · see citing works
Motility allows S. Typhimurium to benefit from the mucosal defence
Stecher, B., Barthel, M., Schlumberger, M. C., Haeberli, L., Rabsch, W., Kremer, M., & Hardt, W. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01118.x · Cited by 198 · see citing works
Biosynthesis and IroC‐dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium
Crouch, M. V., Castor, M., Karlinsey, J. E., Kalhorn, T., & Fang, F. C. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.06089.x · Cited by 187 · see citing works
CsgA is a pathogen‐associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll‐like receptor 2
Tükel, Ç., Raffatellu, M., Humphries, A. D., Wilson, R. P., Andrews‐Polymenis, H. L., Gull, T. B., Figueiredo, J. F., Wong, M. H., Michelsen, K. S., Akçelik, N., et al. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04825.x · Cited by 187 · see citing works
Bacteremia in febrile Malawian children: clinical and microbiologic features
WALSH, A. L., PHIRI, A. J., Graham, S. M., MOLYNEUX, E. M., & Molyneux, M. E. (2000) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200004000-00010 · Cited by 184 · see citing works
Responses to Amyloids of Microbial and Host Origin Are Mediated through Toll-like Receptor 2
Tükel, Ç., Wilson, R. P., Nishimori, J. H., Pezeshki, M., Chromy, B. A., & Bäumler, A. J. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.020 · Cited by 183 · see citing works
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted
Cummings, L. A., Wilkerson, W. D., Bergsbaken, T., & Cookson, B. T. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05271.x · Cited by 179 · see citing works
Immunity to Systemic Salmonella Infections
Mastroeni, P. (2002) · Current Molecular Medicine · doi:10.2174/1566524023362492 · Cited by 168 · see citing works
Injection of Flagellin into the Host Cell Cytosol by Salmonella enterica Serotype Typhimurium
Sun, Y., Rolán, H. G., & Tsolis, R. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700181200 · Cited by 165 · see citing works
Interleukin-23 Orchestrates Mucosal Responses to Salmonella enterica Serotype Typhimurium in the Intestine
Godinez, I., Raffatellu, M., Chu, H., da Paixão, T. A., Haneda, T., Santos, R. L., Bevins, C. L., Tsolis, R. M., & Bäumler, A. J. (2008) · Infection and Immunity · doi:10.1128/iai.00933-08 · Cited by 163 · see citing works
Manipulating cellular transport and immune responses: dynamic interactions between intracellular Salmonella enterica and its host cells
Abrahams, G. L., & Hensel, M. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00706.x · Cited by 152 · see citing works
T Cells Help To Amplify Inflammatory Responses Induced bySalmonella entericaSerotype Typhimurium in the Intestinal Mucosa
Godinez, I., Haneda, T., Raffatellu, M., George, M. D., da Paixão, T. A., Rolán, H. G., Santos, R. L., Dandekar, S., Tsolis, R. M., & Bäumler, A. J. (2008) · Infection and Immunity · doi:10.1128/iai.01691-07 · Cited by 151 · see citing works
The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation
Müller, A. J., Hoffmann, C., Galle, M., Broeke, A. V. D., Heikenwälder, M. F., Falter, L., Misselwitz, B., Kremer, M., Beyaert, R., & Hardt, W. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.07.007 · Cited by 150 · see citing works
Morphologic and Molecular Characterization of Salmonella typhimurium Infection in Neonatal Calves
Santos, R. L., Zhang, S., Tsolis, R. M., Bäumler, A. J., & Adams, L. G. (2002) · Veterinary Pathology · doi:10.1354/vp.39-2-200 · Cited by 148 · see citing works
IroN, a Novel Outer Membrane Siderophore Receptor Characteristic of Salmonella enterica
Bäumler, A. J., Norris, T. L., Lasco, T., Voigt, W., Reissbrodt, R., Rabsch, W., & Heffron, F. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.6.1446-1453.1998 · Cited by 147 · see citing works
PhoP‐regulated Salmonella resistance to the antimicrobial peptides magainin 2 and polymyxin B
Shi, Y., Cromie, M. J., Hsu, F., TURK, J. W., & Groisman, E. A. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04107.x · Cited by 138 · see citing works
SalmonellaHost Cell Invasion Emerged by Acquisition of a Mosaic of Separate Genetic Elements, IncludingSalmonellaPathogenicity Island 1 (SPI1), SPI5, andsopE2
Mirold, S., Ehrbar, K., Weissmüller, A., Prager, R., Tschäpe, H., Rüssmann, H., & Hardt, W. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.7.2348-2358.2001 · Cited by 133 · see citing works
The record of horizontal gene transfer in Salmonella
Bäumler, A. J. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)01082-2 · Cited by 132 · see citing works
Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12
Hensel, M., Shea, J. E., Bäumler, A. J., Gleeson, C., Blattner, F. R., & Holden, D. W. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.4.1105-1111.1997 · Cited by 124 · see citing works
Salmonella enterica serotype Typhimurium Std fimbriae bind terminal α(1,2)fucose residues in the cecal mucosa
Chessa, D., Winter, M. G., Jakomin, M., & Bäumler, A. J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06566.x · Cited by 123 · see citing works
Rapid detection of Salmonella enterica with primers specific for iroB
Bäumler, A. J., Heffron, F., & Reissbrodt, R. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.5.1224-1230.1997 · Cited by 117 · see citing works
T lymphocytes in host defense against bacterial translocation from the gastrointestinal tract
Gautreaux, M. D., Deitch, E. A., & Berg, R. D. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2874-2884.1994 · Cited by 114 · see citing works
Molecular Epidemiology of 3 Putative Virulence Genes forEscherichia coliUrinary Tract Infection—usp, iha,andiroNE. coli
Bauer, R., Zhang, L., Foxman, B., Siitonen, A., Jantunen, M. E., Saxén, H., & Marrs, C. F. (2002) · The Journal of Infectious Diseases · doi:10.1086/340206 · Cited by 107 · see citing works
Murine NKT cells produce Th17 cytokine interleukin-22
Goto, M., Murakawa, M., Kadoshima-Yamaoka, K., Tanaka, Y., Nagahira, K., Fukuda, Y., & Nishimura, T. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2008.10.002 · Cited by 104 · see citing works
Instruments of microbial warfare: Bacteriocin synthesis, toxicity and immunity
Baba, T., & Schneewind, O. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(97)01196-7 · Cited by 104 · see citing works
The crucial role of polymorphonuclear leukocytes in resistance to Salmonella dublin infections in genetically susceptible and resistant mice
Vassiloyanakopoulos, A. P., Okamoto, S., & Fierer, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7676 · Cited by 101 · see citing works
Contribution of Flagellin Pattern Recognition to Intestinal Inflammation duringSalmonella entericaSerotype Typhimurium Infection
Winter, S., Thiennimitr, P., Nuccio, S., Haneda, T., Winter, M. G., Wilson, R. P., Russell, J. M., Henry, T., Tran, Q. T., Lawhon, S. D., et al. (2009) · Infection and Immunity · doi:10.1128/iai.01341-08 · Cited by 101 · see citing works
Developmentally Regulated Intestinal Expression of IFN-γ and Its Target Genes and the Age-Specific Response to Enteric Salmonella Infection
Rhee, S., Walker, W. A., & Cherayil, B. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.2.1127 · Cited by 97 · see citing works
The impact of bacteraemia on HIV infection. Nine years experience in a large Italian University Hospital
Tumbarello, M., Tacconelli, E., Caponera, S., Cauda, R., & Ortona, L. (1995) · Journal of Infection · doi:10.1016/s0163-4453(95)92110-9 · Cited by 96 · see citing works
Paneth Cell α-Defensin Synthesis and Function
Ouellette, A. J. (2006) · Springer eBooks · doi:10.1007/3-540-29916-5_1 · Cited by 95 · see citing works
The Capsule Encoding theviaBLocus Reduces Interleukin-17 Expression and Mucosal Innate Responses in the Bovine Intestinal Mucosa during Infection withSalmonella entericaSerotype Typhi
Raffatellu, M., Santos, R. L., Chessa, D., Wilson, R. P., Winter, S., Rossetti, C., Lawhon, S. D., Chu, H., Lau, T., Bevins, C. L., et al. (2007) · Infection and Immunity · doi:10.1128/iai.01571-06 · Cited by 93 · see citing works
Characterization of an iroBCDEN Gene Cluster on a Transmissible Plasmid of Uropathogenic Escherichia coli : Evidence for Horizontal Transfer of a Chromosomal Virulence Factor
Sorsa, L. J., Dufke, S., Heesemann, J., & Schubert, S. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3285-3293.2003 · Cited by 85 · see citing works
Secreted Effector Proteins ofSalmonella entericaSerotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis
Zhang, S., Adams, L. G., Nunes, J. S., Khare, S., Tsolis, R. M., & Bäumler, A. J. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4795-4803.2003 · Cited by 81 · see citing works
Non-typhoidal Salmonella Bacteraemia Without Gastroenteritis: a Marker of Underlying Immunosuppression. Review of Casesat St. Thomas' Hospital 1970–1999
Brown, M. J., & Eykyn, S. J. (2000) · Journal of Infection · doi:10.1053/jinf.2000.0750 · Cited by 74 · see citing works
Genetic flux over time in the Salmonella lineage
Vernikos, G. S., Thomson, N. R., & Parkhill, J. (2007) · Genome biology · doi:10.1186/gb-2007-8-6-r100 · Cited by 73 · see citing works
Innate Immune Activation of CD4 T Cells in Salmonella-Infected Mice Is Dependent on IL-18
Srinivasan, A., Salazar-Gonzalez, R.-M., Jarcho, M. P., Sandau, M. M., Lefrançois, L., & McSorley, S. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6342 · Cited by 70 · see citing works
Neutrophils prevent extracellular colonization of the liver microvasculature by Salmonella typhimurium
Conlan, J. W. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.1043-1047.1996 · Cited by 63 · see citing works
Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis
Siegemund, S., Schütze, N., Freudenberg, M. A., Lutz, M. B., Straubinger, R. K., & Alber, G. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.09.004 · Cited by 52 · see citing works
Neutrophil influx during non-typhoidal salmonellosis: who is in the driver's seat?
kel, Ã. T. ⁄., Raffatellu, M., Chessa, D., Wilson, R. P., AkÃ§elik, M., & Bäumler, A. J. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2006.00051.x · Cited by 46 · see citing works
Salmonella meningitis in children in Blantyre, Malawi, 1996–1999
MOLYNEUX, E. M., Walsh, A. L., Malenga, G. J., Rogerson, S. J., & Molyneux, M. E. (2000) · Annals of Tropical Paediatrics · doi:10.1080/02724930092057 · Cited by 42 · see citing works
RosE represses Std fimbrial expression in Salmonella enterica serotype Typhimurium
Chessa, D., Winter, M. G., Nuccio, S., Tükel, Ç., & Bäumler, A. J. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06185.x · Cited by 38 · see citing works
Salmonella infections in a cancer center
Noriega, L. M., van der Auwera, P., DANEAU, D., Meunier, F., & Aoun, M. (1994) · Supportive Care in Cancer · doi:10.1007/bf00572093 · Cited by 32 · see citing works
Salmonella bacteremia in African patients with human immunodeficiency virus infection
Wit, S. D., Taelman, H., de Perre, P. V., Rouvroy, D., & Clumeck, N. (1988) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01962170 · Cited by 24 · see citing works

Flagged first, then by citations

2 of the 100 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

[85]Frenzen P 1999 Salmonella cost estimate update using FoodNet data Food Review 22 10 15

Sorted by citations

Gut inflammation provides a respiratory electron acceptor for Salmonella
Winter, S., Thiennimitr, P., Winter, M. G., Butler, B. P., Huseby, D. L., Crawford, R. W., Russell, J. M., Bevins, C. L., Adams, L. G., Tsolis, R. M., et al. (2010) · Nature · doi:10.1038/nature09415 · Cited by 1,271 · see citing works
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
Thiennimitr, P., Winter, S., Winter, M. G., Byndloss, M. X., Tolstikov, V., Huseby, D. L., Sterzenbach, T., Tsolis, R. M., Roth, J. R., & Bäumler, A. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107857108 · Cited by 611 · see citing works
Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut
Liu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328 · see citing works
Self-citation
Salmonella Typhimurium and inflammation: a pathogen-centric affair
Galán, J. E. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00561-4 · Cited by 325 · see citing works
Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons
Deriu, E., Boxx, G. M., He, X., Pan, C., Benavidez, S. D., Cen, L., Rozengurt, N., Shi, W., & Cheng, G. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005572 · Cited by 280 · see citing works
The Cost of Virulence: Retarded Growth of Salmonella Typhimurium Cells Expressing Type III Secretion System 1
Sturm, A., Heinemann, M., Arnoldini, M., Benecke, A., Ackermann, M., Benz, M., Dormann, J., & Hardt, W. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002143 · Cited by 266 · see citing works
Microbiome and pathogen interaction with the immune system
Kogut, M. H., Lee, A., & Santín, E. (2020) · Poultry Science · doi:10.1016/j.psj.2019.12.011 · Cited by 254 · see citing works
Innate immune response to Salmonella typhimurium , a model enteric pathogen
Brož, P., Ohlson, M. B., & Monack, D. M. (2012) · Gut Microbes · doi:10.4161/gmic.19141 · Cited by 228 · see citing works
Metabolic host responses to infection by intracellular bacterial pathogens
Eisenreich, W., Heesemann, J., Rudel, T., & Goebel, W. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00024 · Cited by 217 · see citing works
Host Specificity of Bacterial PathogensPreprint
Bäumler, A. J., & Fang, F. C. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a010041 · Cited by 202 · see citing works
The Impact of Dietary Transition Metals on Host-Bacterial Interactions
Lopez, C. A., & Skaar, E. P. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.008 · Cited by 190 · see citing works
Modulation of immune homeostasis by commensal bacteria
Ivanov, I. I., & Littman, D. R. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.12.003 · Cited by 183 · see citing works
The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response
Kaiser, P., Diard, M., Stecher, B., & Hardt, W. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01070.x · Cited by 181 · see citing works
Macrophages in the gut: Masters in multitasking
Delfini, M., Stakenborg, N., Viola, M. F., & Boeckxstaens, G. E. (2022) · Immunity · doi:10.1016/j.immuni.2022.08.005 · Cited by 174 · see citing works
Multiplicity of S almonella entry mechanisms, a new paradigm for S almonella pathogenesis
Velge, P., Wiedemann, A., Rosselin, M., Abed, N., Boumart, Z., Chaussé, A., Grépinet, O., Namdari, F., Roche, S., Rossignol, A., et al. (2012) · MicrobiologyOpen · doi:10.1002/mbo3.28 · Cited by 157 · see citing works
Quantitative Assessment of Cytosolic Salmonella in Epithelial Cells
Knodler, L. A., Nair, V., & Steele‐Mortimer, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084681 · Cited by 149 · see citing works
The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut
Rivera-Chávez, F., & Bäumler, A. J. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104108 · Cited by 143 · see citing works
Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda
Griffin, A. J., & McSorley, S. J. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.2 · Cited by 143 · see citing works
Bacterial Metabolism Shapes the Host–Pathogen Interface
Passalacqua, K. D., Charbonneau, M., & O’Riordan, M. X. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0027-2015 · Cited by 143 · see citing works
The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis
Lopez, C. A., Rivera-Chávez, F., Byndloss, M. X., & Bäumler, A. J. (2015) · Infection and Immunity · doi:10.1128/iai.00351-15 · Cited by 138 · see citing works
Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial Genome
Ilyas, B., Tsai, C. N., & Coombes, B. K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00428 · Cited by 128 · see citing works
Salmonella, the host and its microbiota
Thiennimitr, P., Winter, S., & Bäumler, A. J. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.10.002 · Cited by 126 · see citing works
Scientific Opinion on monitoring and assessment of the public health risk of “SalmonellaTyphimurium-like” strains
(BIOHAZ), E. P. O. B. H. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1826 · Cited by 117 · see citing works
Protective Host Immune Responses to Salmonella Infection
Pham, O. H., & McSorley, S. J. (2015) · Future Microbiology · doi:10.2217/fmb.14.98 · Cited by 115 · see citing works
Influence of Salmonella enterica serovar Enteritidis infection on the composition of chicken cecal microbiota
Videnska, P., Šišák, F., Havlíčková, H., Faldynová, M., & Rychlı́k, I. (2013) · BMC Veterinary Research · doi:10.1186/1746-6148-9-140 · Cited by 98 · see citing works
Spatial Segregation of Virulence Gene Expression during Acute Enteric Infection with Salmonella enterica serovar Typhimurium
Laughlin, R. C., Knodler, L. A., Barhoumi, R., Payne, H. R., Wu, J., Gomez, G., Pugh, R., Lawhon, S. D., Bäumler, A. J., Steele‐Mortimer, O., et al. (2014) · mBio · doi:10.1128/mbio.00946-13 · Cited by 95 · see citing works
Microbial Amyloids Induce Interleukin 17A (IL-17A) and IL-22 Responses via Toll-Like Receptor 2 Activation in the Intestinal Mucosa
Nishimori, J. H., Newman, T., Oppong, G. O., Rapsinski, G. J., Yen, J.-H. J., Biesecker, S. G., Wilson, R. P., Butler, B. P., Winter, M. G., Tsolis, R. M., et al. (2012) · Infection and Immunity · doi:10.1128/iai.00911-12 · Cited by 92 · see citing works
Salmonella Non-typhoidal
Mølbak, K., Kirk, M., Olsen, J. E., & Besser, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822521-9.00090-3 · Cited by 91 · see citing works
Identification of a common immune signature in murine and human systemic Salmonellosis
Lee, S., Liang, L., Juárez, S., Nanton, M. R., Gondwe, E. N., Msefula, C. L., Kayala, M. A., Necchi, F., Heath, J. N., Hart, P. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111413109 · Cited by 90 · see citing works
Salmonella Typhimurium metabolism affects virulence in the host – A mini-review
Herrero-Fresno, A., & Olsen, J. E. (2017) · Food Microbiology · doi:10.1016/j.fm.2017.04.016 · Cited by 90 · see citing works
Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection
Songhet, P., Barthel, M., Stecher, B., Müller, A. J., Kremer, M., Hansson, G. C., & Hardt, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022459 · Cited by 86 · see citing works
Opposing roles of IL-10 in acute bacterial infection
Peñaloza, H. F., Schultz, B. M., Nieto, P. A., Salazar, G. A., Suazo, I. D., González, P. A., Riedel, C. A., Álvarez-Lobos, M. M., Kalergis, A. M., & Bueno, S. M. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.07.003 · Cited by 88 · see citing works
Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota
Drumo, R., Pesciaroli, M., Ruggeri, J., Tarantino, M., Chirullo, B., Pistoia, C., Petrucci, P., Martinelli, N., Moscati, L., Manuali, E., et al. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00106 · Cited by 78 · see citing works
Siderophore-based immunization strategy to inhibit growth of enteric pathogens
Sassone-Corsi, M., Chairatana, P., Zheng, T., Perez-Lopez, A., Edwards, R. A., George, M. D., Nolan, E. M., & Raffatellu, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606290113 · Cited by 75 · see citing works
Self-citation
Microbial-Induced Th17: Superhero or Supervillain?
McGeachy, M. J., & McSorley, S. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201834 · Cited by 73 · see citing works
Salmonella Typhimurium Impedes Innate Immunity with a Mast-Cell-Suppressing Protein Tyrosine Phosphatase, SptP
Choi, H. W., Brooking-Dixon, R., Neupane, S., Lee, C.-J., Miao, E. A., Staats, H. F., & Abraham, S. N. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.009 · Cited by 72 · see citing works
High Iron-Sequestrating Bifidobacteria Inhibit Enteropathogen Growth and Adhesion to Intestinal Epithelial Cells In vitro
Vazquez-Gutierrez, P., de Wouters, T., Werder, J., Chassard, C., & Lacroix, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01480 · Cited by 71 · see citing works
Salmonellosis in cattle: Advantages of being an experimental model
da Costa, L. F., da Paixão, T. A., Tsolis, R. M., Bäumler, A. J., & Santos, R. L. (2012) · Research in Veterinary Science · doi:10.1016/j.rvsc.2012.03.002 · Cited by 70 · see citing works
Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature
Heithoff, D. M., Shimp, W. R., House, J. K., Xie, Y., Weimer, B. C., Sinsheimer, R. L., & Mahan, M. J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002647 · Cited by 69 · see citing works
Salmonella Transiently Reside in Luminal Neutrophils in the Inflamed Gut
Loetscher, Y., Wieser, A., Lengefeld, J., Kaiser, P., Schubert, S., Heikenwälder, M. F., Hardt, W., & Stecher, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034812 · Cited by 66 · see citing works
Inducible NO synthase and antibacterial host defence in times of Th17/Th22/T22 immunity
Mühl, H., Bachmann, M., & Pfeilschifter, J. M. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01559.x · Cited by 66 · see citing works
Dietary rice bran promotes resistance to Salmonella enterica serovar Typhimurium colonization in mice
Kumar, A., Henderson, A. J., Forster, G. M., Goodyear, A., Weir, T. L., Leach, J. E., DOW, S. W., & Ryan, E. P. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-71 · Cited by 65 · see citing works
An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
Müller‐Hauser, A. A., Dolowschiak, T., Sellin, M. E., Felmy, B., Verbree, C. T., Sandra, G., Westermann, A. J., Vogel, J., LeibundGut‐Landmann, S., & Hardt, W. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005723 · Cited by 59 · see citing works
Vaccination against Salmonella Infection: the Mucosal Way
Gayet, R., Bioley, G., Rochereau, N., Paul, S., & Corthésy, B. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00007-17 · Cited by 64 · see citing works
Interaction of Salmonella spp. with the Intestinal Microbiota
Ahmer, B. M. M., & Gunn, J. S. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00101 · Cited by 74 · see citing works
A Rapid Change in Virulence Gene Expression during the Transition from the Intestinal Lumen into Tissue Promotes Systemic Dissemination of Salmonella
Winter, S., Winter, M. G., Godinez, I., Yang, H., Rüssmann, H., Andrews‐Polymenis, H. L., & Bäumler, A. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001060 · Cited by 62 · see citing works
A review on development of novel strategies for controlling Salmonella Enteritidis colonization in laying hens: Fiber-based molt diets
Ricke, S. C., Dunkley, C. S., & Durant, J. A. (2013) · Poultry Science · doi:10.3382/ps.2012-02763 · Cited by 61 · see citing works
Salmonellain Swine: Microbiota Interactions
Kim, H. B., & Isaacson, R. E. (2016) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-022516-022834 · Cited by 61 · see citing works
Pathobiology of Salmonella, Intestinal Microbiota, and the Host Innate Immune Response
Santos, R. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00252 · Cited by 59 · see citing works
Lentiviral vectors in clinical trials: Current status.
D’Costa, J., Mansfield, S. G., & Humeau, L. M. P. F. (2009) · PubMed · Cited by 59 · see citing works
Spread ofSalmonella entericain the body during systemic infection: unravelling host and pathogen determinants
Mastroeni, P., & Grant, A. J. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001840 · Cited by 57 · see citing works
Modelling the Gastrointestinal Carriage of Klebsiella pneumoniae Infections
Calderón-Gonzalez, R., Lee, A., López-Campos, G., Hancock, S. J., Sá-Pessoa, J., Dumigan, A., McMullan, R., Campbell, E. L., & Bengoechea, J. (2022) · bioRxiv · doi:10.1128/mbio.03121-22 · Cited by 53 · see citing works
In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection
Miller, A. L., Pasternak, J. A., Medeiros, N. J., Nicastro, L. K., Tursi, S. A., Hansen, E. G., Krochak, R., Sokaribo, A. S., MacKenzie, K. D., Palmer, M. B., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008591 · Cited by 56 · see citing works
Involvement of MicroRNAs in Probiotics-Induced Reduction of the Cecal Inflammation by Salmonella Typhimurium
Chen, Q., Tong, C., Ma, S., Zhou, L., Zhao, L., & Zhao, X. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00704 · Cited by 53 · see citing works
NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium
Felmy, B., Songhet, P., Slack, E. M. C., Müller, A. J., Kremer, M., Maele, L. V., Cayet, D., Heikenwälder, M. F., Sirard, J., & Hardt, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077204 · Cited by 56 · see citing works
The Type VI Secretion System Encoded in SPI-6 Plays a Role in Gastrointestinal Colonization and Systemic Spread of Salmonella enterica serovar Typhimurium in the Chicken
Pezoa, D., Yang, H., Blondel, C. J., Santiviago, C. A., Andrews‐Polymenis, H. L., & Contreras, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063917 · Cited by 52 · see citing works
Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages
Sun, Y., Reid, B., Ferreira, F., Luxardi, G., Ma, L., Lokken, K. L., Zhu, K., Xu, G., Sun, Y., Ryzhuk, V., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000044 · Cited by 52 · see citing works
The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens
Ijaz, A., Veldhuizen, E. J. A., Broere, F., Rutten, V. P. M. G., & Jansen, C. A. (2021) · Pathogens · doi:10.3390/pathogens10111512 · Cited by 49 · see citing works
Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
Liu, J., Gu, Z., Song, F., Zhang, H., Zhao, J., & Chen, W. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00299 · Cited by 49 · see citing works
Current knowledge and perspectives of potential impacts of Salmonella enterica on the profile of the gut microbiota
Aljahdali, N. H., Sanad, Y. M., Han, J., & Foley, S. L. (2020) · BMC Microbiology · doi:10.1186/s12866-020-02008-x · Cited by 49 · see citing works
Type 1 fimbriae are important factors limiting the dissemination and colonization of mice by Salmonella Enteritidis and contribute to the induction of intestinal inflammation during Salmonella invasion
Kuźmińska-Bajor, M., Grzymajło, K., & Ugorski, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00276 · Cited by 48 · see citing works
Type I Interferons Control Proliferation and Function of the Intestinal Epithelium
Katlinskaya, Y. V., Katlinski, K. V., Lasri, A., Li, N., Beiting, D. P., Durham, A. C., Yang, T., Pikarsky, E., Lengner, C. J., Johnson, F. B., et al. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00988-15 · Cited by 44 · see citing works
Chicken-Specific Kinome Array Reveals that Salmonella enterica Serovar Enteritidis Modulates Host Immune Signaling Pathways in the Cecum to Establish a Persistence Infection
Kogut, M. H., Swaggerty, C. L., Byrd, J. A., Selvaraj, R. K., & Arsenault, R. J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081207 · Cited by 46 · see citing works
Typhoid fever
Wangdi, T., Winter, S., & Bäumler, A. J. (2012) · Gut Microbes · doi:10.4161/gmic.18602 · Cited by 45 · see citing works
Malaria, anemia, and invasive bacterial disease: A neutrophil problem?
Mooney, J. P., Galloway, L. J., & Riley, E. M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri1018-400r · Cited by 45 · see citing works
Early MyD88-Dependent Induction of Interleukin-17A Expression during Salmonella Colitis
Keestra, A. M., Godinez, I., Byndloss, M. X., Winter, M. G., Winter, S., Tsolis, R. M., & Bäumler, A. J. (2011) · Infection and Immunity · doi:10.1128/iai.00018-11 · Cited by 44 · see citing works
Salmonella enterica serovar Typhimurium-infected pigs with different shedding levels exhibit distinct clinical, peripheral cytokine and transcriptomic immune response phenotypes
Knetter, S., Bearson, S. M. D., Huang, T.-H., Kurkiewicz, D., Schroyen, M., Nettleton, D. S., Berman, D., Cohen, V. J., Lunney, J. K., Ramer‐Tait, A. E., et al. (2014) · Innate Immunity · doi:10.1177/1753425914525812 · Cited by 44 · see citing works
Neutrophils Are a Source of Gamma Interferon during Acute Salmonella enterica Serovar Typhimurium Colitis
Spees, A. M., Kingsbury, D. D., Wangdi, T., Byndloss, M. X., Tsolis, R. M., & Bäumler, A. J. (2014) · Infection and Immunity · doi:10.1128/iai.01508-13 · Cited by 43 · see citing works
Enhancing the role of veterinary vaccines reducing zoonotic diseases of humans: Linking systems biology with vaccine development
Adams, L. G., Khare, S., Lawhon, S. D., Rossetti, C., Lewin, H. A., Lipton, M. S. W., Turse, J. E., Wylie, D., Bai, Y., & Drake, K. L. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.05.080 · Cited by 42 · see citing works
The Interleukins Orchestrate Mucosal Immune Responses to Salmonella Infection in the Intestine
Huang, F. (2021) · Cells · doi:10.3390/cells10123492 · Cited by 42 · see citing works
The Role of the Host in Driving Phenotypic Heterogeneity in Salmonella
Tsai, C. N., & Coombes, B. K. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.01.004 · Cited by 38 · see citing works
Anti-inflammatory Effect of Probiotic Limosilactobacillus reuteri KUB-AC5 Against Salmonella Infection in a Mouse Colitis Model
Buddhasiri, S., Sukjoi, C., Kaewsakhorn, T., Nambunmee, K., Nakphaichit, M., Nitisinprasert, S., & Thiennimitr, P. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.716761 · Cited by 37 · see citing works
Host-Derived Metabolites Modulate Transcription of Salmonella Genes Involved in l -Lactate Utilization during Gut Colonization
Gillis, C. C., Winter, M. G., Chanin, R. B., Zhu, W., Spiga, L., & Winter, S. (2019) · Infection and Immunity · doi:10.1128/iai.00773-18 · Cited by 35 · see citing works
A Role for the Non-Canonical Wnt-β-Catenin and TGF-β Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella enterica Serovar Enteritidis Persistent Cecal Infection in Chickens
Kogut, M. H., & Arsenault, R. J. (2015) · Frontiers in Veterinary Science · doi:10.3389/fvets.2015.00033 · Cited by 35 · see citing works
The in vivo extracellular life of facultative intracellular bacterial parasites: Role in pathogenesis
Silva, M. T., & Pestana, N. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.05.011 · Cited by 34 · see citing works
How bacterial pathogens use type III and type IV secretion systems to facilitate their transmission
Byndloss, M. X., Rivera-Chávez, F., Tsolis, R. M., & Bäumler, A. J. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.08.007 · Cited by 32 · see citing works
Absence of Poly(ADP-Ribose) Polymerase 1 Delays the Onset of Salmonella enterica Serovar Typhimurium-Induced Gut Inflammation
Altmeyer, M., Barthel, M., Eberhard, M., Rehrauer, H., Hardt, W., & Hottiger, M. O. (2010) · Infection and Immunity · doi:10.1128/iai.00211-10 · Cited by 34 · see citing works
SPI-1 encoded genes of Salmonella Typhimurium influence differential polarization of porcine alveolar macrophages in vitro
Kýrová, K., Štěpánová, H., Rychlı́k, I., Faldyna, M., & Volf, J. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-115 · Cited by 33 · see citing works
STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium
Wilson, R. P., Tursi, S. A., Rapsinski, G. J., Medeiros, N. J., Le, L. S., Kotredes, K. P., Patel, S., Liverani, E., Sun, S., Zhu, W., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007745 · Cited by 31 · see citing works
Salmonella vaccines: lessons from the mouse model or bad teaching?
Strugnell, R. A., Scott, T. A., Wang, N., Yang, C., Peres, N., Bedoui, S., & Kupz, A. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.12.004 · Cited by 32 · see citing works
Attenuated Salmonella enterica serovar Typhimurium lacking the ZnuABC transporter: An efficacious orally-administered mucosal vaccine against salmonellosis in pigs
Gradassi, M., Pesciaroli, M., Martinelli, N., Ruggeri, J., Petrucci, P., Hassan, W. H., Raffatellu, M., Scaglione, F. E., Ammendola, S., Battistoni, A., et al. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.05.105 · Cited by 32 · see citing works
The role of myeloid-derived suppressor cells in chronic infectious diseases and the current methodology available for their study
Peñaloza, H. F., Alvarez, D., Muñoz‐Durango, N., Schultz, B. M., González, P. A., Kalergis, A. M., & Bueno, S. M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0618-233r · Cited by 32 · see citing works
Contribution of the Cpx envelope stress system to metabolism and virulence regulation in Salmonella enterica serovar Typhimurium
Subramaniam, S., Müller, V. S., Hering, N. A., Mollenkopf, H., Becker, D., Heroven, A. K., Dersch, P., Pohlmann, A., Tedin, K., Porwollik, S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211584 · Cited by 32 · see citing works
Multiple Salmonella-pathogenicity island 2 effectors are required to facilitate bacterial establishment of its intracellular niche and virulence
Knuff-Janzen, K., Tupin, A., Yurist‐Doutsch, S., Rowland, J. L., & Finlay, B. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235020 · Cited by 29 · see citing works
Living Therapeutics: The Next Frontier of Precision Medicine
Kelly, V. W., Liang, B. K., & Sirk, S. J. (2020) · ACS Synthetic Biology · doi:10.1021/acssynbio.0c00444 · Cited by 30 · see citing works
SPI-23 of S. Derby: Role in Adherence and Invasion of Porcine Tissues
Hayward, M. R., AbuOun, M., Ragione, R. M. L., Tchórzewska, M. A., Cooley, W. A., Everest, D. J., Petrovska, L., Jansen, V. A. A., & Woodward, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107857 · Cited by 31 · see citing works
Dynamics of spread of Salmonella enterica in the systemic compartment
Mastroeni, P., & Grant, A. J. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.10.003 · Cited by 29 · see citing works
Intestinal microbiota and blue baby syndrome
Ellis, C. L., Rutledge, J. C., & Underwood, M. A. (2010) · Gut Microbes · doi:10.4161/gmic.1.6.14077 · Cited by 29 · see citing works
Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against Nontyphoidal Salmonella
Sargun, A., Sassone‐Corsi, M., Zheng, T., Raffatellu, M., & Nolan, E. M. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00005 · Cited by 28 · see citing works
Role of Inflammasomes in Salmonella Infection
Franchi, L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00008 · Cited by 28 · see citing works
Protective effects of milk fermented by Lactobacillus plantarum B7 from Brazilian artisanal cheese on a Salmonella enterica serovar Typhimurium infection in BALB/c mice
Acúrcio, L. B., Bastos, R. W., Sandes, S. H. C., Guimarães, A. C. D. C., Alves, C. G., dos Reis, D. C., Wuyts, S., Nunes, Á. C., Cassali, G. D., Lebeer, S., et al. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.010 · Cited by 28 · see citing works
Identification of an outer membrane protein of Salmonella enterica serovar Typhimurium as a potential vaccine candidate for Salmonellosis in mice
Yang, Y., Wan, C., Xu, H., Aguilar, Z. P., Tan, Q., Xu, F., Lai, W., Xiong, Y., & Wei, H. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.02.005 · Cited by 26 · see citing works
Salmonella
Graziani, C., Losasso, C., Luzzi, I., Ricci, A., Scavia, G., & Pasquali, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-385007-2.00005-x · Cited by 25 · see citing works
Identification and characterization of OmpL as a potential vaccine candidate for immune-protection against salmonellosis in mice
Yang, Y., Wan, C., Xu, H., & Wei, H. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.04.044 · Cited by 25 · see citing works
Transient Loss of Protection Afforded by a Live Attenuated Non-typhoidal Salmonella Vaccine in Mice Co-infected with Malaria
Mooney, J. P., Lee, S., Lokken, K. L., Nanton, M. R., Nuccio, S., McSorley, S. J., & Tsolis, R. M. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004027 · Cited by 25 · see citing works
Cytokine Signaling in Splenic Leukocytes from Vaccinated and Non-Vaccinated Chickens after Intravenous Infection with Salmonella Enteritidis
Matulova, M. E., Štěpánová, H., Šišák, F., Havlíčková, H., Faldynová, M., Kýrová, K., Volf, J., & Rychlı́k, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032346 · Cited by 24 · see citing works
Milk fermented by Lactobacillus species from Brazilian artisanal cheese protect germ-free-mice against Salmonella Typhimurium infection
Acúrcio, L. B., Sandes, S. H. C., Bastos, R. W., de Sant’Anna, F. M., Pedroso, S. H. S. P., dos Reis, D. C., Nunes, Á. C., Cassali, G. D., de Souza, M. R., & Nicoli, J. R. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0163 · Cited by 24 · see citing works
Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar Typhi
Valenzuela, L. M., Hidalgo, A. A., Rodríguez, L. M., Urrutia, Í. M., Ortega, A., Villagra, N. A., Paredes‐Sabja, D., Calderón, I. L., Gil, F., Saavedra, C. P., et al. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.04.021 · Cited by 23 · see citing works
Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens
Elfenbein, J. R., Knodler, L. A., Nakayasu, E. S., Ansong, C. K., Brewer, H. M., Bogomolnaya, L. M., Adams, L. G., McClelland, M., Adkins, J., & Andrews‐Polymenis, H. L. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005472 · Cited by 22 · see citing works
Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine
Wang, H., Zeng, X., Mo, Y., He, B., Lin, H., & Lin, J. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00358-19 · Cited by 22 · see citing works

Authors: Santos, R. L., Raffatellu, M., Bevins, C. L., Adams, L. G., Tükel, Ç., Tsolis, R. M., & Bäumler, A. J.
Affiliations: Universidade Federal de Minas Gerais (BR)
University of California, Irvine (US)
University of California, Davis (US)
Texas A&M University (US)
Corresponding author: Bäumler, Andreas J.
ORCID: Santos, Renato L.
Raffatellu, Manuela
Bevins, Charles L.
Adams, L. Garry
Tsolis, Renée M.
Bäumler, Andreas J.
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2009-11
Volume: 17
Issue: 11
Pages: 498-506
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2009.08.008
PMC: PMC3235402
OpenAlex: W2075058732
Cited by: 197
References: 100
Citations by year: 2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 12 · 2013: 19 · 2012: 17
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI044170, AI 040124, AI044170, AI079173, R21AI079173, R01AI032738, R29AI040124, R01AI050843, R01AI076246, R01AI040124, R01AI050553, AI050553, AI076246, R37AI032738)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: non-typhoidal Salmonella, intestinal inflammation, host-pathogen interaction, gut microbiota, tissue macrophages, IL-23/IL-17 axis, mucosal barrier, antimicrobial resistance, fecal-oral transmission
MeSH terms: Animals, Humans, Intestinal Mucosa, Intestines, Macrophages, Models, Biological, Salmonella, Salmonella Infections, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Life in the inflamed intestine, Salmonella style

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks