The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Clostridium difficile spore biology: sporulation, germination, and spore structural proteins
Open accessAbstract
Clostridium difficile is a Gram-positive, spore-forming obligate anaerobe and a major nosocomial pathogen of world-wide concern. Due to its strict anaerobic requirements, the infectious and transmissible morphotype is the dormant spore. In susceptible patients, C. difficile spores germinate in the colon to form the vegetative cells that initiate Clostridium difficile infections (CDI). During CDI, C. difficile induces a sporulation pathway that produces more spores; these spores are responsible for the persistence of C. difficile in patients and horizontal transmission between hospitalized patients. While important to the C. difficile lifecycle, the C. difficile spore proteome is poorly conserved when compared to members of the Bacillus genus. Further, recent studies have revealed significant differences between C. difficile and B. subtilis at the level of sporulation, germination and spore coat and exosporium morphogenesis. In this review, the regulation of the sporulation and germination pathways and the morphogenesis of the spore coat and exosporium will be discussed.
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Cites
Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals
Setlow, P. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02736.x · Cited by 1,540
Clostridium difficile infection: new developments in epidemiology and pathogenesis
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“The clinical symptoms are caused by the secretion of two large toxins, the enterotoxin TcdA and the cytotoxin TcdB, which cause massive damage to the epithelium and induce strong inflammatory responses [1].”
BackgroundClostridium difficile— More Difficult Than Ever
Kelly, C. P., & LaMont, J. T. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0707500 · Cited by 1,313
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Sebaihia, M., Wren, B. W., Mullany, P., Fairweather, N. F., Minton, N., Stabler, R., Thomson, N. R., Roberts, A. P., Cerdeño-Tárraga, A. M., Wang, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1830 · Cited by 879
Setlow, P. (2003) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.10.001 · Cited by 822
Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores
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Self-citationThe Bacillus subtilis endospore: assembly and functions of the multilayered coat
McKenney, P. T., Driks, A., & Eichenberger, P. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2921 · Cited by 650
Structure, Assembly, and Function of the Spore Surface Layers
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Recent progress in Bacillus subtilis sporulation
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Cited by
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation
Browne, H. P., Forster, S. C., Anonye, B. O., Kumar, N., Neville, B. A., Stares, M. D., Goulding, D., & Lawley, T. D. (2016) · Nature · doi:10.1038/nature17645 · Cited by 1,299
Clostridium difficile infection
Smits, W. K., Lyras, D., Lacy, D. B., Wilcox, M. H., & Kuijper, E. J. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.20 · Cited by 853
Prebiotics‐Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer
Zheng, D., Li, R., An, J., Xie, T., Han, Z., Xu, R., Fang, Y., & Zhang, X. (2020) · Advanced Materials · doi:10.1002/adma.202004529 · Cited by 274
The role of gut microbiota in Clostridium difficile infection
Samarkos, M., Mastrogianni, E., & Kampouropoulou, O. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.02.006 · Cited by 75
Fu, Y., Li, J., Cai, W., Huang, Y., Liu, X., Ma, Z., Tang, Z., Bian, X., Zheng, J., Jiang, J., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.11.018 · Cited by 48
Metadata
- Authors
- Paredes-Sabja, D., Shen, A., & Sorg, J. A.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 22
- Issue
- 7
- Pages
- 406-416
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2010470461
- Cited by
- 419
- References
- 67
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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