The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Biofilm Matrixome: Extracellular Components in Structured Microbial Communities
Open accessAbstract
Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix is composed of a complex array of extracellular polymeric substances (EPS) that contribute to the unique attributes of biofilm lifestyle and virulence. This ensemble of chemically and functionally diverse biomolecules is termed the 'matrixome'. The composition and mechanisms of EPS matrix formation, and its role in biofilm biology, function, and microenvironment are being revealed. This perspective article highlights recent advances about the multifaceted role of the 'matrixome' in the development, physical-chemical properties, and virulence of biofilms. We emphasize that targeting biofilm-specific conditions such as the matrixome could lead to precise and effective antibiofilm approaches. We also discuss the limited knowledge in the context of polymicrobial biofilms, and the need for more in-depth analyses of the EPS matrix in mixed communities that are associated with many human infectious diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biofilms: an emergent form of bacterial life
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S. A., & Kjelleberg, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.94 · Cited by 5,979
Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms
Turnbull, L., Toyofuku, M., Hynen, A. L., Kurosawa, M., Pessi, G., Petty, N. K., Osvath, S. R., Cárcamo-Oyarce, G., Gloag, E. S., Shimoni, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms11220 · Cited by 709
Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
Influence of saliva on the oral microbiota
Marsh, P. D., Do, T., Beighton, D., & Devine, D. A. (2016) · Periodontology 2000 · doi:10.1111/prd.12098 · Cited by 381
Novel Entries in a Fungal Biofilm Matrix Encyclopedia
Zarnowski, R., Westler, W. M., Lacmbouh, G. A., Marita, J. M., Bothe, J. R., Bernhardt, J., Lounes-Hadj Sahraoui, A., Fontaine, J., Sanchez, H., Hatfield, R. D., et al. (2014) · mBio · doi:10.1128/mbio.01333-14 · Cited by 315
Hwang, G., Liu, Y., Kim, D., Li, Y., Krysan, D. J., & Koo, H. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006407 · Cited by 214
Self-citationSpatio-temporal assembly of functional mineral scaffolds within microbial biofilms
Oppenheimer-Shaanan, Y., Sibony-Nevo, O., Bloom-Ackermann, Z., Suissa, R., Steinberg, N., Kartvelishvily, E., Brumfeld, V., & Kolodkin-Gal, I. (2016) · npj Biofilms and Microbiomes · doi:10.1038/npjbiofilms.2015.31 · Cited by 131
Candida glabrata Biofilms: How Far Have We Come?
Rodrigues, C., Rodrigues, M., Silva, S., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010011 · Cited by 129
The Role of Exopolysaccharides in Oral Biofilms
Cugini, C., Shanmugam, M., Landge, N., & Ramasubbu, N. (2019) · Journal of Dental Research · doi:10.1177/0022034519845001 · Cited by 124
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity
Snarr, B. D., Baker, P., Bamford, N. C., Sato, Y., Liu, H., Lehoux, M., Gravelat, F. N., Ostapska, H., Baistrocchi, S. R., Cerone, R. P., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702798114 · Cited by 95
Cited by
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
“An essential part of the extracellular matrix are β-1,3-glucans, which significantly contribute to the biofilm’s resistance to antifungal drugs because they prevent contact with target cells [36].”
BackgroundMicrobial extracellular polymeric substances in the environment, technology and medicine
Flemming, H.-C., van Hullebusch, E. D., Little, B. J., Neu, T. R., Nielsen, P. H., Seviour, T., Stoodley, P., Wingender, J., & Wuertz, S. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01098-y · Cited by 420
Microscopy Methods for Biofilm Imaging: Focus on SEM and VP-SEM Pros and Cons
Relucenti, M., Familiari, G., Donfrancesco, O., Taurino, M., Li, X., Chen, R., Artini, M., Papa, R., & Selan, L. (2021) · Biology · doi:10.3390/biology10010051 · Cited by 228
Vandana, & Das, S. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119536 · Cited by 199
Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms
Songca, S. P., & Adjei, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063209 · Cited by 175
Metadata
- Authors
- Karygianni, L., Ren, Z., Koo, H., & Thurnheer, T.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 28
- Issue
- 8
- Pages
- 668-681
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W3019884735
- Cited by
- 1,487
- References
- 12
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biofilm Matrixome: Extracellular Components in Structured Microbial Communities. https://app.cochat.ai/papers/10.1016/j.tim.2020.03.016
- The paper
- Karygianni, L., Ren, Z., Koo, H., & Thurnheer, T. (2020). Biofilm Matrixome: Extracellular Components in Structured Microbial Communities. Trends in Microbiology. https://doi.org/10.1016/j.tim.2020.03.016
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
