Genomic integrity and the ageing brain

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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Genome maintenance mechanisms for preventing cancer

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Mammalian microRNAs predominantly act to decrease target mRNA levels

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A microRNA component of the p53 tumour suppressor network

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ATM and related protein kinases: safeguarding genome integrity

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Understanding the odd science of aging

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MicroRNA profiling: approaches and considerations

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The DNA Damage Response: Ten Years After

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HDAC2 negatively regulates memory formation and synaptic plasticity

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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

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miR-34a repression of SIRT1 regulates apoptosis

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Neural mechanisms of ageing and cognitive decline

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Recovery of learning and memory is associated with chromatin remodelling

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

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Living on a break: cellular senescence as a DNA-damage response

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Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

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DNA hypomethylation leads to elevated mutation rates

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Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

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DNA methylation and healthy human aging

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Senescence and apoptosis: dueling or complementary cell fates?

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Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

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The Expression of MicroRNA miR-107 Decreases Early in Alzheimer's Disease and May Accelerate Disease Progression through Regulation of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1

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DNA damage checkpoints: from initiation to recovery or adaptation

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Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

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Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81714-6 · Cited by 688 · see citing works

Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

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MicroRNA-125b is a novel negative regulator of p53Preprint

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DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

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Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair

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miR-29 miRNAs activate p53 by targeting p85α and CDC42

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DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

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Meiotic recombination in mammals: localization and regulation

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Mosaic Copy Number Variation in Human Neurons

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Methylation of Histone H4 Lysine 20 Controls Recruitment of Crb2 to Sites of DNA Damage

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Initiating Cellular Stress Responses

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Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

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Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

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The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoPreprint

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Sirtuins, Aging, and Medicine

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

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Tudor, MBT and chromo domains gauge the degree of lysine methylation

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DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

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Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease

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p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

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Epigenetic mechanisms in neurological disease

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miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

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SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

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Tet family proteins and 5-hydroxymethylcytosine in development and disease

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Alterations in mitochondrial membrane fluidity by lipid peroxidation products

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Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage

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ATM and ataxia telangiectasia

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SIRT1 promotes DNA repair activity and deacetylation of Ku70

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Ionizing Radiation-Induced Oxidative Stress Alters miRNA Expression

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Chromosomal variation in neurons of the developing and adult mammalian nervous system

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Telomere position effect: regulation of gene expression with progressive telomere shortening over long distancesPreprint

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DNA repair deficiency and neurological disease

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Constitutional Aneuploidy in the Normal Human Brain

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Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3

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Repression of the miR‐17‐92 cluster by p53 has an important function in hypoxia‐induced apoptosis

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Lithium, a Common Drug for Bipolar Disorder Treatment, Regulates Amyloid-β Precursor Protein Processing

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The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

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miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells

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Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death

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Functional links between telomeres and proteins of the DNA-damage response

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The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

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The sirtuins, oxidative stress and aging: an emerging link

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miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

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Aneuploidy and DNA Replication in the Normal Human Brain and Alzheimer's Disease

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SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein

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Down‐regulation of BRCA1 expression by miR‐146a and miR‐146b‐5p in triple negative sporadic breast cancers

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ATM is down-regulated by N-Myc–regulated microRNA-421

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Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

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MiR-26b, upregulated in Alzheimer’s disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons

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The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer

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Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

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