The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Targeting adenosine A2A receptors in Parkinson's disease
Open accessAbstract
The adenosine A2A receptor has emerged as an attractive non-dopaminergic target in the pursuit of improved therapy for Parkinson's disease (PD), based in part on its unique CNS distribution. It is highly enriched in striatopallidal neurons and can form functional heteromeric complexes with other G-protein-coupled receptors, including dopamine D2, metabotropic glutamate mGlu5 and adenosine A1 receptors. Blockade of the adenosine A2A receptor in striatopallidal neurons reduces postsynaptic effects of dopamine depletion, and in turn lessens the motor deficits of PD. A2A antagonists might partially improve not only the symptoms of PD but also its course, by slowing the underlying neurodegeneration and reducing the maladaptive neuroplasticity that complicates standard 'dopamine replacement' treatments. Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics.
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Cites
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Cited by
Polazzi, E., Mengoni, I., Caprini, M., Peña-Altamira, E., Kurtys, E., & Monti, B. (2013) · Neurosignals · doi:10.1159/000337115 · Cited by 8,994
Dichotomous dopaminergic control of striatal synaptic plasticity
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Epidemiology and etiology of Parkinson's disease: a review of the evidence
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Neural Control of the Lower Urinary Tract
de Groat, W. C., Griffiths, D., & Yoshimura, N. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130056 · Cited by 553
Metadata
- Authors
- Schwarzschild, M. A., Agnati, L., Fuxe, K., Chen, J.-F., & Morelli, M.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 29
- Issue
- 11
- Pages
- 647-654
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1987380827
- Cited by
- 433
- References
- 76
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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