Cited by 481Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

The coming out of the brain mineralocorticoid receptor

Joëls, Marian, Karst, Henk, DeRijk, Roel, de Kloet, E. Ronald·2008·Trends in Neurosciences

DOI 10.1016/j.tins.2007.10.005

Open this paper in CoChat — free account

Abstract

Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in limbic neurons. The role of mineralocorticoid receptors in higher brain functions has never been well understood. Here we argue that the recently discovered low-affinity membrane version of the mineralocorticoid receptor contributes to the initial phase of the stress reaction; this is complemented by the glucocorticoid receptor which terminates the stress response. This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2007.10.005

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Self-citation
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Self-citation
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Stress and cognition: are corticosteroids good or bad guys?
de Kloet, E. R., Oitzl, M. S., & Joëls, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01438-1 · Cited by 1,258
Self-citation

Flagged first, then by citations

Show all 55 references

Research works printed but not linked: 1

Olijslagers, 2006, Rapid enhancement of hippocampal glutamate transmission by corticosterone is mediated via the MEK/ERK pathway, FENS Forum Meeting

Sorted by citations

Items 301–400 of 475

Socio-Ecological Challenges as Modulators of Women's Reproductive Trajectories
Nepomnaschy, P. A., Rowlands, A., Costa, A. P. P., & Salvante, K. G. (2020) · Annual Review of Anthropology · doi:10.1146/annurev-anthro-102317-045930 · Cited by 13
Loss of central mineralocorticoid or glucocorticoid receptors impacts auditory nerve processing in the cochlea
Marchetta, P., Eckert, P., Łukowski, R., Ruth, P., Singer, W., Rüttiger, L., & Knipper, M. (2022) · iScience · doi:10.1016/j.isci.2022.103981 · Cited by 11
Insights into isoform-specific mineralocorticoid receptor action in the hippocampus
Gaudenzi, C., Mifsud, K. R., & Reul, J. M. H. M. (2023) · Journal of Endocrinology · doi:10.1530/joe-22-0293 · Cited by 11
Molecular regulation of chronic stress responses in European sea bass, Dicentrarchus labrax
Σαμαράς, Α., Kollias, S., & Pavlidis, M. A. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1611667 · Cited by 11
The stressed brain: regional and stress‐related corticosterone and stress‐regulated gene expression in the adult zebra finch (Taeniopygia guttata)
Rensel, M. A., & Schlinger, B. A. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12852 · Cited by 10
Stress and Memory Consolidation
Drexler, S. M., & Wolf, O. T. (2017) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-319-45066-7_17 · Cited by 12
Brain Mineralocorticoid Receptors and Resilience to Stress
Kanatsou, S., Joëls, M., & Krugers, H. J. (2018) · Vitamins and hormones · doi:10.1016/bs.vh.2018.11.001 · Cited by 14
Self-citation
Spironolactone decreases the somatic signs of opiate withdrawal by blocking the mineralocorticoid receptors (MR)
Zaragoza, J. N., Laorden, M. L., & Milanés, M. V. (2014) · Toxicology · doi:10.1016/j.tox.2014.10.002 · Cited by 12
Stress and Emotional Learning in Humans: Evidence for Sex Differences
Merz, C. J., & Wolf, O. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00007-x · Cited by 11
Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Marissal‐Arvy, N., & Moisan, M. (2022) · Metabolism Open · doi:10.1016/j.metop.2022.100202 · Cited by 13
Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis
van Eekelen, J. A. M., Ellis, J. A., Pennell, C. E., Saffery, R., Mattes, E., Craig, J. M., & Olsson, C. A. (2012) · Mental Illness · doi:10.4081/mi.2012.e21 · Cited by 10
Mineralocorticoid receptor function in depressed patients and healthy individuals
Hinkelmann, K., Hellmann‐Regen, J., Wingenfeld, K., Kuehl, L. K., Mews, M. R., Fleischer, J., Heuser, I., & Otte, C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.08.003 · Cited by 10
Contrasting seasonal and aseasonal environments across stages of the annual cycle in the rufous‐collared sparrow, Zonotrichia capensis: Differences in endocrine function, proteome and body condition
González‐Gómez, P. L., Echeverría, V., Estades, C. F., Pérez, J. H., Krause, J. S., Sabat, P., Li, J., Kültz, D., & Wingfield, J. C. (2018) · Journal of Animal Ecology · doi:10.1111/1365-2656.12846 · Cited by 10
Associations between cortisol awakening response and resting electroencephalograph asymmetry
Duan, H., Fang, H., Zhang, Y., Shi, X., & Zhang, L. (2019) · PeerJ · doi:10.7717/peerj.7059 · Cited by 10
Examining sex differences in pleiotropic effects for depression and smoking using polygenic and gene‐region aggregation techniques
Schmitz, L., Gard, A. M., & Ware, E. B. (2019) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32748 · Cited by 11
Brain Transcriptome Responses to Dexamethasone Depending on Dose and Sex Reveal Factors Contributing to Sex-Specific Vulnerability to Stress-Induced Disorders
Muráni, E., Trakooljul, N., Hadlich, F., Ponsuksili, S., & Wimmers, K. (2021) · Neuroendocrinology · doi:10.1159/000516500 · Cited by 10
Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior
Bogdan, R., Carré, J. M., & Hariri, A. R. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_182 · Cited by 10
Consistently increased dorsolateral prefrontal cortex activity during the exposure to acute stressors
Meier, J. K., & Schwabe, L. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae159 · Cited by 14
Neurobiología del estrés agudo y crónico: su efecto en el eje hipotálamohipófisis- adrenal y la memoria
Rodríguez-Fernández, J. M., García-Acero, M., & Franco, P. (2013) · Universitas Médica · doi:10.11144/javeriana.umed54-4.neac · Cited by 9
Relationship between Cytotoxicity in the Hippocampus and an Abnormal High Intensity Area on the Diffusion-weighted Images of Three Patients with Transient Global Amnesia
Ogawa, K., Suzuki, Y., Akimoto, T., Shiobara, K., Hara, M., Morita, A., Kamei, S., & Soma, M. (2018) · Internal Medicine · doi:10.2169/internalmedicine.0251-17 · Cited by 9
Memory retrieval of everyday information under stress
Stock, L.-M., & Merz, C. J. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.05.008 · Cited by 9
CA1 LTP Attenuated by Corticosterone is Canceled by Effusol via Rescuing Intracellular Zn2+ Dysregulation
Tamano, H., Sato, Y., Takiguchi, M., Murakami, T., Fukuda, T., Kawagishi, H., Suzuki, M., & Takeda, A. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00693-5 · Cited by 9
Gene expression in the female tree swallow brain is associated with inter- and intra-population variation in glucocorticoid levels
Zimmer, C., Taff, C. C., Ardia, D. R., Rosvall, K. A., Kallenberg, C., Bentz, A. B., Taylor, A. R., Johnson, L. S., & Vitousek, M. N. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105280 · Cited by 10
Acute and lasting effects of single mineralocorticoid antagonism on offensive aggressive behaviour in rats
Ruiz‐Aizpurua, L., Buwalda, B., & de Boer, S. F. (2013) · Behavioural Processes · doi:10.1016/j.beproc.2013.05.011 · Cited by 9
Depression and the hypothalamic-pituitary-adrenal axis: increasing the scope
Andreatini, R. (2012) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00645.x · Cited by 9
The mineralocorticoid receptor: a new player controlling energy homeostasis
Kuhn, E., & Lombès, M. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0033 · Cited by 10
The Role of Stressful Parenting and Mineralocorticoid Receptor Haplotypes on Social Development During Adolescence and Young Adulthood
Endedijk, H. M., Nelemans, S. A., Schür, R. R., Boks, M. P., van Lier, P. A. C., Meeus, W., Vinkers, C. H., Sarabdjitsingh, R. A., & Branje, S. (2019) · Journal of Youth and Adolescence · doi:10.1007/s10964-019-00988-2 · Cited by 10
Role of Stress and Hormones of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in Aging
Gupta, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_12 · Cited by 8
Developmental activity-based anorexia alters hippocampal non-genomic stress response and induces structural instability and spatial memory impairment in female rats
Mottarlini, F., Targa, G., Rizzi, B., Fumagalli, F., & Caffino, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111065 · Cited by 8
Central mineralocorticoid receptors, sympathetic activity, and hypertension
McManus, F., MacKenzie, S. M., & Freel, E. M. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0039-0 · Cited by 8
Yokukansan, a Herbal Medicine in Japan, Buffers Social Crowding Stress via Ameliorating Glucocorticoid Secretion Response to Vasopressin
Tamano, H., Morioka, H., Iwaki, H., Suzuki, H., Sato, Y., & Takeda, A. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00052 · Cited by 8
Expression of glucocorticoid and mineralocorticoid receptor genes co-varies with a stress-related colour signal in barn owls
Béziers, P., Ducrest, A., San‐Jose, L. M., Simon, C., & Roulin, A. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113224 · Cited by 8
The Protective Side of the Mineralocorticoid Receptor
Gómez-Sánchez, C. E., & Gómez-Sánchez, E. P. (2012) · Endocrinology · doi:10.1210/en.2011-2184 · Cited by 7
Socially oriented thinking and the biological stress response: Thinking of friends and family predicts trajectories of salivary cortisol decline
Vine, V., Hilt, L. M., Marroquín, B. M., & Gilbert, K. (2019) · Psychophysiology · doi:10.1111/psyp.13461 · Cited by 8
Mineralocorticoid replacement therapy in salt‐wasting congenital adrenal hyperplasia
Lang, K., Quinkler, M. O., & Kienitz, T. (2023) · Clinical Endocrinology · doi:10.1111/cen.14959 · Cited by 7
Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth
Christiaens, I., Ang, Q. W., Gordon, L. N., Fang, X., Williams, S. M., Pennell, C. E., & Olson, D. M. (2015) · BMC Medical Genetics · doi:10.1186/s12881-015-0205-y · Cited by 7
Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates
Ong, S. X., Chng, K., Meaney, M. J., & Buschdorf, J. P. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0218 · Cited by 7
Neonatal corticosterone administration in rodents as a tool to investigate the maternal programming of emotional and immune domains
Macrı̀, S. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.12.001 · Cited by 7
Stress, Corticosterone, and Hippocampal Plasticity
Maggio, N., & Segal, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813146-6.00008-4 · Cited by 7
Utilization of the allen gene expression atlas to gain further insight into glucocorticoid physiology in the adult mouse brain
Kalafatakis, K., Γιαννακέας, Ν., Lightman, S. L., Charalampopoulos, I., Russell, G. M., Tsipouras, M. G., & Tzallas, A. T. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.05.020 · Cited by 7
Decreased serotonin content and release in the ventral hippocampus of prenatally stressed male rats in response to forced swim test
Vásquez, F. D. J. J., Guerrero, D. M., Rubio‐Osornio, M., Rubio, C., Orozco-Suárez, S. A., & Retana‐Márquez, S. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-029 · Cited by 7
Autonomous nervous system modulation in supine and standing postures in children with probable developmental coordination disorder
Gama, D. T., Ferracioli, M. D. C., Barela, J. Â., Takahashi, A. C. D. M., Pellegrini, A. M., & Hiraga, C. Y. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06111 · Cited by 7
Effects of individual stressors used in a battery of “chronic unpredictable stress” on long-term plasticity in the hippocampus of juvenile rats
Gorbunova, A. A., Kudryashova, I. V., Манолова, А. О., Novikova, M. R., Stepanichev, M. Y., & Gulyaeva, N. V. (2017) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-058 · Cited by 7
Rapid Intracellular Zn2+ Dysregulation via Membrane Corticosteroid Receptor Activation Affects In Vivo CA1 LTP
Suzuki, M., Sato, Y., Tamura, K., Tamano, H., & Takeda, A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1159-9 · Cited by 7
Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general‐population study
Terock, J., der Auwera, S. V., Janowitz, D., Wittfeld, K., Teumer, A., & Grabe, H. J. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1345 · Cited by 7
Stress Research: Past, Present, and Future
de Kloet, E. R., & Joëls, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_72 · Cited by 6
Self-citation
Adverse neuropsychological effects associated with cumulative doses of corticosteroids to treat childhood acute lymphoblastic leukemia: A literature review
Pépin, A.-J., Cloutier-Bergeron, A., Malboeuf‐Hurtubise, C., Achille, M. A., Krajinović, M., Laverdière, C., Lippé, S., Marcoux, S., Sinnett, D., & Sultan, S. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.09.001 · Cited by 7
Manipulating the Brain Corticosteroid Receptor Balance: Focus on Ligands and Modulators
de Kloet, E. R., Zacarı́as, N. V. O., & Meijer, O. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00037-1 · Cited by 8
Behavioural and physiological responses to a conditioning protocol for adult zebrafish, Danio rerio, held in groups
Σαμαράς, Α., & Pavlidis, M. A. (2020) · Behavioural Processes · doi:10.1016/j.beproc.2020.104201 · Cited by 7
Elevated insulin growth factor-1 in dentate gyrus induces cognitive deficits in pre-term newborns
Sharma, D. R., Cheng, B., Jaiswal, M. K., Zhang, X., Kumar, A., Parikh, N. S., Singh, D., Sheth, H., Varghese, M., Dobrenis, K., et al. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhac516 · Cited by 6
Early life nutrient restriction affects hypothalamic-pituitary-interrenal axis gene expression in a diet type-specific manner
Shephard, A. M., Lagon, S. R., & Ledón‐Rettig, C. C. (2024) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2024.114490 · Cited by 6
The role of the glucocorticoid receptor gene ( NR3C1 ) for the processing of aversive stimuli
Schneider, K. K., Frings, C., Meyer, J., & Schote, A. B. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.11.008 · Cited by 6
Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests
He, Z., Payne, E. K., Mukherjee, B., Lee, S., Smith, J. A., Ware, E. B., Sánchez, B. N., Seeman, T. E., Kardia, S. L. R., & Roux, A. V. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126637 · Cited by 7
Stress Effects on Learning and Memory in Humans
Wolf, O. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00031-0 · Cited by 7
The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction
Wu, F., Yun, L., & Liu, Q. (2018) · Endocrine · doi:10.1007/s12020-018-1610-8 · Cited by 6
Relationship between heart failure and central serous chorioretinopathy: A cohort study in Taiwan
Huang, K.-H., Chen, Y., Lee, L.-C., Tai, M., Chung, C., Chen, J., Liang, C., Chien, W., & Chen, C. (2019) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000207 · Cited by 6
Corticosteroid Receptor Involvement in the Stress Response
de Kloet, E. R., DeRijk, R. H., & Meijer, O. C. (2011) · Wiley eBooks · doi:10.1002/9781118083222.ch3 · Cited by 6
Self-citation
The effects of stress on working-memory-related prefrontal processing: an fNIRS study
Geissler, C. F., Frings, C., & Domes, G. (2025) · Stress · doi:10.1080/10253890.2025.2472067 · Cited by 5
“Unpredictable Stress”: Ambiguity of Stress Reactivity in Studies of Long-Term Plasticity
Kudryashova, I. V., & Gulyaeva, N. V. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0496-x · Cited by 5
Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions
Lakhawat, S. S., Mech, P., Kumar, A., Malik, N., Kumar, V., Sharma, V., Bhatti, J. S., Jaswal, S. K., Kumar, S., & Sharma, P. K. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01453-1 · Cited by 6
Pränatale Entwicklung und neurobiologische Grundlagen der psychischen Entwicklung
Roth, G., & Strüber, N. (2011) · Springer eBooks · doi:10.1007/978-3-642-20296-4_1 · Cited by 5
Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
Berretz, G., Packheiser, J., Höffken, O., Wolf, O. T., & Ocklenburg, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-00896-1 · Cited by 5
Zinc Signal in Brain Functions
Takeda, A. (2014) · Springer eBooks · doi:10.1007/978-4-431-55114-0_8 · Cited by 5
Prenatal corticosterone altered glucocorticoid receptor and glucocorticoid metabolic enzyme gene expression in chicken ovary
Ahmed, A. A., Sifaldin, A. Z., Musa, H. H., Musa, T. H., & Fedail, J. S. (2016) · Asian Pacific Journal of Reproduction · doi:10.1016/j.apjr.2016.04.007 · Cited by 5
Different Polymorphisms of the Mineralocorticoid Receptor Gene Are Associated with either Glucocorticoid or Mineralocorticoid Levels in Hypertension
Sun, B., Chamarthi, B., Williams, J. S., Krug, A. W., Lasky-Su, J. A., Raby, B. A., Hopkins, P. N., Jeunemaı̂tre, X., Ferri, C., & Williams, G. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1486 · Cited by 5
Mineralocorticoid Receptor, A Promising Target for Improving Management of Low Back Pain by Epidural Steroid Injections
Ibrahim, S. I. A., Strong, J., & Zhang, J. (2016) · Journal of Anesthesia and Perioperative Medicine · doi:10.24015/japm.2016.0023 · Cited by 5
Hormones and Cognition
Gurvich, C., & Thomas, N. (2021) · Brain Sciences · doi:10.3390/brainsci11030318 · Cited by 5
The Neurobiology of Stress
Kleshchova, O., & Weierich, M. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-81245-4_2 · Cited by 4
Single-cell characterization of the adult male hippocampus suggests a prominent, and cell-type specific, role for Nrgn and Sgk1 in response to a social stressor
Donno, C. D., López, J. P., Luecken, M. D., Kos, A., Brivio, E., Bordes, J., Yang, H., Deussing, J. M., Schmidt, M. V., Theis, F. J., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-025-03417-y · Cited by 4
Neuroendocrine and stress pathways in bipolar disorders
Juruena, M. F., Cleare, A. J., & Young, A. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821398-8.00018-7 · Cited by 4
Differential effects of acute cortisol administration on deep and shallow episodic memory traces: A study on healthy males
Cioncoloni, D., Galli, G., Mazzocchio, R., Feurra, M., Giovannelli, F., Santarnecchi, E., Bonifazi, M., Rossi, A., & Rossi, S. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.06.007 · Cited by 4
Stress Research: Past, Present, and Future 64
Joëls, M. (2013) · Cited by 4
Self-citation
Corticosteroid Hormones in Stress and Anxiety – Role of Receptor Variants and Environmental Inputs
DeRijk, R. H., Kitraki, E., & de Kloet, E. R. (2009) · doi:10.1002/9783527628346.ch7 · Cited by 4
Self-citation
Challenging the human circadian clock by Daylight Saving Time and Shift-Work
Kantermann, T. (2008) · doi:10.5282/edoc.9428 · Cited by 4
Glucocorticoid effects on oxidative stress and mitochondrial dysfunction
Tang, V. M. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072794 · Cited by 4
Effects of Stress on Memory: Relevance for Human Aging
Wolf, O. T. (2015) · Springer eBooks · doi:10.1007/978-981-287-080-3_172-1 · Cited by 5
Glucocorticoid receptor alpha as a core survival receptor: mechanisms, and implications for health and critical illness
Meduri, G. U. (2025) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2025.101451 · Cited by 3
Mineralocorticoid Receptor and Sleep Quality in Chronic Kidney Disease
de la Puente-Aldea, J., Lopez-Llanos, O., Horrillo, D., Marcos-Sánchez, H., Sanz-Ballesteros, S., Franco, R., Jaisser, F., Senovilla, L., & Palacios, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212320 · Cited by 3
Corticosteroid receptor antagonism in the medial prefrontal cortex reduces morphine-induced place preference and dopamine transporter expression decline in rats
Raise‐Abdullahi, P., Rahmani, M., Tabaei, N. S., Rezamohammadi, F., Vafaei, A. A., Ghanbari, A., Rashidipour, H., Meamar, M., & Rashidy‐Pour, A. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.012 · Cited by 3
Mineralocorticoid receptor and embryonic stem cell models: Molecular insights and pathophysiological relevance
Menuet, D. L., Munier, M., Campostrini, G., & Lombès, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.036 · Cited by 3
Aldosterone Secretion and Action
Fuller, P. J., & Young, M. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00101-3 · Cited by 4
Glucocorticoid receptor expression in blood, but not across brain regions, reveals long-term effects of early life adversity in zebra finches
Jimeno, B., Gerritsma, Y. H., Mulder, G., & Verhulst, S. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114310 · Cited by 3
rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood
Leggieri, A., García‐González, J., Hosseinian, S., Ashdown, P., Anagianni, S., Wang, X., Havelange, W., Fernàndez‐Castillo, N., Cormand, B., & Brennan, C. H. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03703-x · Cited by 3
Impacts of Maternal High-Fat Diet on Stress-Related Behaviour and the Endocrine Response to Stress in Offspring
Abuaish, S., & McGowan, P. O. (2017) · Springer eBooks · doi:10.1007/978-3-319-60289-9_17 · Cited by 6
When glucocorticoids change from protective to harmful. Lessons from a type 1 diabetes animal model.
Revsin, Y., & de Kloet, E. R. (2009) · PubMed · Cited by 3
Effect of the aerobic exercise and the environmental enrichment on the reduction of the anxiety levels in the aging
Sampedro, P. (2015) · European Journal of Investigation in Health Psychology and Education · doi:10.1989/ejihpe.v5i2.112 · Cited by 3
Susceptibility to experimental autoimmune encephalomyelitis (model of multiple sclerosis) and anxiety in genetically heterogeneous rats
Martínez-Membrives, E. (2012) · TDX (Tesis Doctorals en Xarxa) · Cited by 3
Stress and Glucocorticoid Action in the Brain and Ear: Implications for Tinnitus
de Kloet, E. R., & Szczepek, A. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-58397-6_2 · Cited by 3
Brain Corticosteroid Receptor Function in Response to Psychosocial Stressors
de Kloet, E. R., Datson, N. A., Revsin, Y., Champagne, D. L., & Oitzl, M. S. (2008) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-540-79288-8_10 · Cited by 3
Stress and Glucocorticoids as Experience-Dependent Modulators of Huntington's Disease
Mo, C., Renoir, T., & Hannan, A. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813146-6.00020-5 · Cited by 4
Preconditioning by Moderate Hypoxia Increases the Amount of Corticosteroid Receptors in the Rat Brain in a Model of Depression
Baranova, K. A. (2020) · Neurochemical Journal · doi:10.1134/s1819712420030022 · Cited by 2
Stress and Novelty: Two interventions to modulate emotional memory in adolescents
Custodio, J. B., & Justel, N. R. (2023) · Journal of Cognitive Enhancement · doi:10.1007/s41465-023-00258-x · Cited by 3
Oral cortisol and dexamethasone intake: Differential physiology and transcriptional responses in the marine juvenile Sparus aurata
Barany-Ruiz, A., Fuentes, J., Valderrama, V., Broz-Ruiz, A., Martı́nez-Rodrı́guez, G., & Mancera, J. M. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114371 · Cited by 2
Does the stress axis mediate behavioural flexibility in a social cichlid, Neolamprologus pulcher?
Fischer, S., Ferlinc, Z., Hirschenhauser, K., Barbara Taborsky, A., Fusani, L., & Tebbich, S. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114694 · Cited by 2
GLUCOCORTICOIDS AND LEARNING DURING INFANCY
Gunnar, M. R. (2015) · Monographs of the Society for Research in Child Development · doi:10.1111/mono.12218 · Cited by 2
Cibles rétiniennes d’action des médicaments
Béhar‐Cohen, F. (2011) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2011.01.003 · Cited by 2
Stress en veerkracht: de rol van de mineralocorticoïd receptor
Vinkers, C. H., ter Heegde, F., & Rijk, R. H. D. (2016) · Neuropraxis · doi:10.1007/s12474-016-0116-5 · Cited by 2
Genetic Findings on the Relationship between Smoking and the Stress System
Rovaris, D. L., Mota, N. R., & Bau, C. H. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00020-1 · Cited by 2
Adrenal Stress Hormone Effects on Memory
Roozendaal, B., & Hermans, E. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00015-8 · Cited by 2
The Role of Metrics in Performance-Based Design
Konis, K., & Selkowitz, S. E. (2017) · Green energy and technology · doi:10.1007/978-3-319-39463-3_2 · Cited by 2

Authors: Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R.
Affiliations: University of Amsterdam (NL)
Leiden University (NL)
Corresponding author: Joëls, Marian
ORCID: Joëls, Marian
Karst, Henk
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2008-01
Volume: 31
Issue: 1
Pages: 1-7
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2007.10.005
OpenAlex: W2148731425
Cited by: 481
References: 55
Citations by year: 2026: 3 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 24 · 2020: 16 · 2019: 29 · 2018: 26 · 2017: 32 · 2016: 47 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 32
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Koninklijke Nederlandse Akademie van Wetenschappen
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: mineralocorticoid receptor, glucocorticoid receptor, corticosteroids, stress response, limbic system, genetic variants, psychological stress
MeSH terms: Animals, Brain Chemistry, Humans, Stress, Psychological, Receptors, Mineralocorticoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The coming out of the brain mineralocorticoid receptor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks