Cited by 481Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

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The coming out of the brain mineralocorticoid receptor

Joëls, Marian, Karst, Henk, DeRijk, Roel, de Kloet, E. Ronald·2008·Trends in Neurosciences

DOI 10.1016/j.tins.2007.10.005

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Abstract

Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in limbic neurons. The role of mineralocorticoid receptors in higher brain functions has never been well understood. Here we argue that the recently discovered low-affinity membrane version of the mineralocorticoid receptor contributes to the initial phase of the stress reaction; this is complemented by the glucocorticoid receptor which terminates the stress response. This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor.

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Authors: Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R.
Affiliations: University of Amsterdam (NL)
Leiden University (NL)
Corresponding author: Joëls, Marian
ORCID: Joëls, Marian
Karst, Henk
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2008-01
Volume: 31
Issue: 1
Pages: 1-7
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2007.10.005
OpenAlex: W2148731425
Cited by: 481
References: 55
Citations by year: 2026: 3 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 24 · 2020: 16 · 2019: 29 · 2018: 26 · 2017: 32 · 2016: 47 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 32
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Koninklijke Nederlandse Akademie van Wetenschappen
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: mineralocorticoid receptor, glucocorticoid receptor, corticosteroids, stress response, limbic system, genetic variants, psychological stress
MeSH terms: Animals, Brain Chemistry, Humans, Stress, Psychological, Receptors, Mineralocorticoid

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