Cited by 481Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

The coming out of the brain mineralocorticoid receptor

Joëls, Marian, Karst, Henk, DeRijk, Roel, de Kloet, E. Ronald·2008·Trends in Neurosciences

DOI 10.1016/j.tins.2007.10.005

Open this paper in CoChat — free account

Abstract

Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in limbic neurons. The role of mineralocorticoid receptors in higher brain functions has never been well understood. Here we argue that the recently discovered low-affinity membrane version of the mineralocorticoid receptor contributes to the initial phase of the stress reaction; this is complemented by the glucocorticoid receptor which terminates the stress response. This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2007.10.005

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Self-citation
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Self-citation
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Stress and cognition: are corticosteroids good or bad guys?
de Kloet, E. R., Oitzl, M. S., & Joëls, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01438-1 · Cited by 1,258
Self-citation

Flagged first, then by citations

Show all 55 references

Research works printed but not linked: 1

Olijslagers, 2006, Rapid enhancement of hippocampal glutamate transmission by corticosterone is mediated via the MEK/ERK pathway, FENS Forum Meeting

Sorted by citations

Items 201–300 of 475

The effects of glucocorticoids on the inhibition of emotional information: A dose–response study
Taylor, V. A., Ellenbogen, M. A., Washburn, D., & Joober, R. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.10.001 · Cited by 37
Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus
Iyo, A. H., Feyissa, A. M., Chandran, A., Austin, M. C., Regunathan, S., & Karolewicz, B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.023 · Cited by 37
Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level
de la Tremblaye, P. B., Raymond, J., Milot, M. R., Merali, Z., & Plamondon, H. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.01.003 · Cited by 37
Selective attention to emotional cues and emotion recognition in healthy subjects: the role of mineralocorticoid receptor stimulation
Schultebraucks, K., Deuter, C. E., Duesenberg, M., Schulze, L., Hellmann‐Regen, J., Domke, A., Lockenvitz, L., Kuehl, L. K., Otte, C., & Wingenfeld, K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4380-0 · Cited by 36
Hypothalamic Attack: A Wonderful Artifact or a Useful Perspective on Escalation and Pathology in Aggression? A Viewpoint
Kruk, M. R. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_313 · Cited by 38
The Mineralocorticoid Receptor Is a Constitutive Nuclear Factor in Cardiomyocytes due to Hyperactive Nuclear Localization Signals
Hernández-Díaz, I., Giráldez, T., Arnau, M. R., Smits, V. A. J., Jaisser, F., Farman, N., & de la Rosa, D. Á. (2010) · Endocrinology · doi:10.1210/en.2010-0099 · Cited by 37
A Refill for the Brain Mineralocorticoid Receptor: The Benefit of Cortisol Add-On to Dexamethasone Therapy
Meijer, O. C., & de Kloet, E. R. (2016) · Endocrinology · doi:10.1210/en.2016-1495 · Cited by 37
Stimulation of the mineralocorticoid receptor improves memory in young and elderly healthy individuals
Hinkelmann, K., Wingenfeld, K., Kuehl, L. K., Fleischer, J., Heuser, I., Wiedemann, K., & Otte, C. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.008 · Cited by 35
Temporal modulation of hippocampal excitatory transmission by corticosteroids and stress
Chaouloff, F., & Groc, L. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.004 · Cited by 50
Overexpression of Mineralocorticoid Receptors Partially Prevents Chronic Stress-Induced Reductions in Hippocampal Memory and Structural Plasticity
Kanatsou, S., Fearey, B. C., Kuil, L. E., Lucassen, P. J., Harris, A. P., Seckl, J. R., Krugers, H. J., & Joëls, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142012 · Cited by 35
Self-citation
Recovery from Disrupted Ultradian Glucocorticoid Rhythmicity Reveals a Dissociation Between Hormonal and Behavioural Stress Responsiveness
Sarabdjitsingh, R. A., Spiga, F., Oitzl, M. S., Kershaw, Y., Meijer, O. C., Lightman, S. L., & De Kloet, E. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02004.x · Cited by 35
Sleep, cognition and cortisol in addison’s disease: a mechanistic relationship
Henry, M., Thomas, K. G. F., & Ross, I. L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.694046 · Cited by 34
Evolutionary conserved neural signature of early life stress affects animal social competence
Nyman, C., Fischer, S., Aubin‐Horth, N., & Taborsky, B. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.2344 · Cited by 33
Associations between Basal Cortisol Levels and Memory Retrieval in Healthy Young Individuals
Ackermann, S., Hartmann, F., Papassotiropoulos, A., de Quervain, D. J. ‐., & Rasch, B. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00440 · Cited by 35
Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression
Schlosser, N., Wolf, O. T., & Wingenfeld, K. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.79 · Cited by 33
Preventive effect of theanine intake on stress-induced impairments of hippocamapal long-term potentiation and recognition memory
Tamano, H., Fukura, K., Suzuki, M., Sakamoto, K., Yokogoshi, H., & Takeda, A. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.02.005 · Cited by 33
Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment
Rovaris, D. L., Mota, N. R., Bertuzzi, G. P., Aroche, A. P., Callegari-Jacques, S. M., Guimarães, L. S. P., Pezzi, J. C., Viola, T. W., Bau, C. H. D., & Grassi‐Oliveira, R. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.06.008 · Cited by 35
PRECLINICAL STUDY: Mifepristone and spironolactone differently alter cocaine intravenous self‐administration and cocaine‐induced locomotion in C57BL/6J mice
Fiancette, J.-F., Balado, É., Piazza, P., & Deroche‐Gamonet, V. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00178.x · Cited by 33
Mineralocorticoid Receptors Guide Spatial and Stimulus-Response Learning in Mice
Arp, J. M., ter Horst, J. P., Kanatsou, S., Fernández, G., Joëls, M., Krugers, H. J., & Oitzl, M. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086236 · Cited by 32
Self-citation
Risk assessment behaviors associated with corticosterone trigger the defense reaction to social isolation in rats: Role of the anterior cingulate cortex
Reis, F. M., Albrechet‐Souza, L., Franci, C. R., & Brandão, M. L. (2011) · Stress · doi:10.3109/10253890.2011.623740 · Cited by 31
Psychological Stress-Induced Lower Serum Zinc and Zinc Redistribution in Rats
Tao, L., Zheng, Y., Shen, Z., Li, Y., Xue, T., Dou, X., Qian, J., & Shen, H. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9762-0 · Cited by 31
Sex-Dependent Modulation of Acute Stress Reactivity After Early Life Stress in Mice: Relevance of Mineralocorticoid Receptor Expression
Bonapersona, V., Damsteegt, R., Adams, M. L., van Weert, L. T. C. M., Meijer, O. C., Joëls, M., & Sarabdjitsingh, R. A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00181 · Cited by 32
Self-citation
FKBP5: A Key Mediator of How Vertebrates Flexibly Cope with Adversity
Zimmer, C., Hanson, H. E., Wildman, D. E., Uddin, M., & Martin, L. B. (2020) · BioScience · doi:10.1093/biosci/biaa114 · Cited by 29
Early parent-child interactions and substance use disorder: An attachment perspective on a biopsychosocial entanglement
Gerra, M. L., Gerra, M. C., Tadonio, L., Pellegrini, P., Marchesi, C., Mattfeld, E., Gerra, G., & Ossola, P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.052 · Cited by 36
In vitro modeling of the neurobiological effects of glucocorticoids: A review
Bassil, K. C., Krontira, A. C., Leroy, T., Escoto, A. I. H., Snijders, C., Pernia, C. D., Pasterkamp, R. J., de Nijs, L., van den Hove, D., Kenis, G., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100530 · Cited by 35
Mineralocorticoid receptor associates with pro‐inflammatory bias in the hippocampus of spontaneously hypertensive rats
Brocca, M. E., Pietranera, L., Meyer, M., Lima, A. E., Roig, P., de Kloet, E. R., & Nicola, A. F. D. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12489 · Cited by 30
Proposed glucocorticoid-mediated zinc signaling in the hippocampus
Takeda, A., & Tamano, H. (2012) · Metallomics · doi:10.1039/c2mt20018j · Cited by 30
MECHANISMS IN ENDOCRINOLOGY: Does circadian and ultradian glucocorticoid exposure affect the brain?
Kalafatakis, K., Russell, G. M., & Lightman, S. L. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0853 · Cited by 29
Mineralocorticoid Receptor Overexpression Facilitates Differentiation and Promotes Survival of Embryonic Stem Cell-Derived Neurons
Munier, M., Law, F., Méduri, G., Menuet, D. L., & Lombès, M. (2012) · Endocrinology · doi:10.1210/en.2011-1436 · Cited by 32
Cognitive function in older adults with major depression: Effects of mineralocorticoid receptor stimulation
Otte, C., Wingenfeld, K., Kuehl, L. K., Richter, S., Regen, F., Piber, D., & Hinkelmann, K. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.08.001 · Cited by 29
Blocking the Mineralocorticoid Receptor Improves Effectiveness of Steroid Treatment for Low Back Pain in Rats
Ye, L., Xie, W., Strong, J. A., & Zhang, J. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000277 · Cited by 27
Memories of and influenced by the Trier Social Stress Test
Wolf, O. T. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.031 · Cited by 29
Assessing the neuroendocrine stress response in the functional neuroimaging context
King, A. P. J., & Liberzon, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.055 · Cited by 28
Linking genetic variants of the mineralocorticoid receptor and negative memory bias: Interaction with prior life adversity
Vogel, S., Gerritsen, L., van Oostrom, I., Vásquez, A. A., Rijpkema, M., Joëls, M., Franke, B., Tendolkar, I., & Fernández, G. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.010 · Cited by 27
Self-citation
Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors
Cai, G., Ziko, I., Barwood, J. M., Soch, A., Sominsky, L., Molero, J. C., & Spencer, S. J. (2016) · Scientific Reports · doi:10.1038/srep21097 · Cited by 26
Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics
Danan, D., Todder, D., Zohar, J., & Cohen, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116050 · Cited by 26
Intracellular glucocorticoid receptors in spleen, but not skin, vary seasonally in wild house sparrows ( Passer domesticus )
Lattin, C. R., Waldron-Francis, K., & Romero, L. M. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.3033 · Cited by 26
Mineralocorticoid receptor haplotype moderates the effects of oral contraceptives and menstrual cycle on emotional information processing
Hamstra, D. A., de Kloet, E. R., Tollenaar, M. S., Verkuil, B., Manaï, M., Putman, P., & van der Does, W. A. J. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116647504 · Cited by 25
Correlations between changes in the hypothalamic-pituitary-adrenal axis and neurochemistry of the anterior cingulate gyrus in postpartum depression
de Rezende, M. G., Rosa, C. E., Garcia-Leal, C., de Figueiredo, F. P., Cavalli, R. D. C., Bettiol, H., Salmón, C. E. G., Barbieri, M. A., de Castro, M., dos Santos, A. C., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.028 · Cited by 25
RETRACTED: Inhibition of glucocorticoid receptors ameliorates hypobaric hypoxia induced memory impairment in rat
Baitharu, I., Deep, S. N., Jain, V., Prasad, D. N., & Ilavazhagan, G. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.11.005 · Cited by 25
Retracted
MR and GR functional SNPs may modulate tobacco smoking susceptibility
Rovaris, D. L., Mota, N. R., de Azeredo, L. A., Cupertino, R. B., Bertuzzi, G. P., Polina, E. R., Contini, V., Kortmann, G. L., Vitola, E. S., Grevet, E. H., et al. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1012-2 · Cited by 27
Changes in plasma concentrations of progesterone, dehydroepiandrosterone and corticosterone in response to acute stress of capture, handling and restraint in two subspecies of white-crowned sparrows
Krause, J. S., Dorsa, D., & Wingfield, J. C. (2014) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2014.07.019 · Cited by 24
Glucocorticoid exerts its non‐genomic effect on IPSC by activation of a phospholipase C‐dependent pathway in prefrontal cortex of rats
Teng, Z., Zhang, M., Zhao, M., & Zhang, W. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.254961 · Cited by 24
Quantification of extracellular levels of corticosterone in the basolateral amygdaloid complex of freely-moving rats: A dialysis study of circadian variation and stress-induced modulation
Bouchez, G., Millan, M. J., Rivet, J., Billiras, R., Boulanger, R., & Gobert, A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.010 · Cited by 24
A bird's eye view of the hippocampus beyond space: Behavioral, neuroanatomical, and neuroendocrine perspectives
Madison, F. N., Bingman, V. P., Smulders, T. V., & Lattin, C. R. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105451 · Cited by 26
Insight into cognitive decline from Zn 2+ dynamics through extracellular signaling of glutamate and glucocorticoids
Takeda, A., & Tamano, H. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.021 · Cited by 24
The Role of Fludrocortisone in Cognition and Mood in Patients with Primary Adrenal Insufficiency (Addison's Disease)
Schultebraucks, K., Wingenfeld, K., Otte, C., & Quinkler, M. O. (2015) · Neuroendocrinology · doi:10.1159/000438791 · Cited by 23
Low-dose neonatal domoic acid causes persistent changes in behavioural and molecular indicators of stress response in rats
Gill, D. A., Perry, M. A., McGuire, E. P., Pérez‐Gómez, A., & Tasker, R. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.02.036 · Cited by 23
Stress disrupts the reconsolidation of fear memories in men
Drexler, S. M., & Wolf, O. T. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.027 · Cited by 25
Moderate within-person variability in cortisol is related to executive function in early childhood
Blair, C., & Berry, D. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.026 · Cited by 24
Neural Signaling of Cortisol, Childhood Emotional Abuse, and Depression-Related Memory Bias
Abercrombie, H. C., Frost, C. P., Walsh, E. C., Hoks, R. M., Cornejo, M. D., Sampe, M., Gaffey, A. E., Plante, D. T., Ladd, C. O., & Birn, R. M. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.11.005 · Cited by 26
Circadian and Ultradian Variations in Corticosterone Level Influence Functioning of the Male Mouse Basolateral Amygdala
den Boon, F. S., de Vries, T., Baelde, M., Joëls, M., & Karst, H. (2019) · Endocrinology · doi:10.1210/en.2018-00767 · Cited by 23
Self-citation
L-Theanine: From Tea Leaf to Trending Supplement—Does the Science Match the Hype for Brain Health and Relaxation?
Dashwood, R., & Visioli, F. (2025) · Nutrition Research · doi:10.1016/j.nutres.2024.12.008 · Cited by 22
Stressors, coping styles, and anxiety & depression in pediatric nurses with different lengths of service in six tertiary hospitals in Chengdu, China
Liao, H. L., Tang, W., Huang, Y., Liu, M., Zhang, Y., Zhang, L., & Ai, T. (2020) · Translational Pediatrics · doi:10.21037/tp-20-439 · Cited by 22
From vasotocin to stress and cognition
de Kloet, E. R. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.017 · Cited by 22
Depressed patients in remission show an interaction between variance in the mineralocorticoid receptor NR3C2 gene and childhood trauma on negative memory bias
Vrijsen, J. N., Vogel, S., Vásquez, A. A., Franke, B., Fernández, G., Becker, E. S., Speckens, A. E. M., & van Oostrom, I. (2015) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000081 · Cited by 24
The Mineralocorticoid Agonist Fludrocortisone Promotes Survival and Proliferation of Adult Hippocampal Progenitors
Gesmundo, I., Villanova, T., Gargantini, E., Arvat, E., Ghigo, E., & Granata, R. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00066 · Cited by 22
In search of optimal resilience ratios: Differential influences of neurobehavioral factors contributing to stress-resilience spectra
Lambert, K. G., Hunter, R. G., Bartlett, A. A., Lapp, H. E., & Kent, M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100802 · Cited by 23
There is no correlation between glucocorticoid receptor mRNA expression and protein binding in the brains of house sparrows (Passer domesticus)
Medina, C. O., Lattin, C. R., McVey, M., & Romero, L. M. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.07.008 · Cited by 21
Photoperiod and stress regulation of corticosteroid receptor, brain-derived neurotrophic factor, and glucose transporter GLUT3 mRNA in the hippocampus of male Siberian hamsters (Phodopus sungorus)
Walton, J. C., Grier, A., Weil, Z. M., & Nelson, R. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.043 · Cited by 23
NADPH oxidase-mediated Rac1 GTP activity is necessary for nongenomic actions of the mineralocorticoid receptor in the CA1 region of the rat hippocampus
Kawakami-Mori, F., Shimosawa, T., Mu, S., Wang, H., Ogura, S., Yatomi, Y., & Fujita, T. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2011 · Cited by 22
Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder
Wingenfeld, K., Kuehl, L. K., Dziobek, I., Roepke, S., Otte, C., & Hinkelmann, K. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0441-4 · Cited by 22
Behavioral Abnormality Induced by Enhanced Hypothalamo-Pituitary-Adrenocortical Axis Activity under Dietary Zinc Deficiency and Its Usefulness as a Model
Takeda, A., Tamano, H., Nishio, R., & Murakami, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071149 · Cited by 25
Brain cortisol receptor expression differs in Arctic charr displaying opposite coping styles
Vindas, M. A., Magnhagen, C., Brännäs, E., Øverli, Ø., Winberg, S., Nilsson, J. Å., & Bäckström, T. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.04.024 · Cited by 21
Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain
Ibrahim, S. I. A., Xie, W., Strong, J. A., Tonello, R., Berta, T., & Zhang, J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00453 · Cited by 21
Mineralcorticoid receptor blockers in chronic kidney disease
Erraez, S., López-Mesa, M., & Gómez-Fernández, P. (2021) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2021.08.001 · Cited by 22
Developmental Stress and Correlated Cognitive Traits in Songbirds
Farrell, T. M., Kriengwatana, B. P., & MacDougall‐Shackleton, S. A. (2015) · Comparative Cognition & Behavior Reviews · doi:10.3819/ccbr.2015.100001 · Cited by 21
Decreased sympathetic cardiovascular influences and hormone‐physiological changes in response to Covid‐19‐related adaptations under different learning environments
Gellisch, M., Wolf, O. T., Minkley, N., Kirchner, W. H., Brüne, M., & Brand‐Saberi, B. (2022) · Anatomical Sciences Education · doi:10.1002/ase.2213 · Cited by 26
Mineralocorticoid receptors in the ventral tegmental area regulate dopamine efflux in the basolateral amygdala during the expression of conditioned fear
de Oliveira, A. R., Reimer, A. E., & Brandão, M. L. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.02.010 · Cited by 21
Corticosterone exposure augments sensitivity to the behavioral and neuroplastic effects of fluoxetine in C57BL/6 mice
Robinson, S. A., Brookshire, B. R., & Lucki, I. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.12.005 · Cited by 19
Manipulating cognitive reserve: Pre-injury environmental conditions influence the severity of concussion symptomology, gene expression, and response to melatonin treatment in rats
Yamakawa, G. R., Salberg, S., Barlow, K. M., Brooks, B. L., Esser, M. J., Yeates, K. O., & Mychasiuk, R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.06.001 · Cited by 20
Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens
Wu, B., Liang, Y., Dong, Z., Chen, Z., Zhang, G., Lin, W., Wang, S., Wang, B., Ge, R., & Lian, Q. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.029 · Cited by 20
Differential Diagnosis of Major Depressive Disorder and Bipolar Disorder: Genetic and Hormonal Assessment and the Influence of Early-Life Stress
Menezes, I. C., Baes, C. V. W., Fígaro-Drumond, F. V., Macedo, B. B. D., Bueno, A. C., Lacchini, R., Mello, M. F., de Castro, M., & Juruena, M. F. (2022) · Brain Sciences · doi:10.3390/brainsci12111476 · Cited by 19
Effects of mineralocorticoid receptor stimulation via fludrocortisone on memory in women with borderline personality disorder
Wingenfeld, K., Kuehl, L. K., Janke, K., Hinkelmann, K., Eckert, F. C., Roepke, S., & Otte, C. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.02.013 · Cited by 19
Glucocorticoid Negative Feedback in Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Rhesus Monkeys With Various Types of Adaptive Behavior: Individual and Age-Related Differences
Goncharova, N. D., Chigarova, О. А., Rudenko, N., & Oganyan, T. E. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00024 · Cited by 17
Sex‐Specific Effects of Stress on Respiratory Control: Plasticity, Adaptation, and Dysfunction
Lopes, L. T., & Kinkead, R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200022 · Cited by 28
Rank- and sex-specific differences in the neuroendocrine regulation of glucocorticoids in a wild group-living fish
Culbert, B. M., Ligocki, I. Y., Salena, M. G., Wong, M. Y. L., Hamilton, I. M., Aubin‐Horth, N., Bernier, N. J., & Balshine, S. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.105079 · Cited by 17
Phenotypic flexibility of glucocorticoid signaling in skeletal muscles of a songbird preparing to migrate
Pradhan, D. S., Ness, R. V., Jalabert, C., Hamden, J. E., Austin, S. H., Soma, K. K., Ramenofsky, M., & Schlinger, B. A. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104586 · Cited by 18
Effect of mineralocorticoid receptor blockade on hippocampal‐dependent memory in adults with obesity
Rotenstein, L. S., Sheridan, M. A., Garg, R., & Adler, G. K. (2015) · Obesity · doi:10.1002/oby.21104 · Cited by 17
Weathering the storm: Do arctic blizzards cause repeatable changes in stress physiology and body condition in breeding songbirds?
Krause, J. S., Pérez, J. H., Chmura, H. E., Meddle, S., Hunt, K. E., Gough, L., Boelman, N. T., & Wingfield, J. C. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.07.004 · Cited by 17
Maternal stress and the maternal microbiome have sex-specific effects on offspring development and aggressive behavior in Siberian hamsters (Phodopus sungorus)
Cusick, J. A., Wellman, C. L., & Demas, G. E. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105146 · Cited by 17
Eyeblink conditional discrimination learning in healthy young men is impaired after stress exposure
Wolf, O. T., Bauser, D. A. S., & Daum, I. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01294.x · Cited by 18
Stress specifically deteriorates working memory in peripheral neuropathic pain and fibromyalgia
Jacobsen, H. B., Brun, A., Stubhaug, A., & Rème, S. E. (2023) · Brain Communications · doi:10.1093/braincomms/fcad194 · Cited by 15
Targeting the mineralocorticoid receptor in cardiovascular disease
Young, M. J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.748750 · Cited by 15
Mineralocorticoid and glucocorticoid receptor mRNA expression in the brain of translocated chukar (Alectoris chukar)
Dickens, M. J., Meddle, S., & Romero, L. M. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.11.018 · Cited by 14
Imipramine counteracts corticosterone-induced enhancement of glutamatergic transmission and impairment of long-term potentiation in the rat frontal cortex
Bobula, B., Wabno, J., & Grzegorz, H. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70704-6 · Cited by 15
The Potential Role of Glucocorticoids and the HPA Axis in Alcohol Dependence
Stephens, M. A. C., McCaul, M. E., & Wand, G. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00021-3 · Cited by 19
Tissue specific expression of 11BHSD and its effects on plasma corticosterone during the stress response
Pérez, J. H., Swanson, R. E., Lau, H. J., Cheah, J. C., Bishop, V. R., Snell, K. R. S., Reid, A. M. A., Meddle, S., Wingfield, J. C., & Krause, J. S. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.209346 · Cited by 15
Coping with the multifaceted and multifunctional role of cortisol in the brain
de Kloet, E. R. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104047 · Cited by 18
Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challenge
Jimeno, B., & Rubalcaba, J. G. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0501 · Cited by 15
Stress-induced cortisol response predicts empathy for pain: The role of task-based connectivity between the insula and sensorimotor cortex during acute stress
Tang, Z., Liu, Y., Zhao, X., Hu, W., Zhang, M., Ren, Y., Wei, Z., & Yang, J. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100682 · Cited by 14
Bloqueantes del receptor mineralcorticoide en la enfermedad renal crónica
Erraez, S., López-Mesa, M., & Gómez-Fernández, P. (2020) · Nefrología · doi:10.1016/j.nefro.2020.10.001 · Cited by 15
Acute restraint stress does not alter corticosteroid receptors or 11β-hydroxysteroid dehydrogenase gene expression at hypothalamic–pituitary-adrenal axis regulatory sites in captive male white-crowned sparrows (Zonotrichia leucophrys gambelii)
Krause, J. S., Pérez, J. H., Reid, A. M. A., Cheah, J. C., Bishop, V. R., Wingfield, J. C., & Meddle, S. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113701 · Cited by 14
Impact of adolescent stress on the expression of stress‐related receptors in the hippocampus of animals exposed to alcohol prenatally
Raineki, C., Ellis, L. A., & Weinberg, J. (2017) · Hippocampus · doi:10.1002/hipo.22823 · Cited by 14
The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain
Reshetnikov, V. V., Александровна, С. А., Ryabushkina, J., Merkulova, T. I., & Bondar, N. P. (2018) · Behaviour · doi:10.1163/1568539x-00003482 · Cited by 13
Hypothalamic-pituitary-adrenal axis responsiveness, startle response, and sensorimotor gating in late pregnancy
Breedh, J., Comasco, E., Hellgren, C., Papadopoulos, F. C., Skalkidou, A., & Poromaa, I. S. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.008 · Cited by 13
The Hypothalamus-Pituitary-Adrenal Axis and Social Cognition in Borderline Personality Disorder
Kulakova, E., Graumann, L., & Wingenfeld, K. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230804085639 · Cited by 14
Glucocorticoid feedback paradox: a homage to Mary Dallman
de Kloet, E. R. (2023) · Stress · doi:10.1080/10253890.2023.2247090 · Cited by 11
Behavioral, metabolic, and biochemical alterations caused by an acute stress event in a zebrafish larvae model
Vieira, R. S. F., Venâncio, C. A. S., & Félix, L. M. (2024) · Fish Physiology and Biochemistry · doi:10.1007/s10695-024-01421-7 · Cited by 12
Childhood maltreatment and within-person associations between cortisol and affective experience
Kuhlman, K. R., Abelson, J. L., Mayer, S. E., Rajaram, N., Briggs, H., & Young, E. A. (2021) · Stress · doi:10.1080/10253890.2021.1928069 · Cited by 12

Authors: Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R.
Affiliations: University of Amsterdam (NL)
Leiden University (NL)
Corresponding author: Joëls, Marian
ORCID: Joëls, Marian
Karst, Henk
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2008-01
Volume: 31
Issue: 1
Pages: 1-7
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2007.10.005
OpenAlex: W2148731425
Cited by: 481
References: 55
Citations by year: 2026: 3 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 24 · 2020: 16 · 2019: 29 · 2018: 26 · 2017: 32 · 2016: 47 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 32
FWCI: 1.96
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Koninklijke Nederlandse Akademie van Wetenschappen
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: mineralocorticoid receptor, glucocorticoid receptor, corticosteroids, stress response, limbic system, genetic variants, psychological stress
MeSH terms: Animals, Brain Chemistry, Humans, Stress, Psychological, Receptors, Mineralocorticoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The coming out of the brain mineralocorticoid receptor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks