The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The coming out of the brain mineralocorticoid receptor
Abstract
Corticosteroids - secreted after stress - have profound effects on brain and behavior. These effects are mediated by mineralocorticoid and glucocorticoid receptors, which are abundantly expressed in limbic neurons. The role of mineralocorticoid receptors in higher brain functions has never been well understood. Here we argue that the recently discovered low-affinity membrane version of the mineralocorticoid receptor contributes to the initial phase of the stress reaction; this is complemented by the glucocorticoid receptor which terminates the stress response. This concept may explain why human carriers of a mineralocorticoid receptor gene variant display enhanced neuroendocrine and autonomic responsiveness to a psychological stressor.
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“Although GRs are ubiquitously expressed in the brain, they are most abundant in the PVN and the hippocampus. In contrast, MR expression appears mostly confined to a few limbic sites regulating salt appetite and autonomic outflow (70, 71).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [70]
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Physiology and neurobiology of stress and adaptation: central role of the brain
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Stress and the brain: from adaptation to disease
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Self-citationBrain corticosteroid receptor balance in health and disease
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Self-citationTwo receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
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THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
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Stress and cognition: are corticosteroids good or bad guys?
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Research works printed but not linked: 1
- Olijslagers, 2006, Rapid enhancement of hippocampal glutamate transmission by corticosterone is mediated via the MEK/ERK pathway, FENS Forum Meeting
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Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Self-citationKeller, J., Gomez, R., Williams, G., Lembke, A., Lazzeroni, L., Murphy, G. M., & Schatzberg, A. F. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.120 · Cited by 922
Stress and the HPA axis: role of glucocorticoids in alcohol dependence
Stephens, M. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.4.11 · Cited by 571
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
Glucocorticoids and the circadian clock
Dickmeis, T. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0415 · Cited by 494
Metadata
- Authors
- Joëls, M., Karst, H., DeRijk, R., & de Kloet, E. R.
- Affiliations
- University of Amsterdam (NL)
- Leiden University (NL)
- Corresponding author
- Joëls, Marian
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 31
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2148731425
- Cited by
- 481
- References
- 55
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 24 · 2020: 16 · 2019: 29 · 2018: 26 · 2017: 32 · 2016: 47 · 2015: 30 · 2014: 41 · 2013: 36 · 2012: 32
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- mineralocorticoid receptor, glucocorticoid receptor, corticosteroids, stress response, limbic system, genetic variants, psychological stress
- MeSH terms
- Animals, Brain Chemistry, Humans, Stress, Psychological, Receptors, Mineralocorticoid
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