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Cited by 157Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersTreatment of Major Depression

Dendritic spine dynamics--a key role for kalirin-7

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Penzes, Peter, Jones, Kelly A.·2008·Trends in Neurosciences
DOI 10.1016/j.tins.2008.06.001PMC PMC3973420
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Abstract

Changes in the structure and function of dendritic spines contribute to numerous physiological processes such as synaptic transmission and plasticity, as well as behavior, including learning and memory. Moreover, altered dendritic spine morphogenesis and plasticity is an endophenotype of many neurodevelopmental and neuropsychiatric disorders. Hence, the molecular mechanisms that control spine plasticity and pathology have been under intense investigation over the past few years. A series of recent studies has improved our understanding of spine dynamics by establishing kalirin-7 as an important regulator of dendritic spine development as well as structural and functional plasticity, providing a model for the molecular control of structural plasticity and implicating kalirin-7 in synaptic pathology in several disorders including schizophrenia and Alzheimer's disease.

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  • Dynamic rearrangements of actin are regulated by Rho-like small GTPases, Rho-guanine-nucleotide exchange factors (GEFs) and Rho-GTPase activating proteins (GAPs).

    “Dynamic rearrangements of actin are regulated by Rho-like small GTPases, Rho-guanine-nucleotide exchange factors (GEFs) and Rho-GTPase activating proteins (GAPs) (Cingolani and Goda, 2008; Penzes and Jones, 2008).”

    From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Penzes and Jones, 2008

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Authors
Penzes, P., & Jones, K. A.
Affiliations
Northwestern University (US)
Corresponding author
Penzes, Peter
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2008-08
Volume
31
Issue
8
Pages
419-427
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2008.06.001
PMC
PMC3973420
OpenAlex
W2062335102
Cited by
157
References
9
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 13 · 2013: 17 · 2012: 18
FWCI
1.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH071316-01A1, R56MH071316, R01MH071316)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
dendritic spines, Kalirin-7, spine morphogenesis, synaptic plasticity, structural plasticity, synaptic transmission, learning and memory, neurodevelopmental disorders, neuropsychiatric disorders, schizophrenia, Alzheimer's disease, synaptic pathology
MeSH terms
Animals, Humans, Nerve Tissue Proteins, Neurons, Signal Transduction, Protein Serine-Threonine Kinases, Guanine Nucleotide Exchange Factors, Cell Shape, Dendritic Spines

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