Cited by 374Attention Deficit Hyperactivity DisorderGenetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

Open access
Lesch, Klaus-Peter, Timmesfeld, Nina, Renner, Tobias J., Halperin, Rebecca, Röser, Christoph, Nguyen, T. Trang, Craig, David W., Romanos, Jasmin +10 more·2008·Journal of Neural Transmission

Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

Integrity signals

Registry

Crossref · 10.1007/s00702-008-0119-3

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lesch, K.-P., Timmesfeld, N., Renner, T. J., Halperin, R., Röser, C., Nguyen, T. T., Craig, D. W., Romanos, J., Heine, M., Meyer, J., Freitag, C., Warnke, A., Romanos, M., Schäfer, H., Walitza, S., Reif, A., Stephan, D. A., & Jacob, C.
Affiliations
  • University of Würzburg (DE)
  • Philipps University of Marburg (DE)
  • Translational Genomics Research Institute (US)
  • Universität Trier (DE)
  • Universitätsklinikum des Saarlandes (DE)
Corresponding author
Lesch, Klaus-Peter
Venue
Journal of Neural Transmission
Published
2008-10-07
Volume
115
Issue
11
Pages
1573-1585
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2066179547
Cited by
374
References
59
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 15 · 2020: 22 · 2019: 18 · 2018: 23 · 2017: 28 · 2016: 27 · 2015: 33 · 2014: 26 · 2013: 26 · 2012: 31
FWCI
18.92
Type
journal article
Language
en
Open access
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
adult ADHD, attention deficit hyperactivity disorder, genome-wide association study, linkage analysis, extended pedigrees, substance use disorders, risk genes, adhesion molecules, CDH13, ASTN2, synaptic plasticity, CTNNA2, KALRN, addiction vulnerability, multifactorial etiology
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Chromosomes, DNA, Female, Genotype, Humans, Genetic Linkage, Male, Molecular Biology, Neuronal Plasticity, Cell Adhesion Molecules, Genome, Human, Polymorphism, Single Nucleotide, Genome-Wide Association Study

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review