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Cited by 289Neuroscience and Neuropharmacology ResearchCell Adhesion Molecules ResearchGenetics and Neurodevelopmental Disorders

Cadherins and catenins at synapses: Roles in synaptogenesis and synaptic plasticity.

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Arikkath, Jyothi, Reichardt, Louis F.·2008·Trends in Neurosciences
DOI 10.1016/j.tins.2008.07.001PMC PMC2623250
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Abstract

Synapse formation involves reciprocal interactions between cells resulting in formation of a structure optimized for efficient information transfer. Recent work has implicated constituents of the cadherin-catenin cell-adhesion complex in both synapse formation and plasticity. In this review, we describe recent interesting discoveries on mechanisms of cadherin complex function, in addition to regulating adhesion, that are relevant for understanding the role of this complex in synaptogenesis and plasticity. We describe how this complex acts via (i) recruitment/stabilization of intracellular partners; (ii) regulation of intracellular signaling pathways; (iii) regulation of cadherin surface levels, stability and turnover; (iv) stabilization of receptors; and (v) regulation of gene expression. These exciting discoveries provide insights into novel functional roles of the complex beyond regulating cell adhesion.

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  • Cadherin signaling has been linked to synaptic adhesion stability and neurodegeneration.

    “Cadherin signaling has also been linked to synaptic adhesion stability and neurodegeneration (Ando et al., 2011; Arikkath and Reichardt, 2008; Laszlo and Lele, 2022; Mysore et al., 2008), and APOE isoforms differentially modulate components of cadherin–catenin complexes (Ahmad et al., 2020; Zhang et al., 2024).”

    From Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch (2026) · cites this paper as Arikkath and Reichardt, 2008

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Authors
Arikkath, J., & Reichardt, L. F.
Affiliations
University of California, San Francisco (US)
Corresponding author
Reichardt, Louis F.
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2008-09
Volume
31
Issue
9
Pages
487-494
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2008.07.001
PMC
PMC2623250
OpenAlex
W2067814945
Cited by
289
References
0
Citations by year
2026: 7 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 7 · 2021: 26 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 17 · 2015: 17 · 2014: 15 · 2013: 21 · 2012: 24
FWCI
2.50
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Centre National de la Recherche Scientifique
  • National Institute of Neurological Disorders and Stroke (P01NS016033)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
cadherins, catenins, synaptogenesis, synaptic plasticity, cadherin-catenin complex, cell adhesion, intracellular signaling, receptor stabilization, gene expression regulation
MeSH terms
Adaptation, Physiological, Animals, Cell Adhesion, Central Nervous System, Humans, Neuronal Plasticity, Neurons, Synapses, Cadherins, Catenins

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