Cited by 335Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Limbic and cortical information processing in the nucleus accumbens

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Goto, Yukiori, Grace, Anthony A.·2008·Trends in Neurosciences

DOI 10.1016/j.tins.2008.08.002PMC PMC2884964

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Abstract

The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.

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NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
Large-scale recording of neuronal ensembles
Buzsáki, G. (2004) · Nature Neuroscience · doi:10.1038/nn1233 · Cited by 1,875
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034
Self-citation
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
Synaptic interactions among excitatory afferents to nucleus accumbens neurons: hippocampal gating of prefrontal cortical input
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Self-citation
Increased dopamine transmission in schizophrenia: relationship to illness phases
Laruelle, M. A., Abi‐Dargham, A., Gil, R. B., Kegeles, L. S., & Innis, R. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00067-0 · Cited by 724
The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications
Harrison, P. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1761-y · Cited by 693

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Gao, Q., Khan, S., & Zhang, L. (2020) · Scientific Data · doi:10.1038/s41597-020-00709-6 · Cited by 13
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Chakroborty, S., Geisbush, T. R., Dale, E., Pehrson, A. L., Sánchez, C., & West, A. R. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00764 · Cited by 13
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Vázquez‐Roque, R. A., Solís, Ó., Camacho‐Abrego, I., Moreno, A. R., de la Cruz, F., Zamudio, S., & Flores, G. (2011) · Synapse · doi:10.1002/syn.21517 · Cited by 13
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Gmaz, J. M., Carmichael, J. E., & van der Meer, M. A. A. (2018) · eLife · doi:10.7554/elife.37275 · Cited by 15
Hippocampal serotonin depletion facilitates the enhancement of prepulse inhibition by risperidone: Possible role of 5-HT2C receptors in the dorsal hippocampus
Adams, W. K., & van den Buuse, M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.018 · Cited by 11
Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens
Stenner, M., Dürschmid, S., Rutledge, R. B., Zaehle, T., Schmitt, F. C., Kaufmann, J., Voges, J., Heinze, H., Dolan, R. J., & Schoenfeld, M. A. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00142.2016 · Cited by 10
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Yu, C.-C., Lu, C.-Y., Chen, M., Chen, Y., Lu, C.-H., Lin, Y.-Y., Chou, K., & Lin, W. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11080702 · Cited by 10
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Biernacki, K., Molokotos, E. K., Han, C., Dillon, D. G., Leventhal, A. M., & Janes, A. C. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.110890 · Cited by 9
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Stenner, M., Rutledge, R. B., Zaehle, T., Schmitt, F. C., Kopitzki, K., Kowski, A. B., Voges, J., Heinze, H., & Dolan, R. J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00260.2015 · Cited by 9
Impact of neonatal NOS-1 inhibitor exposure on neurobehavioural measures and prefrontal-temporolimbic integration in the rat nucleus accumbens
Dec, A. M., Kohlhaas, K. L., Nelson, C. L., Hoque, K. E., Leilabadi, S. N., Folk, J., Wolf, M. E., & West, A. R. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000990 · Cited by 9
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Zhou, J., Wu, B., Lin, X., Dai, Y., Li, T., Zheng, W., Guo, W. M., Vakal, S., Chen, X., & Chen, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00130 · Cited by 9
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Belardetti, F. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.10.30 · Cited by 9
Larger striatal volume is associated with increased adult psychopathy
Choy, O., Raine, A., & Schug, R. A. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.006 · Cited by 8
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Shi, M., Wu, X., Wei, C., Yang, M., Liu, Z., & Ren, W. (2011) · Neuroreport · doi:10.1097/wnr.0b013e32834ae32e · Cited by 8
Electrical stimulation of the hippocampal fimbria facilitates neuronal nitric oxide synthase activity in the medial shell of the rat nucleus accumbens: Modulation by dopamine D1 and D2 receptor activation
Hoque, K. E., Blume, S. R., Sammut, S., & West, A. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.005 · Cited by 8
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Catanese, J., & van der Meer, M. A. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.021 · Cited by 7
Linking haploinsufficiency of the autism- and schizophrenia-associated gene Cyfip1 with striatal-limbic-cortical network dysfunction and cognitive inflexibility
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“In ventral striatum, nucleus accumbens (NAc) dysfunction has been heavily implicated in schizophrenia [19, 20].”
Background
The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders
Grace, A. A., & Uliana, D. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03513-7 · Cited by 5
Self-citation
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Quintero, E., Vargas, J. P., Díaz, E., Arrieta, M. D. E., Carrasco, M., & López, J. C. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.08.008 · Cited by 6
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Fisher, M. L., Pauly, J. R., Froeliger, B., & Turner, J. R. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039776 · Cited by 7
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San‐Galli, A., Marchand, A. R., Decorte, L., & Scala, G. D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.024 · Cited by 5
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Wolf, M. E. (2010) · Springer eBooks · doi:10.1007/978-1-4614-0785-0_21 · Cited by 5
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Muñoz-Capote, A., Gómez-Martínez, D. G., Flores, T. D. C. R., Robles, F., Ramos, M. A., & Ramos, F. (2022) · Neurocomputing · doi:10.1016/j.neucom.2022.05.104 · Cited by 5
Differential transcriptome profile underlying risky choice in a rat gambling task
Kwak, M. J., Kim, W. Y., Jung, S., Chung, Y., & Kim, J. (2022) · Journal of Behavioral Addictions · doi:10.1556/2006.2022.00068 · Cited by 5
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Jardri, R., & Sommer, I. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4121-2_20 · Cited by 5
Excitability range of medium spiny neurons widens through the combined effects of inward rectifying potassium current inactivation and dopaminergic modulation
Steephen, J. E. (2011) · Neurocomputing · doi:10.1016/j.neucom.2011.08.003 · Cited by 4
Dopaminergic receptor blockade changes a functional connectivity network centred on the amygdala
Haaker, J., Menz, M. M., Fadai, T., Eippert, F., & Büchel, C. (2016) · Human Brain Mapping · doi:10.1002/hbm.23302 · Cited by 4
How neurodegeneration, dopamine and maladaptive behavioral learning interact to produce impulse control disorders in Parkinson’s disease
Cilia, R. (2012) · Basal Ganglia · doi:10.1016/j.baga.2012.08.004 · Cited by 5
Amphetamine dephosphorylates ERM proteins in the nucleus accumbens core and lithium attenuates its effects
Kim, W. Y., Jang, J. K., Shin, J.-K., & Kim, J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.07.037 · Cited by 4
Neurochemical Imaging of Addictive Disorders
Broft, A. I., & Martínez, D. (2012) · Neuromethods · doi:10.1007/7657_2012_48 · Cited by 4
Modulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro : Effect of sub‐chronic phencyclidine pretreatment
Ferdinand, J., Peters, K. Z., Yavas, E., & Young, A. M. J. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24843 · Cited by 4
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O’Donnell, P. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00021-4 · Cited by 3
Representations of Distinct Salience Signals in the Nucleus Accumbens
Murty, V. P., Stanek, J. K., & Heusser, A. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3002-13.2013 · Cited by 3
Cocaine exposure alters dopaminergic modulation of prefronto-accumbens transmission
Wang, X., Liu, L., Adams, W. K., Li, S., Zhang, Q., Li, B., Wang, M., & Cui, R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.042 · Cited by 3
aPKC-Mediated Persistent Increase in AMPA/NMDA Ratio in the VTA Participates in the Neuroadaptive Signal Necessary to Induce NAc Synaptic Plasticity After Cocaine Administration
Vaquer-Alicea, A. D. C., Vázquez‐Torres, R., Devarie‐Hornedo, M., Vicenty‐Padilla, J. C., Santos‐Vera, B., Maria-Rios, C. E., Vélez-Hernández, M. E., Sacktor, T. C., & Jiménez‐Rivera, C. A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.011 · Cited by 3
Gating of Cortical Input Through the Striatum
Murer, M. G., & O’Donnell, P. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00022-2 · Cited by 4
Phase de-synchronization effects auditory gating in the ventral striatum but not auditory cortex
Woldeit, M. L., Schulz, A. L., & Ohl, F. W. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.058 · Cited by 3
Synergistic Effect of Several Neurotransmitters in PFC-NAc-VTA Neural Circuit for the Anti-Depression Effect of Shuganheweitang in a Chronic Unpredictable Mild Stress Model
Chen, X., Ma, Y., Mou, X.-J., Liu, H., Ming, H., Chen, Y., Liu, Y., & Liu, S. (2021) · Natural Product Communications · doi:10.1177/1934578x211002415 · Cited by 4
Optogenetics: Illuminating the Neural Circuits of Depression
Muir, J., & Bagot, R. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00014-7 · Cited by 3
Anatomy and Physiology of Limbic System Dysfunction in Parkinson's Disease
Grace, A. A. (2011) · Parkinson s Disease · doi:10.1002/9781444397970.ch6 · Cited by 3
Self-citation
Biphasic Model of Addiction: Neurobehavioral Adaptations
Aggarwal, D., Naik, J., & Lindquist, D. H. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-025-00314-0 · Cited by 3
From lobotomy to connectomics: a critical review of contemporary psychosurgery
González, V., Rumià, J., Brell, M., Roset, C., de Miguel, J., Arboleya, S., Aguirre, I., Alegre, D., Goliney, V. G., & Ibáñez, J. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1785333 · Cited by 3
Sound evoked fos-like immunoreactivity in the big brown bat
Salles, A., Lee, S. M., & Moss, C. F. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.02.005 · Cited by 2
Alcohol disrupts long-term potentiation at hippocampus-medium spiny neuron synapses in the medial shell of the nucleus accumbens
Copenhaver, A. E., Snider, S. A., Campbell, J. R., & LeGates, T. A. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150577 · Cited by 2
Leptin in the nucleus accumbens blocks the increase of GluA1 phosphorylation induced by acute cocaine administration
Lee, J. W., Kim, W. Y., & Kim, J. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001001 · Cited by 2
Ezrin-radixin-moesin proteins are regulated by Akt-GSK3β signaling in the rat nucleus accumbens core
Kim, W. Y., Cai, W. T., Jang, J. K., & Kim, J. (2020) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2020.24.1.121 · Cited by 2
Modeling the schizophrenias: subunit-specific NMDAR antagonism dissociates frontal δ and hippocampal θ modulation of ~140 Hz oscillationsPreprint
Pittman-Polletta, B., Hu, K., & Kocsis, B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/191882 · Cited by 2
Methylphenidate and sustained attention in rats: a systematic review
Batanero-Geraldo, A., Montiel-Herrera, F., López, J. C., & Vargas, J. P. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07007-w · Cited by 1
[Progressive activation of brain areas induced by daily ingestion of a sweet snack].
Blancas‐Velazquez, A. S., & Briones, C. E. (2013) · PubMed · Cited by 1
Brain Networks, Hormones and Genes Implicated in Depression
Bennett, M. R. (2012) · Springer eBooks · doi:10.1007/978-94-007-5748-6_5 · Cited by 1
10.6 Dopamine Modulation of Forebrain Pathways and the Pathophysiology of Psychiatric Disorders
Grace, A. A. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195373035.003.0041 · Cited by 1
Self-citation
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Authors: Goto, Y., & Grace, A. A.
Affiliations: McGill University (CA)
University of Pittsburgh (US)
Corresponding author: Goto, Yukiori
ORCID: Goto, Yukiori
Grace, Anthony A.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2008-11
Volume: 31
Issue: 11
Pages: 552-558
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2008.08.002
PMC: PMC2884964
OpenAlex: W2070712548
Cited by: 332
References: 60
Citations by year: 2026: 11 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 17 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
FWCI: 2.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health (2r01mh057440-26a1)
National Institute of Mental Health (R01-MH057440, R37MH057440)
National Institute on Drug Abuse (R01DA015408)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, limbic system, prefrontal cortex, goal-directed behavior, drug addiction, dopamine, mental illness, information processing
MeSH terms: Animals, Cerebral Cortex, Humans, Limbic System, Mental Processes, Models, Biological, Neural Pathways, Nucleus Accumbens

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Limbic and cortical information processing in the nucleus accumbens

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