The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Limbic and cortical information processing in the nucleus accumbens
Open accessAbstract
The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.
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“In ventral striatum, nucleus accumbens (NAc) dysfunction has been heavily implicated in schizophrenia [19, 20].”
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Cites
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
Large-scale recording of neuronal ensembles
Buzsáki, G. (2004) · Nature Neuroscience · doi:10.1038/nn1233 · Cited by 1,875
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors
Grace, A. A., Floresco, S. B., Goto, Y., & Lodge, D. J. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.003 · Cited by 1,034
Self-citationDopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
O’Donnell, P., & Grace, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Self-citationIncreased dopamine transmission in schizophrenia: relationship to illness phases
Laruelle, M. A., Abi‐Dargham, A., Gil, R. B., Kegeles, L. S., & Innis, R. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00067-0 · Cited by 724
Harrison, P. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1761-y · Cited by 693
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Rocha-Neves, J. P. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/ax92-wk60
Deep Brain Stimulation in Treatment-Refractory Addiction
Lavano, A., Guzzi, G., Torre, A. D., Gabriele, D., Chirchiglia, D., Stroscio, C. A., & Volpentesta, G. (2018) · InTech eBooks · doi:10.5772/intechopen.73694
Wolter, S. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7020
浅原, 悟. (2010) · 近代中小企業
Shin, J.-K., Kim, W. Y., Rim, H., & Kim, J. (2021) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2022.26.1.59
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Amidfar, M., & Kim, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_3
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Bahari‐Javan, S. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4280
Interindividuelle Unterschiede der Impulsivität und Impulskontrolle
Nerenberg, L. (2013) · doi:10.53846/goediss-3793
Wright, M. (2017) · WikiJournal of Medicine · doi:10.15347/wjm/2017.003
Regulation of AMPA Receptor Trafficking in the Nucleus Accumbens by Dopamine and Cocaine
Wolf, M. E. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7264-3_24
An arbiter model of motivational selectionPreprint
McNally, G. P. (2019) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/b7eux
Muir, J., Tse, Y., Iyer, E., Sorensen, J., Eid, R., Cvetkovska, V., Wassef, K., Gostlin, S. K., Spencer, N., & Bagot, R. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.04.510865
Ma, L., He, L., Xu, Z., Yang, M., & Zhang, Y. (2023) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102304
Wang, Q., Gao, Y., Shangguan, Q., Zeng, Y., Jin, W., Wang, P., Hu, Y., & Chen, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120312 · Cited by 2
Evolutionary specializations of the human limbic system
August, I., Lew, C. H., & Semendeferi, K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00007-5
PACAP Signalling Network in the Nucleus Accumbens Core Regulates Reinstatement Behaviour in Rat
Bose, S., Simandl, G. J., Hess, E. M., Kong, L., Raddatz, N. J., Maunze, B., Choi, S., & Baker, D. L. (2025) · Addiction Biology · doi:10.1111/adb.70090 · Cited by 1
John, J., & Manchanda, R. (2009) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-642-03882-2_299
Reinforced Hippocampus-Accumbens pathway marks a shift towards cognitive decline in agingPreprint
Ribera, A., Fernandes-Dias, B., Yugay, L., Deneuville, E., Dias‐Silva, M., Violain, M., Bouet, T., Bethus, I., Lopes, L. V., Vanhoutte, P., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.19.700256
Le, T., Giménez‐Gómez, P., & Martin, G. E. (2026) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.70243
Enhancement of calcium responses by KIR current inactivation in medium spiny neurons
Steephen, J. E., Padmakumar, M., & Manchanda, R. (2026) · Journal of Biosciences · doi:10.1007/s12038-025-00579-3
Dopamine et contrôle de l’action : implication et maturation de la voie mésocorticale chez le rat
Naneix, F. (2011) · theses.fr (ABES) · doi:10.70675/001d4221ze950z4b8dz8178z8e2211b1bc4c
O'Connor, S. A., Narain, P., Mahajan, A., Bancroft, G. L., Haas, H. A., Wallen-Friedman, E., Vasisht, S., Takano, H., Kiffer, F. C., Eisch, A. J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.26.714605
Campos, R. C. (2017) · theses.fr (ABES) · doi:10.70675/03a75158z9d38z4e81zb3aczea487daa9f14
The Hippocampal-Prefrontal-Striatal network during successive learning and set-shifting
Oberto, V. J. (2017) · theses.fr (ABES) · doi:10.70675/d64848adzf26az4072zb8e2z0dc40420582c
Han, J., Kwak, M. J., Kim, W. Y., & Kim, J. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04015-4
Castell, L. (2020) · theses.fr (ABES) · doi:10.70675/1b15015az415cz4441zb0bdz7ce3de06f632
O'Connor, S. A., Narain, P., Mahajan, A., Bancroft, G. L., Haas, H. A., Wallen-Friedman, E., Vasisht, S., Takano, H., Kiffer, F. C., Eisch, A. J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9476558/v1
Flores, G. D., Damon, Z. F., Ford, M., Gancz, N. N., Savoca, P. W., Esfand, S. M., Chu, K. A., Querdasi, F. R., McCann, C. F., Westman, J. G., et al. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101275
Metadata
- Authors
- Goto, Y., & Grace, A. A.
- Affiliations
- McGill University (CA)
- University of Pittsburgh (US)
- Corresponding author
- Goto, Yukiori
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 31
- Issue
- 11
- Pages
- 552-558
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2884964
- OpenAlex
- W2070712548
- Cited by
- 332
- References
- 60
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 17 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (2r01mh057440-26a1)
- National Institute of Mental Health (R01-MH057440, R37MH057440)
- National Institute on Drug Abuse (R01DA015408)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus accumbens, limbic system, prefrontal cortex, goal-directed behavior, drug addiction, dopamine, mental illness, information processing
- MeSH terms
- Animals, Cerebral Cortex, Humans, Limbic System, Mental Processes, Models, Biological, Neural Pathways, Nucleus Accumbens
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