Cited by 335Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

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Limbic and cortical information processing in the nucleus accumbens

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Goto, Yukiori, Grace, Anthony A.·2008·Trends in Neurosciences

DOI 10.1016/j.tins.2008.08.002PMC PMC2884964

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Abstract

The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.

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Authors: Goto, Y., & Grace, A. A.
Affiliations: McGill University (CA)
University of Pittsburgh (US)
Corresponding author: Goto, Yukiori
ORCID: Goto, Yukiori
Grace, Anthony A.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2008-11
Volume: 31
Issue: 11
Pages: 552-558
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2008.08.002
PMC: PMC2884964
OpenAlex: W2070712548
Cited by: 332
References: 60
Citations by year: 2026: 11 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 10 · 2021: 17 · 2020: 17 · 2019: 23 · 2018: 17 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
FWCI: 2.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health (2r01mh057440-26a1)
National Institute of Mental Health (R01-MH057440, R37MH057440)
National Institute on Drug Abuse (R01DA015408)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens, limbic system, prefrontal cortex, goal-directed behavior, drug addiction, dopamine, mental illness, information processing
MeSH terms: Animals, Cerebral Cortex, Humans, Limbic System, Mental Processes, Models, Biological, Neural Pathways, Nucleus Accumbens

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Limbic and cortical information processing in the nucleus accumbens

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