The DOI matches its Crossref record; 94 of the 97 references it cites were found in a registry or an index.
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Open accessAbstract
Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms. Additionally, it remains unclear whether structural plasticity and its synaptic concomitants drive addictive behaviors or whether they reflect homeostatic compensations to the drug not related to addiction per se. Here, we discuss recent paradoxical data, which either support or oppose the hypothesis that drug-induced changes in dendritic spines drive addictive behavior. We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies.
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“According to this model there are distinguishable associative and nonassociative components of addiction, and the molecular mechanisms and neural substrates underlying these processes may overlap with those involved in canonical forms of memory (Anagnostaras and Robinson, 1996; Anagnostaras et al., 2002; Russo et al., 2010).”
From Proteasome phosphorylation regulates cocaine-induced sensitization (2018) · cites this paper as Russo et al., 2010
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Self-citationStructural basis of long-term potentiation in single dendritic spines
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Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105
Self-citationTranscriptional and epigenetic mechanisms of addiction
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Self-citationSocial influences on neuroplasticity: stress and interventions to promote well-being
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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612
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Metadata
- Authors
- Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Stanford Medicine (US)
- Corresponding author
- Russo, Scott J.
- ORCID
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 33
- Issue
- 6
- Pages
- 267-276
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2891948
- OpenAlex
- W2084967673
- Cited by
- 654
- References
- 97
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 27 · 2023: 25 · 2022: 31 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 53 · 2017: 57 · 2016: 48 · 2015: 45 · 2014: 49 · 2013: 49 · 2012: 56
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (F32DA019727, T32DA007290, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- addiction, nucleus accumbens, synaptic plasticity, structural plasticity, dendritic spines, medium spiny neurons, limbic system, homeostatic compensation, ultrastructure, electrophysiology, behavioral plasticity
- MeSH terms
- Animals, Models, Biological, Neuronal Plasticity, Neurons, Nucleus Accumbens, Illicit Drugs, Synapses, Signal Transduction, Substance-Related Disorders, Dendritic Spines
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