The DOI matches its Crossref record; 94 of the 97 references it cites were found in a registry or an index.
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Open accessAbstract
Addictive drugs cause persistent restructuring of several neuronal cell types in the limbic regions of brain thought to be responsible for long-term behavioral plasticity driving addiction. Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms. Additionally, it remains unclear whether structural plasticity and its synaptic concomitants drive addictive behaviors or whether they reflect homeostatic compensations to the drug not related to addiction per se. Here, we discuss recent paradoxical data, which either support or oppose the hypothesis that drug-induced changes in dendritic spines drive addictive behavior. We define areas where future investigation can provide a more detailed picture of drug-induced synaptic reorganization, including ultrastructural, electrophysiological and behavioral studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“According to this model there are distinguishable associative and nonassociative components of addiction, and the molecular mechanisms and neural substrates underlying these processes may overlap with those involved in canonical forms of memory (Anagnostaras and Robinson, 1996; Anagnostaras et al., 2002; Russo et al., 2010).”
From Proteasome phosphorylation regulates cocaine-induced sensitization (2018) · cites this paper as Russo et al., 2010
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationStructural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,382
Self-citationChanging subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,377
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131
Structural plasticity associated with exposure to drugs of abuse
Robinson, T. E., & Kolb, B. E. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.025 · Cited by 1,130
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108
Self-citationHarris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 1,036
Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction
Koob, G. F., & Le Moal, M. (2005) · Nature Neuroscience · doi:10.1038/nn1105-1442 · Cited by 963
Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854
Do thin spines learn to be mushroom spines that remember?
Bourne, J., & Harris, K. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.009 · Cited by 843
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Conrad, K. L., Tseng, K. Y., Uejima, J. L., Reimers, J. M., Heng, L.-J., Shaham, Y., Marinelli, M., & Wolf, M. E. (2008) · Nature · doi:10.1038/nature06995 · Cited by 790
Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R. C., Hall, M. E., & Pollard, T. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3739 · Cited by 773
Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764
Self-citationRobinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726
WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac
Miki, H., Suetsugu, S., & Takenawa, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6932 · Cited by 705
Robinson, T. E., & Kolb, B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-21-08491.1997 · Cited by 704
Belin, D., & Everitt, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.019 · Cited by 697
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T., Goodman, R. H., & Impey, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508448102 · Cited by 696
Development of long-term dendritic spine stability in diverse regions of cerebral cortex
Zuo, Y., Lin, A., Chang, P., & Gan, W.-B. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.001 · Cited by 684
Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity
Maze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., et al. (2010) · Science · doi:10.1126/science.1179438 · Cited by 665
Self-citationInduction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
Miki, H., Sasaki, T., Takai, Y., & Takenawa, T. (1998) · Nature · doi:10.1038/34208 · Cited by 644
Thomas, M. J., Beurrier, C., Bonci, A., & Malenka, R. C. (2001) · Nature Neuroscience · doi:10.1038/nn757 · Cited by 629
Self-citationRegulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625
Self-citationMolecular mechanisms of dendritic spine morphogenesis
Tada, T., & Sheng, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.12.001 · Cited by 615
Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons
Nägerl, U. V., Eberhorn, N., Cambridge, S. B., & Bonhoeffer, T. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.016 · Cited by 602
Hope, B. T., Nye, H. E., Kelz, M. B., Self, D. W., Iadarola, M. J., Nakabeppu, Y., Duman, R. S., & Nestler, E. J. (1994) · Neuron · doi:10.1016/0896-6273(94)90061-2 · Cited by 562
Self-citationEffects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Bibb, J. A., Chen, J., Taylor, J. R., Svenningsson, P., Nishi, A., Snyder, G. L., Yan, Z., Sagawa, Z. K., Ouimet, C. C., Nairn, A. C., et al. (2001) · Nature · doi:10.1038/35066591 · Cited by 483
Self-citationBoudreau, A. C., & Wolf, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2252-05.2005 · Cited by 481
Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466
Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
Kourrich, S., Rothwell, P. E., Klug, J. R., & Thomas, M. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1859-07.2007 · Cited by 444
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
Farnsworth, C. L., Freshney, N. W., Rosen, L. B., Ghosh, A., Greenberg, M. E., & Feig, L. A. (1995) · Nature · doi:10.1038/376524a0 · Cited by 434
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1
Krapivinsky, G. B., Krapivinsky, L., Manasian, Y., Ivanov, A., Tyzio, R., Pellegrino, C., Ben‐Ari, Y., Clapham, D. E., & Medina, I. (2003) · Neuron · doi:10.1016/s0896-6273(03)00645-7 · Cited by 431
Nestler, E. J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02439.1992 · Cited by 421
Self-citationEdlund, S., Landström, M., Heldin, C., & Aspenström, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0398 · Cited by 418
Robinson, T. E., Gorny, G., Mitton, E., & Kolb, B. E. (2001) · Synapse · doi:10.1002/1098-2396(20010301)39:3 · Cited by 411
Transcriptional mechanisms of addiction: role of ΔFosB
Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 411
Self-citationGenome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins
Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H. E., Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.026 · Cited by 409
Self-citationGraham, D. L., Edwards, S., Bachtell, R. K., Dileone, R., Rios, M., & Self, D. W. (2007) · Nature Neuroscience · doi:10.1038/nn1929 · Cited by 401
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 390
Lee, K.-W., Kim, Y. D., Kim, A. M., Helmin, K. A., Nairn, A. C., & Greengard, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511244103 · Cited by 369
Tolias, K. F., Bikoff, J. B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R. J., & Greenberg, M. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.024 · Cited by 365
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors
Bateup, H. S., Santini, E., Shen, W., Birnbaum, S. G., Valjent, E., Surmeier, D., Fisone, G., Nestler, E. J., & Greengard, P. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1009874107 · Cited by 361
Self-citationSpine architecture and synaptic plasticity
Carlisle, H. J., & Kennedy, M. B. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.008 · Cited by 357
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307
Signalling and crosstalk of Rho GTPases in mediating axon guidance
Yuan, X., Jin, M., Xu, X., Song, Y., Wu, C.-P., Poo, M., & Duan, S. (2002) · Nature Cell Biology · doi:10.1038/ncb895 · Cited by 302
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
Anderson, S. M., Famous, K. R., Sadri-Vakili, G., Kumaresan, V., Schmidt, H. D., Bass, C. E., Terwilliger, E. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Nature Neuroscience · doi:10.1038/nn2054 · Cited by 295
In Vivo Cocaine Experience Generates Silent Synapses
Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G. A., Marie, H., Liu, W., Yan, Z., Sorg, B. A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.007 · Cited by 291
Murphy, D. D., & Segal, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1482 · Cited by 290
Cocaine Regulates MEF2 to Control Synaptic and Behavioral Plasticity
Pulipparacharuvil, S., Renthal, W., Hale, C. F., Taniguchi, M., Xiao, G., Kumar, A., Russo, S. J., Sikder, D., Dewey, C. M., Davis, M. M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.020 · Cited by 281
Self-citationChronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.
Sklair‐Tavron, L., Shi, W. X., Lane, S. B., Harris, H. W., Bunney, B. S., & Nestler, E. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11202 · Cited by 279
Self-citationNeurotrophic factors and structural plasticity in addiction
Russo, S. J., Mazei‐Robison, M. S., Ables, J. L., & Nestler, E. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.059 · Cited by 278
Self-citationBoudreau, A. C., Reimers, J. M., Milovanovic, M., & Wolf, M. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2163-07.2007 · Cited by 277
An essential role for ΔFosB in the nucleus accumbens in morphine action
Zachariou, V., Bolaños, C. A., Selley, D. E., Theobald, D. E. H., Cassidy, M. P., Kelz, M. B., Shaw-Lutchman, T., Berton, O., Sim‐Selley, L. J., Dileone, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1636 · Cited by 267
Self-citationVav2 Is an Activator of Cdc42, Rac1, and RhoA
Abe, K., Rossman, K. L., Liu, B., Ritola, K., Chiang, D. Y., Campbell, S. L., Burridge, K., & Der, C. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10141 · Cited by 264
The sequence of events that underlie quantal transmission at central glutamatergic synapses
Lisman, J. E., Raghavachari, S., & Tsien, R. W. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2191 · Cited by 260
Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259
Self-citationNorrholm, S. D., Bibb, J. A., Nestler, E. J., Ouimet, C. C., Taylor, J. R., & Greengard, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00560-2 · Cited by 249
Self-citationNuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward
Russo, S. J., Wilkinson, M. B., Mazei‐Robison, M. S., Dietz, D., Maze, I. S., Krishnan, V., Renthal, W. R., Graham, A., Birnbaum, S. G., Green, T. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6173-08.2009 · Cited by 248
Self-citationCell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
Bateup, H. S., Svenningsson, P., Kuroiwa, M., Gong, S., Nishi, A., Heintz, N., & Greengard, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2153 · Cited by 233
Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB
Marie, H., Morishita, W., Yu, X., Calakos, N., & Malenka, R. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.039 · Cited by 226
Self-citationRobinson, T. E., Gorny, G., Savage, V. R., & Kolb, B. E. (2002) · Synapse · doi:10.1002/syn.10146 · Cited by 224
Elias, G. M., Elias, L. A. B., Apostolides, P. F., Kriegstein, A. R., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811025106 · Cited by 223
Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats
Shen, H., Toda, S., Moussawi, K., Bouknight, A., Zahm, D. S., & Kalivas, P. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5638-08.2009 · Cited by 219
Distinct patterns of ΔFosB induction in brain by drugs of abuse
Perrotti, L. I., Weaver, R. R., Robison, B., Renthal, W. R., Maze, I. S., Yazdani, S., Elmore, R. G., Knapp, D. J., Selley, D. E., Martin, B. R., et al. (2008) · Synapse · doi:10.1002/syn.20500 · Cited by 218
Self-citationIRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
Russo, S. J., Bolaños, C. A., Theobald, D. E. H., DeCarolis, N. A., Renthal, W. R., Kumar, A., Winstanley, C. A., Renthal, N. E., Wiley, M. D., Self, D. W., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1812 · Cited by 215
Self-citationShaw-Lutchman, T. Z., Barrot, M., Wallace, T. L., Gilden, L., Zachariou, V., Impey, S., Duman, R. S., Storm, D. R., & Nestler, E. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03663.2002 · Cited by 205
Self-citationInduction of Spine Growth and Synapse Formation by Regulation of the Spine Actin Cytoskeleton
Zito, K., Knott, G. W., Shepherd, G. M., Shenolikar, S., & Svoboda, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.022 · Cited by 202
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking
Ambroggi, F., Turiault, M., Milet, A., Deroche‐Gamonet, V., Parnaudeau, S., Balado, É., Barik, J., van der Veen, R., Maroteaux, G., Lemberger, T., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2282 · Cited by 194
Li, Y., Acerbo, M. J., & Robinson, T. E. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03612.x · Cited by 180
Cocaine Increases Actin Cycling: Effects in the Reinstatement Model of Drug Seeking
Toda, S., Shen, H., Peters, J., Cagle, S., & Kalivas, P. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4132-05.2006 · Cited by 149
BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal
Pu, L., Liu, Q.-S., & Poo, M. (2006) · Nature Neuroscience · doi:10.1038/nn1687 · Cited by 142
Two-color, two-photon uncaging of glutamate and GABA
Kantevari, S., Matsuzaki, M., Kanemoto, Y., Kasai, H., & Ellis‐Davies, G. C. R. (2009) · Nature Methods · doi:10.1038/nmeth.1413 · Cited by 139
Berglind, W. J., Whitfield, T. W., LaLumiere, R. T., Kalivas, P. W., & McGinty, J. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5457-08.2009 · Cited by 131
Distinct Behavioral Responses to Ethanol Are Regulated by Alternate RhoGAP18B Isoforms
Rothenfluh, A., Threlkeld, R. J., Bainton, R. J., Tsai, L. T.-Y., Lasek, A. W., & Heberlein, U. (2006) · Cell · doi:10.1016/j.cell.2006.09.010 · Cited by 121
Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens
Kim, Y. D., Teylan, M., Baron, M. L., Sands, A., Nairn, A. C., & Greengard, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813179106 · Cited by 121
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
Sung, J. Y., Engmann, O., Teylan, M. A., Nairn, A. C., Greengard, P., & Kim, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712180105 · Cited by 117
Wang, J. Q., Tang, Q., Parelkar, N. K., Liu, Z., Samdani, S., Choe, E. S., Yang, L., & Mao, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:1:01 · Cited by 113
Fasano, S., D'Antoni, A., Orban, P. C., Valjent, E., Putignano, E., Vara, H., Pizzorusso, T., Giustetto, M., Yoon, B.-J., Soloway, P. D., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.014 · Cited by 107
Cdk5 Modulates Cocaine Reward, Motivation, and Striatal Neuron Excitability
Benavides, D. R., Quinn, J. J., Zhong, P., Hawasli, A. H., Dileone, R., Kansy, J. W., Olausson, P., Yan, Z., Taylor, J. R., & Bibb, J. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4061-07.2007 · Cited by 97
Hamilton, G. F., Whitcher, L. T., & Klintsova, A. Y. (2009) · Synapse · doi:10.1002/syn.20711 · Cited by 97
Acute cocaine exposure alters spine density and long‐term potentiation in the ventral tegmental area
Sarti, F., Borgland, S. L., Kharazia, V., & Bonci, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05689.x · Cited by 93
Regulation of CRE‐mediated transcription in mouse brain by amphetamine
Shaw‐Lutchman, T. Z., Impey, S., Storm, D. R., & Nestler, E. J. (2003) · Synapse · doi:10.1002/syn.10172 · Cited by 92
Self-citationHomer Isoforms Differentially Regulate Cocaine-Induced Neuroplasticity
Szumlinski, K. K., Abernathy, K., Oleson, E. B., Klugmann, M., Lominac, K. D., He, D., Dorit Ron, A., During, M. J., & Kalivas, P. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300890 · Cited by 86
Bachtell, R. K., Choi, K., Simmons, D. L., Falcón, E., Monteggia, L. M., Neve, R. L., & Self, D. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06199.x · Cited by 80
Regulation of fosB and ΔfosB mRNA expression: In vivo and in vitro studies
Alibhai, I. N., Green, T. A., Potashkin, J. A., & Nestler, E. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.069 · Cited by 80
Self-citationMolecular Mechanisms of Psychostimulant-induced Structural Plasticity
Dietz, D., Dietz, K. C., Nestler, E. J., & Russo, S. J. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1202847 · Cited by 78
Self-citationSpijker, S., Houtzager, S. W. J., de Gunst, M. C. M., de Boer, W. P. H., Schoffelmeer, A. N. M., & Smit, A. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-0612fje · Cited by 72
Cocaine-evoked synaptic plasticity: a key to addiction?
Lüscher, C., & Bellone, C. (2008) · Nature Neuroscience · doi:10.1038/nn0708-737 · Cited by 48
Cocaine regulates ezrin–radixin–moesin proteins and RhoA signaling in the nucleus accumbens
Kim, W. Y., Shin, S., Kim, S., Jeon, S., & Kim, J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.067 · Cited by 33
Suzuki, S., Zhou, H., Neumaier, J. F., & Pham, T. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21424 · Cited by 22
The expanding role of PSD-95: a new link to addiction
Roche, K. W. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.09.002 · Cited by 18
Flagged first, then by citations
3 of the 97 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling
Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105
Self-citationTranscriptional and epigenetic mechanisms of addiction
Robison, A. J., & Nestler, E. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3111 · Cited by 993
Self-citationSocial influences on neuroplasticity: stress and interventions to promote well-being
Davidson, R. J., & McEwen, B. S. (2012) · Nature Neuroscience · doi:10.1038/nn.3093 · Cited by 892
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612
Self-citation
Metadata
- Authors
- Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Stanford Medicine (US)
- Corresponding author
- Russo, Scott J.
- ORCID
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 33
- Issue
- 6
- Pages
- 267-276
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC2891948
- OpenAlex
- W2084967673
- Cited by
- 654
- References
- 97
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 27 · 2023: 25 · 2022: 31 · 2021: 37 · 2020: 35 · 2019: 45 · 2018: 53 · 2017: 57 · 2016: 48 · 2015: 45 · 2014: 49 · 2013: 49 · 2012: 56
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (F32DA019727, T32DA007290, R01DA014133)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- addiction, nucleus accumbens, synaptic plasticity, structural plasticity, dendritic spines, medium spiny neurons, limbic system, homeostatic compensation, ultrastructure, electrophysiology, behavioral plasticity
- MeSH terms
- Animals, Models, Biological, Neuronal Plasticity, Neurons, Nucleus Accumbens, Illicit Drugs, Synapses, Signal Transduction, Substance-Related Disorders, Dendritic Spines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review