The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
The multiple pathways for itch and their interactions with pain
Open accessAbstract
Multiple neural pathways and molecular mechanisms responsible for producing the sensation of itch have recently been identified, including histamine-independent pathways. Physiological, molecular, behavioral and brain imaging studies are converging to describe these pathways and their close association with pain processing. Some conflicting results have arisen, and the precise relationship between itch and pain remains controversial. A better understanding of the generation of itch and of the intrinsic mechanisms that inhibit itch after scratching should facilitate the search for new methods to alleviate clinical pruritus (itch). In this review, we describe the current understanding of the production and inhibition of itch. A model of itch processing within the central nervous system (CNS) is proposed.
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Cites
Proteinase-activated Receptors
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Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
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Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus
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A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
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Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin
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Cited by
Cevikbas, F., Wang, X., Akiyama, T., Kempkes, C., Savinko, T., Antal, A., Kukova, G., Buhl, T., Ikoma, A., Buddenkotte, J., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.10.048 · Cited by 804
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
The Impact of Pruritus on Quality of Life: The Skin Equivalent of Pain
Kini, S. P. (2011) · Archives of Dermatology · doi:10.1001/archdermatol.2011.178 · Cited by 324
Gate control of mechanical itch by a subpopulation of spinal cord interneurons
Bourane, S., Duan, B., Koch, S. C., Dalet, A., Britz, O., Garcia-Campmany, L., Kim, E., Cheng, L., Ghosh, A., Ma, Q., et al. (2015) · Science · doi:10.1126/science.aac8653 · Cited by 296
Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
Liu, X.-Y., Liu, Z.-C., Sun, Y.-G., Ross, M., Kim, S., Tsai, F.-F., Li, Q.-F., Jeffry, J., Kim, J.-Y., Loh, H. H., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.043 · Cited by 291
Metadata
- Authors
- Davidson, S., & Giesler, G. J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 33
- Issue
- 12
- Pages
- 550-558
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2081548166
- Cited by
- 261
- References
- 100
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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