The neurobiology of anhedonia and other reward-related deficits

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Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

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Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders

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Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior

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Multidimensional behavioral profiles associated with resilience and susceptibility after inescapable stress

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A change in taste: the role of microRNAs in altering hedonic value

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The amygdalostriatal and corticostriatal effective connectivity in anticipation and evaluation of facial attractiveness

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New Directions in Medication-Facilitated Behavioral Treatment for Substance Use Disorders

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Individual differences in self-reported reward-approach tendencies relate to resting-state and reward-task-based fMRI measures

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Genetically modified mice related to schizophrenia and other psychoses: Seeking phenotypic insights into the pathobiology and treatment of negative symptoms

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Anhedonia and emotional numbing in treatment-seeking veterans: behavioural and electrophysiological responses to reward

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Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus

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Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis

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Unveiling diverse clinical symptom patterns and neural activity profiles in major depressive disorder subtypes

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Cognitive deficits, obesity and disability in schizophrenia

Strassnig, M., Cáceda, R., Newcomer, J. W., & Harvey, P. D. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0046-5 · Cited by 14

Is placebo useful in the treatment of major depression in clinical practice?

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A randomized controlled double-blind clinical trial comparing versus placebo the effect of an edible algal extract (Ulva Lactuca) on the component of depression in healthy volunteers with anhedonia

Allaert, F., Demais, H., & Collén, P. N. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1784-x · Cited by 30

Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral Amygdala Neural Activation

Cabeza, L., Ramadan, B., Cramoisy, S., Houdayer, C., Haffen, É., Risold, P., FELLMANN, D., & Peterschmitt, Y. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.717701 · Cited by 19

Affective biases and their interaction with other reward-related deficits in rodent models of psychiatric disorders

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Appetitive motivation in depressive anhedonia: Effects of piece-rate cash rewards on cardiac and behavioral outcomes.

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Reward Processing and Smoking

Bruijnzeel, A. W. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw303 · Cited by 14

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Wang, H., Chen, Y., Zhao, A., Shen, Z., & Zhang, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1709060 · Cited by 18

Fatigue in de novo Parkinson’s Disease: Expanding the Neuropsychiatric Triad?

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Anhedonia modulates benzodiazepine and opioid demand among persons in treatment for opioid use disorder

Greenwald, M. K., Moses, T. E. H., Lundahl, L. H., & Roehrs, T. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1103739 · Cited by 13

Alterations in subcortical magnetic susceptibility and disease-specific relationship with brain volume in major depressive disorder and schizophrenia

Shibukawa, S., Kan, H., Honda, S., Wada, M., Tarumi, R., Tsugawa, S., Tobari, Y., Maikusa, N., Mimura, M., Uchida, H., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02862-7 · Cited by 13

Adverse childhood experience and depression: the role of gut microbiota

Bai, Y., Shu, C., Hou, Y., & Wang, G. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1309022 · Cited by 16

The Use of Ketamine for the Treatment of Anhedonia in Depression

Patarroyo-Rodríguez, L., Cavalcanti, S., Voort, J. L. V., & Singh, B. (2024) · CNS Drugs · doi:10.1007/s40263-024-01099-8 · Cited by 13

Role of prefrontal cortical 5-HT2A receptors and serotonin transporter in the behavioral deficits in post-pubertal rats following neonatal lesion of the ventral hippocampus

Mitazaki, S., Nakagawasai, O., Onogi, H., Watanabe, K., Takahashi, K., Tan–No, K., Quirion, R., Srivastava, L. K., & Tadano, T. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112226 · Cited by 16

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno‐Fernández, R. D., Rosell‐Valle, C., Bacq, A., Zanoletti, O., Cifuentes, M., Pérez‐Martín, M., Gavito, A., Garcia‐Fernandez, M. I., Estivill‐Torrús, G., de Fonseca, F. R., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107896 · Cited by 13

Signals of anticipation of reward and of mean reward rates in the human brain

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Striatal connectopic maps link to functional domains across psychiatric disorders

Mulders, P. C. R., van Eijndhoven, P., van Oort, J., Oldehinkel, M., Duyser, F. A., Kist, J. D., Collard, R. M., Vrijsen, J. N., Haak, K. V., Beckmann, C. F., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02273-6 · Cited by 14

Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice

Farahbakhsh, Z. Z., Song, K., Branthwaite, H. E., Erickson, K. R., Mukerjee, S., Nolan, S. O., & Siciliano, C. A. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01547-x · Cited by 13

Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

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Cortisol level in depressed patients and its relation with suicidal risk and anhedonia

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Link Between Anhedonia and Depression During Early Alcohol Abstinence: Gender Matters

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Clueless about cues: the impact of reward-paired cues on decision making under uncertainty

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Pupillary response in reward processing in adults with major depressive disorder in remission

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Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior

Grilo, M. L. P. D. M., de Sousa, G. M., de Mendonça, L. A. C., Soares, B. L., de Sousa, M. B. C., Palhano-Fontes, F., de Araújo, D. B., Perkins, D., Hallak, J. E. C., & Coelho, N. L. G. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.901425 · Cited by 16

Chronic stress and stressful emotional contagion affect the empathy-like behavior of rats

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Electrophysiological Correlates of Reward Anticipation in Subjects with Schizophrenia: An ERP Microstate Study

Perrottelli, A., Giordano, G. M., Koenig, T. W., Caporusso, E., Giuliani, L., Pezzella, P., Bucci, P., Mucci, A., & Galderisi, S. (2023) · Brain Topography · doi:10.1007/s10548-023-00984-7 · Cited by 13

Increased brain nucleus accumbens functional connectivity in melancholic depression

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Is it more effective for anhedonia and avolition? A systematic review and meta‐analysis of non‐invasive brain stimulation interventions for negative symptoms in schizophrenia

Chen, Y., Li, Z., Yan, C., & Zou, L. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14645 · Cited by 11

Dorsal raphe neurons integrate the values of reward amount, delay, and uncertainty in multi-attribute decision-making

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Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula

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Stress vulnerability promotes an alcohol‐prone phenotype in a preclinical model of sustained depression

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Psychosocial factors and multiple health risk behaviors among early adolescents: a latent profile analysis

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Examining the Association between Inflammation and Motivational Anhedonia in Neuropsychiatric Disorders: A Systematic Review

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Development of Reward Circuitry During Adolescence: Depression, Social Context, and Considerations for Future Research on Disparities in Sexual and Gender Minority Youth

Eckstrand, K., Lenniger, C. J., & Forbes, E. E. (2022) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-120920-040820 · Cited by 13

Aberrant intrinsic hippocampal and orbitofrontal connectivity in drug-naive adolescent patients with major depressive disorder

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Antidepressant treatment effects on dopamine transporter availability in patients with major depression: a prospective 123I-FP-CIT SPECT imaging genetic study

Hellwig, S., Frings, L., Masuch, A., Vach, W., Domschke, K., Normann, C., & Meyer, P. T. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1863-7 · Cited by 12

Behavioral Paradigms to Probe Individual Mouse Differences in Value-Based Decision Making

Alabi, O. O., Fortunato, M. P., & Fuccillo, M. V. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00050 · Cited by 11

Multivariate pattern analysis of the neural correlates of smoking cue attentional bias

Elton, A., Chanon, V. W., & Boettiger, C. A. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.001 · Cited by 14

Neurostimulation for treatment-resistant posttraumatic stress disorder: an update on neurocircuitry and therapeutic targets

Larkin, M. B., McGinnis, J. P., Snyder, R. I., Storch, E. A., Goodman, W. K., Viswanathan, A., & Sheth, S. A. (2020) · Journal of neurosurgery · doi:10.3171/2020.4.jns2061 · Cited by 12

Can pharmacotherapy improve treatment outcomes in people with co-occurring major depressive and cocaine use disorders?

Angarita, G. A., Hadizadeh, H., Cerdena, I. L., & Potenza, M. N. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1931684 · Cited by 11

Striatal Functional Connectivity Alterations After Two-Week Antidepressant Treatment Associated to Enduring Clinical Improvement in Major Depressive Disorder

An, J., Li, L., Wang, L., Su, Y., Wang, Y., Li, K., Zeng, Y., Kong, Q., Yan, C., & Si, T. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00884 · Cited by 12

Neural Correlates of Anhedonia in Major Depressive Disorder: Insights from Concurrent Analysis of Feedback-Related Negativity and Stimulus-Preceding Negativity

Sun, Y., Huang, Z., Gao, X., Chen, L., Wang, J., Zhou, Z., & Zhou, H. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s435017 · Cited by 13

Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex

Kim, J., Seol, S., Kim, T., Lee, J. L., Koo, J. W., & Kang, H. J. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01156-8 · Cited by 11

The influence of drug class on reward in substance use disorders

Jones, J. D., Arout, C. A., Luba, R. R., Murugesan, D., Madera, G., Gorsuch, L., Schusterman, R., & Martinez, S. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173771 · Cited by 12

Meta-analysis of structural and functional abnormalities in behavioral addictions

Mei, B., Tao, Q., Dang, J., Niu, X., Sun, J., Zhang, M., Wang, W., Zhang, Y., Zhang, Y., & Cheng, J. (2024) · Addictive Behaviors · doi:10.1016/j.addbeh.2024.108088 · Cited by 12

Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring

Searles, C. T., Vogt, M. E., Adedokun, I., & Murphy, A. Z. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110372 · Cited by 12

Acute stress worsens the deficits in appetitive behaviors for social and sexual stimuli displayed by rats after long-term withdrawal from morphine

Bai, Y., Belin, D., Zheng, X., Liu, Z., & Zhang, Y. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4571-3 · Cited by 13

Influence of aging on chronic unpredictable mild stress-induced depression-like behavior in male C57BL/6J mice

Wang, S., Huang, G., Yan, J. Y., Li, C., Feng, J., Chen, Q., Zheng, X., Li, H., Li, J., Wang, L., et al. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113486 · Cited by 11

Anticipatory and consummatory pleasure in avoidant/restrictive food intake disorder

Dolan, S. C., Kambanis, P. E., Stern, C. M., Becker, K. R., Breithaupt, L. E., Gydus, J. E., Smith, S. E., Misra, M., Micali, N., Lawson, E. A., et al. (2023) · Journal of Eating Disorders · doi:10.1186/s40337-023-00921-w · Cited by 12

The neural basis underlying female vulnerability to depressive disorders

Kim, M., Kim, W., & Chung, C. (2023) · Animal Cells and Systems · doi:10.1080/19768354.2023.2276815 · Cited by 13

Preliminary validation of natural depression in macaques with acute treatments of the fast-acting antidepressant ketamine

Chu, X. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.044 · Cited by 10

The role of avoidance motivation in the relationship between reward sensitivity and depression symptoms in adolescents: An ERP study

Ellis, A. J., Salgari, G. C., Miklowitz, D. J., & Loo, S. K. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.03.011 · Cited by 11

Anhedonia as a Potential Risk Factor of Alzheimer’s Disease in a Community-Dwelling Elderly Sample: Results from the ZARADEMP Project

Vaquero-Puyuelo, D., De‐la‐Cámara, C., Olaya, B., Gracia‐García, P., Lobo, A., López‐Antón, R., & Santabárbara, J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041370 · Cited by 11

Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure

Danielsson, K., Lagström, O., Ericson, M., Söderpalm, B., & Adermark, L. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108638 · Cited by 11

The efficacy of levomilnacipran ER across symptoms of major depressive disorder: a post hoc analysis of 5 randomized, double-blind, placebo-controlled trials

McIntyre, R. S., Gommoll, C., Chen, C., & Ruth, A. (2016) · CNS Spectrums · doi:10.1017/s1092852915000899 · Cited by 11

Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine

Geste, J. R., Levin, B., Wilks, I., Pompilus, M., Zhang, X., Esser, K. A., Febo, M., O’Dell, L. E., & Bruijnzeel, A. W. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz052 · Cited by 11

Psychobiology of the intersection and divergence of depression and anxiety

Pizzagalli, D. A. (2016) · Depression and Anxiety · doi:10.1002/da.22550 · Cited by 11

Positive Affect Treatment for Depression and Anxiety

Craske, M. G., Dour, H. J., Treanor, M., & Meuret, A. E. (2022) · doi:10.1093/med-psych/9780197548523.001.0001 · Cited by 11

Transdiagnostic Correlates of Nonsuicidal Self-Injury: The Roles of Anhedonia, Repetitive Negative Thinking, and Trait Mindfulness

Antezana, L., Garcia, K. M., Carlton, C. N., Andino, M. V., Gatto, A. J., & Richey, J. A. (2024) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-024-10130-7 · Cited by 11

Eupalinolide B alleviates corticosterone-induced PC12 cell injury and improves depression-like behaviors in CUMS rats by regulating the GSK-3β/β-catenin pathway

Wang, T.-T., Zhou, M., Gong, X.-N., Huang, Y., Li, F., Gu, S.-L., Zhang, M., Li, R., Xu, Z.-S., Li, R., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116831 · Cited by 11

Apathy, anhedonia and cognitive dysfunction: common symptoms of depression and neurological disorders

Petelin, D. S., Bairamova, S., Sorokina, O. Y., Niinoja, I. N. V., Борисовна, Л. А., & Volel, B. A. (2022) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2022-5-96-102 · Cited by 13

The Relationship between Social Anhedonia and Perceived Pleasure from Food—An Exploratory Investigation on a Consumer Segment with Depression and Anxiety

Hyldelund, N. B., Byrne, D. V., Chan, R. C. K., & Andersen, B. V. (2022) · Foods · doi:10.3390/foods11223659 · Cited by 11

The Impact of Chronic Stress on Behavior and Body Mass in New Animal Models

Alexa, A. I., Zamfir, C. L., Bogdănici, C. M., Oancea, A., Maștaleru, A., Abdulan, I. M., Brănişteanu, D. C., Ciobica, A. S., Balmuș, I.-M., Stratulat-Alexa, T., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13101492 · Cited by 10

The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies

Bahmani, M., Mehrtabar, S., Jafarizadeh, A., Zoghi, S., Heravi, F. S., Abbasi, A., Sanaie, S., Rahnemayan, S., & Leylabadlo, H. E. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010281892240116081031 · Cited by 10

Decreased expression of 5-HT1A in the circumvallate taste cells in an animal model of depression

Kim, D., Chung, S., Lee, S. H., Koo, J. H., Lee, J.-H., & Jahng, J. W. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.01.005 · Cited by 10

Neural dynamics in co-morbid schizophrenia and OCD: A computational approach

Szalisznyó, K., Silverstein, D. N., & Tóth, J. (2019) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.01.038 · Cited by 10

Ninjin’yoeito, a traditional Japanese Kampo medicine, suppresses the onset of anhedonia induced by dysfunction in the striatal dopamine receptor type 2-expressing medium spiny neurons

Oizumi, H., Imai, R., Suzuki, T., Omiya, Y., Tanaka, K. F., Mimura, M., & Mizoguchi, K. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001667 · Cited by 10

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Early-life iron deficiency persistently disrupts affective behaviour in mice

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Cognitive Signatures of Depressive and Anhedonic Symptoms and Affective States Using Computational Modeling and Neurocognitive Testing

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Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies

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The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders

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Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors

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Structure of the Psychotic Disorders Classification in DSM-5

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Efficacy and safety of tipepidine as adjunctive therapy in major depressive disorder: A randomized, double‐blind, placebo‐controlled clinical trial

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Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease

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The subjective experience of heroin effects among individuals with chronic opioid use: Revisiting reinforcement in an exploratory study

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Development of Dependence in Smokers and Rodents With Voluntary Nicotine Intake: Similarities and Differences

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Self-administration of the synthetic cathinone MDPV enhances reward function via a nicotinic receptor dependent mechanism

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Blunted neural response to gains versus losses associated with both risk‐prone and risk‐averse behavior in a clinically diverse sample

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The Human Laboratory and Drug Development in Alcohol Use Disorder: Recent Updates

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Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence

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Parsing Anhedonia

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Anhedonia in Depression:Definition and Neuralbiological Mechanism

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Pleasure, reward value and prediction error in anhedoniaPreprint

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