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The neurobiology of anhedonia and other reward-related deficits

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Der-Avakian, Andre, Markou, Athina·2012·Trends in Neurosciences

DOI 10.1016/j.tins.2011.11.005PMC PMC3253139

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Abstract

Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia and other neuropsychiatric disorders. Over the past three decades, the clinical definition of anhedonia has remained relatively unchanged, although cognitive psychology and behavioral neuroscience have expanded our understanding of other reward-related processes. Here, we review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity and also closely linked to the constructs of reward valuation, decision-making, anticipation and motivation. The neural circuits subserving these reward-related processes include the ventral striatum, prefrontal cortical regions, and afferent and efferent projections. An understanding of anhedonia and other reward-related constructs will facilitate the diagnosis and treatment of disorders that include reward deficits as key symptoms.

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Authors: Der-Avakian, A., & Markou, A.
Affiliations: University of California San Diego (US)
Corresponding author: Markou, Athina
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2012-01
Volume: 35
Issue: 1
Pages: 68-77
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2011.11.005
PMC: PMC3253139
OpenAlex: W2012129255
Cited by: 1,130
References: 141
Citations by year: 2026: 67 · 2025: 101 · 2024: 76 · 2023: 97 · 2022: 93 · 2021: 168 · 2020: 57 · 2019: 88 · 2018: 69 · 2017: 52 · 2016: 70 · 2015: 60 · 2014: 56 · 2013: 57 · 2012: 18
FWCI: 3.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (F32MH080585, R01MH087989, R01MH62527)
National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, reward processing, reward valuation, decision-making, reward anticipation, motivation, major depressive disorder, schizophrenia, ventral striatum, prefrontal cortex, neural circuits, hedonic capacity
MeSH terms: Animals, Mental Disorders, Humans, Neural Pathways, Neurobiology, Reward, Prefrontal Cortex, Anhedonia

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The neurobiology of anhedonia and other reward-related deficits

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