Cited by 1,130Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesTreatment of Major Depression

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The neurobiology of anhedonia and other reward-related deficits

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Der-Avakian, Andre, Markou, Athina·2012·Trends in Neurosciences

DOI 10.1016/j.tins.2011.11.005PMC PMC3253139

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Abstract

Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia and other neuropsychiatric disorders. Over the past three decades, the clinical definition of anhedonia has remained relatively unchanged, although cognitive psychology and behavioral neuroscience have expanded our understanding of other reward-related processes. Here, we review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity and also closely linked to the constructs of reward valuation, decision-making, anticipation and motivation. The neural circuits subserving these reward-related processes include the ventral striatum, prefrontal cortical regions, and afferent and efferent projections. An understanding of anhedonia and other reward-related constructs will facilitate the diagnosis and treatment of disorders that include reward deficits as key symptoms.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
Schizotaxia, schizotypy, schizophrenia.
Meehl, P. E. (1962) · American Psychologist · doi:10.1037/h0041029 · Cited by 2,036
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254
Diagnostic and Statistical Manual of Mental Disorders
(2018) · Sage eBooks · doi:10.4135/9781506326139.n198 · Cited by 1,244
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.85.4.374 · Cited by 1,234
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216
The amygdala and reward
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
Neuropsychopharmacology: The Fifth Generation of Progress
Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023
Anticipatory and consummatory components of the experience of pleasure: A scale development study
Gard, D. E., Gard, M. G., Kring, A. M., & John, O. P. (2006) · Journal of Research in Personality · doi:10.1016/j.jrp.2005.11.001 · Cited by 1,015
Optimal decision making and the anterior cingulate cortex
Kennerley, S. W., Walton, M. E., Behrens, T. E. J., Buckley, M. J., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1724 · Cited by 948
The Neurobiology of Decision: Consensus and Controversy
Kable, J. W., & Glimcher, P. W. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.003 · Cited by 928
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
Malone, D. A., Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Friehs, G. M., Eskandar, E. N., Rauch, S. L., Rasmussen, S. A., Machado, A. G., Kubu, C. S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.029 · Cited by 897
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878
Choice, uncertainty and value in prefrontal and cingulate cortex
Rushworth, M. F. S., & Behrens, T. E. J. (2008) · Nature Neuroscience · doi:10.1038/nn2066 · Cited by 866
Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.013 · Cited by 865
The hidden island of addiction: the insula
Naqvi, N. H., & Bechara, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.009 · Cited by 833 · cited 1×
“The anterior insula encodes the subjective value of rewards [97] and representations of interoceptive effects of rewards (reviewed in [98]).”
Background
Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G., & Fava, M. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.001 · Cited by 780
Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia
Treadway, M. T., Buckholtz, J. W., Schwartzman, A. N., Lambert, W. E., & Zald, D. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006598 · Cited by 769
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767
Self-citation
Value, pleasure and choice in the ventral prefrontal cortex
Grabenhorst, F., & Rolls, E. T. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.004 · Cited by 766
Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714
The amygdala, reward and emotion
Murray, E. A. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.08.013 · Cited by 679
Relationship between subjective effects of cocaine and dopamine transporter occupancy
Volkow, N. D., Wang, G., Fischman, M. W., Foltin, R. W., Fowler, J. S., Abumrad, N. N., Vitkun, S. A., Logan, J., Gatley, S. J., Pappas, N. R., et al. (1997) · Nature · doi:10.1038/386827a0 · Cited by 657
The Neural Correlates of Anhedonia in Major Depressive Disorder
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., & Phillips, M. L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.019 · Cited by 650
Parallel incentive processing: an integrated view of amygdala function
Balleine, B. W., & Killcross, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.002 · Cited by 622
Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient
Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611
Different representations of pleasant and unpleasant odours in the human brain
Rolls, E. T., Kringelbach, M. L., & de Araújo, I. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02779.x · Cited by 605
Endogenomorphic Depression
Klein, D. F. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760160005001 · Cited by 601
Negative Symptoms in Schizophrenia: Avolition and Occam's Razor
Foussias, G., & Remington, G. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn094 · Cited by 594
Separate neural pathways process different decision costs
Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. S. (2006) · Nature Neuroscience · doi:10.1038/nn1756 · Cited by 580
Opioid modulation of taste hedonics within the ventral striatum
Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526
Reward Processing in Schizophrenia: A Deficit in the Representation of Value
Gold, J. M., Waltz, J. A., Prentice, K. J., Morris, S. E., & Heerey, E. A. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn068 · Cited by 521
Goal Representations and Motivational Drive in Schizophrenia: The Role of Prefrontal-Striatal Interactions
Barch, D. M., & Dowd, E. C. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq068 · Cited by 507
Lack of Ventral Striatal Response to Positive Stimuli in Depressed Versus Normal Subjects
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.10.1784 · Cited by 464
Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure
Salamone, J. D., Cousins, M. S., & Bucher, S. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90108-2 · Cited by 460
Emotional Response Deficits in Schizophrenia: Insights From Affective Science
Kring, A. M., & Moran, E. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn071 · Cited by 458
Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine
Salamone, J. D., Correa, M., Mingote, S., & Weber, S. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.09.004 · Cited by 454
Nucleus accumbens dopamine and the regulation of effort in food-seeking behavior: implications for studies of natural motivation, psychiatry, and drug abuse
Salamone, J. D., Correa, M., Mingote, S., & Weber, S. M. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035063 · Cited by 433
Habenula: crossroad between the basal ganglia and the limbic system
Hikosaka, O., Sesack, S. R., Lecourtier, L., & Shepard, P. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-08.2008 · Cited by 432
Appetitive Behavior
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07085.x · Cited by 416
The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques
Wacker, J., Dillon, D. G., & Pizzagalli, D. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.058 · Cited by 405
Appetitive behavior: impact of amygdala-dependent mechanisms of emotional learning.
Everitt, B. J., Cardinal, R. N., Parkinson, J. A., & Robbins, T. W. (2003) · PubMed · Cited by 386
Glutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 386
Acute stress reduces reward responsiveness: Implications for depression
Bogdan, R., & Pizzagalli, D. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.037 · Cited by 364
The Architecture of Reward Value Coding in the Human Orbitofrontal Cortex
Sescousse, G., Redouté, J., & Dreher, J.-C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-10.2010 · Cited by 353
Psychiatric genetics: search for phenotypes
Leboyer, M., Leboyer, M., Bellivier, F., Jouvent, R., Nosten‐Bertrand, M., Mallet, J. J., & Pauls, D. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01187-9 · Cited by 342
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001501 · Cited by 334
Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models
Markou, A., Chiamulera, C., Geyer, M. A., Tricklebank, M., & Steckler, T. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.173 · Cited by 328
Self-citation
Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game
Seo, H., & Lee, D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2369-07.2007 · Cited by 324
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318
Self-citation
A Patient with a Resistant Major Depression Disorder Treated with Deep Brain Stimulation in the Inferior Thalamic Peduncle
Jiménez, F., Velasco, F., Salin-Pascual, R., Hernández, J. A., Velasco, M., Criales, J. L., & Nicolini, H. (2005) · Neurosurgery · doi:10.1227/01.neu.0000170434.44335.19 · Cited by 291
The role of dopamine in motivation for food in humans: implications for obesity
Wang, G.-J., Volkow, N. D., & Fowler, J. S. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.5.601 · Cited by 285
What Are the Right Targets for Psychopharmacology?
Hyman, S. E., & Fenton, W. S. (2003) · Science · doi:10.1126/science.1077141 · Cited by 282
Reward without dopamine
Cannon, C. M., & Palmiter, R. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10827.2003 · Cited by 280
The Construct of Minor and Major Depression in Alzheimer’s Disease
STARKSTEIN, S. E., Jorge, R. E., Mizrahi, R., & Robinson, R. G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.11.2086 · Cited by 279
A conditional knockout mouse line of the oxytocin receptor
Lee, H.-J., Caldwell, H. K., Macbeth, A. H., Tolu, S. G., & Young, W. S. (2008) · Endocrinology · doi:10.1210/en.2007-1710 · Cited by 269
Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
Pizzagalli, D. A., Oakes, T. R., Fox, A. S., Chung, M. K., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Benca, R. M., & Davidson, R. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001469 · Cited by 265
Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects
Harvey, P.-O., Pruessner, J., Czechowska, Y., & Lepage, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002021 · Cited by 259
A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders
Olivier, J. D. A., van der Hart, M. G. C., van Swelm, R. P. L., Dederen, P. J. W. C., Homberg, J. R., Cremers, T. I. F. H., Deen, P. M. T., Cuppen, E. P. J. G., Cools, A. R., & Ellenbroek, B. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.032 · Cited by 251
TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen, B. B., Duman, C. H., Simen, A. A., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.013 · Cited by 249
Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates
Perera, T. D., Dwork, A. J., Keegan, K. A., Thirumangalakudi, L., Lipira, C. M., Joyce, N., Lange, C., Higley, J. D., Rosoklija, G., Hen, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017600 · Cited by 244
IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors
Chourbaji, S., Urani, A., Inta, I., Sanchis-Segura, C., Brandwein, C., Zink, M., Schwaninger, M., & Gass, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.001 · Cited by 241
Sensitivity to the rewarding effects of food and exercise in the eating disorders
Davis, C., & Woodside, D. B. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.32356 · Cited by 238
Novel Drugs and Therapeutic Targets for Severe Mood Disorders
Mathew, S. J., Manji, H. K., & Charney, D. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301652 · Cited by 229
Sucrose consumption as an hedonic measure following chronic unpredictable mild stress
Matthews, K., Forbes, N., & Reid, I. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00286-e · Cited by 223
Single dose of a dopamine agonist impairs reinforcement learning in humans: Behavioral evidence from a laboratory-based measure of reward responsiveness
Pizzagalli, D. A., Evins, A. E., Schetter, E. C., Frank, M. J., Pajtas, P. E., Santesso, D. L., & Culhane, M. (2008) · Psychopharmacology · doi:10.1007/s00213-007-0957-y · Cited by 219
Adaptation of Reward Sensitivity in Orbitofrontal Neurons
Kobayashi, S., Carvalho, O. P., & Schultz, W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4009-09.2010 · Cited by 214
Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions
Perona, M. T. G., Waters, S., Hall, F. S., Sora, I., Lesch, K., Murphy, D. L., Caron, M. G., & Uhl, G. R. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830cd80f · Cited by 213
Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales
Leventhal, A. M., Chasson, G. S., Tapia, E., Miller, E. K., & Pettit, J. W. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20327 · Cited by 211
Does anhedonia in schizophrenia reflect faulty memory for subjectively experienced emotions?
Horan, W. P., Green, M. F., Kring, A. M., & Nuechterlein, K. H. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.3.496 · Cited by 196
Withdrawal following repeated exposure to d -amphetamine decreases responding for a sucrose solution as measured by a progressive ratio schedule of reinforcement
Barr, A. M., & Phillips, A. G. (1999) · Psychopharmacology · doi:10.1007/s002130050812 · Cited by 190
Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators
Dowd, E. C., & Barch, D. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.020 · Cited by 184
Distinct opioid circuits determine the palatability and the desirability of rewarding events
Wassum, K. M., Ostlund, S. B., Maidment, N. T., & Balleine, B. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905874106 · Cited by 182
Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects
Berlin, I., Givry-Steiner, L., Lecrubier, Y., & Puech, A. (1998) · European Psychiatry · doi:10.1016/s0924-9338(98)80048-5 · Cited by 178
Unipolar depression does not moderate responses to the Sweet Taste Test
Dichter, G. S., Smoski, M. J., Kampov-Polevoy, A. B., Gallop, R., & Garbutt, J. C. (2010) · Depression and Anxiety · doi:10.1002/da.20690 · Cited by 175
Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats
Harrison, A. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00237-2 · Cited by 167
Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia
Karlsson, R.-M., Tanaka, K., Saksida, L. M., Bussey, T. J., Heilig, M., & Holmes, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.215 · Cited by 165
La Psychologie Des Sentiments
Ribot, T., & Nicolas, S. (2005) · Cited by 161
Reduced sensitivity to reward in CB1 knockout mice
Sanchis‐Segura, C., Cline, B. H., Marsicano, G., Lutz, B., & Spanagel, R. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1877-8 · Cited by 158
Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males
Zijlstra, F., Veltman, D. J., Booij, J., van den Brink, W., & Franken, I. H. A. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.07.012 · Cited by 149
Neural markers of symptomatic improvement during antidepressant therapy in severe depression: subgenual cingulate and visual cortical responses to sad, but not happy, facial stimuli are correlated with changes in symptom score
Keedwell, P., Drapier, D., Surguladze, S., Giampietro, V, Brammer, M., & Phillips, M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108093589 · Cited by 149
Bupropion occupancy of the dopamine transporter is low during clinical treatment
Meyer, J. H., Goulding, V. S., Wilson, A. A., Hussey, D. F., Christensen, B. K., & Houle, S. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1166-3 · Cited by 147
Selective Reward Deficit in Mice Lacking β-Endorphin and Enkephalin
Hayward, M. D., Pintar, J. E., & Low, M. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08251.2002 · Cited by 147
γ-Aminobutyric Acid-Type A Receptor Deficits Cause Hypothalamic-Pituitary-Adrenal Axis Hyperactivity and Antidepressant Drug Sensitivity Reminiscent of Melancholic Forms of Depression
Shen, Q., Lal, R., Luellen, B. A., Earnheart, J. C., Andrews, A. M., & Luscher, B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.024 · Cited by 139
Psychoanalysis of behavior : collected papers
Radó, S. (1956) · Grune & Stratton eBooks · Cited by 130
Nucleus accumbens dopamine and work requirements on interval schedules
Correa, M., Carlson, B. B., Wisniecki, A., & Salamone, J. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00292-9 · Cited by 130
Psychoanalysis of Behavior
Ivey, E. P. (1958) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1958.12.4.831 · Cited by 128
Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder
Blood, A. J., Iosifescu, D. V., Makris, N., Perlis, R. H., Kennedy, D. N., Dougherty, D. D., Kim, B. W., Lee, M. J., Wu, S., Lee, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013945 · Cited by 126
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120
Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat.
Faure, A., Richard, J. M., & Berridge, K. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011223 · Cited by 114
Neural mechanisms of acquired phasic dopamine responses in learning
Hazy, T. E., Frank, M. J., & O’Reilly, R. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.019 · Cited by 107
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment
Dremencov, E., Newman, M. E., Kinor, N., Blatman‐Jan, G., Schindler, C. J., Overstreet, D. H., & Yadid, G. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.013 · Cited by 105
Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats
Paterson, N. E., Myers, C., & Markou, A. (2000) · Psychopharmacology · doi:10.1007/s002130000559 · Cited by 103
Self-citation
Observations on Madness and Melancholy
Haslam, J. (1976) · Cited by 93
Epicurus: the extant Remains. With short critical apparatus, translation and notes by Cyril Bailey. Pp. 432. Oxford: Clarendon Press, 1926. 21s.
Vlasenko, N. S. (1927) · The Journal of Hellenic Studies · doi:10.2307/625205 · Cited by 93
Reduced glucose metabolism in the subgenual prefrontal cortex in unipolar depression
Drevets, W. C., Öngür, D., & Price, J. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000380 · Cited by 92
Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia
Harvey, P., Armony, J. L., MALLA, A. K., & Lepage, M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.008 · Cited by 90
Reduced alcohol consumption in mice lacking preprodynorphin
Blednov, Y. A., Walker, D., Martinez, M., & Harris, R. A. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.12.002 · Cited by 88
Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place
Tran, A. H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., & Ono, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409726102 · Cited by 83
Physical anhedonia in Parkinson's disease
Isella, V. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.9.1308 · Cited by 83
Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?
Barkus, C., Feyder, M. J., Graybeal, C., Wright, T., Wiedholz, L. M., Izquierdo, A., Kiselycznyk, C., Schmitt, W. B., Sanderson, D. J., Rawlins, J. N. P., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.005 · Cited by 82
Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell
Paterson, N. E., Balfour, D. J. K., & Markou, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05546.x · Cited by 80
Self-citation
Decreased motivation to eat in µ‐opioid receptor‐deficient mice
Papaleo, F., Kieffer, B. L., Tabarin, A., & Contarino, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05595.x · Cited by 79
Are serotonin transporter knockout mice ‘depressed’?: hypoactivity but no anhedonia
Kalueff, A. V., Gallagher, P. S., & Murphy, D. L. (2006) · Neuroreport · doi:10.1097/01.wnr.0000230514.08962.76 · Cited by 78
Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice
El-Ghundi, M., O’Dowd, B. F., Erclik, M. S., & George, S. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02496.x · Cited by 76
Major depressive disorder, anhedonia and agomelatine: an open-label study.
Giannantonio, M. D., Iorio, G. D., Guglielmo, R., Berardis, D. D., Cm, C., Acciavatti, T., Cornelio, M., & Martinotti, G. (2011) · PubMed · Cited by 72
Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats
Liechti, M. E., & Markou, A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.011 · Cited by 71
Self-citation
Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice
Tran, A. H., Tamura, R., Uwano, T., Kobayashi, T., Katsuki, M., Matsumoto, G., & Ono, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132284599 · Cited by 67
Anhedonia in schizophrenia
Wolf, D. H. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0069-0 · Cited by 66
Medial prefrontal default-mode hypoactivity affecting trait physical anhedonia in schizophrenia
Park, I. H., Kim, J., Chun, J., Jung, Y., Seok, J., Park, H., & Lee, J. D. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.03.010 · Cited by 65
Observations on Madness and Melancholy: Including Practical Remarks on those Diseases together with Cases and an Account of the Morbid Appearances on Dissection
Haslam, J. (2011) · Medical Entomology and Zoology · Cited by 64
Increased successive negative contrast in rats withdrawn from an escalating-dose schedule of d-amphetamine
Barr, A. M., & Phillips, A. G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00664-5 · Cited by 58
Two-Week Administration of the Combined Serotonin-Noradrenaline Reuptake Inhibitor Duloxetine Augments Functioning of Mesolimbic Incentive Processing Circuits
Ossewaarde, L., Verkes, R. J., Hermans, E. J., Kooijman, S. C., Urner, M., Tendolkar, I., van Wingen, G. A., & Fernández, G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.041 · Cited by 57
Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study
Rosso, I. M., Makris, N., Thermenos, H. W., Hodge, S. M., Brown, A., Kennedy, D. N., Caviness, V. S., Faraone, S. V., Tsuang, M. T., & Seidman, L. J. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.06.015 · Cited by 48
Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats
Der‐Avakian, A., & Markou, A. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833c7cc8 · Cited by 44
Self-citation
Dopamine levels modulate the updating of tastant values
Costa, R. M., Gutiérrez, R., de Araújo, I. E., Coelho, M. R. P., Kloth, A. D., Gainetdinov, R. R., Caron, M. G., Nicolelis, M. A. L., & Simon, S. A. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00257.x · Cited by 44
Withdrawal from chronic cocaine administration induces deficits in brain reward function in C57BL/6J mice
Stoker, A. K., & Markou, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.042 · Cited by 43
Self-citation
Neurochemical and behavioral effects elicited by bupropion and diethylpropion in rats
Santamarı́a, A., & Arias, H. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.023 · Cited by 42
Sucrose intake and fasting glucose levels in 5-HT1A and 5-HT1B receptor mutant mice
Bechtholt, A. J., Smith, K. L., Gaughan, S., & Lucki, I. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.006 · Cited by 42
Common variants in PARK loci and related genes and Parkinson's disease
Chung, S. J., Armasu, S. M., Biernacka, J. M., Lesnick, T. G., Rider, D. N., Lincoln, S., Soto‐Ortolaza, A. I., Farrer, M. J., Cunningham, J. M., Rocca, W. A., et al. (2010) · Movement Disorders · doi:10.1002/mds.23376 · Cited by 42
Role of GABAA α5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist
Stephens, D., Pistovčáková, J., Worthing, L., Atack, J. R., & Dawson, G. R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.031 · Cited by 41
Dopamine receptor 3 (D3) knockout mice show regular emotional behaviour
Chourbaji, S., Brandwein, C., Vogt, M. A., Dormann, C., MUELLER, R., Drescher, K. U., GROSS, G., & Gass, P. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.002 · Cited by 38
Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice
Kruzich, P. J., Mitchell, S. H., YOUNKIN, A., & Grandy, D. K. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.1.86 · Cited by 37
Major depressive disorder, anhedonia, and agomelatine: An open-label study
Martinotti, G., Iorio, G. D., Guglielmo, R., Berardis, D. D., Janiri, L., & Giannantonio, M. D. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)72356-2 · Cited by 36
Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: An [11C]raclopride PET study
Egerton, A., Shotbolt, J. P., Stokes, P. R. A., Hirani, E., Ahmad, R., Lappin, J., Reeves, S., Mehta, M. A., Howes, O. D., & Grasby, P. M. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.077 · Cited by 33
Dopamine and Benzodiazepine-Dependent Mechanisms Regulate the EtOH-Enhanced Locomotor Stimulation in the GABAA α1 Subunit Null Mutant Mice
June, H. L., Foster, K. L., Eiler, W. J. A., Goergen, J. J., Cook, J. B., Johnson, N., Mensah‐Zoe, B., Simmons, J. O., June, H. L., Yin, W., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301097 · Cited by 29
Affective and cognitive effects of global deletion of α3-containing gamma-aminobutyric acid-A receptors
Fiorelli, R., Rudolph, U., Straub, C. J., Feldon, J., & Yee, B. K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830dc0c7 · Cited by 27
Appetitive motivational deficits in individuals with Parkinson's Disease
Shore, D. M., Rafal, R. D., & Parkinson, J. A. (2011) · Movement Disorders · doi:10.1002/mds.23736 · Cited by 25
Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression
Yacoubi, M. E., Dubois, M., Gabriel, C., Mocaër, E., & Vaugeois, J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.08.001 · Cited by 23

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Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754
The clinical assessment interview for negative symptoms (CAINS): Final development and validation
Kring, A. M., Gur, R. E., Blanchard, J. J., Horan, W. P., & Reise, S. P. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12010109 · Cited by 726
Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
Duman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714

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Authors: Der-Avakian, A., & Markou, A.
Affiliations: University of California San Diego (US)
Corresponding author: Markou, Athina
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2012-01
Volume: 35
Issue: 1
Pages: 68-77
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2011.11.005
PMC: PMC3253139
OpenAlex: W2012129255
Cited by: 1,130
References: 141
Citations by year: 2026: 67 · 2025: 101 · 2024: 76 · 2023: 97 · 2022: 93 · 2021: 168 · 2020: 57 · 2019: 88 · 2018: 69 · 2017: 52 · 2016: 70 · 2015: 60 · 2014: 56 · 2013: 57 · 2012: 18
FWCI: 3.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (F32MH080585, R01MH087989, R01MH62527)
National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, reward processing, reward valuation, decision-making, reward anticipation, motivation, major depressive disorder, schizophrenia, ventral striatum, prefrontal cortex, neural circuits, hedonic capacity
MeSH terms: Animals, Mental Disorders, Humans, Neural Pathways, Neurobiology, Reward, Prefrontal Cortex, Anhedonia

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The neurobiology of anhedonia and other reward-related deficits

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