The DOI matches its Crossref record; 114 of the 116 references it cites were found in a registry or an index.
The role of inflammatory cytokines as key modulators of neurogenesis
Open accessAbstract
Neurogenesis is an important process in the regulation of brain function and behaviour, highly active in early development and continuing throughout life. Recent studies have shown that neurogenesis is modulated by inflammatory cytokines in response to an activated immune system. To disentangle the effects of the different cytokines on neurogenesis, here we summarise and discuss in vitro studies on individual cytokines. We show that inflammatory cytokines have both a positive and negative role on proliferation and neuronal differentiation. Hence, this strengthens the notion that inflammation is involved in molecular and cellular mechanisms associated with complex cognitive processes and, therefore, that alterations in brain-immune communication are relevant to the development of neuropsychiatric disorders.
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“In response to damage and disease, microglia transition to a proinflammatory state where they release cytokines, such as IL-1β, 1L-6, and TNF-α, which can impair new neuron production and cell survival (reviewed in Borsini et al., 2015) (Figure 2A).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Borsini et al., 2015
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“Microglia participate in stem cell proliferation and survival through their release of important trophic factors and anti-inflammatory cytokines (Battista et al., 2006; Borsini et al., 2015).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Borsini et al., 2015
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Enache, D., Pariante, C. M., & Mondelli, V. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.015 · Cited by 615
“QUIN is regarded as a neurotoxic end product of the kynurenic pathway, while KYNA is neuroprotective (Borsini et al., 2015; Miller and Raison, 2016).”
BackgroundPathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 524
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Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?
Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348
Metadata
- Authors
- Borsini, A., Zunszain, P. A., Thuret, S., & Pariante, C. M.
- Affiliations
- King's College London (GB)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 38
- Issue
- 3
- Pages
- 145-157
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2055823139
- Cited by
- 381
- References
- 116
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 23 · 2023: 29 · 2022: 47 · 2021: 49 · 2020: 39 · 2019: 43 · 2018: 29 · 2017: 30 · 2016: 32 · 2015: 18
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- South London and Maudsley NHS Foundation Trust (MR/J002739/1)
- Psychiatry Research Trust
- Alzheimer's Society
- National Institute for Health and Care Research (MR/J002739/1)
- King's College London
- Medical Research Council (MR/J002739/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neurogenesis, inflammatory cytokines, brain-immune communication, neuronal proliferation, neuronal differentiation, neuroinflammation, neuropsychiatric disorders, cognitive processes
- MeSH terms
- Animals, Brain, Humans, Cytokines, Cell Proliferation, Neurogenesis
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