The role of inflammatory cytokines as key modulators of neurogenesis

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

Mammalian neural stem cells.

Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729

Interferon-γ: an overview of signals, mechanisms and functions

Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120

Mechanisms and Functional Implications of Adult Neurogenesis

Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120

Proinflammatory Cytokines

Dinarello, C. A. (2000) · CHEST Journal · doi:10.1378/chest.118.2.503 · Cited by 2,047

Dynamics of hippocampal neurogenesis in adult humans

Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841

Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

Enache, D., Pariante, C. M., & Mondelli, V. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.015 · Cited by 615

Pathogenesis of depression: Insights from human and rodent studies

Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 524

NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings

Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370

Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies?

Laurent, C., Buée, L., & Blum, D. (2018) · Biomedical Journal · doi:10.1016/j.bj.2018.01.003 · Cited by 348

Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome

Cruz-Pereira, J. S., Rea, K., Nolan, Y. M., O'Leary, O. F., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-122216-011613 · Cited by 320

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

Chesnokova, V., Pechnick, R. N., & Wawrowsky, K. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.017 · Cited by 299

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice

Du Preez, A., Onorato, D., Eiben, I., Musaelyan, K., Egeland, M., Zunszain, P. A., Fernandes, C., Thuret, S., & Pariante, C. M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.015 · Cited by 285

Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder

Haroon, E., Daguanno, A. W., Woolwine, B. J., Goldsmith, D. R., Baer, W. M., Wommack, E. C., Felger, J. C., & Miller, A. H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.026 · Cited by 291

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

Zheng, C., Zhou, X.-W., & Wang, J.-Z. (2016) · Translational Neurodegeneration · doi:10.1186/s40035-016-0054-4 · Cited by 292

Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling

Amani, H., Habibey, R., Shokri, F., Hajmiresmail, S. J., Akhavan, O., Mashaghi, A., & Pazoki–Toroudi, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-42633-9 · Cited by 275

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders

Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 264

Mast cells in neuroinflammation and brain disorders

Hendriksen, E., van Bergeijk, D. A., Oosting, R. S., & Redegeld, F. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.001 · Cited by 249

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

Redondo‐Castro, E., Cunningham, C. J., Miller, J., Martuscelli, L., Sarah, A.-A., Rothwell, N. J., Kielty, C. M., Allan, S. M., & Pinteaux, E. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0531-4 · Cited by 239

Adult neurogenesis, glia, and the extracellular matrix

Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236

The Role of BDNF in the Neuroimmune Axis Regulation of Mood Disorders

Jin, Y., Sun, L., Yang, W., Cui, R., & Xu, S. B. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00515 · Cited by 205

Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: A systematic review

Misiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 209

The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases

Amanollahi, M., Jameie, M., Heidari, A., & Rezaei, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03102-z · Cited by 207

Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: can exercise compensate?

Ryan, S. M., & Nolan, Y. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.12.004 · Cited by 205

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182

Effects of psychotropic drugs on inflammation:Consequence or mediator of therapeutic effects in psychiatric treatment?

Baumeister, D., Ciufolini, S., & Mondelli, V. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4044-5 · Cited by 183

The role of inflammation in suicidal behaviour

Brundin, L., Erhardt, S., Bryleva, E. Y., Achtyes, E. D., & Postolache, T. T. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12458 · Cited by 178

Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

Zheng, J., Li, H., Tian, N., Liu, F., Wang, L., Yin, Y., Yue, L., Ma, L., Wan, Y., & Wang, J. (2020) · Cell stem cell · doi:10.1016/j.stem.2019.12.015 · Cited by 160

Immunological cytokine profiling identifies TNF-α as a key molecule dysregulated in autistic children

Xie, J., Huang, L., Li, X., Li, H., Zhou, Y., Zhu, H., Pan, T., Kendrick, K. M., & Xu, W. (2017) · Oncotarget · doi:10.18632/oncotarget.19326 · Cited by 160

The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder

Foster, J. A., Baker, G. B., & Dursun, S. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.721126 · Cited by 161

Biologics for Inflammatory Bowel Disease and Their Safety in Pregnancy: A Systematic Review and Meta-analysis

Nielsen, O. H., Gubatan, J. M. B., Juhl, C. B., Streett, S. E., & Maxwell, C. V. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.09.021 · Cited by 144

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

Morris, G., Walker, A. J., Berk, M., Maes, M. H. J., & Puri, B. K. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0793-y · Cited by 134

Inflammation and matrix metalloproteinase 9 (Mmp‐9) regulate photoreceptor regeneration in adult zebrafish

Silva, N. J., Nagashima, M., Li, J., Kakuk‐Atkins, L., Ashrafzadeh, M., Hyde, D. R., & Hitchcock, P. F. (2020) · Glia · doi:10.1002/glia.23792 · Cited by 119

The role of IL-6 in neurodevelopment after prenatal stress

Gumusoglu, S. B., Fine, R. S., Murray, S. J., Bittle, J. L., & Stevens, H. E. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.05.015 · Cited by 129

Is Toxoplasma Gondii Infection Related to Brain and Behavior Impairments in Humans? Evidence from a Population-Representative Birth Cohort

Sugden, K., Moffitt, T. E., Pinto, L., Poulton, R., Williams, B. S., & Caspi, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148435 · Cited by 129

Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney

Kandemır, F. M., Yıldırım, S., Küçükler, S., Çağlayan, C., Mahamadu, A., & Dörtbudak, M. B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.048 · Cited by 124

Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

Surget, A., & Belzung, C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01136-8 · Cited by 135

Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms

Borsini, A., Cattaneo, A., Malpighi, C., Thuret, S., Harrison, N. A., MRC ImmunoPsychiatry Consortium, Zunszain, P. A., & Pariante, C. M. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx083 · Cited by 113

Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus

Nikolopoulos, D., Manolakou, T., Polissidis, A., Filia, A., Bertsias, G. K., Koutmani, Y., & Boumpas, D. T. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223506 · Cited by 121

Cognitive impairment after cancer treatment: mechanisms, clinical characterization, and management

Fleming, B., Edison, P., & Kenny, L. M. (2023) · BMJ · doi:10.1136/bmj-2022-071726 · Cited by 128

The birth of new neurons in the maternal brain: Hormonal regulation and functional implications

Leuner, B., & Sabihi, S. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.02.004 · Cited by 116

Matrine ameliorates anxiety and depression-like behaviour by targeting hyperammonemia-induced neuroinflammation and oxidative stress in CCl4 model of liver injury

Khan, A., Shal, B., Naveed, M., Shah, F. A., Atiq, A., Khan, N. U., Kim, Y. S., & Khan, S. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.02.002 · Cited by 109

Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice

Majidi, J., Kosari-Nasab, M., & Salari, A.-A. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.009 · Cited by 109

Mast Cells in Neurodegenerative Disease

Jones, M. K., Nair, A. A., & Gupta, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00171 · Cited by 107

The type of stress matters: repeated injection and permanent social isolation stress in male mice have a differential effect on anxiety- and depressive-like behaviours, and associated biological alterations

Preez, A. D., Law, T., Onorato, D., Lim, Y. M., Eiben, P., Musaelyan, K., Egeland, M. T., Hye, A., Zunszain, P. A., Thuret, S., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01000-3 · Cited by 118

Minocycline inhibits microglial activation and alleviates depressive-like behaviors in male adolescent mice subjected to maternal separation

Han, Y., Zhang, L., Wang, Q., Zhang, D.-D., Zhao, Q., Zhang, J., Xie, L., Liu, G., & You, Z. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.021 · Cited by 109

Long-term exposition to a high fat diet favors the appearance of β-amyloid depositions in the brain of C57BL/6J mice. A potential model of sporadic Alzheimer’s disease

Busquets, O., Ettcheto, M., Pallàs, M., Beas‐Zárate, C., Verdaguer, E., Auladell, C., Folch, J., & Camins, A. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.11.002 · Cited by 107

Involvement of Innate and Adaptive Immune Systems Alterations in the Pathophysiology and Treatment of Depression

Medina-Rodriguez, E. M., Lowell, J. A., Worthen, R. J., Syed, S. A., & Beurel, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00547 · Cited by 106

The CNS Immune Landscape from the Viewpoint of a T Cell

Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.008 · Cited by 107

Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections

Mo, M., Eyo, U. B., Xie, M., Peng, J., Bosco, D. B., Umpierre, A. D., Zhu, X., Tian, D., Xu, P., & Wu, L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0487-19.2019 · Cited by 95

Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma

Inserra, A., Mastronardi, C. A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1359-3 · Cited by 99

Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease

Dubey, S., Heinen, S., Krantic, S. M., McLaurin, J., Branch, D. R., Hynynen, K., & Aubert, I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908658117 · Cited by 95

Dysregulation of neurogenesis by neuroinflammation: key differences in neurodevelopmental and neurological disorders

Pang, Y., & Fan, L. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.202926 · Cited by 96

Pro- and Anti-Inflammatory Properties of Interleukin in Vitro: Relevance for Major Depression and Human Hippocampal Neurogenesis

Borsini, A., Benedetto, M. G. D., Giacobbe, J., & Pariante, C. M. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa055 · Cited by 86

Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms

Capuron, L., & Castanon, N. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_14 · Cited by 95

Friend, Foe or Both? Immune Activity in Alzheimer’s Disease

Frost, G. R., Jonas, L. A., & Li, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00337 · Cited by 88

DNA Methylation Signatures of Mood Stabilizers and Antipsychotics in Bipolar Disorder

Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 90

A survey of neuroimmune changes in pregnant and postpartum female rats

Haim, A., Julian, D. L., Albin-Brooks, C., Brothers, H. M., Lenz, K. M., & Leuner, B. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.026 · Cited by 86

Update on the Relationship Between Depression and Neuroendocrine Metabolism

Qiu, W., Cai, X., Zheng, C., Qiu, S., Ke, H., & Huang, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.728810 · Cited by 90

Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders

Woods, R. M., Lorusso, J. M., Fletcher, J., ElTaher, H., McEwan, F., Harris, I., Kowash, H. M., D'Souza, S. W., Harte, M., Hager, R., et al. (2023) · Neuronal Signaling · doi:10.1042/ns20220064 · Cited by 87

Zika virus differentially infects human neural progenitor cells according to their state of differentiation and dysregulates neurogenesis through the Notch pathway

Ferraris, P., Cochet, M., Hamel, R., Gladwyn-Ng, I. E., Alfano, C., Diop, F., Garcia, D., Talignani, L., Montero‐Menei, C. N., Nougaırède, A., et al. (2019) · Emerging Microbes & Infections · doi:10.1080/22221751.2019.1637283 · Cited by 83

Targeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy

Qin, J., Liu, J., Wei, Z., Li, X., Chen, Z., Li, J., Zheng, W., Liu, H., Xu, S., Yong, T., et al. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01803-1 · Cited by 86

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease

Horgusluoglu, E., Nho, K. T., Risacher, S. L., Kim, S., Foroud, T., Shaw, L. M. J., Trojanowski, J. Q., Aisen, P. S. S., Petersen, R. C., Jack, C. R., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.010 · Cited by 81

Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77

A schizophrenia subgroup with elevated inflammation displays reduced microglia, increased peripheral immune cell and altered neurogenesis marker gene expression in the subependymal zone

North, H., Weissleder, C., Fullerton, J., Sager, R. E. H., Webster, M., & Weickert, C. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01742-8 · Cited by 69

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID

Clough, E., Inigo, J., Chandra, D., Chaves, L., Reynolds, J. L., Aalinkeel, R., Schwartz, S. A., Khmaladze, A., & Mahajan, S. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10015-6 · Cited by 75

Hippocampal neural stem cells and microglia response to experimental inflammatory bowel disease (IBD)

Gampierakis, I. A., Koutmani, Y., Semitekolou, M., Morianos, I., Polissidis, A., Katsouda, A., Charalampopoulos, I., Xanthou, G., Gravanis, A., & Karalis, K. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0651-6 · Cited by 75

Beyond the neuron: Role of non-neuronal cells in stress disorders

Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 72

Towards Neuroecosociality: Mental Health in Adversity

Rose, N., Birk, R. H., & Manning, N. (2021) · Theory Culture & Society · doi:10.1177/0263276420981614 · Cited by 77

Microglia and HPA axis in depression: An overview of participation and relationship

Pereira, G. C., Piton, E., dos Santos, B. M., Ramanzini, L. G., Camargo, L. F. M., da Silva, R. M., & Bochi, G. V. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1939154 · Cited by 72

Stress-Related Dysfunction of Adult Hippocampal Neurogenesis—An Attempt for Understanding Resilience?

Leschik, J., Lutz, B., & Gentile, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147339 · Cited by 77

Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation

Cavaliere, F., Donno, C., & Dâ€TMAmbrosi, N. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00211 · Cited by 67

Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients

Pecorelli, A., Cervellati, F., Belmonte, G., Montagner, G., Waldon, P., Hayek, J., Gambari, R., & Valacchi, G. (2015) · Cytokine · doi:10.1016/j.cyto.2015.10.002 · Cited by 70

Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress

Kovács, D., Eszlári, N., Petschner, P., Pap, D., Vas, S., Kovacs, P. L., Gonda, X., Juhász, G., & Bagdy, G. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.012 · Cited by 67

Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in Alzheimer's disease

Salles, G. N., Calió, M. L., Hölscher, C., Pacheco-Soares, C., Porcionatto, M., & Lobo, A. O. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107813 · Cited by 71

Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish

Dorsemans, A.-C., Soulé, S., Weger, M., Bourdon, E., d’Hellencourt, C. L., Meilhac, O., & Diotel, N. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24065 · Cited by 69

The choroid plexus as a sex hormone target: Functional implications

Santos, C. R. A., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., Palha, J. A., & Gonçalves, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.002 · Cited by 71

Brain-immune crosstalk in the treatment of major depressive disorder

Branchi, I., Poggini, S., Capuron, L., Benedetti, F., Poletti, S., Tamouza, R., Drexhage, H. A., Penninx, B. W. J. H., & Pariante, C. M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.11.016 · Cited by 66

Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis

Marques, A. A., Bevilaqua, M. C. D. N., da Fonseca, A. M. P., Nardi, A. E., Thuret, S., & Dias, G. P. (2016) · Neural Plasticity · doi:10.1155/2016/5026713 · Cited by 78

Sensing the world and its dangers: An evolutionary perspective in neuroimmunology

Kraus, A., Buckley, K. M., & Salinas, I. (2021) · eLife · doi:10.7554/elife.66706 · Cited by 68

Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Functional Similarities and Striking Controversies

Augusto‐Oliveira, M., Arrifano, G. D. P., Malva, J. O., & Lopez, M. E. C. (2019) · Cells · doi:10.3390/cells8020125 · Cited by 65

Systemic maternal inflammation promotes ASD via IL-6 and IFN-γ

Majerczyk, D., Ayad, E., Brewton, K. L., Saing, P., & Hart, P. C. (2022) · Bioscience Reports · doi:10.1042/bsr20220713 · Cited by 63

The Cross-Talks Among Bone Morphogenetic Protein (BMP) Signaling and Other Prominent Pathways Involved in Neural Differentiation

Manzari‐Tavakoli, A., Babajani, A., Farjoo, M. H., Hajinasrollah, M., Bahrami, S., & Niknejad, H. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.827275 · Cited by 62

Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits

Yu, D., Li, T., Delpech, J.-C., Zhu, B., Kishore, P., Koshi, T., Luo, R., Pratt, K. J. B., Popova, G., Nowakowski, T. J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm2545 · Cited by 60

Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice

Zuo, Y., Wang, J., Liao, F., Yan, X., Li, J., Huang, L., & Liu, F. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00401 · Cited by 58

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The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

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Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus

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Microglia Function on Precursor Cells in the Adult Hippocampus and Their Responsiveness to Serotonin Signaling

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Developmental roles of microglia: A window into mechanisms of disease

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The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress‐induced depression in mice

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Progranulin Protects Hippocampal Neurogenesis via Suppression of Neuroinflammatory Responses Under Acute Immune Stress

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Nutritional and immunological factors in breast milk: A role in the intergenerational transmission from maternal psychopathology to child development

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Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 signaling pathway following ischemic stroke in rats

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Relationships between Inflammation and Age-Related Neurocognitive Changes

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Regulation of adult neural progenitor cell functions by purinergic signaling

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Nuclear deterrents: Intrinsic regulators of IL-1β-induced effects on hippocampal neurogenesis

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Early-life inflammation with LPS delays fear extinction in adult rodents

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Reduced adult neurogenesis is associated with increased macrophages in the subependymal zone in schizophrenia

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Adult Neurogenesis and Antidepressant Treatment: The Surprise Finding by Ron Duman and the Field 20 Years Later

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Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

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The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model

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P.1.20 Medial forebrain bundle stimulation induces changes in dopamine neuron activity: role of endocannabinoids and glutamate

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Cytokine dysregulation and hippocampal neurogenesis: A shared mechanism underlying cognitive impairments across neuropsychiatric and neurodegenerative disorders

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Neurogenesis, Inflammation, and Mental Health

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Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

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