Neuropoietic cytokines in normal brain development and neurodevelopmental disorders
Abstract
Inflammation has been implicated in a wide variety of neurological disorders and there is increasing evidence for long-term consequences of inflammation during early brain development. A number of immune mediators, termed neuropoietic cytokines, have a role in normal brain development. Neuropoietic cytokines contribute to proliferation of neural precursors; fate determination and differentiation; migration of neurons and glia; as well as cell survival and activity dependent alteration of synaptic function. Inflammation during development, therefore, may cause widespread injury to the brain by interfering with the normal balance of cytokine signalling and therefore developmental processes. This review will examine the normal role of neuropoietic cytokines and the potential contribution of inflammatory insults to a number of neurodevelopmental disorders. It will also discuss the potential for developmental inflammation to sensitise the brain to later insult, possibly contributing to neurodegenerative disorders later in life. This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'.
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Inflammatory cytokines play a role in early neural development.
“Specifically, inflammatory cytokines play a role in early neural development (Stolp, 2013; Yirmiya and Goshen, 2011)”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Stolp, 2013
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- Authors
- Stolp, H. B.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Stolp, H.B.
- ORCID
- Stolp, H.B.
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 53
- Pages
- 63-68
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2024622507
- Cited by
- 70
- References
- 105
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- brain development, neurodevelopmental disorders, neuroinflammation, neural precursor proliferation, neuronal migration, glial cell migration, neuronal differentiation, synaptic function, neurodegeneration, immune mediators
- MeSH terms
- Animals, Astrocytes, Brain, Brain Diseases, Developmental Disabilities, Humans, Inflammation, Neuroglia, Neurons, Cytokines, Neurogenesis
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