Cited by 70Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanismsTryptophan and brain disorders

Neuropoietic cytokines in normal brain development and neurodevelopmental disorders

Stolp, H.B.·2013·Molecular and Cellular Neuroscience

Abstract

Inflammation has been implicated in a wide variety of neurological disorders and there is increasing evidence for long-term consequences of inflammation during early brain development. A number of immune mediators, termed neuropoietic cytokines, have a role in normal brain development. Neuropoietic cytokines contribute to proliferation of neural precursors; fate determination and differentiation; migration of neurons and glia; as well as cell survival and activity dependent alteration of synaptic function. Inflammation during development, therefore, may cause widespread injury to the brain by interfering with the normal balance of cytokine signalling and therefore developmental processes. This review will examine the normal role of neuropoietic cytokines and the potential contribution of inflammatory insults to a number of neurodevelopmental disorders. It will also discuss the potential for developmental inflammation to sensitise the brain to later insult, possibly contributing to neurodegenerative disorders later in life. This article is part of a Special Issue entitled 'Neuroinflammation in neurodegeneration and neurodysfunction'.

Integrity signals

Registry

Crossref · 10.1016/j.mcn.2012.08.009

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Stolp, H. B.
Affiliations
University of Oxford (GB)
Corresponding author
Stolp, H.B.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2013-03
Volume
53
Pages
63-68
ISSN
1044-7431 (ISSN-L)
OpenAlex
W2024622507
Cited by
70
References
105
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
brain development, neurodevelopmental disorders, neuroinflammation, neural precursor proliferation, neuronal migration, glial cell migration, neuronal differentiation, synaptic function, neurodegeneration, immune mediators
MeSH terms
Animals, Astrocytes, Brain, Brain Diseases, Developmental Disabilities, Humans, Inflammation, Neuroglia, Neurons, Cytokines, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review