RNA–Binding Protein HuD as a Versatile Factor in Neuronal and Non–Neuronal Systems

Tissue-based map of the human proteome

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A census of human RNA-binding proteins

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A brave new world of RNA-binding proteins

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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

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RNA-binding proteins in human genetic disease

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AU-rich elements and associated factors: are there unifying principles?

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RNA-Binding Proteins in Cancer: Old Players and New Actors

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RNA-binding proteins in human genetic disease

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Diverse molecular functions of Hu proteins

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HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal

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Detection of the anti‐Hu antibody in the serum of patients with small cell lung cancer—A quantitative western blot analysis

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The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion

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RNA-binding proteins in tumor progression

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A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons

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Principles and Properties of Eukaryotic mRNPs

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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR

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The elav Gene Product of Drosophila , Required in Neurons, Has Three RNP Consensus Motifs

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Why is Hu where? Shuttling of early-response-gene messenger RNA subsets

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Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions

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The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues.

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Structural basis for recognition of AU-rich element RNA by the HuD protein.

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The RNA-binding protein HuD regulates neuronal cell identity and maturation

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RNA-binding proteins in neurodegeneration: mechanisms in aggregatePreprint

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Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability

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The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA

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Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

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The insulin‐like growth factor mRNA binding‐protein IMP‐1 and the Ras‐regulatory protein G3BP associate with tau mRNA and HuD protein in differentiated P19 neuronal cells

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A psychiatric disease-related circular RNA controls synaptic gene expression and cognition

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The Elav-like Proteins Bind to a Conserved Regulatory Element in the 3′-Untranslated Region of GAP-43 mRNA

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Embryonic Lethal Abnormal Vision-Like RNA-Binding Proteins Regulate Neurite Outgrowth and Tau Expression in PC12 Cells

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Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

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HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects

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Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner

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miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels

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The RNA-binding Protein HuD Is Required for GAP-43 mRNA Stability, GAP-43 Gene Expression, and PKC-dependent Neurite Outgrowth in PC12 Cells

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CARM1 Regulates Proliferation of PC12 Cells by Methylating HuD

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Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway

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p21waf1 mRNA Contains a Conserved Element in Its 3′-Untranslated Region That Is Bound by the Elav-like mRNA-stabilizing Proteins

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Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction

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Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1

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RNA-binding proteins in neurodegeneration: Seq and you shall receive

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A Nuclear Function of Hu Proteins as Neuron-specific Alternative RNA Processing Regulators

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Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

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Poly(A) Tail Length-dependent Stabilization of GAP-43 mRNA by the RNA-binding Protein HuD

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Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation

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RNA-Binding Protein HuD Controls Insulin Translation

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HuD Regulates Coding and Noncoding RNA to Induce APP→Aβ Processing

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The ELAV Protein HuD Stimulates Cap-Dependent Translation in a Poly(A)- and eIF4A-Dependent Manner

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Overexpression of HuD Accelerates Neurite Outgrowth and Increases GAP-43 mRNA Expression in Cortical Neurons and Retinoic Acid-Induced Embryonic Stem Cells in Vitro

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Relation between aberrant α-catenin expression and loss of E-cadherin function in prostate cancer

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Overexpression of HuD, but Not of Its Truncated Form HuD I+II, Promotes GAP‐43 Gene Expression and Neurite Outgrowth in PC12 Cells in the Absence of Nerve Growth Factor

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A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of<i>Msi1</i>mRNA

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<i>cis</i>‐Acting signals and <i>trans</i>‐acting proteins are involved in tau mRNA targeting into neurites of differentiating neuronal cells

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Regulation of Neuron-Specific Alternative Splicing of Neurofibromatosis Type 1 Pre-mRNA

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GAP‐43 mRNA in growth cones is associated with HuD and ribosomes

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Notch3 and the Notch3‐upregulated RNA‐binding protein HuD regulate Ikaros alternative splicing

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A HuD‐ZBP1 ribonucleoprotein complex localizes GAP‐43 mRNA into axons through its 3′ untranslated region AU‐rich regulatory element

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Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease

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Protein kinase C stimulates HuD‐mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture

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Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer

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Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

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Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis

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ELAV proteins along evolution: Back to the nucleus?

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HuD Promotes BDNF Expression in Brain Neurons via Selective Stabilization of the BDNF Long 3′UTR mRNA

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Post-transcriptional Regulation of Neuro-oncological Ventral Antigen 1 by the Neuronal RNA-binding Proteins ELAV

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Post-transcriptional Regulation of Acetylcholinesterase mRNAs in Nerve Growth Factor-treated PC12 Cells by the RNA-binding Protein HuD

Deschênes-Furry, J., Bélanger, G., Perrone-Bizzozero, N., & Jasmin, B. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209383200 · Cited by 65 · see citing works

Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications

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nELAV Proteins Alteration in Alzheimer's Disease Brain: A Novel Putative Target for Amyloid-β Reverberating on AβPP Processing

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HuD, a Neuronal-specific RNA-binding Protein, Increases thein Vivo Stability of MYCN RNA

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In vivo post‐transcriptional regulation of GAP‐43 mRNA by overexpression of the RNA‐binding protein HuD

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HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA

Tebaldi, T., Zuccotti, P., Peroni, D., Köhn, M., Gasperini, L., Potrich, V., Bonazza, V., Dudnakova, T., Rossi, A., Sanguinetti, G., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.032 · Cited by 59 · see citing works

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis

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Systems perspectives on mRNA processing

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Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis

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Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development

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HuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein

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Activity‐dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain

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Role of HuD in nervous system function and pathology

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Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines

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Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members

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Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD

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The RNA-Binding Protein HuD Binds Acetylcholinesterase mRNA in Neurons and Regulates its Expression after Axotomy

Deschênes-Furry, J., Mousavi, K., Bolognani, F., Neve, R. L., Parks, R. J., Perrone-Bizzozero, N. I., & Jasmin, B. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4626-06.2007 · Cited by 43 · see citing works

Coordinated Expression of HuD and GAP-43 in Hippocampal Dentate Granule Cells During Developmental and Adult Plasticity

Bolognani, F., Tanner, D. C., Nixon, S., Okano, H. J., Okano, H., & Perrone‐Bizzozero, N. I. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9388-8 · Cited by 42 · see citing works

The RNA-binding Protein HuD Regulates Autophagosome Formation in Pancreatic β Cells by Promoting Autophagy-related Gene 5 Expression

Kim, C., Kim, W., Lee, H., Ji, E., Choe, Y.-J., Martindale, J. L., Akamatsu, W., Okano, H., Kim, H.-S., Nam, S. W., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.474700 · Cited by 42 · see citing works

HuD Binds to and Regulates Circular RNAs Derived From Neuronal Development- and Synaptic Plasticity-Associated Genes

Dell’Orco, M., Oliver, R. J., & Perrone‐Bizzozero, N. I. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00790 · Cited by 42 · see citing works

Neuroserpin up-regulation in the Alzheimer’s disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression

Subhadra, B. G., Schaller, K., & Seeds, N. W. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.08.010 · Cited by 40 · see citing works

Replication of association between ELAVL4 and Parkinson disease: the GenePD study

DeStefano, A. L., Latourelle, J., Lew, M. F., Suchowersky, O., Klein, C., Golbe, L. I., Mark, M. H., Growdon, J. H., Wooten, G. F., Watts, R., et al. (2008) · Human Genetics · doi:10.1007/s00439-008-0526-4 · Cited by 40 · see citing works

Differential Activity of ELAV-like RNA-binding Proteins in Human Neuroblastoma

Chagnovich, D., Fayos, B. E., & Cohn, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33587 · Cited by 38 · see citing works

Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development

Clayton, G. H., Perez, G. M., Smith, R. L., & Owens, G. C. (1998) · Developmental Brain Research · doi:10.1016/s0165-3806(98)00074-1 · Cited by 38 · see citing works

HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells

Ross, R. A., Lazarova, D. L., Manley, G. T., Smitt, P. S., Spengler, B. A., Posner, J. B., & Biedler, J. L. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00331-6 · Cited by 34 · see citing works

RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics

Hong, Y., Tak, H., Kim, C., Kang, H., Ji, E., Ahn, S., Jung, M., Kim, H. L., Lee, J. H., Kim, W., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0447-x · Cited by 33 · see citing works

Molecular analysis of the HuD gene in neuroendocrine lung cancers

D’Alessandro, V., Muscarella, L. A., la Torre, A., Bisceglia, M., Parrella, P., Scaramuzzi, G., Storlazzi, C. T., Trombetta, D., Kok, K., Cata, A. D., et al. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.03.022 · Cited by 33 · see citing works

Tissue-Specific Expression of the Gene Encoding a Mouse RNA Binding Protein Homologous to Human HuD Antigen

Abe, R. (1994) · DNA Research · doi:10.1093/dnares/1.4.175 · Cited by 30 · see citing works

HuD Promotes Progression of Oral Squamous Cell Carcinoma

Sasahira, T., Kurihara, M., Yamamoto, K., Ueda, N., Nakashima, C., Matsushima, S., BHAWAL, U. K., Kirita, T., & Kuniyasu, H. (2014) · Pathobiology · doi:10.1159/000366022 · Cited by 30 · see citing works

Neuronal <i>HuD</i> gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone

Cuadrado, A., Navarro‐Yubero, C., Furneaux, H., & Muñoz, A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01877.x · Cited by 29 · see citing works

Regulation of β-cell function by RNA-binding proteins

Magro, M. G., & Solimena, M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.003 · Cited by 28 · see citing works

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

Fragkouli, A., Koukouraki, P., Vlachos, I. S., Paraskevopoulou, M. D., Hatzigeorgiou, A. G., & Doxakis, E. (2017) · Scientific Reports · doi:10.1038/srep44507 · Cited by 27 · see citing works

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding

Gomes, C., Lee, S. J., Gardiner, A. S., Smith, T. P., Sahoo, P. K., Patel, P., Thames, E. L., Rodriguez, R., Taylor, R., Yoo, S., et al. (2017) · Journal of Cell Science · doi:10.1242/jcs.201244 · Cited by 27 · see citing works

HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex

Dell’Orco, M., Sardone, V., Gardiner, A. S., Pansarasa, O., Bordoni, M., Perrone‐Bizzozero, N. I., & Cereda, C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105211 · Cited by 26 · see citing works

<i>ELAVL4, PARK10,</i> and the Celts

Haugarvoll, K., Toft, M., Ross, O. A., Stone, J. T., Heckman, M. G., White, L. R., Lynch, T., Gibson, J. M., Wszolek, Z. K., Uitti, R. J., et al. (2007) · Movement Disorders · doi:10.1002/mds.21336 · Cited by 26 · see citing works

RNA-binding protein HuD reduces triglyceride production in pancreatic β cells by enhancing the expression of insulin-induced gene 1

Kim, C., Lee, H., Kang, H., Shin, J. J., Tak, H., Kim, W., Gorospe, M., & Lee, E. K. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.02.017 · Cited by 25 · see citing works

Untitled work

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PKCε Promotes HuD-Mediated Neprilysin mRNA Stability and Enhances Neprilysin-Induced Aβ Degradation in Brain Neurons

Lim, C. S., & Alkon, D. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097756 · Cited by 24 · see citing works

HuD Regulates the cpg15 Expression Via the 3′-UTR and AU-Rich Element

Wang, Z., Li, S.-J., Qi, Y., Zhao, J., Liu, X.-Y., Han, Y., Xu, P., & Chen, X.-H. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0443-0 · Cited by 23 · see citing works

The RNA binding protein HuD: rat cDNA and analysis of the alternative spliced mRNA in neuronal differentiating cell lines P19 and PC12

Steller, U., Kohls, S., Müller, B., Söller, R., Müller, R., Schlender, J., & Blohm, D. H. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00231-g · Cited by 23 · see citing works

Molecular Detection of Neuron-Specific ELAV-Like-Positive Cells in the Peripheral Blood of Patients with Small-Cell Lung Cancer

D’Alessandro, V., Muscarella, L. A., Copetti, M., Zelante, L., Carella, M., & Vendemiale, G. (2008) · Analytical Cellular Pathology · doi:10.1155/2008/958014 · Cited by 23 · see citing works

Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4

Inman, M. V., Levy, S., Mock, B. A., & Owens, G. C. (1998) · Gene · doi:10.1016/s0378-1119(97)00615-x · Cited by 21 · see citing works

Alternative role of HuD splicing variants in neuronal differentiation

Hayashi, S., Yano, M., Igarashi, M., Okano, H. J., & Okano, H. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23496 · Cited by 20 · see citing works

Reduced expression of the RNA‐binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis

Kim, C., Jeong, D. E., Heo, S., Ji, E., Rho, J. G., Jung, M., Ahn, S., Kim, Y., Kim, Y., Nam, S. W., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5135 · Cited by 20 · see citing works

Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer.

D’Alessandro, V., Muscarella, L. A., Copetti, M., et al. (2008) · PubMed · doi:10.3233/clo-2008-0424 · Cited by 19 · see citing works

Characterization of Multiple Exon 1 Variants in Mammalian HuD mRNA and Neuron-Specific Transcriptional Control via Neurogenin 2

Bronicki, L., Bélanger, G., & Jasmin, B. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2247-12.2012 · Cited by 13 · see citing works

Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis

WANG, F., LU, J., Li, S., Huo, X., Liu, X., Du, X., Li, C., Wang, J., & Chen, Z. (2017) · Anticancer Research · doi:10.21873/anticanres.11848 · Cited by 10 · see citing works

The RNA-binding protein, HuD regulates proglucagon biosynthesis in pancreatic α cells

Ahn, S., Tak, H., Kang, H., Ryu, S., Jeong, S. M., Kim, W., & Lee, E. K. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.022 · Cited by 10 · see citing works

Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD

Gong, Q., Stump, M. R., & Zhou, Z. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003720 · Cited by 6 · see citing works

RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA

Kim, C., Ahn, S., & Lee, E. K. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.030 · Cited by 6 · see citing works

Interaction of HuDA and PABP at 5'UTR of mouse insulin2 regulates insulin biosynthesis

Pandey, P. R., Sarwade, R. D., Khalique, A., & Seshadri, V. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194482 · Cited by 5 · see citing works

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

Bowles, K. R., Silva, M. C., Whitney, K., Bertucci, T., Berlind, J. E., Lai, J. D., Garza, J. C., Boles, N. C., Mahali, S., Strang, K. H., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.003 · Cited by 175 · see citing works

A relay velocity model infers cell-dependent RNA velocity

Li, S., Zhang, P., Chen, W., Ye, L., Brannan, K. W., Le, N.-T., Abe, J., Cooke, J. P., & Wang, G. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01728-5 · Cited by 106 · see citing works

Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function

Mortlock, S., Houshdaran, S., Kosti, I., Rahmioğlu, N., NEZHAT, C. R., Vitonis, A. F., Andrews, S. V., Grosjean, P., Paranjpe, M. D., Horne, A. W., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05070-z · Cited by 38 · see citing works

Regulation of Pre-mRNA Splicing: Indispensable Role of Post-Translational Modifications of Splicing Factors

Kretová, M., Selicky, T., Čipáková, I., & Čipák, L. (2023) · Life · doi:10.3390/life13030604 · Cited by 35 · see citing works

ELAV/Hu RNA-binding protein family: key regulators in neurological disorders, cancer, and other diseases

Wutikeli, H., Xie, T., Xiong, W., & Shen, Y. (2025) · RNA Biology · doi:10.1080/15476286.2025.2471133 · Cited by 31 · see citing works

RNA binding proteins in senescence: A potential common linker for age-related diseases?

Varesi, A., Campagnoli, L. I. M., Barbieri, A., Rossi, L., Ricevuti, G., Esposito, C., Chirumbolo, S., Marchesi, N., & Pascale, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101958 · Cited by 28 · see citing works

Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases

Silvestri, B., Mochi, M., Garone, M. G., & Rosa, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314606 · Cited by 28 · see citing works

Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype

Ryu, S., Jung, M., Kim, C., Kang, H., Han, S., Cha, S., Jeong, S. M., & Lee, E. K. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04792-y · Cited by 18 · see citing works

The Antidepressant Effect of Resveratrol Is Related to Neuroplasticity Mediated by the ELAVL4-Bdnf mRNA Pathway

Ge, H., Si, L., Li, C., Huang, J., Sun, L., Wu, L., Xie, Y., Xiao, L., & Wang, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031113 · Cited by 15 · see citing works

RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression

Jung, M., Ryu, S., Kim, C., Cha, S., Kang, H., Ji, E., Hong, Y., Lee, Y., Han, S., Jeong, S. M., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05465-6 · Cited by 13 · see citing works

New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs

Martín-Martín, Y., Pérez-García, A., Torrecilla-Parra, M., Frutos, M. F.-D., Pardo, V., Casarejos, M. J., Busto, R., & Ramírez, C. M. (2022) · Cells · doi:10.3390/cells11162538 · Cited by 13 · see citing works

Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

Shi, S.-Q., Mahoney, C. E., Houdek, P., Zhao, W., Anderson, M. P., Zhuo, X., Beaudet, A. L., Sumová, A., Scammell, T. E., & Johnson, C. H. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.837523 · Cited by 14 · see citing works

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals

Liegro, C. M. D., Schiera, G., Schirò, G., & Liegro, I. D. (2024) · Genes · doi:10.3390/genes15030337 · Cited by 12 · see citing works

Modeling neurodegeneration with mutant-tau organoids

Pellegrini, L., & Lancaster, M. A. (2021) · Cell · doi:10.1016/j.cell.2021.07.031 · Cited by 11 · see citing works

Pum2 and TDP-43 refine area-specific cytoarchitecture post-mitotically and modulate translation of Sox5, Bcl11b, and Rorb mRNAs in developing mouse neocortex

Harb, K., Richter, M., Neelagandan, N., Magrinelli, E., Harfoush, H., Kuechler, K., Henis, M., Hermanns-Borgmeyer, I., de Anda, F. C., & Duncan, K. E. (2022) · eLife · doi:10.7554/elife.55199 · Cited by 11 · see citing works

Evidence of Involvement of the Calcitonin Gene‐Related Peptide in Restless Legs Syndrome

Mogavero, M. P., Fowowe, M., Sanni, A., Goli, M., Lanza, G., L’Episcopo, F., Ferini‐Strambi, L., Mechref, Y. S., & Ferri, R. (2025) · Movement Disorders · doi:10.1002/mds.30125 · Cited by 9 · see citing works

Combining affinity purification and mass spectrometry to define the network of the nuclear proteins interacting with the N-terminal region of FMRP

Kieffer, F., Hilal, F. F., Gay, A.-S., Debayle, D., Pronot, M., Poupon, G., Lacagne, I., Bardoni, B., Martin, S., & Gwizdek, C. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.954087 · Cited by 9 · see citing works

NCBP1 Improves Cognitive Function in Mice by Reducing Oxidative Stress, Neuronal Loss, and Glial Activation After Status Epilepticus

Gao, X., You, Z., Huang, C., Liu, Z., Tan, Z., Li, J., Liu, Y., Liu, X., Wei, F., Fan, Z., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03497-3 · Cited by 7 · see citing works

Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid?

Marchesi, N., Linciano, P., Campagnoli, L. I. M., Fahmideh, F., Rossi, D., Costa, G., Ambrosio, F. A., Barbieri, A., Collina, S., & Pascale, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512201 · Cited by 6 · see citing works

RNY3 modulates cell proliferation and IL13 mRNA levels in a T lymphocyte model: a possible new epigenetic mechanism of IL-13 regulation

Estravís, M., Garcı́a-Sánchez, A., Martin, M. J., Pérez‐Pazos, J., Isidoro‐García, M., Davila, I. J., & Sanz, C. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00920-6 · Cited by 5 · see citing works

Intracellular zinc signaling via Krüppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

Cha, S., Kim, C., Jung, M., Ryu, S., Han, S., Kim, W., & Lee, E. K. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101144 · Cited by 3 · see citing works

Conformational Properties of Poly(A)-Binding Protein Complexed with Poly(A) RNA

Chakrabortty, A., Mondal, S., & Bandyopadhyay, S. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c00704 · Cited by 3 · see citing works

Reducing HuD Levels Alleviates Alzheimer's Disease Pathology in 5xFAD Mice

Ji, E., Pal, A., Claybourne, Q. C., Michel, M., Munk, R. B., McDevitt, R. A., Cui, C., & Gorospe, M. (2025) · Aging Cell · doi:10.1111/acel.70080 · Cited by 2 · see citing works

A Transcriptomic Comparison of the HD10.6 Human Sensory Neuron-Derived Cell Line with Primary and iPSC Sensory NeuronsPreprint

Al-Abbasi, Z., Bhuiyan, S. A., Renthal, W. R., & Molliver, D. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.03.643725 · Cited by 2 · see citing works

Role of Tropomodulins in brain physiology and pathology

Hong, C., Liu, X., Zhou, Z., Xing, Y., Cao, Z., Chang, Y.-Z., & Gao, G. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107006 · Cited by 1 · see citing works

ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation

Bronson, K., Reddick, M. M., MacNicol, K. B., Bolen, C. R., Hardy, L. L., Lagasse, A., Odle, A. K., Childs, G. V., MacNicol, M. C., & MacNicol, A. M. (2026) · Biomolecules · doi:10.3390/biom16081119 · Cited by 1 · see citing works

Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17

Castro-Mendoza, P. B., Weaver, C. M., Chang, W., Medalla, M., Rockland, K. S., Lowery, L., McDonough, E. M., Varghese, M., Hof, P. R., Meyer, D. E., et al. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02819-y · Cited by 1 · see citing works

BmEL‐2 promotes triglyceride metabolism by regulating BmAGPATγ and BmFAF2 expression in Bombyx mori

Ma, D., Zhou, S., Shi, J., Gu, Y., Qin, S., Li, M., & Sun, X. (2024) · Insect Science · doi:10.1111/1744-7917.13446 · Cited by 1 · see citing works

RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression

Seo, J., Ryu, S., Zhang, W., Lee, E. K., & Jeong, S. M. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2542168 · Cited by 1 · see citing works

Altered circadian rhythms and sleep in a new Angelman Syndrome mouse modelPreprint

Shi, S.-Q., Mahoney, C. E., Houdek, P., Zhao, W., Anderson, M. P., Zhuo, X., Beaudet, A. L., Sumová, A., Scammell, T. E., & Johnson, C. H. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.26.465956

Study on the pro-inflammatory mechanism of the HuD antibody in promoting M1 polarization and paraneoplastic neurological syndrome occurrence

Yin, L., Yuan, W.-L., Wu, K., Zhang, L., & Li, Q. (2022) · Bioengineered · doi:10.1080/21655979.2022.2051267

Neurological Syndromes Associated With Autoantibodies to Intracellular Antigens

Georgios, M., & Anastasia, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95702-1.00110-x

Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity

Vijayakumar, A., Vasudevan, S., John, S., Ozbun, M. A., Bartee, E., & Palanisamy, V. (2025) · Immunometabolism · doi:10.1097/in9.0000000000000054

HuD and alpha-crystallin A axis protects neuro-retinal cells in early diabetes

Kim, C., Oh, S., & Park, Y. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05364-2

Change of Guards: ELAVL Proteins Switch miRNA Export Responsibility to Regulate Neuronal DifferentiationPreprint

Ray, S., Bhattacharyya, S. N., & Mukherjee, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.08.669247

Morphine reprograms brain-derived extracellular vesicles from cargo linked to synaptic remodelling in the prefrontal cortexPreprint

Gobira, P. H., Bastos, S., Rossi, R., Vægter, C. B., Chen, F., da Silva, N. R., Müller, H. K., Joca, S. R. L., Boesen, T. P., Viola, T. W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.12.675684

Severe Anti-CV2/CRMP5, Anti-Hu, and Anti-SOX1 Antibody-Positive Paraneoplastic Neurological Syndrome Associated With Tumor Recurrence During Atezolizumab Therapy

Tohge, R., Utsumi, K., Miki, K., Wang, C., Oki, M., Fujii, C., & Kondo, T. (2025) · Cureus · doi:10.7759/cureus.99224

Engineered targeted enhancement of translation in mammalian cell

Liu, J., Lv, Y., Zhou, Z., Huang, L., Lei, K., Tu, Z., Gong, C., Fang, Z., Wang, C., Wang, D., et al. (2026) · BMC Biology · doi:10.1186/s12915-026-02653-0

The RNA-Binding Protein ELAVL4/HuD Promotes Stress-Associated Tumor Survival in Neuroendocrine Cancers

Bishayee, K., Kaviarasan, V., Yoo, S. Y., Lee, S. H., & Park, Y. S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177882

The neuronal RNA-binding protein HuD activates shared biological pathways to regulate distinct stages of neuronal development and maturation

Dell’Orco, M., Gardiner, A. S., Twiss, J. L., Bolognani, F., & Perrone‐Bizzozero, N. I. (2026) · Genomic psychiatry : · doi:10.61373/gp026i.0030

Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction

Bronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works

Role of HuD in nervous system function and pathology

Perrone‐Bizzozero, N. I. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s389 · Cited by 52 · see citing works

The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity

Deschênes‐Furry, J., Perrone‐Bizzozero, N. I., & Jasmin, B. J. (2006) · BioEssays · doi:10.1002/bies.20449 · Cited by 115 · see citing works

Characterization of Multiple Exon 1 Variants and Neuron-specific Transcriptional Control of Mammalian HuD

Bronicki, L. (2013) · uO Research (University of Ottawa) · doi:10.20381/ruor-6404