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Orexins and fear: implications for the treatment of anxiety disorders

Flores, África, Saravia, Rocío, Maldonado, Rafael, Berrendero, Fernando·2015·Trends in Neurosciences

DOI 10.1016/j.tins.2015.06.005

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Abstract

An understanding of the neurobiological mechanisms involved in the regulation of fear is essential for the development of new treatments for anxiety disorders, such as phobias, panic, and post-traumatic stress disorders (PTSD). Orexins, also known as hypocretins, are neuropeptides located exclusively in hypothalamic neurons that have extensive projections throughout the central nervous system. Although this system was initially believed to be primarily involved in the regulation of feeding behavior, recent studies have shown that orexins also modulate neural circuits implicated in the expression and extinction of fear memories. Here, we discuss recent findings involving orexins in anxiety disorders and current clinical trials using orexin ligands that could be applied to identify new therapies for diseases characterized by pathological fear.

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Authors: Flores, Á., Saravia, R., Maldonado, R., & Berrendero, F.
Affiliations: Universitat Pompeu Fabra (ES)
ORCID: Flores, África
Maldonado, Rafael
Berrendero, Fernando
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2015-09
Volume: 38
Issue: 9
Pages: 550-559
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2015.06.005
OpenAlex: W1696117693
Cited by: 102
References: 101
Citations by year: 2026: 4 · 2025: 11 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 10 · 2018: 15 · 2017: 9 · 2016: 6
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: orexin, fear regulation, anxiety disorders, fear extinction, phobia, panic disorder, post-traumatic stress disorder, hypothalamus
MeSH terms: Orexins, Animals, Anxiety Disorders, Brain, Fear, Humans

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Orexins and fear: implications for the treatment of anxiety disorders

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