Maldonado, Rafael

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene

Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 1,722

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

Filliol, D., Ghozland, S., Chluba, J., Martin, M., Matthes, H. W. D., Simonin, F., Befort, K., Gavériaux-Ruff, C., Dierich, A., LeMeur, M., et al. (2000) · Nature Genetics

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 672

The endocannabinoid system in guarding against fear, anxiety and stress

Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience

Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology Research

Cited by 506

Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory

Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D. P., Pagès, G., Valverde, O., et al. (2002) · Neuron

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 456

Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal

Simonin, F., Valverde, O., Smadja, C., Slowe, S., Kitchen, I., Dierich, A., Le Meur, M., Roques, B. P., Maldonado, R., & Kieffer, B. L. (1998) · The EMBO Journal

Neuropeptides and Animal PhysiologyPain Mechanisms and Treatments

Cited by 418

Functional interaction between opioid and cannabinoid receptors in drug self-administration.

Navarro, M., Carrera, M. R. A., Fratta, W., Valverde, O., Cossu, G., Fattore, L., Chowen, J. A., Gómez, R., del Arco, I., Villanúa, M. A., et al. (2001) · The Journal of Neuroscience

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 378

Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses

Busquets-Garcia, A., Puighermanal, E., Pastor, A., de la Torre, R., Maldonado, R., & Ozaita, A. (2011) · Biological Psychiatry

Cannabis and Cannabinoid ResearchMemory and Neural Mechanisms

Cited by 273

Targeting the endocannabinoid system in the treatment of fragile X syndrome

Busquets-Garcia, A., Gomis-González, M., Guegan, T., Agustín-Pavón, C., Pastor, A., Mato, S., Pérez-Samartín, A., Matute, C., de la Torre, R., Dierssen, M., et al. (2013) · Nature Medicine

Genetics and Neurodevelopmental DisordersCannabis and Cannabinoid Research

Cited by 241

Participation of noradrenergic pathways in the expression of opiate withdrawal: biochemical and pharmacological evidence

MALDONADO, R. (1997) · Neuroscience & Biobehavioral Reviews

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 213

Crucial Role of CB2Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

Racz, I., Nadal, X., Alferink, J., Baños, J. E., Rehnelt, J., Martín, M., Pintado, B., Gutierrez-Adan, A., Sanguino, E., Manzanares, J., et al. (2008) · The Journal of Neuroscience

Pain Mechanisms and TreatmentsCannabis and Cannabinoid Research

Cited by 195

Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids

Arnoriaga-Rodríguez, M., Mayneris-Perxachs, J., Burokas, A., Contreras-Rodríguez, O., Blasco, G., Coll, C., Biarnés, C., Miranda-Olivos, R., Latorre, J., Moreno-Navarrete, J.-M., et al. (2020) · Cell Metabolism

Gut microbiota and healthTryptophan and brain disorders

Cited by 157

Cannabis-based medicine reduces multiple pathological processes in AβPP/PS1 mice

Aso, E., Sánchez-Pla, A., Vegas-Lozano, E., Maldonado, R., & Ferrer, I. (2014) · Journal of Alzheimer s Disease

Alzheimer's disease research and treatmentsCannabis and Cannabinoid Research

Cited by 154

Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system

Berrendero, F., Robledo, P., Trigo, J. M., Martín-García, E., & Maldonado, R. (2010) · Neuroscience & Biobehavioral Reviews

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 140

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

Pujadas, L., Rossi, D., Andrés, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., & Soriano, E. (2014) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 129

The blind men and the elephant: Systematic review of systematic reviews of cannabis use related health harms

Campeny, E., López-Pelayo, H., Nutt, D., Blithikioti, C., Oliveras, C., Nuño, L., Maldonado, R., Florez, G., Arias, F., Fernández-Artamendi, S., et al. (2020) · European Neuropsychopharmacology

Cannabis and Cannabinoid ResearchSubstance Abuse Treatment and Outcomes

Cited by 127

A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

Domingo-Rodriguez, L., Ruiz de Azua, I., Dominguez, E., Senabre, E., Serra, I., Kummer, S., Navandar, M., Baddenhausen, S., Hofmann, C., Andero, R., et al. (2020) · Nature Communications

Neurotransmitter Receptor Influence on BehaviorEating Disorders and Behaviors

Cited by 109

Orexins and fear: Implications for the treatment of anxiety disorders

Flores, Á., Saravia, R., Maldonado, R., & Berrendero, F. (2015) · Trends in Neurosciences

Sleep and Wakefulness ResearchMemory and Neural Mechanisms

Cited by 102

Involvement of the opioid and cannabinoid systems in pain control: New insights from knockout studies

Nadal, X., La Porta, C., Andreea Bura, S., & Maldonado, R. (2013) · European Journal of Pharmacology

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 76

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate

La Porta, C., Bura, S. A., Aracil-Fernández, A., Manzanares, J., & Maldonado, R. (2013) · Pain

Cannabis and Cannabinoid ResearchPain Mechanisms and Treatments

Cited by 75

Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cγ gene

Célérier, E., Simonnet, G., & Maldonado, R. (2004) · Neuropharmacology

Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 36

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

Gutiérrez‐Martos, M., Girard, B., Mendonça‐Netto, S., Perroy, J., Valjent, E., Maldonado, R., & Martin, M. (2018) · Addiction Biology

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 35

Frustrated expected reward induces differential transcriptional changes in the mouse brain: Microarrays and frustration

Martín-García, E., Fernández-Castillo, N., Burokas, A., Gutiérrez-Cuesta, J., Sánchez-Mora, C., Casas, M., Ribasés, M., Cormand, B., & Maldonado, R. (2015) · Addiction Biology

Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Cited by 16