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Cited by 439Mitochondrial Function and PathologyEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapy

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

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Paillusson, Sebastien, Stoica, Radu, Gomez-Suaga, Patricia, Lau, Dawn H.W., Mueller, Sarah, Miller, Tanya, Miller, Christopher C.J.·2016·Trends in Neurosciences
DOI 10.1016/j.tins.2016.01.008PMC PMC4780428
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Abstract

Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or 'MAM'). Moreover, several recent studies have shown that disturbances to ER-mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings.

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Authors
Paillusson, S., Stoica, R., Gomez-Suaga, P., Lau, D. H. W., Mueller, S., Miller, T., & Miller, C. C. J.
Affiliations
  • King's College London (GB)
  • Churchill Hospital (GB)
Corresponding author
  • Miller, Tanya
  • Miller, Christopher C.J.
ORCID
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2016-03
Volume
39
Issue
3
Pages
146-157
ISSN
0166-2236 (ISSN-L)
DOI
10.1016/j.tins.2016.01.008
PMC
PMC4780428
OpenAlex
W2279311208
Cited by
439
References
15
Citations by year
2026: 27 · 2025: 40 · 2024: 31 · 2023: 44 · 2022: 46 · 2021: 55 · 2020: 62 · 2019: 28 · 2018: 52 · 2017: 41 · 2016: 12
FWCI
4.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Neurosciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by)
Funders
  • Wellcome Trust
  • Parkinson's UK (G1308)
  • Motor Neurone Disease Association (MILLER/OCT08/6247)
  • Rosetrees Trust
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council (BB/L019299/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondria-associated membranes, ER-mitochondria contact sites, endoplasmic reticulum, mitochondria, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, neurodegenerative diseases, pathogenesis, therapeutic target
MeSH terms
Animals, Endoplasmic Reticulum, Humans, Mitochondria, Neurodegenerative Diseases

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