The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease
Open accessAbstract
It has been known for decades that degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs in both Alzheimer’s disease (AD) and Parkinson’s disease (PD), but it was given scant attention. It is now recognized that hyperphosphorylated tau in the LC is the first detectable AD-like neuropathology in the human brain, α-synuclein inclusions in the LC represent an early step in PD, and experimental LC lesions exacerbate neuropathology and cognitive/behavioral deficits in animal models. The purpose of this review is to consider the causes and consequences of LC pathology, dysfunction, and degeneration, as well as their implications for early detection and treatment.
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Cites
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Staging of brain pathology related to sporadic Parkinson’s disease
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Cited by
Locus coeruleus: a new look at the blue spot
Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720
Self-citationLocus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Betts, M. J., Kirilina, E., Otaduy, M. C. G., Ivanov, D., Acosta-Cabronero, J., Callaghan, M. F., Lambert, C., Cardenas-Blanco, A., Pine, K., Passamonti, L., et al. (2019) · Brain · doi:10.1093/brain/awz193 · Cited by 365
Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan
Dahl, M. J., Mather, M., Sander, M. C., & Werkle-Bergner, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0398-19.2020 · Cited by 72
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
Maciejewska, K., Czarnecka, K., & Szymański, P. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00293-5 · Cited by 64
Singh, A., Allen, D., Fracassi, A., Tumurbaatar, B., Natarajan, C., Scaduto, P., Woltjer, R., Kayed, R., Limon, A., Krishnan, B., et al. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200716 · Cited by 56
Metadata
- Authors
- Weinshenker, D.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 41
- Issue
- 4
- Pages
- 211-223
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2788770082
- Cited by
- 323
- References
- 141
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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