Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors
Open accessAbstract
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored. In the present study, we studied the effect of genetic deletion of P2rx7 on neurochemical changes in the hippocampus that might underlie the antidepressant phenotype. P2X7 receptor deficient mice (P2rx7-/-) displayed decreased immobility in the tail suspension test (TST) and an attenuated anhedonia response in the sucrose preference test (SPT) following bacterial endotoxin (LPS) challenge. The attenuated anhedonia was reproduced through systemic treatments with P2rx7 antagonists. The activation of P2rx7 resulted in the concentration-dependent release of [(3)H]glutamate in P2rx7+/+ but not P2rx7-/- mice, and the NR2B subunit mRNA and protein was upregulated in the hippocampus of P2rx7-/- mice. The brain-derived neurotrophic factor (BDNF) expression was higher in saline but not LPS-treated P2rx7-/- mice; the P2rx7 antagonist Brilliant blue G elevated and the P2rx7 agonist benzoylbenzoyl ATP (BzATP) reduced BDNF level. This effect was dependent on the activation of NMDA and non-NMDA receptors but not on Group I metabotropic glutamate receptors (mGluR1,5). An increased 5-bromo-2-deoxyuridine (BrdU) incorporation was also observed in the dentate gyrus derived from P2rx7-/- mice. Basal level of 5-HT was increased, whereas the 5HIAA/5-HT ratio was lower in the hippocampus of P2rx7-/- mice, which accompanied the increased uptake of [(3)H]5-HT and an elevated number of [(3)H]citalopram binding sites. The LPS-induced elevation of 5-HT level was absent in P2rx7-/- mice. In conclusion there are several potential mechanisms for the antidepressant phenotype of P2rx7-/- mice, such as the absence of P2rx7-mediated glutamate release, elevated basal BDNF production, enhanced neurogenesis and increased 5-HT bioavailability in the hippocampus.
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Brilliant Blue G attenuated the anhedonia induced by lipopolysaccharide.
“Initial evidence from Csolle et al. showed that treatment with Brilliant Blue G (BBG), a P2X7R antagonist, attenuated the anhedonia induced by lipopolysaccharide (LPS) [20] and decreased the immobility time of mice exposed to TST [85].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [20]
Treatment with P2X7R antagonists induces antidepressant-like effects in various animal models.
“Evidence from pharmacological studies have further corroborated this hypothesis, since treatment with P2X7R antagonists induce antidepressant-like effects in various animal models.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [20]
P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.
“Based on these findings, P2X7R-mediated increase in 5-HT levels might be an important mechanism involved in behavioral adaptation to stress.”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [20]
The BzATP-induced decrease in BDNF levels was mediated by P2X7R.
“suggesting that this response was mediated by P2X7R [20].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [20]
P2X7R KO mice present enhanced neurogenesis.
“These suggestions are supported by results showing that P2X7R KO mice presents enhanced neurogenesis [20].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [20]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645 · see citing works
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · cited 1× · see citing works
“In addition to TST, which examines active coping with behavioral stress, we also employed the sucrose preference test (SPT) to assess anhedonia, which is another core symptom of depression [53].”
MethodDecreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
Altered Cytokine Production in Mice Lacking P2X7Receptors
Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Interaction between BDNF and Serotonin: Role in Mood Disorders
Martinowich, K., & Lu, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301571 · Cited by 793 · see citing works
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787 · see citing works
Tovar, K. R., & Westbrook, G. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04180.1999 · Cited by 777 · see citing works
Development of β-adrenergic receptor subsensitivity by antidepressants
Banerjee, S. P., Kung, L. S., Riggi, S. J., & Chanda, S. K. (1977) · Nature · doi:10.1038/268455a0 · Cited by 722 · see citing works
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Zigova, T., Pencea, V., Wiegand, S. J., & Luskin, M. B. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0684 · Cited by 525 · see citing works
P2X <sub>7</sub> Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes
Duan, S., Anderson, C. M., Keung, E. C., Chen, Y., Chen, Y., & Swanson, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01320.2003 · Cited by 489 · see citing works
Frenois, F., Moreau, M., O’Connor, J., Lawson, M., Micon, C., Lestage, J., Kelley, K. W., Dantzer, R., & Castanon, N. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.005 · Cited by 438 · see citing works
Peng, W., Cotrina, M. L., Han, X., Yu, H., Bekar, L. K., Blum, L., Takano, T., Tian, G.-F., Goldman, S. A., & Nedergaard, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902531106 · Cited by 425 · see citing works
Is it time to reassess the BDNF hypothesis of depression?
Groves, J. O. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002075 · Cited by 403 · see citing works
P2X7 receptors in the nervous system
Sperlágh, B., Vizi, E. S., Wirkner, K., & Illés, P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.007 · Cited by 374 · see citing works
Self-citationSkolnick, P., Layer, R. T., Popik, P., Nowak, G., Paul, I. A., & Trullás, R. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979537 · Cited by 344 · see citing works
Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons
Thomas, C. G., Miller, A., & Westbrook, G. L. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00771.2005 · Cited by 286 · see citing works
Alterations of neuroplasticity in depression: the hippocampus and beyond
Fuchs, E., Czéh, B., Kole, M. H. P., Michaelis, T., & Lucassen, P. J. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.002 · Cited by 271 · see citing works
Sperlágh, B., Köfalvi, A., Deuchars, J., Atkinson, L., J. Milligan, C., Buckley, N. J., & Vizi, E. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00920.x · Cited by 264 · see citing works
Self-citationLucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl166 · Cited by 261 · see citing works
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_3942 · Cited by 245 · see citing works
Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine
Monleón, S., Parra, A., SIMON, V. M., Brain, P. F., D’Aquila, P. S., & Willner, P. (1995) · Psychopharmacology · doi:10.1007/bf02246218 · Cited by 235 · see citing works
Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224 · see citing works
NR2B-Containing Receptors Mediate Cross Talk among Hippocampal Synapses
Scimemi, A., Fine, A., Kullmann, D., & Rusakov, D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-04.2004 · Cited by 221 · see citing works
Implications of adult hippocampal neurogenesis in antidepressant action
Malberg, J. E. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0422 · Cited by 217 · see citing works
Rodrigues, R. J., Almeida, T., Richardson, P. J., Oliveira, C. R., & Cunha, R. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0628-05.2005 · Cited by 214 · see citing works
Boyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 209 · see citing works
Vanhoutte, P., & Bading, H. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00073-4 · Cited by 208 · see citing works
Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons
Anderson, C. M., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.003 · Cited by 207 · see citing works
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.07.001 · Cited by 206 · see citing works
Barden, N., Harvey, M., Gagné, B., Shink, É., Tremblay, M., Raymond, C., Labbé, M., Villeneuve, A., Rochette, D., Bordeleau, L., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30303 · Cited by 201 · see citing works
Balu, D. T., Hoshaw, B. A., Malberg, J. E., Rosenzweig-Lipson, S., Schechter, L. E., & Lucki, I. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.023 · Cited by 194 · see citing works
A new chapter in the field of memory: adult hippocampal neurogenesis
Koehl, M., & Abrous, D. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07609.x · Cited by 183 · see citing works
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 180 · see citing works
Molecular and cellular actions of chronic electroconvulsive seizures.
Duman, R. S., & Vaidya, V. A. (1998) · PubMed · Cited by 176 · see citing works
Stokes, L., Fuller, S. J., Sluyter, R., Skarratt, K. K., Gu, B. J., & Wiley, J. S. (2010) · The FASEB Journal · doi:10.1096/fj.09-150862 · Cited by 174 · see citing works
Neuroplasticity: from MRI to depressive symptoms
Fossati, P., Radtchenko, A., & Boyer, P. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.09.001 · Cited by 154 · see citing works
Molecular and Cellular Actions of Chronic Electroconvulsive Seizures
Duman, R. S., & Vaidya, V. A. (1998) · Journal of Ect · doi:10.1097/00124509-199809000-00004 · Cited by 154 · see citing works
Deltheil, T., Guiard, B. P., Cerdan, J., David, D. J., Tanaka, K. F., Repérant, C., Guilloux, J.-P., Coudoré, F., Hen, R., & Gardier, A. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.001 · Cited by 153 · see citing works
Toro, C. T., & Deakin, J. F. W. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.07.003 · Cited by 151 · see citing works
Wager‐Smith, K., & Markou, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.010 · Cited by 150 · see citing works
Szapacs, M. E., Mathews, T. A., Tessarollo, L., Lyons, W. E., Mamounas, L. A., & Andrews, A. M. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.03.026 · Cited by 147 · see citing works
Barbaccia, M. L., Gandolfi, O., Chuang, D. M., & Costa, E. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.16.5134 · Cited by 143 · see citing works
P2X7 receptor‐stimulation causes fever <i>via</i> PGE2 and IL‐1β release
Barberà‐Cremades, M., Baroja‐Mazo, A., Gomez, A. I., Machado, F., Di Virgilio, F., & Pelegrín, P. (2012) · The FASEB Journal · doi:10.1096/fj.12-205765 · Cited by 142 · see citing works
Law, A. J., Weickert, C. S., Webster, M. J., Herman, M. M., Kleinman, J. E., & Harrison, P. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02850.x · Cited by 141 · see citing works
Acute and chronic restraint stress alter the incidence of social conflict in male rats
Wood, G. E., Young, L. T., Reagan, L. P., & McEwen, B. S. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00026-0 · Cited by 141 · see citing works
Lavebratt, C., Åberg, E., Sjöholm, L. K., & Forsell, Y. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.02.113 · Cited by 140 · see citing works
Dı́az-Hernández, M., del Puerto, A., Díaz‐Hernandéz, J. I., Diez-Zaera, M., Lucas, J. J., Garrido, J. J., & Miras‐Portugal, M. T. (2008) · Journal of Cell Science · doi:10.1242/jcs.034082 · Cited by 136 · see citing works
ATP induces the release of IL-1 from LPS-primed cells in vivo.
Griffiths, R., Stam, E. J., Downs, J. T., & Otterness, I. G. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2821 · Cited by 128 · see citing works
McQuillin, A., Bass, N. J., Choudhury, K., Puri, V., Kosmin, M., Lawrence, J., Curtis, D., & Gurling, H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.6 · Cited by 117 · see citing works
Masin, M., Young, C., Lim, K., Barnes, S. J., Xu, X., Marschall, V., Brutkowski, W., Mooney, E. R., Górecki, D. C., & Murrell‐Lagnado, R. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01624.x · Cited by 112 · see citing works
Schnydrig, S., Korner, L., Landweer, S., Ernst, B., Walker, G., Otten, U., & Kunz, D. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.067 · Cited by 109 · see citing works
Boucher, A. A., Arnold, J. C., Hunt, G. E., Spiro, A., Spencer, J., Brown, C., McGregor, I. S., Bennett, M. R., & Kassiou, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.049 · Cited by 108 · see citing works
Csölle, C., Andó, R. D., Kittel, Á., Gölöncsér, F., Baranyi, M., Soproni, K., Zelena, D., Haller, J., Németh, T., Mócsai, A., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001933 · Cited by 108 · cited 9× · see citing works
“Under basal conditions, we detected a dysregulation of monoaminergic transmission, and these results are consistent with our previous findings in the amygdala [25].”
BackgroundResultInfluentialSelf-citationLabrousse, V. F., Costes, L., Aubert, A., Darnaudéry, M., Ferreira, G., Amédée, T., & Layé, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006006 · Cited by 106 · see citing works
Mundo, E., Tharmalingham, S., Neves-Pereira, M., Dalton, E. J., Macciardi, F. M., Parikh, S. V., Bolonna, A. A., Kerwin, R. W., Arranz, M. J., MAKOFF, A. J., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001218 · Cited by 105 · see citing works
BDNF and trkB mRNA expression in the hippocampal formation of aging rats
Lapchak, P. A., Araujo, D. M., Beck, K. D., Finch, C. E., Johnson, S. A., & Hefti, F. F. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90087-r · Cited by 104 · see citing works
Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
Papp, L., Vizi, E. S., & Sperlágh, B. (2004) · Neuroreport · doi:10.1097/00001756-200410250-00017 · Cited by 102 · see citing works
Self-citationAssociation between depression and the Gln460Arg polymorphism of P2RX7 gene: A dimensional approach
Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari‐Szekely, M., & Nemoda, Z. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30799 · Cited by 100 · see citing works
P2X7 Receptors in Rat Brain: Presence in Synaptic Terminals and Granule Cells
Miras‐Portugal, M. T., Dı́az-Hernández, M., Giráldez, L., Hervás, C., Gómez‐Villafuertes, R., Pérez‐Sen, R., Gualix, J., & Pintor, J. J. (2003) · Neurochemical Research · doi:10.1023/a:1025690913206 · Cited by 98 · see citing works
Adult Neurogenesis and Hippocampal Memory Function: New Cells, More Plasticity, New Memories?
Kitabatake, Y., Sailor, K. A., Ming, G., & Song, H. (2007) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2006.10.008 · Cited by 96 · see citing works
Shukla, V., Zimmermann, H., Wang, L., Kettenmann, H., Raab, S., Hammer, K., Sévigny, J., Robson, S. C., & Braun, N. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20508 · Cited by 94 · see citing works
Soronen, P., Mantere, O., Melartin, T. K., Suominen, K. H., Vuorilehto, M. S., Rytsälä, H. J., Arvilommi, P., Holma, I. A. K., Holma, M., Jylhä, P. J., et al. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31179 · Cited by 91 · see citing works
Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor
Delarasse, C., Gonnord, P., Galante, M., Auger, R., Daniel, H., Motta, I., & Kanellopoulos, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06008.x · Cited by 89 · see citing works
ATP and the purine type 2 X7 receptor affect sleep
Krueger, J. M., Taishi, P., De, A., Davis, C. J., Winters, B. D., Clinton, J. M., Szentirmai, É., & Zielinski, M. R. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00586.2010 · Cited by 89 · see citing works
Abnormal Kainate Receptor Expression in Prefrontal Cortex in Schizophrenia
Meador‐Woodruff, J. H. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00189-5 · Cited by 80 · see citing works
Purinergic receptor regulation of LPS-induced signaling and pathophysiology
Guerra, A. N., Fisette, P. L., Pfeiffer, Z. A., Quinchia-Rios, B. H., Prabhu, U., Aga, M., Denlinger, L. C., Guadarrama, A. G., Abozeid, S. H., Sommer, J. A., et al. (2003) · Journal of Endotoxin Research · doi:10.1177/09680519030090040701 · Cited by 74 · see citing works
Deltheil, T., Guiard, B. P., Guilloux, J., Nicolas, L., Deloménie, C., Repérant, C., Maître, E. L., Leroux‐Nicollet, I., Benmansour, S., Coudoré, F., et al. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.018 · Cited by 72 · see citing works
Negative and positive allosteric modulators of the P2X 7 receptor
Michel, A. D., Chambers, L. J., & WALTER, D. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707625 · Cited by 69 · see citing works
P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?
Green, E., Grozeva, D., Raybould, R., Elvidge, G. P., MacGregor, S., Craig, I., FARMER, A. E., McGuffin, P., Forty, L., Jones, L. A., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30931 · Cited by 66 · see citing works
Functional maturation of isolated neural progenitor cells from the adult rat hippocampus
Hogg, R. C., Chipperfield, H., Whyte, K. A., Stafford, M. R., Hansen, M. A., Cool, S. M., Nurcombe, V., & Adams, D. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03346.x · Cited by 66 · see citing works
Williams, S. N., & Undieh, A. S. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.158535 · Cited by 66 · see citing works
Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype
Guiard, B. P., David, D. J. P., Deltheil, T., Chenu, F., Maître, E. L., Renoir, T., Leroux‐Nicollet, I., Sokoloff, P., Lanfumey, L., Hamon, M., et al. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707007857 · Cited by 65 · see citing works
Nowak, G., Legutko, B., Skolnick, P., & Popik, P. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01589-6 · Cited by 61 · see citing works
cDNA gene expression profile of rat hippocampus after chronic treatment with antidepressant drugs
Driguès, N., Poltyrev, T., Bejar, C., Weinstock, M., & Youdim, M. B. H. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0077-8 · Cited by 60 · see citing works
P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide
Zhang, L., Su, T., Choi, K. H., Maree, W., Li, C., Chung, M., Chen, Y.-S., Bai, Y., Chou, Y.-H., Barker, J. L., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.08.012 · Cited by 59 · see citing works
Functional evidence for presynaptic P2X7 receptors in adult rat cerebrocortical nerve terminals
Alloisio, S., Cervetto, C., Passalacqua, M., Barbieri, R., Maura, G., Nobile, M., & Marcoli, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.041 · Cited by 56 · see citing works
P2 receptor-mediated modulation of neurotransmitter release—an update
Sperlágh, B., Heinrich, A., & Csölle, C. (2007) · Purinergic Signalling · doi:10.1007/s11302-007-9080-0 · Cited by 56 · see citing works
Self-citationGrigoroiu‐Serbânescu, M., Herms, S., Mühleisen, T. W., Georgi, A., Diaconu, C. C., Strohmaier, J., Czerski, P. M., Hauser, J., Leszczyńska-Rodziewicz, A., Jamra, R. A., et al. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30952 · Cited by 55 · see citing works
Chromatographic analysis of dopamine metabolism in a Parkinsonian model
Baranyi, M., Milusheva, E., Vizi, E. S., & Sperlágh, B. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.018 · Cited by 51 · see citing works
Self-citationCognitive manic symptoms associated with the P2RX7 gene in bipolar disorder
Backlund, L., Nikamo, P., Hukic, D. S., Ek, I. R., Träskman‐Bendz, L., Landén, M., Edman, G., Schalling, M., Frisén, L., & Ösby, U. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00952.x · Cited by 50 · see citing works
Hracskó, Z., Baranyi, M., Csölle, C., Gölöncsér, F., Madarász, E., Kittel, Á., & Sperlágh, B. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-28 · Cited by 50 · see citing works
Self-citationP2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats
Gourine, A. V., Poputnikov, D. M., Zhernosek, N., Melenchuk, E. V., Gerstberger, R., Spyer, K. M., & Gourine, V. N. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706287 · Cited by 48 · see citing works
P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients
Nagy, G., Rónai, Z., Somogyi, A., Sasvári‐Székely, M., Rahman, O. A., Máté, A., Varga, T., & Nemoda, Z. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.08.021 · Cited by 47 · see citing works
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.08.001 · Cited by 47 · see citing works
Patti, L., Raiteri, L., Grilli, M., Parodi, M., Raiteri, M., & Marchi, M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.016 · Cited by 46 · see citing works
Brautigam, V. M., Frasier, C., Nikodémová, M., & Watters, J. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.012 · Cited by 46 · see citing works
Papp, L., Balázsa, T., Köfalvi, A., Erdélyi, F., Szabó, G., Vizi, E. S., & Sperlágh, B. (2004) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.066712 · Cited by 41 · see citing works
Self-citationVerderio, C., Bianco, F., Blanchard, M. P., Bergami, M., Canossa, M., Scarfone, E., & Matteoli, M. (2007) · Journal of Neurocytology · doi:10.1007/s11068-007-9011-6 · Cited by 40 · see citing works
Sanacora, G. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.003 · Cited by 39 · see citing works
Balázsa, T., Bíró, J., Gullai, N., Ledent, C. A., & Sperlágh, B. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.008 · Cited by 33 · see citing works
Self-citationViwatpinyo, K., & Chongthammakun, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.020 · Cited by 29 · see citing works
Pain and the Brain: Diabetic Neuropathic Pain
Jain, R. K. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.0808e22 · Cited by 27 · see citing works
Barnholtz‐Sloan, J. S., de Andrade, M., Page, G. P., King, T. M., Peterson, L. E., & Amos, C. I. (1999) · Genetic Epidemiology · doi:10.1002/gepi.1370170709 · Cited by 14 · see citing works
Reviewing Medications for Bipolar Disorder
Sanacora, G. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.7128br6c.e02 · Cited by 4 · see citing works
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Neuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107 · see citing works
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 395 · see citing works
P2X7 receptor: an emerging target in central nervous system diseases
Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390 · see citing works
Self-citationYue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0865-y · Cited by 334 · see citing works
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 327 · see citing works
ATP as a multi-target danger signal in the brain
Rodrigues, R. J., Tomé, Â. R., & Cunha, R. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00148 · Cited by 262 · see citing works
Oligodendrocyte lineage cells and depression
Zhou, B., Zhu, Z., Ransom, B. R., & Tong, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00930-0 · Cited by 239 · see citing works
The microglial ATP‐gated ion channel P2X7 as a CNS drug target
Bhattacharya, A., & Biber, K. (2016) · Glia · doi:10.1002/glia.23001 · Cited by 221 · see citing works
The P2X7 Receptor: Central Hub of Brain Diseases
Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works
Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology
Miras‐Portugal, M. T., Sebastián‐Serrano, Á., García, L. D. D., & Dı́az-Hernández, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3104-16.2017 · Cited by 154 · see citing works
Ullrich (2018) · doi:10.1038/mp.2017.188 · Cited by 145 · see citing works
Role of neuro-immunological factors in the pathophysiology of mood disorders
Bhattacharya, A., Derecki, N. C., Lovenberg, T. W., & Drevets, W. C. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4214-0 · Cited by 149 · see citing works
Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation
Chen, S., Qin, T., Seidel, J. L., Zheng, Y. Z., Eikermann, M., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Moskowitz, M. A., Ayata, C., & Eikermann‐Haerter, K. (2017) · Brain · doi:10.1093/brain/awx085 · Cited by 137 · see citing works
P2X7 Receptor Signaling in Stress and Depression
Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works
Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics
Ortiz, R., Ulrich, H., Zarate, C. A., & Machado‐Vieira, R. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.016 · Cited by 126 · see citing works
Recent advances in CNS P2X7 physiology and pharmacology: Focus on neuropsychiatric disorders
Bhattacharya, A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00030 · Cited by 115 · see citing works
P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System
Puchałowicz, K., Tarnowski, M., Baranowska‐Bosiacka, I., Chlubek, D., & Dziedziejko, V. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223672 · Cited by 109 · see citing works
Ion Channels and Receptors as Determinants of Microglial Function
Izquierdo, P., Attwell, D., & Madry, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.007 · Cited by 102 · see citing works
Purinergic mechanisms in neuroinflammation: An update from molecules to behavior
Beamer, E. H., Gölöncsér, F., Horváth, G., Bekő, K., Otrokocsi, L., Koványi, B., & Sperlágh, B. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.09.019 · Cited by 103 · see citing works
Self-citationP2X7 Receptor: A Potential Therapeutic Target for Depression?
Deussing, J. M., & Arzt, E. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.07.005 · Cited by 97 · see citing works
Purinergic receptors in psychiatric disorders
Krügel, U. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.032 · Cited by 95 · see citing works
Allsopp, R. C., Dayl, S. A., Schmid, R., & Evans, R. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00732-5 · Cited by 87 · see citing works
Su, W.-J., Zhang, T., Jiang, C.-L., & Wang, W. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00412 · Cited by 84 · see citing works
Farooq, R. K., Tanti, A., Ainouche, S., Roger, S., Belzung, C., & Camus, V. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.016 · Cited by 83 · see citing works
Regulation of P2X7 receptor expression and function in the brain
Jimenez-Mateos, E. M., Smith, J., Nicke, A., & Engel, T. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.008 · Cited by 79 · see citing works
Pathological ATPergic Signaling in Major Depression and Bipolar Disorder
Illés, P., Verkhratsky, A., & Tang, Y. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00331 · Cited by 77 · see citing works
The evolution of P2X7 antagonists with a focus on CNS indications
Rech, J. C., Bhattacharya, A., Letavic, M. A., & Savall, B. M. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.06.048 · Cited by 77 · see citing works
Bhattacharya, A., & Drevets, W. C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_43 · Cited by 76 · see citing works
Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 73 · see citing works
Astrocytes and major depression: The purinergic avenue
Zhao, Y. F., Verkhratsky, A., Tang, Y. C., & Illés, P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109252 · Cited by 73 · see citing works
Recourt, K., de Boer, P., van der Ark, P. D., Beneš, H., van Gerven, J., Ceusters, M., Nueten, L. V., Drevets, W. C., Bhatacharya, A., Browning, M. D., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02557-5 · Cited by 69 · see citing works
Li, R., Wang, J., Li, R., Zhu, F., Xu, W., Zha, G., He, G., Cao, H., Wang, Y., & Yang, J. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.03.002 · Cited by 68 · see citing works
P2X7 Antagonists as Potential Therapeutic Agents for the Treatment of CNS Disorders
Chrovian, C. C., Rech, J. C., Bhattacharya, A., & Letavic, M. A. (2014) · Progress in medicinal chemistry · doi:10.1016/b978-0-444-63380-4.00002-0 · Cited by 67 · see citing works
Purinergic Signaling and Related Biomarkers in Depression
Bartoli, F., Burnstock, G., Crocamo, C., & Carrà, G. (2020) · Brain Sciences · doi:10.3390/brainsci10030160 · Cited by 64 · see citing works
Sebastián‐Serrano, Á., Engel, T., de Diego-García, L., Olivos-Oré, L. A., Arribas-Blázquez, M., Martínez-Frailes, C., Pérez-Díaz, C., Millán, J. L., Artalejo, A. R., Miras‐Portugal, M. T., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw248 · Cited by 63 · see citing works
Recourt, K., van der Aart, J., Jacobs, G. E., de Kam, M., Drevets, W. C., Nueten, L. V., Kanhai, K. M. S., Siebenga, P. S., Zuiker, R. G. J. A., Ravenstijn, P. G. M., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120914206 · Cited by 61 · see citing works
Understanding the role of P2X7 in affective disorders—are glial cells the major players?
Stokes, L., Spencer, S. J., & Jenkins, T. A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00258 · Cited by 58 · see citing works
P2X7 receptors drive poly(I:C) induced autism-like behavior in mice
Horváth, G., Otrokocsi, L., Bekő, K., Baranyi, M., Kittel, Á., Fritz-Ruenes, P. A., & Sperlágh, B. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1895-18.2019 · Cited by 56 · see citing works
Self-citationA novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334
Lord, B., Ameriks, M. K., Wang, Q., Fourgeaud, L., Vliegen, M., Verluyten, W. L. M., Haspeslagh, P., Carruthers, N. I., Lovenberg, T. W., Bonaventure, P., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.09.026 · Cited by 55 · see citing works
The role of P2X7 receptors in a rodent PCP-induced schizophrenia model
Koványi, B., Csölle, C., Calovi, S., Hanuska, A., Kató, E., Köles, L., Bhattacharya, A., Haller, J., & Sperlágh, B. (2016) · Scientific Reports · doi:10.1038/srep36680 · Cited by 52 · see citing works
Self-citationP2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression
Otrokocsi, L., Kittel, Á., & Sperlágh, B. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx046 · Cited by 52 · see citing works
Self-citationGallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor
Wen, L., Tang, L., Zhang, M., Wang, C., Li, S., Wen, Y., Tu, H., Tian, H., Wei, J., Liang, P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116159 · Cited by 50 · see citing works
Gampe, K., Stefani, J., Hammer, K., Brendel, P., Pötzsch, A., Enikolopov, G., Enjyoji, K., Acker‐Palmer, A., Robson, S. C., & Zimmermann, H. (2014) · Stem Cells · doi:10.1002/stem.1846 · Cited by 47 · see citing works
Gürsel (2018) · doi:10.1016/j.neubiorev.2018.02.005 · Cited by 47 · see citing works
Ribeiro, D. E., Müller, H. K., Elfving, B., Eskelund, A., Joca, S. R., & Wegener, G. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119872173 · Cited by 45 · see citing works
Arıcıoğlu, F., Özkartal, C. Ş., Bastaskin, T., Tüzün, E., Kandemir, C., Şirvancı, S., Küçükali, C. İ., & Utkan, T. (2019) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2019.17.2.261 · Cited by 44 · see citing works
Mitochondria: A Connecting Link in the Major Depressive Disorder Jigsaw
Sharma, S., & Akundi, R. S. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180302120322 · Cited by 42 · see citing works
Ahn, Y. H., Tang, Y., & Illés, P. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2258281 · Cited by 41 · see citing works
Zhao, Y.-F., Ren, W.-J., Zhang, Y., He, J., Yin, H., Liao, Y., Rubini, P., Deussing, J. M., Verkhratsky, A., Yuan, Z., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031904 · Cited by 40 · see citing works
Li, R., Shang, Y., Hu, X., Yuan, Y. L., Zhou, T., Xiong, W., & Zou, X. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111708 · Cited by 38 · see citing works
Association of purinergic receptor P2RX7 gene polymorphisms with depression symptoms
Vereczkei, A., Abdul-Rahman, O., Halmai, Z., Nagy, G., Székely, A., Somogyi, A., Faludi, G., & Nemoda, Z. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.01.006 · Cited by 37 · see citing works
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works
Lei, L., Wang, Y., Chen, C.-Y., Wang, Y., & Zhang, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122988 · Cited by 37 · see citing works
Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved?
Leonard, B. E. (2015) · Modern trends in psychiatry · doi:10.1159/000435930 · Cited by 32 · see citing works
Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse
Troubat, R., Leman, S., Pinchaud, K., Surget, A., Barone, P. R., Roger, S., Guisquet, A. L., Brizard, B., Belzung, C., & Camus, V. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.012 · Cited by 33 · see citing works
Mitchell, N. C., Gould, G. G., Smolik, C. M., Koek, W., & Daws, L. C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00131 · Cited by 30 · see citing works
The roles of purinergic signaling in psychiatric disorders.
Cieślak, M., Czarnecka, J., & Roszek, K. (2015) · Acta Biochimica Polonica · doi:10.18388/abp.2015_1004 · Cited by 28 · see citing works
Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor
Gil, B., Smith, J., Tang, Y., Illés, P., & Engel, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042380 · Cited by 26 · see citing works
Gölöncsér, F., Baranyi, M., Balázsfi, D., Demeter, K., Haller, J., Freund, T. F. F., Zelena, D., & Sperlágh, B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00325 · Cited by 25 · see citing works
Self-citationMonoamine involvement in the antidepressant-like effect induced by P2 blockade
Diniz, C. R. A. F., Rodrigues, M., Casarotto, P. C., Pereira, V. S., Crestani, C. C., & Joca, S. R. L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.011 · Cited by 25 · see citing works
Chrovian, C. C., Soyode-Johnson, A., Ao, H., Bacani, G. M., Carruthers, N. I., Lord, B., Nguyen, L., Rech, J. C., Wang, Q., Bhattacharya, A., et al. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00303 · Cited by 25 · see citing works
Purinergic transmission in depressive disorders
Szopa, A., Socała, K., Serefko, A., Doboszewska, U., Wróbel, A., Poleszak, E., & Właź, P. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107821 · Cited by 25 · see citing works
Domingos, L. B., Hott, S. C., Terzian, A. L. B., & Resstel, L. B. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.005 · Cited by 25 · see citing works
P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex
Ren, W., Zhao, Y.-F., Li, J., Rubini, P., Yuan, Z., Tang, Y., & Illés, P. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad166 · Cited by 24 · see citing works
Purinergic P2X7 receptor as a potential therapeutic target in depression
Wang, Q., Jin, X., & Guan, W. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115959 · Cited by 22 · see citing works
Ribeiro, D. E., Casarotto, P. C., Staquini, L., Pinto e Silva, M. A., Biojone, C., Wegener, G., & Joca, S. (2019) · PeerJ · doi:10.7717/peerj.7834 · Cited by 21 · see citing works
P2X7 Receptor-Related Genetic Mouse Models – Tools for Translational Research in Psychiatry
Urbina-Treviño, L., von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.876304 · Cited by 22 · see citing works
Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists
Ziff, J., Rudolph, D. A., Stenne, B., Koudriakova, T. B., Lord, B., Bonaventure, P., Lovenberg, T. W., Carruthers, N. I., Bhattacharya, A., Letavic, M. A., et al. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00304 · Cited by 20 · see citing works
P2X7 Receptor as a Potential Target for Major Depressive Disorder
Huang, Z., & Tan, S. (2021) · Current Drug Targets · doi:10.2174/1389450122666210120141908 · Cited by 20 · see citing works
Tang, Y., Illes, P., Zhang, Y., Yin, H.-Y., & Rubini, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220302152400 · Cited by 20 · see citing works
Self-citationPurinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease
Ribeiro, D. E., Petiz, L. L., Glaser, T., Oliveira‐Giacomelli, Á., Andrejew, R., Saab, F. D. A. R., Milanis, M. D. S., Campos, H. C., Arnaud-Sampaio, V. F., de Oliveira, S. L. B., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109371 · Cited by 20 · see citing works
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Gonçalves, M. C. B., Andrejew, R., & Gubert, C. (2022) · CNS Drugs · doi:10.1007/s40263-022-00934-0 · Cited by 19 · see citing works
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Sun, B.-X., Peng, A., Liu, P., Wang, M., Ding, H., Hu, Y., & Kang, L. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09879-x · Cited by 19 · see citing works
Maraula, G., Lana, D., Coppi, E., Gentile, F., Mello, T., Melani, A., Galli, A., Giovannini, M. G., Pedata, F., & Pugliese, A. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115273 · Cited by 19 · see citing works
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von Mücke-Heim, I.-A., & Deussing, J. M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109366 · Cited by 18 · see citing works
Huang, H., Zheng, S., Chen, M., Xie, L., Li, Z., Guo, M. A., Wang, J., Lu, M., & Zhu, X. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101993 · Cited by 18 · see citing works
Calovi, S., Mut-Arbona, P., Tod, P., Iring, A., Nicke, A., Mato, S., Vizi, E. S., Tønnesen, J., & Sperlágh, B. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.566251 · Cited by 18 · see citing works
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Lee, S., Ha, H., Jang, J., & Byun, Y. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629141418 · Cited by 16 · see citing works
Kovács, G., Környei, Z., Tóth, K., Baranyi, M., Brunner, J., Neubrandt, M., Dénes, Á., & Sperlágh, B. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.07.010 · Cited by 16 · see citing works
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Self-citationda Silva, R. B., Siebel, A. M., & Bonan, C. D. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.05.005 · Cited by 14 · see citing works
Wang, T., Yang, J., Zhu, Y., Niu, N., Ding, B., Wang, P., Zhao, H., Li, N., Chao, Y., Gao, S., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.114 · Cited by 13 · see citing works
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Simões, J. L. B., Galvan, A. C. L., da Silva, E. L. M., Ignácio, Z. M., & Bagatini, M. D. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01215-6 · Cited by 13 · see citing works
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Mayhew, J., Graham, B. A., Biber, K. P. H., Nilsson, M., & Walker, F. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.06.023 · Cited by 13 · see citing works
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Cherninskyi, A., Storozhuk, M., Maximyuk, O. P., Kulyk, V. B., & Krishtal, O. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00986-8 · Cited by 11 · see citing works
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Yao, C., Jiang, X., Ye, X., Xie, T., & Bai, R. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200007 · Cited by 10 · see citing works
The P2X7 receptor in depression: Novel insights and therapeutic implications
Zhong, Y.-T., Pi, C., Zuo, Y., Yan, W., Li, W., Jiang, Y., Lei, T., Zheng, W., Jiang, J., Yang, Y., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107011 · Cited by 9 · see citing works
Ren, X.-Y., Rubini, P., Engel, T., Tang, Y., & Illés, P. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107989 · Cited by 9 · see citing works
Zhang, Z., Wang, T., Luo, Z., Zaib, M. H., Yi, M., Zeng, H., Li, P., Tang, D., Verkhratsky, A., & Nie, H. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09979-2 · Cited by 9 · see citing works
Szabó, D., Otrokocsi, L., & Sperlágh, B. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03509-0 · Cited by 8 · see citing works
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Sikka, P., Behl, T., Chandel, P., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., & Meraya, A. M. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00550-2 · Cited by 7 · see citing works
Yang, G., Zhou, S., Feng, Y., Lang, J., Chen, Y., & Ren, H. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s454670 · Cited by 8 · see citing works
Targeting inflammasome complexes as a novel therapeutic strategy for mood disorders
de Miranda, A. S., Toscano, E. C. D. B., O’Connor, J. C., & Teixeira, A. L. (2024) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2024.2366872 · Cited by 9 · see citing works
Kristóf, Z., Gál, Z., Török, D., Eszlári, N., Sütöri, S., Sperlágh, B., Anderson, I. M., Deakin, J. F. W., Bagdy, G., Juhász, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020865 · Cited by 7 · see citing works
Self-citationWan, M.-M., Fu, Z.-Y., Jin, T., Wang, Z.-Y., Sun, X., & Gao, W. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-09991-0 · Cited by 7 · see citing works
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Charvériat, M., & Guiard, B. P. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.006 · Cited by 7 · see citing works
Domingos, L. B., da Silva-Júnior, A. F., Diniz, C. R. A. F., Rosa, J., Terzian, A. L. B., & Resstel, L. B. M. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110177 · Cited by 6 · see citing works
Repurposing Anti-inflammatory Agents for Mood Disorders: an Updated Review of Current Evidence
Kittur, M. E., Jones, B. D. M., Dai, N., Mahboob, M., & Husain, M. I. (2022) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-022-00267-1 · Cited by 6 · see citing works
Major depressive disorder (mdd): emerging immune targets at preclinical level
Varma, M., Kaur, A., Bhandari, R., Kumar, A., & Kuhad, A. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2225216 · Cited by 5 · see citing works
- Authors
- Csölle, C., Baranyi, M., Zsilla, G., Kittel, Á., Gölöncsér, F., Illes, P., Papp, E., Vizi, E. S., & Sperlágh, B.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Semmelweis University (HU)
- Corresponding author
- Sperlágh, Beáta
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-06-21
- Volume
- 8
- Issue
- 6
- Pages
- e66547
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3689833
- OpenAlex
- W2089887997
- Cited by
- 128
- References
- 109
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 10 · 2022: 19 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 12 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 7 · 2013: 1
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- Egészségügyi Tudományos Tanács
- Gedeon Richter
- National Institutes of Health
- Directorate for Biological Sciences
- University of California, Davis (95616, CA 95616)
- Medical Research Council
- National Cancer Institute (P01CA095616)
- National Institute of Neurological Disorders and Stroke (U24NS050606)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- P2X7 receptor, gene deletion, hippocampus, brain-derived neurotrophic factor, glutamate release, NR2B subunit, anhedonia, endotoxin, serotonin, neurogenesis, dentate gyrus, NMDA receptor, non-NMDA receptors
- MeSH terms
- Adenosine Triphosphate, Animals, Lipopolysaccharides, Serotonin, Gene Deletion, Mice, Knockout, Glutamic Acid, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Mice, Neurogenesis, Receptors, Purinergic P2X7, Anhedonia
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