The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy
Open accessAbstract
Extracellular vesicles (EVs) are membrane-delimited particles that are secreted by nearly all cell types. EVs mediate crucial physiological functions and pathophysiological processes in the CNS. As carriers of diverse bioactive cargoes (e.g., proteins, lipids, and nucleic acids) that can be modified in response to external stimuli, EVs have emerged as pathological mediators following neurotrauma such as spinal cord injury (SCI). We discuss the roles of endogenous EVs in the CNS as well as crosstalk with peripheral EVs in relation to neurotrauma, with a particular focus on SCI. We then summarize the status of EV-based therapeutic advances in preclinical animal models for these conditions. Finally, we discuss new bioengineering strategies that are poised to enhance CNS-specific therapeutic capabilities of EVs.
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“These EVs, originating from reactive astrocytes, are found to be rich in certain small GTPases, such as profilin-1 and fascin actin-bundling protein 1, as well as proteins like IL-1β and HIV-1 protein Nef, and miRNAs [197].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [197]
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Cites
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New Technologies for Analysis of Extracellular Vesicles
Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,697
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Immune response following traumatic spinal cord injury: Pathophysiology and therapies
Sterner, R. C., & Sterner, R. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084101 · Cited by 258
Liu, C., Hu, F., Jiao, G., Guo, Y., Zhou, P., Zhang, Y., Zhang, Z., Yi, J., You, Y., Li, Z., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01273-4 · Cited by 233
LncRNA-encoded peptides in cancer
Zhang, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01591-0 · Cited by 131
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Xie, Y., Sun, Y. X., Liu, Y., Zhao, J., Liu, Q., Xu, J., Qin, Y., He, R., Yuan, F., Wu, T., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04423 · Cited by 114
Metadata
- Authors
- Dutta, D., Khan, N., Wu, J., & Jay, S. M.
- Affiliations
- University of Maryland, College Park (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Wu, Junfang
- Jay, Steven M.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 44
- Issue
- 6
- Pages
- 492-506
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC8159852
- OpenAlex
- W3127311347
- Cited by
- 112
- References
- 119
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 26 · 2023: 29 · 2022: 15 · 2021: 7
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 358 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Trends in Neurosciences (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Maryland Stem Cell Research Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- extracellular vesicles, spinal cord injury, neurotrauma, EV cargo, EV-based therapeutics, preclinical animal models, pathobiology
- MeSH terms
- Extracellular Vesicles, Animals, Biological Transport, Proteins, Spinal Cord Injuries
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