Cited by 114Extracellular vesicles in diseaseSpinal Cord Injury ResearchNanoparticle-Based Drug Delivery

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Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy

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Dutta, Dipankar, Khan, Niaz, Wu, Junfang, Jay, Steven M.·2021·Trends in Neurosciences

DOI 10.1016/j.tins.2021.01.003PMC PMC8159852

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Abstract

Extracellular vesicles (EVs) are membrane-delimited particles that are secreted by nearly all cell types. EVs mediate crucial physiological functions and pathophysiological processes in the CNS. As carriers of diverse bioactive cargoes (e.g., proteins, lipids, and nucleic acids) that can be modified in response to external stimuli, EVs have emerged as pathological mediators following neurotrauma such as spinal cord injury (SCI). We discuss the roles of endogenous EVs in the CNS as well as crosstalk with peripheral EVs in relation to neurotrauma, with a particular focus on SCI. We then summarize the status of EV-based therapeutic advances in preclinical animal models for these conditions. Finally, we discuss new bioengineering strategies that are poised to enhance CNS-specific therapeutic capabilities of EVs.

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Authors: Dutta, D., Khan, N., Wu, J., & Jay, S. M.
Affiliations: University of Maryland, College Park (US)
University of Maryland, Baltimore (US)
Corresponding author: Wu, Junfang
Jay, Steven M.
ORCID: Dutta, Dipankar
Khan, Niaz
Wu, Junfang
Jay, Steven M.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2021-06
Volume: 44
Issue: 6
Pages: 492-506
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2021.01.003
PMC: PMC8159852
OpenAlex: W3127311347
Cited by: 112
References: 119
Citations by year: 2026: 18 · 2025: 17 · 2024: 26 · 2023: 29 · 2022: 15 · 2021: 7
FWCI: 2.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 358 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Trends in Neurosciences (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Maryland Stem Cell Research Fund
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: extracellular vesicles, spinal cord injury, neurotrauma, EV cargo, EV-based therapeutics, preclinical animal models, pathobiology
MeSH terms: Extracellular Vesicles, Animals, Biological Transport, Proteins, Spinal Cord Injuries

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Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy

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