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Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours

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A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues

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Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors

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Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs

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Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration

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A neural circuit for competing approach and defense underlying prey capture

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A distinct parabrachial–to–lateral hypothalamus circuit for motivational suppression of feeding by nociception

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A forebrain neural substrate for behavioral thermoregulation

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Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity

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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats

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Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus–Ventral Tegmental Area Neurocircuitry Depends on Energy State

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Effects of GABA and Leptin Receptor‐Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis

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Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

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Modulation of Feeding and Associated Behaviors by Lateral Hypothalamic Circuits

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High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus

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Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway

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Assessment of Safety and Outcome of Lateral Hypothalamic Deep Brain Stimulation for Obesity in a Small Series of Patients With Prader-Willi Syndrome

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Activation of a lateral hypothalamic-ventral tegmental circuit gates motivation

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An Iterative Neural Processing Sequence Orchestrates Feeding

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Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

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Increased orexin and melanin-concentrating hormone expression in the perifornical lateral hypothalamus of rats prone to overconsuming a fat-rich diet

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Activation of lateral hypothalamic area neurotensin-expressing neurons promotes drinking

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Lateral Hypothalamic Mc3R-Expressing Neurons Modulate Locomotor Activity, Energy Expenditure, and Adiposity in Male Mice

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Maternal Obesity Alters Neurotrophin-Associated MAPK Signaling in the Hypothalamus of Male Mouse Offspring

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Resting‐State Brain Connectivity Predicts Weight Loss and Cognitive Control of Eating Behavior After Vertical Sleeve Gastrectomy

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Lateral hypothalamic activity indicates hunger and satiety states in humans

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Lateral Hypothalamic GABAergic Neurons Encode and Potentiate Sucrose's Palatability

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Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice

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Deep Brain Stimulation of the Hypothalamus Leads to Increased Metabolic Rate in Refractory Obesity

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Cue-induced food seeking after punishment is associated with increased Fos expression in the lateral hypothalamus and basolateral and medial amygdala.

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Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area

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Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus

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Neural interfaces: Bridging the brain to the world beyond healthcare

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Hypothalamic obesity: from basic mechanisms to clinical perspectives

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The cognitive (lateral) hypothalamus

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Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases

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Neuro-endocrine-immune regulation of metabolic homeostasis

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Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections

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Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles

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Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway

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High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats

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Hypothalamic neural circuits regulating energy expenditure

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The GABAergic pathway from anterior cingulate cortex to lateral hypothalamus area regulates irritable bowel syndrome in mice and its underlying mechanism

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Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update

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A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake

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Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

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Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health

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CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state

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Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons

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The rostromedial tegmental nucleus gates fat overconsumption through ventral tegmental area output in male rats

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Obesity-driven hunger: From pathophysiology to intervention

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Does the lateral hypothalamus govern the transition between appetitive and consummatory feeding?

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Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions

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A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit

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GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism

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Cellular properties and axonal projections of thyrotropin-releasing hormone-expressing neurons in the mouse lateral hypothalamic area

Khuu, M. A., Antony, M. S., Lesser, J. H., Springer, K., Wainman, E. M., Driver, F. C., Mulkey, D. K., & Jackson, A. C. (2026) · Journal of Neurophysiology · doi:10.1152/jn.00616.2024 · Cited by 2 · see citing works

Primary cilia and melanin-concentrating hormone

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Melanin-concentrating hormone attenuates the hedonic feeding induced by orexin-A in the ventral tegmental area of high-fat diet male mice

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Functional properties of aged hypothalamic cells

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The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity

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Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling

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Zebrafish as a translational model for stress neurobiology: Mechanisms, tools, and advances

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Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch

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Balancing acts: lateral hypothalamic circuits coordinating feeding, anxiety, and social interactions

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Lateral hypothalamic orexinergic neurons as central mediators of pain modulation and non-pharmacological analgesia

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The nucleus accumbens shell regulates hedonic feeding via a rostral hotspotPreprint

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Diving Deep for Sleep: How pH and Blood Volume in the Lateral Hypothalamus Impact REM

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The potential effect of α7 nicotinic receptors modulation on palatable food-induced dependence-like behaviors

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A striosomal accumbens pathway drives compulsive seeking behaviors through an aversive Esr1+ hypothalamic-habenula circuitPreprint

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The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot

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Hypothalamic and physiological regulation of sleep in cancer

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The nucleus accumbens shell regulates hedonic feeding via a rostral hotspotPreprint

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Recent Advances in Hypothalamic Segmentation for Neuroimaging: A Comprehensive Review

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An Ultra-High-Resolution 17.2 T MRI Atlas (HypoAtlas) and Multimodal Pipeline to Study the Mouse Hypothalamus: Sexual Dimorphism and Lateralization InsightsPreprint

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Mechanisms that create a sequence of feeding-related behaviors in the mollusk Aplysia

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Dependence of energy balance and hypothalamic neuropeptide gene expression on initial tumor load in mice

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Hardwired differences: Sexually dimorphic neural connectomes in the brain-lung axis

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Hypothalamic insulin resistance in type 2 diabetes is localized to the posterior hypothalamus

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